DE122008000003I2 - Antivirale Verbindungen - Google Patents

Antivirale Verbindungen

Info

Publication number
DE122008000003I2
DE122008000003I2 DE122008000003C DE122008000003C DE122008000003I2 DE 122008000003 I2 DE122008000003 I2 DE 122008000003I2 DE 122008000003 C DE122008000003 C DE 122008000003C DE 122008000003 C DE122008000003 C DE 122008000003C DE 122008000003 I2 DE122008000003 I2 DE 122008000003I2
Authority
DE
Germany
Prior art keywords
antiviral compounds
compounds
prophylaxis
processes
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE122008000003C
Other languages
English (en)
Other versions
DE122008000003I1 (de
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of DE122008000003I1 publication Critical patent/DE122008000003I1/de
Publication of DE122008000003I2 publication Critical patent/DE122008000003I2/de
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DE122008000003C 1987-05-30 1988-05-27 Antivirale Verbindungen Active DE122008000003I2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878712745A GB8712745D0 (en) 1987-05-30 1987-05-30 Antiviral compounds

Publications (2)

Publication Number Publication Date
DE122008000003I1 DE122008000003I1 (de) 2008-04-17
DE122008000003I2 true DE122008000003I2 (de) 2010-02-04

Family

ID=10618179

Family Applications (2)

Application Number Title Priority Date Filing Date
DE122008000003C Active DE122008000003I2 (de) 1987-05-30 1988-05-27 Antivirale Verbindungen
DE3855522T Expired - Lifetime DE3855522T2 (de) 1987-05-30 1988-05-27 Antivirale Verbindungen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE3855522T Expired - Lifetime DE3855522T2 (de) 1987-05-30 1988-05-27 Antivirale Verbindungen

Country Status (31)

Country Link
US (2) US5424295A (de)
EP (1) EP0294114B1 (de)
JP (1) JP2667873B2 (de)
KR (1) KR970009474B1 (de)
CN (1) CN1020107C (de)
AT (1) ATE142636T1 (de)
AU (1) AU622403B2 (de)
CA (1) CA1330990C (de)
CS (1) CS277006B6 (de)
CY (2) CY2001A (de)
DD (2) DD293962A5 (de)
DE (2) DE122008000003I2 (de)
DK (1) DK171670B1 (de)
ES (1) ES2091750T3 (de)
FI (1) FI89805C (de)
GB (1) GB8712745D0 (de)
GR (1) GR3021257T3 (de)
HK (1) HK78497A (de)
HU (2) HU199870B (de)
IL (1) IL86531A (de)
LU (1) LU91370I2 (de)
MC (1) MC1935A1 (de)
MY (1) MY103567A (de)
NL (1) NL300302I2 (de)
NO (2) NO172543C (de)
NZ (1) NZ224813A (de)
PH (1) PH27292A (de)
PL (1) PL157684B1 (de)
PT (1) PT87592B (de)
SA (1) SA99200688A (de)
ZA (2) ZA883829B (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8712745D0 (en) * 1987-05-30 1987-07-01 Wellcome Found Antiviral compounds
US6054441A (en) * 1987-10-28 2000-04-25 Pro-Neuron, Inc. Oxypurine nucleosides and their congeners, and acyl derivatives thereof, for improvement of hematopoiesis
DD293498A5 (de) * 1989-07-20 1991-09-05 Zi Fuer Molekularbiologie Der Adw,De Verfahren zur herstellung eines mittels fuer die behandlung oder prophylaxe von hepatits-infektionen bei mensch und tier
US6337209B1 (en) 1992-02-26 2002-01-08 Glaxo Wellcome Inc. Molecular constructs containing a carcinoembryonic antigen regulatory sequence
GB8919607D0 (en) * 1989-08-30 1989-10-11 Wellcome Found Novel entities for cancer therapy
KR910007655A (ko) * 1989-10-03 1991-05-30 엠. 피. 잭슨 치료용 뉴클레오시드
US5206351A (en) * 1990-06-15 1993-04-27 Ash Stevens, Inc. Process for the preparation of 2-amino (2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl)adenine
GB9015914D0 (en) * 1990-07-19 1990-09-05 Wellcome Found Heterocyclic compounds
US5283331A (en) * 1990-12-20 1994-02-01 Nippon Kayaku Kabushiki Kaisha 2-halogeno-oxetanocin A and phosphoric ester thereof
GB9104165D0 (en) * 1991-02-27 1991-04-17 Wellcome Found Novel entities for hiv therapy
US5961987A (en) * 1996-10-31 1999-10-05 University Of Iowa Research Foundation Ocular protein stimulants
JP3619017B2 (ja) 1998-06-24 2005-02-09 日本臓器製薬株式会社 新規アラビノシルアデニン誘導体
US6653318B1 (en) * 1999-07-21 2003-11-25 Yale University 5-(E)-Bromovinyl uracil analogues and related pyrimidine nucleosides as anti-viral agents and methods of use
KR100695717B1 (ko) * 2000-02-18 2007-03-15 서던리서치인스티튜트 2-클로로-9-(2-데옥시-2-플루오로-베타-디-아라비노퓨라노실)-9에이치-퓨린-6-아민의 합성방법
US6753322B2 (en) * 2000-06-06 2004-06-22 Pfizer Inc 2-aminocarbonyl-9H-purine derivatives
JP3421330B2 (ja) * 2000-11-02 2003-06-30 持田製薬株式会社 ビダラビン注射用乾燥製剤
US7321033B2 (en) * 2001-11-27 2008-01-22 Anadys Pharmaceuticals, Inc. 3-B-D-ribofuranosylthiazolo [4,5-d] pyrimidine nucleosides and uses thereof
KR100718371B1 (ko) 2001-11-27 2007-05-14 애나디스 파마슈티칼스, 인코포레이티드 ３-β-Ｄ-리보푸라노실티아졸로[４,５-ｄ]피리디민누클레오시드 및 이의 용도
TW200418498A (en) * 2002-09-30 2004-10-01 Genelabs Tech Inc Nucleoside derivatives for treating hepatitis C virus infection
AR052995A1 (es) 2004-12-17 2007-04-18 Anadys Pharmaceuticals Inc Compuestos de 3h-oxazolo y 3h-tiazolo[4, 5 - d]pirimidin-2-ona3, 5-disustituidos y 3, 5, 7-trisustituidos con actividad inmunomoduladora, sus profarmacos, composiciones farmaceuticas que los contienen y su empleo en el tratamiento de enfermedades de origen viral
US20060178512A1 (en) * 2005-02-04 2006-08-10 Cheruthur Govindan Method for preparing amino acid esters of nucleoside analogues
AU2006318260B2 (en) 2005-11-21 2012-05-17 Anadys Pharmaceuticals, Inc. Process for the preparation of 5-amino-3H- thiazolo [4 , 5 -d] pyrimidin- 2 -one
KR101461604B1 (ko) * 2006-06-22 2014-11-18 애나디스 파마슈티칼스, 인코포레이티드 5-아미노-3-(3''-데옥시-β-Ｄ-리보퓨라노실)-티아졸로［4,5-ｄ］파이리미딘-2,7-다이온의 프로드럭
WO2008011406A2 (en) 2006-07-18 2008-01-24 Anadys Pharmaceuticals, Inc. Carbonate and carbamate prodrugs of thiazolo [4,5-d] pyrimidines
CN101092441A (zh) * 2007-07-17 2007-12-26 北京本草天源药物研究院 一种奈拉滨的合成方法
US7846912B2 (en) * 2007-09-13 2010-12-07 Protia, Llc Deuterium-enriched nelarabine
CN101768197A (zh) * 2008-12-29 2010-07-07 北京德众万全药物技术开发有限公司 一种奈拉滨的制备方法
CN103665076B (zh) * 2012-08-30 2018-01-09 上海阳帆医药科技有限公司 奈拉滨的制备方法
CN104892709B (zh) * 2015-06-04 2018-01-19 新乡学院 一种合成奈拉滨的方法
WO2018133835A1 (en) * 2017-01-20 2018-07-26 National Institute Of Biological Sciences, Beijing Nucleoside analogue regulating mammalian circadian rhythm
WO2022258014A1 (zh) * 2021-06-09 2022-12-15 正大天晴药业集团股份有限公司 用于制备奈拉滨的重组基因工程菌及其应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE759011A (fr) * 1969-11-17 1971-05-17 Wellcome Found Aminopurines
US3758684A (en) * 1971-09-07 1973-09-11 Burroughs Wellcome Co Treating dna virus infections with amino purine derivatives
US4055718A (en) * 1976-05-17 1977-10-25 Parke, Davis & Company 9-(2-O-Acyl-β-D-arabinofuranosyl)-adenine compounds and method for their production
US4055717A (en) * 1976-05-17 1977-10-25 Parke, Davis & Company 9-(3-O-Acyl-β-D-arabinofuranosyl)adenine compounds, 9-(2,3-di-O-acyl-β-D-arabinofuranosyl)-adenine compounds, and method for their production
US4048432A (en) * 1976-05-17 1977-09-13 Parke, Davis & Company 9-(3,5-Di-O-acyl-β-D-arabinofuranosyl)adenine compounds and method for their production
US4371613A (en) * 1977-08-10 1983-02-01 Ajinomoto Company Incorporated Method for producing purine arabinosides
JPS5515716A (en) * 1978-07-18 1980-02-04 Ajinomoto Co Inc Production of purine arabinoside
JPS6053941B2 (ja) * 1977-08-10 1985-11-28 日本電気株式会社 バイアスライト駆動方式
GB1573777A (en) * 1977-11-03 1980-08-28 Wellcome Found 9-d-arabinonucleosides and an enzymatic process for their preparation
US4495180A (en) * 1982-06-21 1985-01-22 Merck & Co., Inc. Prodrugs of Ara-A an antiviral agent
JPS58225097A (ja) * 1982-06-23 1983-12-27 Yamasa Shoyu Co Ltd ヌクレオシド５′−アルキルもしくはアルケニルりん酸
CA1285935C (en) * 1985-03-16 1991-07-09 Janet Lister Rideout Therapeutic nucleosides
GB8712745D0 (en) * 1987-05-30 1987-07-01 Wellcome Found Antiviral compounds

Also Published As

Publication number Publication date
ATE142636T1 (de) 1996-09-15
NO882357D0 (no) 1988-05-27
JP2667873B2 (ja) 1997-10-27
IL86531A0 (en) 1988-11-15
PL272729A1 (en) 1989-02-06
NO172543B (no) 1993-04-26
DE122008000003I1 (de) 2008-04-17
EP0294114A3 (de) 1990-01-24
FI882511A0 (fi) 1988-05-27
CY2008001I1 (el) 2009-11-04
US5424295A (en) 1995-06-13
GB8712745D0 (en) 1987-07-01
ZA883829B (en) 1990-01-31
ES2091750T3 (es) 1996-11-16
AU622403B2 (en) 1992-04-09
NO172543C (no) 1993-08-04
EP0294114A2 (de) 1988-12-07
DE3855522T2 (de) 1997-02-06
CA1330990C (en) 1994-07-26
CY2008001I2 (el) 2009-11-04
SA99200688A (ar) 2005-12-03
DD282694A5 (de) 1990-09-19
NO2007016I2 (no) 2008-06-23
PL157684B1 (pl) 1992-06-30
CS8803635A2 (en) 1990-09-12
NL300302I1 (nl) 2008-01-02
IL86531A (en) 1993-07-08
GR3021257T3 (en) 1997-01-31
MC1935A1 (fr) 1989-05-19
NL300302I2 (nl) 2008-05-01
FI89805B (fi) 1993-08-13
EP0294114B1 (de) 1996-09-11
FI882511A (fi) 1988-12-01
US5539098A (en) 1996-07-23
JPS63310831A (ja) 1988-12-19
HU205001B (en) 1992-03-30
NZ224813A (en) 1991-04-26
HK78497A (en) 1997-06-20
DD293962A5 (de) 1991-09-19
ZA897598B (en) 1990-01-31
DK289788A (da) 1988-12-01
PH27292A (en) 1993-05-04
HU895829D0 (en) 1990-01-28
HU199870B (en) 1990-03-28
DK289788D0 (da) 1988-05-27
PT87592A (pt) 1989-05-31
CY2001A (en) 1997-12-05
LU91370I2 (fr) 2007-12-10
KR970009474B1 (ko) 1997-06-13
AU1671888A (en) 1988-12-01
FI89805C (fi) 1993-11-25
NO2007016I1 (no) 2008-01-14
CS277006B6 (en) 1992-11-18
DE3855522D1 (de) 1996-10-17
HUT47129A (en) 1989-01-30
PT87592B (pt) 1992-09-30
KR880013967A (ko) 1988-12-22
CN1020107C (zh) 1993-03-17
CN1031233A (zh) 1989-02-22
NO882357L (no) 1988-12-01
DK171670B1 (da) 1997-03-10
MY103567A (en) 1993-08-28

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