MXPA04003479A - Novedosos derivados de 4-fenil-4[1h-imidazol-2-il]piperidina sustituida y su uso como agonistas selectivos no peptidicos de opiodes delta. - Google Patents

Novedosos derivados de 4-fenil-4[1h-imidazol-2-il]piperidina sustituida y su uso como agonistas selectivos no peptidicos de opiodes delta.

Info

Publication number
MXPA04003479A
MXPA04003479A MXPA04003479A MXPA04003479A MXPA04003479A MX PA04003479 A MXPA04003479 A MX PA04003479A MX PA04003479 A MXPA04003479 A MX PA04003479A MX PA04003479 A MXPA04003479 A MX PA04003479A MX PA04003479 A MXPA04003479 A MX PA04003479A
Authority
MX
Mexico
Prior art keywords
imidazol
phenyl
piperidine derivatives
opioid agonists
selective non
Prior art date
Application number
MXPA04003479A
Other languages
English (en)
Inventor
Theo Frans Meert
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MXPA04003479A publication Critical patent/MXPA04003479A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

La presente invencion se relaciona con novedosos derivados de 4-fenil-4-piperidina de acuerdo con la formula (I)(Ver formula I),las sales de accion de acido o base farmaceuticamente aceptable de los mismos, las formas estereoquimicas isomericas de los mismos, las formas tautomericas de los mismos y las formas de N-oxido de los mismos; en especial se reclaman compuestos de acuerdo con la formula (I) en los cuales A=B es C=O o SO2,X es un enlace covalente, R1 es alquiloxi, alquiloxialquilo, Ar o NR9R10es independientemente hidrogeno, o Aro A=B y R1 juntos forman un radical benzoxazolilo; p es cero, R3 es bencilo opcionalmente sustituido con hidroxi, alquilo o alquiloxicarbonilo y cada uno de R4 y R5 es hidrogeno; la invencion se relaciona asimismo con procedimientos para la preparacion de los compuestos de acuerdo con la presente invencion y su uso en medicina, en especial como agonistas selectivos no peptidicos de opioides d para usar en el tratamiento de diversos trastornos dolorosos.
MXPA04003479A 2001-10-15 2002-10-10 Novedosos derivados de 4-fenil-4[1h-imidazol-2-il]piperidina sustituida y su uso como agonistas selectivos no peptidicos de opiodes delta. MXPA04003479A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01203926 2001-10-15
PCT/EP2002/011372 WO2003033486A1 (en) 2001-10-15 2002-10-10 Novel substituted 4-phenyl-4-[1h-imidazol-2-yl]-piperidine derivatives and their use as selective non-peptide delta opioid agonists

Publications (1)

Publication Number Publication Date
MXPA04003479A true MXPA04003479A (es) 2004-07-30

Family

ID=8181080

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04003479A MXPA04003479A (es) 2001-10-15 2002-10-10 Novedosos derivados de 4-fenil-4[1h-imidazol-2-il]piperidina sustituida y su uso como agonistas selectivos no peptidicos de opiodes delta.

Country Status (26)

Country Link
US (2) US7282508B2 (es)
EP (1) EP1438304B1 (es)
JP (1) JP4417108B2 (es)
KR (1) KR100898562B1 (es)
CN (1) CN100354273C (es)
AR (1) AR037506A1 (es)
AT (1) ATE347549T1 (es)
AU (1) AU2002346994B2 (es)
BR (1) BR0213327A (es)
CA (1) CA2462953C (es)
CY (1) CY1106356T1 (es)
DE (1) DE60216627T2 (es)
EA (1) EA006507B1 (es)
ES (1) ES2278065T3 (es)
HR (1) HRP20040324A2 (es)
HU (1) HUP0600447A3 (es)
IL (2) IL161348A0 (es)
MX (1) MXPA04003479A (es)
MY (1) MY137356A (es)
NO (1) NO327602B1 (es)
NZ (1) NZ531679A (es)
PL (1) PL367967A1 (es)
PT (1) PT1438304E (es)
UA (1) UA76224C2 (es)
WO (1) WO2003033486A1 (es)
ZA (1) ZA200402818B (es)

Families Citing this family (15)

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MXPA04003480A (es) * 2001-10-15 2004-07-30 Janssen Pharmaceutica Nv Derivados de 4-fenil-4-(1h-imidazol-2-il)-piperidina sustituida para la reduccion de la lesion isquemica.
TW200403058A (en) * 2002-04-19 2004-03-01 Bristol Myers Squibb Co Heterocyclo inhibitors of potassium channel function
US6982268B2 (en) 2002-05-08 2006-01-03 Neurogen Corporation Substituted imidazolylmethyl pyridine and pyrazine derivatives GABAA receptor ligands
JP2005535650A (ja) * 2002-07-03 2005-11-24 グラクソ　グループ　リミテッド タキキニンアンタゴニストおよびセロトニン再取り込み阻害剤としての置換４−フェニル−ピペリジン−アミド
CL2004000754A1 (es) * 2003-04-11 2005-02-25 Janssen Pharmaceutica Nv Uso de compuestos derivados de 4-fenil-4-(1h-imidazol-2-il)piperidina, como agonistas delta-opioides no peptidicos, para preparar un medicamento util en prevenir o tratar trastornos del sistema nervioso central.
KR20140015122A (ko) 2003-10-01 2014-02-06 아돌로 코포레이션 스피로시클릭 헤테로시클릭 유도체 및 이의 사용 방법
SI1725537T1 (sl) * 2004-03-15 2011-11-30 Janssen Pharmaceutica Nv Nove spojine kot modulatorji opioidnih receptorjev
AU2013205089B2 (en) * 2004-03-15 2013-12-19 Janssen Pharmaceutica, N.V. Novel compounds as opioid receptor modulators
US7598261B2 (en) 2005-03-31 2009-10-06 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
US7576207B2 (en) 2006-04-06 2009-08-18 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
BRPI0715004A2 (pt) 2006-09-12 2013-05-28 Adolor Corp mÉtodo para melhorar a funÇço cognitiva de composiÇço
IT1396951B1 (it) * 2009-12-18 2012-12-20 Neuroscienze Pharmaness S C A R L Composti farmaceutici
US9675587B2 (en) 2013-03-14 2017-06-13 Allergan Holdings Unlimited Company Opioid receptor modulator dosage formulations
TWI652264B (zh) * 2013-09-26 2019-03-01 東麗股份有限公司 Cyclic amine derivatives and their medical uses
EP3697410A4 (en) 2017-10-19 2021-08-11 Amgen Inc. BENZIMIDAZOLE DERIVATIVES AND THEIR USES

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JP2985322B2 (ja) 1991-03-01 1999-11-29 東レ株式会社 イソキノリン誘導体およびその医薬用途
US5354863A (en) * 1992-01-21 1994-10-11 G. D. Searle & Co. Opioid agonist compounds
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Also Published As

Publication number Publication date
DE60216627D1 (de) 2007-01-18
CY1106356T1 (el) 2011-10-12
US7282508B2 (en) 2007-10-16
PL367967A1 (en) 2005-03-07
HRP20040324A2 (en) 2005-04-30
EP1438304A1 (en) 2004-07-21
DE60216627T2 (de) 2007-09-20
KR100898562B1 (ko) 2009-05-20
ATE347549T1 (de) 2006-12-15
WO2003033486A1 (en) 2003-04-24
JP4417108B2 (ja) 2010-02-17
KR20050035121A (ko) 2005-04-15
IL161348A0 (en) 2004-09-27
EA006507B1 (ru) 2005-12-29
UA76224C2 (en) 2006-07-17
ES2278065T3 (es) 2007-08-01
CN100354273C (zh) 2007-12-12
CA2462953C (en) 2011-01-04
ZA200402818B (en) 2005-06-29
CN1568321A (zh) 2005-01-19
AR037506A1 (es) 2004-11-17
NO327602B1 (no) 2009-08-31
PT1438304E (pt) 2007-03-30
BR0213327A (pt) 2004-10-13
AU2002346994B2 (en) 2007-09-06
EA200400545A1 (ru) 2004-08-26
JP2005505625A (ja) 2005-02-24
NZ531679A (en) 2005-02-25
US20080096925A1 (en) 2008-04-24
IL161348A (en) 2010-11-30
HUP0600447A2 (en) 2006-09-28
HUP0600447A3 (en) 2008-03-28
MY137356A (en) 2009-01-30
NO20041666L (no) 2004-04-22
US20040260096A1 (en) 2004-12-23
EP1438304B1 (en) 2006-12-06
CA2462953A1 (en) 2003-04-24

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