EA200400545A1 - Новые замещенные 4-фенил-4-[1h-имидазол-2-ил] пиперидиновые производные и их применение в качестве селективных непептидных агонистов дельта-опиоидов - Google Patents

Новые замещенные 4-фенил-4-[1h-имидазол-2-ил] пиперидиновые производные и их применение в качестве селективных непептидных агонистов дельта-опиоидов

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Publication number
EA200400545A1
EA200400545A1 EA200400545A EA200400545A EA200400545A1 EA 200400545 A1 EA200400545 A1 EA 200400545A1 EA 200400545 A EA200400545 A EA 200400545A EA 200400545 A EA200400545 A EA 200400545A EA 200400545 A1 EA200400545 A1 EA 200400545A1
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EA
Eurasian Patent Office
Prior art keywords
imidazol
phenyl
agonists
selective
nepeptida
Prior art date
Application number
EA200400545A
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English (en)
Other versions
EA006507B1 (ru
Inventor
Франс Эдуард Янссенс
Йозеф Элизабет Ленартс
Франсиско Хавьер Фернандес-Гадеа
Антонио Гомес-Санчес
Тео Франс Мерт
Original Assignee
Янссен Фармацевтика Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармацевтика Н.В. filed Critical Янссен Фармацевтика Н.В.
Publication of EA200400545A1 publication Critical patent/EA200400545A1/ru
Publication of EA006507B1 publication Critical patent/EA006507B1/ru

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
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    • A61P17/00—Drugs for dermatological disorders
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P17/06—Antipsoriatics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P19/00—Drugs for skeletal disorders
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Настоящее изобретение относится к новым 4-фенил-4-[1H-имидазол-2-ил]пиперидиновым производным формулы (I)их фармацевтически приемлемым солям присоединения кислот или оснований, их стереохимически изомерным формам, их таутомерным формам и их N-оксидам. В частности, заявлены соединения формулы (I), где A=B представляет собой C=O или SO, X представляет собой ковалентную связь, Rпредставляет собой алкилокси, алкилоксиалкил, Ar или NRR, где Rи R, каждый независимо, представляют собой водород или Ar; или A=B и Rвместе образуют радикал бензоксазолил; p равен нулю, Rпредставляет собой бензил, необязательно замещенный гидрокси, алкилом или алкилоксикарбонилом, и каждый из Rи Rпредставляет собой водород. Изобретение также относится к способам получения соединений по изобретению и их применению в медицине, в частности, в качестве селективных непептидных агонистов d-опиоидов, для применения при лечении различных болей.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200400545A 2001-10-15 2002-10-10 Новые замещенные 4-фенил-4-[1h-имидазол-2-ил] пиперидиновые производные и их применение в качестве селективных непептидных агонистов дельта-опиоидов EA006507B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01203926 2001-10-15
PCT/EP2002/011372 WO2003033486A1 (en) 2001-10-15 2002-10-10 Novel substituted 4-phenyl-4-[1h-imidazol-2-yl]-piperidine derivatives and their use as selective non-peptide delta opioid agonists

Publications (2)

Publication Number Publication Date
EA200400545A1 true EA200400545A1 (ru) 2004-08-26
EA006507B1 EA006507B1 (ru) 2005-12-29

Family

ID=8181080

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200400545A EA006507B1 (ru) 2001-10-15 2002-10-10 Новые замещенные 4-фенил-4-[1h-имидазол-2-ил] пиперидиновые производные и их применение в качестве селективных непептидных агонистов дельта-опиоидов

Country Status (26)

Country Link
US (2) US7282508B2 (ru)
EP (1) EP1438304B1 (ru)
JP (1) JP4417108B2 (ru)
KR (1) KR100898562B1 (ru)
CN (1) CN100354273C (ru)
AR (1) AR037506A1 (ru)
AT (1) ATE347549T1 (ru)
AU (1) AU2002346994B2 (ru)
BR (1) BR0213327A (ru)
CA (1) CA2462953C (ru)
CY (1) CY1106356T1 (ru)
DE (1) DE60216627T2 (ru)
EA (1) EA006507B1 (ru)
ES (1) ES2278065T3 (ru)
HR (1) HRP20040324A2 (ru)
HU (1) HUP0600447A3 (ru)
IL (2) IL161348A0 (ru)
MX (1) MXPA04003479A (ru)
MY (1) MY137356A (ru)
NO (1) NO327602B1 (ru)
NZ (1) NZ531679A (ru)
PL (1) PL367967A1 (ru)
PT (1) PT1438304E (ru)
UA (1) UA76224C2 (ru)
WO (1) WO2003033486A1 (ru)
ZA (1) ZA200402818B (ru)

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DE60330794D1 (de) * 2002-07-03 2010-02-11 Glaxo Group Ltd Substituierte 4-phenylpiperidinamide als tachykininantagonisten und serotoninwiederaufnahmehemmer
CL2004000754A1 (es) * 2003-04-11 2005-02-25 Janssen Pharmaceutica Nv Uso de compuestos derivados de 4-fenil-4-(1h-imidazol-2-il)piperidina, como agonistas delta-opioides no peptidicos, para preparar un medicamento util en prevenir o tratar trastornos del sistema nervioso central.
NZ546834A (en) 2003-10-01 2010-03-26 Adolor Corp Spirocyclic heterocyclic derivatives and methods of their use
SI2653465T1 (sl) 2004-03-15 2016-10-28 Janssen Pharmaceutica N.V. Modulatorji opiodnih receptorjev
AU2013205089B2 (en) * 2004-03-15 2013-12-19 Janssen Pharmaceutica, N.V. Novel compounds as opioid receptor modulators
US7598261B2 (en) 2005-03-31 2009-10-06 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
US7576207B2 (en) 2006-04-06 2009-08-18 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
JP2010503669A (ja) 2006-09-12 2010-02-04 アドラー コーポレーション 認知機能の強化のためのｎ含有スピロ化合物の使用
IT1396951B1 (it) * 2009-12-18 2012-12-20 Neuroscienze Pharmaness S C A R L Composti farmaceutici
US9675587B2 (en) 2013-03-14 2017-06-13 Allergan Holdings Unlimited Company Opioid receptor modulator dosage formulations
TWI652264B (zh) * 2013-09-26 2019-03-01 東麗股份有限公司 Cyclic amine derivatives and their medical uses
CN111417394B (zh) 2017-10-19 2023-11-07 帝人制药株式会社 苯并咪唑衍生物及其用途

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Also Published As

Publication number Publication date
ATE347549T1 (de) 2006-12-15
EA006507B1 (ru) 2005-12-29
HUP0600447A3 (en) 2008-03-28
ES2278065T3 (es) 2007-08-01
JP4417108B2 (ja) 2010-02-17
KR100898562B1 (ko) 2009-05-20
EP1438304B1 (en) 2006-12-06
NZ531679A (en) 2005-02-25
HUP0600447A2 (en) 2006-09-28
IL161348A0 (en) 2004-09-27
US20080096925A1 (en) 2008-04-24
PT1438304E (pt) 2007-03-30
UA76224C2 (en) 2006-07-17
NO20041666L (no) 2004-04-22
DE60216627D1 (de) 2007-01-18
EP1438304A1 (en) 2004-07-21
AU2002346994B2 (en) 2007-09-06
US20040260096A1 (en) 2004-12-23
KR20050035121A (ko) 2005-04-15
MY137356A (en) 2009-01-30
IL161348A (en) 2010-11-30
CN100354273C (zh) 2007-12-12
ZA200402818B (en) 2005-06-29
WO2003033486A1 (en) 2003-04-24
JP2005505625A (ja) 2005-02-24
CA2462953C (en) 2011-01-04
NO327602B1 (no) 2009-08-31
HRP20040324A2 (en) 2005-04-30
PL367967A1 (en) 2005-03-07
MXPA04003479A (es) 2004-07-30
AR037506A1 (es) 2004-11-17
US7282508B2 (en) 2007-10-16
CN1568321A (zh) 2005-01-19
CY1106356T1 (el) 2011-10-12
CA2462953A1 (en) 2003-04-24
BR0213327A (pt) 2004-10-13
DE60216627T2 (de) 2007-09-20

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