NL300302I2 - Antivirale verbindingen. - Google Patents

Antivirale verbindingen.

Info

Publication number: NL300302I2
Authority: NL; Netherlands
Prior art keywords: antiviral compounds; compounds; prophylaxis; processes; pharmaceutically acceptable
Prior art date: 1987-05-30

Application number

NL300302C

Other languages

English (en)

Other versions

NL300302I1 (nl

Original Assignee

Wellcome Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-05-30

Filing date

2007-11-02

Publication date

2008-05-01

2007-11-02 Application filed by Wellcome Found filed Critical Wellcome Found

2008-01-02 Publication of NL300302I1 publication Critical patent/NL300302I1/nl

2008-05-01 Publication of NL300302I2 publication Critical patent/NL300302I2/nl

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals

NL300302C 1987-05-30 2007-11-02 Antivirale verbindingen. NL300302I2 (nl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB878712745A GB8712745D0 (en)	1987-05-30	1987-05-30	Antiviral compounds

Publications (2)

Publication Number	Publication Date
NL300302I1 NL300302I1 (nl)	2008-01-02
NL300302I2 true NL300302I2 (nl)	2008-05-01

Family

ID=10618179

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL300302C NL300302I2 (nl)	1987-05-30	2007-11-02	Antivirale verbindingen.

Country Status (31)

Country	Link
US (2)	US5424295A (nl)
EP (1)	EP0294114B1 (nl)
JP (1)	JP2667873B2 (nl)
KR (1)	KR970009474B1 (nl)
CN (1)	CN1020107C (nl)
AT (1)	ATE142636T1 (nl)
AU (1)	AU622403B2 (nl)
CA (1)	CA1330990C (nl)
CS (1)	CS277006B6 (nl)
CY (2)	CY2001A (nl)
DD (2)	DD293962A5 (nl)
DE (2)	DE122008000003I2 (nl)
DK (1)	DK171670B1 (nl)
ES (1)	ES2091750T3 (nl)
FI (1)	FI89805C (nl)
GB (1)	GB8712745D0 (nl)
GR (1)	GR3021257T3 (nl)
HK (1)	HK78497A (nl)
HU (2)	HU205001B (nl)
IL (1)	IL86531A (nl)
LU (1)	LU91370I2 (nl)
MC (1)	MC1935A1 (nl)
MY (1)	MY103567A (nl)
NL (1)	NL300302I2 (nl)
NO (2)	NO172543C (nl)
NZ (1)	NZ224813A (nl)
PH (1)	PH27292A (nl)
PL (1)	PL157684B1 (nl)
PT (1)	PT87592B (nl)
SA (1)	SA99200688A (nl)
ZA (2)	ZA883829B (nl)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8712745D0 (en) *	1987-05-30	1987-07-01	Wellcome Found	Antiviral compounds
US6060459A (en) *	1987-10-28	2000-05-09	Pro-Neuron, Inc.	Enhancing blood cell count with oxypurine nucleosides
DD293498A5 (de) *	1989-07-20	1991-09-05	Zi Fuer Molekularbiologie Der Adw,De	Verfahren zur herstellung eines mittels fuer die behandlung oder prophylaxe von hepatits-infektionen bei mensch und tier
GB8919607D0 (en) *	1989-08-30	1989-10-11	Wellcome Found	Novel entities for cancer therapy
US6337209B1 (en)	1992-02-26	2002-01-08	Glaxo Wellcome Inc.	Molecular constructs containing a carcinoembryonic antigen regulatory sequence
KR910007655A (ko) *	1989-10-03	1991-05-30	엠. 피. 잭슨	치료용 뉴클레오시드
US5206351A (en) *	1990-06-15	1993-04-27	Ash Stevens, Inc.	Process for the preparation of 2-amino (2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl)adenine
GB9015914D0 (en) *	1990-07-19	1990-09-05	Wellcome Found	Heterocyclic compounds
US5283331A (en) *	1990-12-20	1994-02-01	Nippon Kayaku Kabushiki Kaisha	2-halogeno-oxetanocin A and phosphoric ester thereof
GB9104165D0 (en) *	1991-02-27	1991-04-17	Wellcome Found	Novel entities for hiv therapy
US5961987A (en) *	1996-10-31	1999-10-05	University Of Iowa Research Foundation	Ocular protein stimulants
JP3619017B2 (ja)	1998-06-24	2005-02-09	日本臓器製薬株式会社	新規アラビノシルアデニン誘導体
US6653318B1 (en) *	1999-07-21	2003-11-25	Yale University	5-(E)-Bromovinyl uracil analogues and related pyrimidine nucleosides as anti-viral agents and methods of use
NZ520852A (en) *	2000-02-18	2004-03-26	Southern Res Inst	Intermediates and methods for synthesizing 2-chloro-9- (2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine
US6753322B2 (en) *	2000-06-06	2004-06-22	Pfizer Inc	2-aminocarbonyl-9H-purine derivatives
JP3421330B2 (ja) *	2000-11-02	2003-06-30	持田製薬株式会社	ビダラビン注射用乾燥製剤
KR100718371B1 (ko) *	2001-11-27	2007-05-14	애나디스 파마슈티칼스, 인코포레이티드	３-β-Ｄ-리보푸라노실티아졸로[４,５-ｄ]피리디민누클레오시드 및 이의 용도
US7321033B2 (en) *	2001-11-27	2008-01-22	Anadys Pharmaceuticals, Inc.	3-B-D-ribofuranosylthiazolo [4,5-d] pyrimidine nucleosides and uses thereof
TW200418498A (en) *	2002-09-30	2004-10-01	Genelabs Tech Inc	Nucleoside derivatives for treating hepatitis C virus infection
PL2561872T3 (pl)	2004-12-17	2015-03-31	Anadys Pharmaceuticals Inc	3,5-Dipodstawione oraz 3,5,7-tripodstawione związki 3H-oksazolo[4,5-d]pirymidyn-2-onowe i ich proleki
US20060178512A1 (en) *	2005-02-04	2006-08-10	Cheruthur Govindan	Method for preparing amino acid esters of nucleoside analogues
TWI383987B (zh)	2005-11-21	2013-02-01	Anadys Pharmaceuticals Inc	製備５-胺基-３Ｈ-噻唑并〔４，５-ｄ〕嘧啶-２-酮之新穎方法
JP5345527B2 (ja) *	2006-06-22	2013-11-20	アナディスファーマシューティカルズインク	プロドラッグである５−アミノ−３−（３’−デオキシ−β−Ｄ−リボフラノシル）−チアゾロ［４，５−ｄ］ピリミジン−２，７−ジオン
EP2040712B1 (en)	2006-07-18	2011-03-02	Anadys Pharmaceuticals, Inc.	Carbonate and carbamate prodrugs of thiazolo [4,5-d] pyrimidines
CN101092441A (zh) *	2007-07-17	2007-12-26	北京本草天源药物研究院	一种奈拉滨的合成方法
US7846912B2 (en) *	2007-09-13	2010-12-07	Protia, Llc	Deuterium-enriched nelarabine
CN101768197A (zh) *	2008-12-29	2010-07-07	北京德众万全药物技术开发有限公司	一种奈拉滨的制备方法
CN103665076B (zh) *	2012-08-30	2018-01-09	上海阳帆医药科技有限公司	奈拉滨的制备方法
CN104892709B (zh) *	2015-06-04	2018-01-19	新乡学院	一种合成奈拉滨的方法
WO2018133835A1 (en) *	2017-01-20	2018-07-26	National Institute Of Biological Sciences, Beijing	Nucleoside analogue regulating mammalian circadian rhythm
WO2022258014A1 (zh) *	2021-06-09	2022-12-15	正大天晴药业集团股份有限公司	用于制备奈拉滨的重组基因工程菌及其应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE759011A (fr) *	1969-11-17	1971-05-17	Wellcome Found	Aminopurines
US3758684A (en) *	1971-09-07	1973-09-11	Burroughs Wellcome Co	Treating dna virus infections with amino purine derivatives
US4055717A (en) *	1976-05-17	1977-10-25	Parke, Davis & Company	9-(3-O-Acyl-β-D-arabinofuranosyl)adenine compounds, 9-(2,3-di-O-acyl-β-D-arabinofuranosyl)-adenine compounds, and method for their production
US4055718A (en) *	1976-05-17	1977-10-25	Parke, Davis & Company	9-(2-O-Acyl-β-D-arabinofuranosyl)-adenine compounds and method for their production
US4048432A (en) *	1976-05-17	1977-09-13	Parke, Davis & Company	9-(3,5-Di-O-acyl-β-D-arabinofuranosyl)adenine compounds and method for their production
JPS5515716A (en) *	1978-07-18	1980-02-04	Ajinomoto Co Inc	Production of purine arabinoside
US4371613A (en) *	1977-08-10	1983-02-01	Ajinomoto Company Incorporated	Method for producing purine arabinosides
JPS6053941B2 (ja) *	1977-08-10	1985-11-28	日本電気株式会社	バイアスライト駆動方式
GB1573777A (en) *	1977-11-03	1980-08-28	Wellcome Found	9-d-arabinonucleosides and an enzymatic process for their preparation
US4495180A (en) *	1982-06-21	1985-01-22	Merck & Co., Inc.	Prodrugs of Ara-A an antiviral agent
JPS58225097A (ja) *	1982-06-23	1983-12-27	Yamasa Shoyu Co Ltd	ヌクレオシド５′−アルキルもしくはアルケニルりん酸
EP0199451B1 (en) *	1985-03-16	1996-03-06	The Wellcome Foundation Limited	Therapeutic nucleosides
GB8712745D0 (en) *	1987-05-30	1987-07-01	Wellcome Found	Antiviral compounds

1987
- 1987-05-30 GB GB878712745A patent/GB8712745D0/en active Pending
1988
- 1988-05-27 IL IL86531A patent/IL86531A/xx active Protection Beyond IP Right Term
- 1988-05-27 ZA ZA883829A patent/ZA883829B/xx unknown
- 1988-05-27 CA CA000567966A patent/CA1330990C/en not_active Expired - Lifetime
- 1988-05-27 AU AU16718/88A patent/AU622403B2/en not_active Expired
- 1988-05-27 DD DD88340139A patent/DD293962A5/de not_active IP Right Cessation
- 1988-05-27 MY MYPI88000569A patent/MY103567A/en unknown
- 1988-05-27 PT PT87592A patent/PT87592B/pt not_active IP Right Cessation
- 1988-05-27 DD DD88316143A patent/DD282694A5/de not_active IP Right Cessation
- 1988-05-27 NO NO882357A patent/NO172543C/no not_active IP Right Cessation
- 1988-05-27 KR KR1019880006295A patent/KR970009474B1/ko not_active IP Right Cessation
- 1988-05-27 CN CN88103820A patent/CN1020107C/zh not_active Expired - Lifetime
- 1988-05-27 JP JP63128562A patent/JP2667873B2/ja not_active Expired - Lifetime
- 1988-05-27 DE DE122008000003C patent/DE122008000003I2/de active Active
- 1988-05-27 AT AT88304813T patent/ATE142636T1/de active
- 1988-05-27 DK DK289788A patent/DK171670B1/da not_active IP Right Cessation
- 1988-05-27 HU HU895829A patent/HU205001B/hu unknown
- 1988-05-27 PL PL1988272729A patent/PL157684B1/pl unknown
- 1988-05-27 NZ NZ224813A patent/NZ224813A/en unknown
- 1988-05-27 FI FI882511A patent/FI89805C/fi not_active IP Right Cessation
- 1988-05-27 ES ES88304813T patent/ES2091750T3/es not_active Expired - Lifetime
- 1988-05-27 DE DE3855522T patent/DE3855522T2/de not_active Expired - Lifetime
- 1988-05-27 MC MC881981A patent/MC1935A1/xx unknown
- 1988-05-27 EP EP88304813A patent/EP0294114B1/en not_active Expired - Lifetime
- 1988-05-27 HU HU882706A patent/HU199870B/hu active Protection Beyond IP Right Term
- 1988-05-27 CS CS883635A patent/CS277006B6/cs not_active IP Right Cessation
1989
- 1989-09-01 PH PH39191A patent/PH27292A/en unknown
- 1989-10-05 ZA ZA897598A patent/ZA897598B/xx unknown
1993
- 1993-08-23 US US08/110,487 patent/US5424295A/en not_active Expired - Lifetime
1995
- 1995-03-14 US US08/403,363 patent/US5539098A/en not_active Expired - Lifetime
1996
- 1996-10-03 GR GR960402608T patent/GR3021257T3/el unknown
1997
- 1997-06-12 HK HK78497A patent/HK78497A/xx not_active IP Right Cessation
- 1997-12-05 CY CY200197A patent/CY2001A/xx unknown
1999
- 1999-10-18 SA SA99200688A patent/SA99200688A/ar unknown
2007
- 2007-10-10 LU LU91370C patent/LU91370I2/fr unknown
- 2007-11-02 NL NL300302C patent/NL300302I2/nl unknown
- 2007-12-21 NO NO2007016C patent/NO2007016I2/no unknown
2008
- 2008-01-25 CY CY200800001C patent/CY2008001I1/el unknown

Also Published As

Publication number	Publication date
NZ224813A (en)	1991-04-26
DE122008000003I1 (de)	2008-04-17
GB8712745D0 (en)	1987-07-01
NL300302I1 (nl)	2008-01-02
EP0294114B1 (en)	1996-09-11
FI89805C (fi)	1993-11-25
DD282694A5 (de)	1990-09-19
GR3021257T3 (en)	1997-01-31
DK289788D0 (da)	1988-05-27
KR880013967A (ko)	1988-12-22
HU895829D0 (en)	1990-01-28
JP2667873B2 (ja)	1997-10-27
PL157684B1 (pl)	1992-06-30
FI882511A0 (fi)	1988-05-27
EP0294114A3 (en)	1990-01-24
HK78497A (en)	1997-06-20
PT87592A (pt)	1989-05-31
HUT47129A (en)	1989-01-30
CY2001A (en)	1997-12-05
PH27292A (en)	1993-05-04
ES2091750T3 (es)	1996-11-16
JPS63310831A (ja)	1988-12-19
IL86531A0 (en)	1988-11-15
CN1020107C (zh)	1993-03-17
CN1031233A (zh)	1989-02-22
CS8803635A2 (en)	1990-09-12
ZA883829B (en)	1990-01-31
NO172543C (no)	1993-08-04
NO172543B (no)	1993-04-26
NO882357D0 (no)	1988-05-27
PT87592B (pt)	1992-09-30
ATE142636T1 (de)	1996-09-15
DK289788A (da)	1988-12-01
PL272729A1 (en)	1989-02-06
IL86531A (en)	1993-07-08
SA99200688A (ar)	2005-12-03
US5424295A (en)	1995-06-13
HU199870B (en)	1990-03-28
DK171670B1 (da)	1997-03-10
DE122008000003I2 (de)	2010-02-04
FI89805B (fi)	1993-08-13
US5539098A (en)	1996-07-23
CY2008001I2 (el)	2009-11-04
NO2007016I2 (no)	2008-06-23
CS277006B6 (en)	1992-11-18
ZA897598B (en)	1990-01-31
KR970009474B1 (ko)	1997-06-13
DE3855522T2 (de)	1997-02-06
NO2007016I1 (no)	2008-01-14
LU91370I2 (fr)	2007-12-10
EP0294114A2 (en)	1988-12-07
FI882511A (fi)	1988-12-01
DE3855522D1 (de)	1996-10-17
AU622403B2 (en)	1992-04-09
CA1330990C (en)	1994-07-26
AU1671888A (en)	1988-12-01
DD293962A5 (de)	1991-09-19
MY103567A (en)	1993-08-28
CY2008001I1 (el)	2009-11-04
NO882357L (no)	1988-12-01
MC1935A1 (fr)	1989-05-19
HU205001B (en)	1992-03-30