UA76224C2 - Substituted 4-phenyl 4-[1h-imidazol-2-yl]-piperidine derivatives and use thereof as selective non-peptide delta-opioid agonists - Google Patents

Substituted 4-phenyl 4-[1h-imidazol-2-yl]-piperidine derivatives and use thereof as selective non-peptide delta-opioid agonists Download PDF

Info

Publication number: UA76224C2
Authority: UA; Ukraine
Prior art keywords: group; compounds; phenyl; reaction; compound
Prior art date: 2001-10-15

Application number

UA20040503667A

Other languages

English (en)

Ukrainian (uk)

Inventor

Frans Eduard Janssens

Joseph Elisabeth Leenaerts

Francisco Javi Fernandez-Gadea

Theo Frans Meert

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-10-15

Filing date

2002-10-10

Publication date

2006-07-17

2002-10-10 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2006-07-17 Publication of UA76224C2 publication Critical patent/UA76224C2/uk

Links

229940127450 Opioid Agonists Drugs 0.000 title abstract description 4
108090000765 processed proteins & peptides Proteins 0.000 title abstract description 4
GBANLFWFVPIRMO-UHFFFAOYSA-N 4-(1h-imidazol-2-yl)-4-phenylpiperidine Chemical class C1CNCCC1(C=1C=CC=CC=1)C1=NC=CN1 GBANLFWFVPIRMO-UHFFFAOYSA-N 0.000 title abstract 2
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Classifications

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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Immunology (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Nutrition Science (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

UA20040503667A 2001-10-15 2002-10-10 Substituted 4-phenyl 4-[1h-imidazol-2-yl]-piperidine derivatives and use thereof as selective non-peptide delta-opioid agonists UA76224C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP01203926		2001-10-15
PCT/EP2002/011372 WO2003033486A1 (en)	2001-10-15	2002-10-10	Novel substituted 4-phenyl-4-[1h-imidazol-2-yl]-piperidine derivatives and their use as selective non-peptide delta opioid agonists

Publications (1)

Publication Number	Publication Date
UA76224C2 true UA76224C2 (en)	2006-07-17

Family

ID=8181080

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UA20040503667A UA76224C2 (en)	2001-10-15	2002-10-10	Substituted 4-phenyl 4-[1h-imidazol-2-yl]-piperidine derivatives and use thereof as selective non-peptide delta-opioid agonists

Country Status (26)

Country	Link
US (2)	US7282508B2 (es)
EP (1)	EP1438304B1 (es)
JP (1)	JP4417108B2 (es)
KR (1)	KR100898562B1 (es)
CN (1)	CN100354273C (es)
AR (1)	AR037506A1 (es)
AT (1)	ATE347549T1 (es)
AU (1)	AU2002346994B2 (es)
BR (1)	BR0213327A (es)
CA (1)	CA2462953C (es)
CY (1)	CY1106356T1 (es)
DE (1)	DE60216627T2 (es)
EA (1)	EA006507B1 (es)
ES (1)	ES2278065T3 (es)
HR (1)	HRP20040324A2 (es)
HU (1)	HUP0600447A3 (es)
IL (2)	IL161348A0 (es)
MX (1)	MXPA04003479A (es)
MY (1)	MY137356A (es)
NO (1)	NO327602B1 (es)
NZ (1)	NZ531679A (es)
PL (1)	PL367967A1 (es)
PT (1)	PT1438304E (es)
UA (1)	UA76224C2 (es)
WO (1)	WO2003033486A1 (es)
ZA (1)	ZA200402818B (es)

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CA2462374C (en) *	2001-10-15	2011-01-18	Janssen Pharmaceutica N.V.	Substituted 4-phenyl-4-(1h-imidazol-2-yl)-piperidine derivatives for reducing ischaemic damage
TW200403058A (en) *	2002-04-19	2004-03-01	Bristol Myers Squibb Co	Heterocyclo inhibitors of potassium channel function
CA2484936A1 (en) *	2002-05-08	2004-05-21	Neurogen Corporation	Substituted imidazolylmethyl pyridine and pyrazine derivatives and their use as gabaa receptor ligands
DE60330794D1 (de) *	2002-07-03	2010-02-11	Glaxo Group Ltd	Substituierte 4-phenylpiperidinamide als tachykininantagonisten und serotoninwiederaufnahmehemmer
AR044010A1 (es) *	2003-04-11	2005-08-24	Janssen Pharmaceutica Nv	Uso de derivados de 4-fenil-4- [1h-imidazol-2-il]- piperidina sustituidos como agonistas delta opioideos no peptidos selectivos, con actividad antidepresiva y ansiolitica
NZ593444A (en)	2003-10-01	2012-12-21	Adolor Corp	4-[(2-N,N-diethylaminocarbonyl)pyrid-5-yl]-spiro[1,2-dihydronaphthalene-2,4'-piperidine] and methods of its use
AU2013205089B2 (en) *	2004-03-15	2013-12-19	Janssen Pharmaceutica, N.V.	Novel compounds as opioid receptor modulators
ES2367576T3 (es)	2004-03-15	2011-11-04	Janssen Pharmaceutica Nv	Nuevos compuestos como moduladores de receptores opioides.
US7598261B2 (en)	2005-03-31	2009-10-06	Adolor Corporation	Spirocyclic heterocyclic derivatives and methods of their use
US7576207B2 (en)	2006-04-06	2009-08-18	Adolor Corporation	Spirocyclic heterocyclic derivatives and methods of their use
WO2008033299A2 (en)	2006-09-12	2008-03-20	Adolor Corporation	Use of n-containing spirocompounds for the enhancement of cognitive function
IT1396951B1 (it) *	2009-12-18	2012-12-20	Neuroscienze Pharmaness S C A R L	Composti farmaceutici
US9675587B2 (en)	2013-03-14	2017-06-13	Allergan Holdings Unlimited Company	Opioid receptor modulator dosage formulations
TWI652264B (zh) *	2013-09-26	2019-03-01	東麗股份有限公司	Cyclic amine derivatives and their medical uses
MA50413A (fr)	2017-10-19	2020-08-26	Amgen Inc	Dérivés de benzimidazole et leurs utilisations

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JP2985322B2 (ja)	1991-03-01	1999-11-29	東レ株式会社	イソキノリン誘導体およびその医薬用途
US5354863A (en) *	1992-01-21	1994-10-11	G. D. Searle & Co.	Opioid agonist compounds
GB9202238D0 (en)	1992-02-03	1992-03-18	Wellcome Found	Compounds
CN1043641C (zh)	1993-08-06	1999-06-16	史密丝克莱恩比彻姆制药股份公司	氢化异喹啉衍生物
US5618934A (en)	1994-05-17	1997-04-08	Merck & Co., Inc.	Boronic acid compound
WO1996022276A1 (fr)	1995-01-20	1996-07-25	Nippon Shinyaku Co., Ltd.	Derives d'ethylamine et medicaments
IT1307327B1 (it)	1995-09-12	2001-10-30	Smithkline Beecham Spa	Derivati idroisochinolinici sostituiti
TW548271B (en)	1996-12-20	2003-08-21	Astra Pharma Inc	Novel piperidine derivatives having an exocyclic double bond with analgesic effects
SE9604786D0 (sv)	1996-12-20	1996-12-20	Astra Pharma Inc	New compounds
DE19805370A1 (de)	1997-03-14	1998-09-17	Gruenenthal Gmbh	Substituierte Aminoverbindungen und ihre Verwendung als analgetisch wirksame Substanzen
GB9709972D0 (en)	1997-05-19	1997-07-09	Pfizer Ltd	Tetrazoles
SI1144411T1 (en) *	1998-12-19	2005-10-31	Janssen Pharmaceutica N.V.	Antihistaminic spiro compounds
EP1038872A1 (en) *	1999-02-22	2000-09-27	Pfizer Products Inc.	4-Phenyl-4-heteroarylpiperdine derivatives as opioid receptor ligands
JP2005231995A (ja)	1999-12-22	2005-09-02	Meiji Seika Kaisha Ltd	オピオイドδ受容体アゴニスト／アンタゴニストとして有用なスピロ化合物

2002
- 2002-10-10 ES ES02782881T patent/ES2278065T3/es not_active Expired - Lifetime
- 2002-10-10 BR BR0213327-0A patent/BR0213327A/pt not_active IP Right Cessation
- 2002-10-10 DE DE60216627T patent/DE60216627T2/de not_active Expired - Lifetime
- 2002-10-10 HU HU0600447A patent/HUP0600447A3/hu unknown
- 2002-10-10 PT PT02782881T patent/PT1438304E/pt unknown
- 2002-10-10 CN CNB028203275A patent/CN100354273C/zh not_active Expired - Fee Related
- 2002-10-10 AU AU2002346994A patent/AU2002346994B2/en not_active Ceased
- 2002-10-10 UA UA20040503667A patent/UA76224C2/uk unknown
- 2002-10-10 EA EA200400545A patent/EA006507B1/ru not_active IP Right Cessation
- 2002-10-10 MX MXPA04003479A patent/MXPA04003479A/es active IP Right Grant
- 2002-10-10 KR KR1020047002381A patent/KR100898562B1/ko not_active IP Right Cessation
- 2002-10-10 NZ NZ531679A patent/NZ531679A/en not_active IP Right Cessation
- 2002-10-10 PL PL02367967A patent/PL367967A1/xx unknown
- 2002-10-10 EP EP02782881A patent/EP1438304B1/en not_active Expired - Lifetime
- 2002-10-10 WO PCT/EP2002/011372 patent/WO2003033486A1/en active IP Right Grant
- 2002-10-10 US US10/491,379 patent/US7282508B2/en not_active Expired - Fee Related
- 2002-10-10 AT AT02782881T patent/ATE347549T1/de active
- 2002-10-10 IL IL16134802A patent/IL161348A0/xx unknown
- 2002-10-10 CA CA2462953A patent/CA2462953C/en not_active Expired - Lifetime
- 2002-10-10 JP JP2003536226A patent/JP4417108B2/ja not_active Expired - Fee Related
- 2002-10-11 MY MYPI20023800A patent/MY137356A/en unknown
- 2002-10-11 AR ARP020103837A patent/AR037506A1/es unknown
2004
- 2004-04-06 HR HR20040324A patent/HRP20040324A2/xx not_active Application Discontinuation
- 2004-04-13 ZA ZA2004/02818A patent/ZA200402818B/en unknown
- 2004-04-13 IL IL161348A patent/IL161348A/en not_active IP Right Cessation
- 2004-04-22 NO NO20041666A patent/NO327602B1/no not_active IP Right Cessation
2007
- 2007-03-06 CY CY20071100311T patent/CY1106356T1/el unknown
- 2007-05-25 US US11/753,830 patent/US20080096925A1/en not_active Abandoned

Also Published As

Publication number	Publication date
MXPA04003479A (es)	2004-07-30
JP4417108B2 (ja)	2010-02-17
CN1568321A (zh)	2005-01-19
HRP20040324A2 (en)	2005-04-30
EA200400545A1 (ru)	2004-08-26
DE60216627T2 (de)	2007-09-20
US20040260096A1 (en)	2004-12-23
MY137356A (en)	2009-01-30
ZA200402818B (en)	2005-06-29
AR037506A1 (es)	2004-11-17
DE60216627D1 (de)	2007-01-18
AU2002346994B2 (en)	2007-09-06
CY1106356T1 (el)	2011-10-12
ATE347549T1 (de)	2006-12-15
NO327602B1 (no)	2009-08-31
IL161348A (en)	2010-11-30
PL367967A1 (en)	2005-03-07
CN100354273C (zh)	2007-12-12
BR0213327A (pt)	2004-10-13
JP2005505625A (ja)	2005-02-24
KR100898562B1 (ko)	2009-05-20
CA2462953A1 (en)	2003-04-24
PT1438304E (pt)	2007-03-30
NO20041666L (no)	2004-04-22
IL161348A0 (en)	2004-09-27
EP1438304A1 (en)	2004-07-21
EA006507B1 (ru)	2005-12-29
HUP0600447A3 (en)	2008-03-28
WO2003033486A1 (en)	2003-04-24
US20080096925A1 (en)	2008-04-24
US7282508B2 (en)	2007-10-16
ES2278065T3 (es)	2007-08-01
HUP0600447A2 (en)	2006-09-28
CA2462953C (en)	2011-01-04
NZ531679A (en)	2005-02-25
KR20050035121A (ko)	2005-04-15
EP1438304B1 (en)	2006-12-06

Publication	Publication Date	Title
US10377745B2 (en)	2019-08-13	Heterocyclic compounds as NaV channel inhibitors and uses thereof
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