MXPA03011980A - Agonista de oxitocina. - Google Patents

Agonista de oxitocina.

Info

Publication number
MXPA03011980A
MXPA03011980A MXPA03011980A MXPA03011980A MXPA03011980A MX PA03011980 A MXPA03011980 A MX PA03011980A MX PA03011980 A MXPA03011980 A MX PA03011980A MX PA03011980 A MXPA03011980 A MX PA03011980A MX PA03011980 A MXPA03011980 A MX PA03011980A
Authority
MX
Mexico
Prior art keywords
oxytocin agonists
general formula
compounds
agonists
group
Prior art date
Application number
MXPA03011980A
Other languages
English (en)
Inventor
William Pitt Gary Robert
Original Assignee
Ferring Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferring Bv filed Critical Ferring Bv
Publication of MXPA03011980A publication Critical patent/MXPA03011980A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Current-Collector Devices For Electrically Propelled Vehicles (AREA)
  • Tea And Coffee (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Los compuestos de acuerdo con la formula general 1: en donde G1 es NR6R7 o un grupo policiclico fusionado, son novedosos. Son agonistas de oxitocina selectivos y potentes. Las composiciones farmaceuticas de estos compuestos son utiles en el tratamiento de, entre otras cosas, disfuncion erectil.
MXPA03011980A 2001-06-25 2002-06-24 Agonista de oxitocina. MXPA03011980A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0115515.9A GB0115515D0 (en) 2001-06-25 2001-06-25 Oxytocin agonisys
PCT/GB2002/002872 WO2003000692A2 (en) 2001-06-25 2002-06-24 Oxytocin agonists

Publications (1)

Publication Number Publication Date
MXPA03011980A true MXPA03011980A (es) 2004-03-26

Family

ID=9917320

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03011980A MXPA03011980A (es) 2001-06-25 2002-06-24 Agonista de oxitocina.

Country Status (23)

Country Link
US (1) US20040235753A1 (es)
EP (1) EP1399436B1 (es)
JP (1) JP2005500317A (es)
KR (1) KR20040010762A (es)
CN (1) CN1606553A (es)
AT (1) ATE291021T1 (es)
CA (1) CA2450480A1 (es)
CZ (1) CZ20033414A3 (es)
DE (1) DE60203290T2 (es)
DK (1) DK1399436T3 (es)
ES (1) ES2239717T3 (es)
GB (1) GB0115515D0 (es)
HK (1) HK1064666A1 (es)
HU (1) HUP0400368A3 (es)
IL (1) IL159289A0 (es)
MX (1) MXPA03011980A (es)
NO (1) NO20035772L (es)
NZ (1) NZ530035A (es)
PL (1) PL367538A1 (es)
PT (1) PT1399436E (es)
RU (1) RU2309156C2 (es)
WO (1) WO2003000692A2 (es)
ZA (1) ZA200309626B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4179782B2 (ja) 2000-04-26 2008-11-12 富士通株式会社 無線受信装置及び無線通信システム
EP1480998B1 (en) 2002-02-27 2006-11-22 Ferring BV Intermediates and methods for making heptapeptide oxytocin analogues
EP1449844A1 (en) * 2003-02-14 2004-08-25 Ferring B.V. benzamide derivatives as oxytocin agonists and vasopressin antagonists
EP1512687A1 (en) * 2003-09-05 2005-03-09 Ferring B.V. Piperazines as oxytocin agonists
EP1632494A1 (en) * 2004-08-24 2006-03-08 Ferring B.V. Vasopressin v1a antagonists
AU2006306547A1 (en) * 2005-10-24 2007-05-03 Wyeth Tricyclic compounds useful as oxytocin receptor agonists
WO2008141081A1 (en) * 2007-05-10 2008-11-20 Amr Technology, Inc. Aryl- and heteroaryl-substituted tetrahydrobenzo-1,4-diazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
AR067336A1 (es) * 2007-06-28 2009-10-07 Novartis Ag Moduladores de calicreina 7
WO2009033820A2 (en) * 2007-09-11 2009-03-19 Mondobiotech Laboratories Ag Use of a peptide as a therapeutic agent
ATE522225T1 (de) * 2007-09-11 2011-09-15 Mondobiotech Lab Ag Verwendung des peptids phpfhlfvy (renin- inhibitor) in anti-angiogenischer therapie von gewissen erkrankungen
WO2009046826A1 (en) * 2007-09-11 2009-04-16 Mondobiotech Laboratories Ag Use of a cyclic penta-peptide as a therapeutic agent
RU2010114024A (ru) * 2007-09-11 2011-10-20 Мондобайотек Лабораториз Аг (Li) Применение гонадорелина в качестве терапевтического средства
JP2010538989A (ja) * 2007-09-11 2010-12-16 モンドバイオテック ラボラトリーズ アクチエンゲゼルシャフト Ｈｂｖ感染等の治療における治療剤としてのｎｆ−カッパーｂインヒビターｓｎ５０の使用、及び必要に応じたアンギオテンシンｉｉｉの使用
AR068509A1 (es) * 2007-09-19 2009-11-18 Jerini Ag Antagosnistas del receptor de bradiquinina b1
US8853158B2 (en) 2010-05-25 2014-10-07 Institut National De La Santé Et De La Recherche Médicale (Inserm) Methods for the treatment of a feeding disorder with onset during neonate development using an agonist of the oxytocin receptor
GB201105537D0 (en) * 2011-03-31 2011-05-18 Vantia Ltd New process
CN103159641A (zh) * 2011-12-14 2013-06-19 天津泰普药品科技发展有限公司 托伐普坦中间体2-甲酸-5-(2-甲基苯甲酰氨基)甲苯的制备方法
WO2016089797A1 (en) 2014-12-05 2016-06-09 Merck Sharp & Dohme Corp. Novel tricyclic compounds as inhibitors of mutant idh enzymes
CN107922420B (zh) * 2015-07-06 2021-12-31 金奥克斯治疗有限公司 用于治疗社交障碍和药物使用障碍的治疗性化合物和组合物
CN110248944A (zh) 2016-12-12 2019-09-17 悉尼大学 非肽催产素受体激动剂
KR20170035351A (ko) 2017-01-06 2017-03-30 셰플러코리아(유) 볼베어링용 케이지
WO2021042178A1 (en) * 2019-09-06 2021-03-11 Kinoxis Therapeutics Pty Ltd Treatment of opioid withdrawal
EP4378526A1 (en) * 2022-11-30 2024-06-05 Université de Strasbourg Non peptidergic agonists of oxytocin receptor
EP4378525A1 (en) * 2022-11-30 2024-06-05 Université de Strasbourg Non peptidergic agonists of oxytocin receptor

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2665441B1 (fr) * 1990-07-31 1992-12-04 Sanofi Sa Derives de la n-sulfonyl indoline, leur preparation, les compositions pharmaceutiques en contenant.
WO2000046224A2 (en) * 1999-02-04 2000-08-10 American Home Products Corporation Tricyclic pyridine n-oxides vasopressin agonists
GB0000079D0 (en) * 2000-01-05 2000-02-23 Ferring Bv Novel antidiuretic agents
GB0015601D0 (en) * 2000-06-26 2000-08-16 Ferring Bv Novel antidiuretic agents

Also Published As

Publication number Publication date
DE60203290D1 (de) 2005-04-21
ES2239717T3 (es) 2005-10-01
NZ530035A (en) 2004-06-25
ZA200309626B (en) 2004-05-12
ATE291021T1 (de) 2005-04-15
RU2003136152A (ru) 2005-05-20
EP1399436A2 (en) 2004-03-24
RU2309156C2 (ru) 2007-10-27
IL159289A0 (en) 2004-06-01
NO20035772L (no) 2003-12-22
PT1399436E (pt) 2005-07-29
CA2450480A1 (en) 2003-01-03
HK1064666A1 (en) 2005-02-04
WO2003000692A2 (en) 2003-01-03
JP2005500317A (ja) 2005-01-06
GB0115515D0 (en) 2001-08-15
WO2003000692A3 (en) 2003-05-15
HUP0400368A2 (hu) 2004-08-30
CN1606553A (zh) 2005-04-13
DK1399436T3 (da) 2005-05-30
US20040235753A1 (en) 2004-11-25
EP1399436B1 (en) 2005-03-16
KR20040010762A (ko) 2004-01-31
DE60203290T2 (de) 2006-02-02
CZ20033414A3 (en) 2004-05-12
PL367538A1 (en) 2005-02-21
HUP0400368A3 (en) 2007-05-29

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