UA85394C2 - Замещенные хинолины в качестве ингибиторов ферментов протеинтирозиновых киназ - Google Patents
Замещенные хинолины в качестве ингибиторов ферментов протеинтирозиновых киназInfo
- Publication number
- UA85394C2 UA85394C2 UAA200604144A UAA200604144A UA85394C2 UA 85394 C2 UA85394 C2 UA 85394C2 UA A200604144 A UAA200604144 A UA A200604144A UA A200604144 A UAA200604144 A UA A200604144A UA 85394 C2 UA85394 C2 UA 85394C2
- Authority
- UA
- Ukraine
- Prior art keywords
- tyrosine kinase
- protein tyrosine
- enzyme inhibitors
- kinase enzyme
- substituted quinolines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
В соответствии с данным изобретением предложены соединения формулы 1, имеющей структуру,где R, R, Rопределены в описании изобретения. Соединения проявляют активность противораковых агентов путем ингибирования рецепторов HER-2 и EGFR.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US66227303A | 2003-09-15 | 2003-09-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
UA85394C2 true UA85394C2 (ru) | 2009-01-26 |
Family
ID=34435322
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA200604144A UA85394C2 (ru) | 2003-09-15 | 2003-10-15 | Замещенные хинолины в качестве ингибиторов ферментов протеинтирозиновых киназ |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1670473A1 (ru) |
AU (1) | AU2003304497B2 (ru) |
BR (1) | BR0318503A (ru) |
CA (1) | CA2537978C (ru) |
MX (1) | MXPA06002846A (ru) |
UA (1) | UA85394C2 (ru) |
WO (1) | WO2005034955A1 (ru) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE602006021142D1 (de) | 2005-02-03 | 2011-05-19 | Gen Hospital Corp | Verfahren zur behandlung von gefitinib-resistentem krebs |
CN101203494A (zh) * | 2005-05-25 | 2008-06-18 | 惠氏公司 | 合成经取代3-氰基喹啉和其中间物的方法 |
CN103110948A (zh) | 2005-11-04 | 2013-05-22 | 惠氏公司 | mTOR抑制剂、赫赛汀和/或HKI-272的抗肿瘤组合 |
PL2010496T3 (pl) * | 2006-04-14 | 2011-01-31 | Astrazeneca Ab | 4-Anilinochinolino-3-karboksyamidy jako inhibitory kinazy CSF-1R |
US8022216B2 (en) | 2007-10-17 | 2011-09-20 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
DK2656844T3 (en) | 2008-06-17 | 2015-03-02 | Wyeth Llc | ANTINEOPLASTIC COMBINATIONS CONTAINING HKI-272 AND VINORELBINE |
CN105963313A (zh) | 2008-08-04 | 2016-09-28 | 惠氏有限责任公司 | 4-苯胺基-3-氰基喹啉和卡培他滨的抗肿瘤组合 |
CN101723854A (zh) | 2008-10-24 | 2010-06-09 | 上海特化医药科技有限公司 | 6-取代氨基-3-氰基喹啉类化合物的制备方法及其中间体 |
AU2010234968B2 (en) | 2009-04-06 | 2015-05-14 | Wyeth Llc | Treatment regimen utilizing neratinib for breast cancer |
GB0922302D0 (en) * | 2009-12-22 | 2010-02-03 | Imp Innovations Ltd | Compounds |
CN102146084B (zh) * | 2010-02-04 | 2014-05-07 | 江苏恒瑞医药股份有限公司 | 3-氰基-6-氨基喹啉类衍生物、其制备方法及其在医药上的应用 |
WO2012127441A1 (en) | 2011-03-23 | 2012-09-27 | Semorex Technologies Ltd. | Treatment of proliferative disorders with a chemiluminescent agent |
CN102718679B (zh) * | 2011-03-30 | 2016-06-08 | 北京万全阳光医药科技有限公司 | 一种诺那替尼关键中间体的制备方法 |
CN102731395B (zh) * | 2011-04-15 | 2015-02-04 | 中国科学院上海药物研究所 | 抗肿瘤药物来那替尼的中间体及其制备与应用 |
TWI532727B (zh) | 2012-01-17 | 2016-05-11 | 安斯泰來製藥股份有限公司 | 吡羧醯胺化合物 |
CN104926669A (zh) * | 2014-03-18 | 2015-09-23 | 江苏豪森医药集团连云港宏创医药有限公司 | 反式-4-二甲基胺基巴豆酸盐酸盐的制备方法 |
EP3677583A4 (en) * | 2017-09-01 | 2021-07-21 | Shanghai Pharmaceuticals Holding Co., Ltd. | NITROGEN HETEROCYCLIC COMPOUND, MANUFACTURING PROCESS, INTERMEDIATE, COMPOSITION AND USE |
CN110357854A (zh) * | 2018-03-26 | 2019-10-22 | 江苏创诺制药有限公司 | 一种来那替尼的制备方法 |
CN111848581B (zh) * | 2020-08-19 | 2021-08-10 | 昆明学院 | 3-氰基-4-苯胺基-6-氨基喹啉衍生物的制备方法 |
CN111995618B (zh) * | 2020-09-02 | 2021-06-11 | 重庆医科大学 | 一种来那替尼杂质g的制备方法 |
CN111943933B (zh) * | 2020-09-02 | 2021-05-28 | 重庆医科大学 | 一种来那替尼杂质d的制备方法 |
CN114920695B (zh) * | 2022-06-29 | 2023-06-20 | 深圳大学总医院 | 一种喹唑啉衍生物及其制备方法、药物组合物和应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6288082B1 (en) * | 1998-09-29 | 2001-09-11 | American Cyanamid Company | Substituted 3-cyanoquinolines |
PL370137A1 (en) * | 2001-11-27 | 2005-05-16 | Wyeth Holdings Corporation | 3-cyanoquinolines as inhibitors of egf-r and her2 kinases |
-
2003
- 2003-10-15 WO PCT/US2003/032612 patent/WO2005034955A1/en active Application Filing
- 2003-10-15 CA CA2537978A patent/CA2537978C/en not_active Expired - Lifetime
- 2003-10-15 AU AU2003304497A patent/AU2003304497B2/en active Active
- 2003-10-15 UA UAA200604144A patent/UA85394C2/ru unknown
- 2003-10-15 MX MXPA06002846A patent/MXPA06002846A/es active IP Right Grant
- 2003-10-15 EP EP03818857A patent/EP1670473A1/en not_active Withdrawn
- 2003-10-15 BR BRPI0318503-6A patent/BR0318503A/pt not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2537978A1 (en) | 2005-04-21 |
CA2537978C (en) | 2011-08-02 |
WO2005034955A1 (en) | 2005-04-21 |
AU2003304497B2 (en) | 2010-06-24 |
MXPA06002846A (es) | 2006-06-14 |
EP1670473A1 (en) | 2006-06-21 |
BR0318503A (pt) | 2006-09-12 |
AU2003304497A1 (en) | 2005-04-27 |
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