HUP0600447A3 - Substituted 4-phenyl-4-[1h-imidazol-2-yl]-piperidine derivatives, pharmaceutical compositions containing them and their use as selective non-peptide delta opioid agonists - Google Patents

Substituted 4-phenyl-4-[1h-imidazol-2-yl]-piperidine derivatives, pharmaceutical compositions containing them and their use as selective non-peptide delta opioid agonists

Info

Publication number: HUP0600447A3
Authority: HU; Hungary
Prior art keywords: imidazol; phenyl; substituted; pharmaceutical compositions; compositions containing
Prior art date: 2001-10-15

Application number

HU0600447A

Other languages

English (en)

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-10-15

Filing date

2002-10-10

Publication date

2008-03-28

2002-10-10 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2006-09-28 Publication of HUP0600447A2 publication Critical patent/HUP0600447A2/hu

2008-03-28 Publication of HUP0600447A3 publication Critical patent/HUP0600447A3/hu

Links

GBANLFWFVPIRMO-UHFFFAOYSA-N 4-(1h-imidazol-2-yl)-4-phenylpiperidine Chemical class C1CNCCC1(C=1C=CC=CC=1)C1=NC=CN1 GBANLFWFVPIRMO-UHFFFAOYSA-N 0.000 title 1
229940127450 Opioid Agonists Drugs 0.000 title 1
239000008194 pharmaceutical composition Chemical class 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Nutrition Science (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

HU0600447A 2001-10-15 2002-10-10 Substituted 4-phenyl-4-[1h-imidazol-2-yl]-piperidine derivatives, pharmaceutical compositions containing them and their use as selective non-peptide delta opioid agonists HUP0600447A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP01203926		2001-10-15
PCT/EP2002/011372 WO2003033486A1 (en)	2001-10-15	2002-10-10	Novel substituted 4-phenyl-4-[1h-imidazol-2-yl]-piperidine derivatives and their use as selective non-peptide delta opioid agonists

Publications (2)

Publication Number	Publication Date
HUP0600447A2 HUP0600447A2 (en)	2006-09-28
HUP0600447A3 true HUP0600447A3 (en)	2008-03-28

Family

ID=8181080

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU0600447A HUP0600447A3 (en)	2001-10-15	2002-10-10	Substituted 4-phenyl-4-[1h-imidazol-2-yl]-piperidine derivatives, pharmaceutical compositions containing them and their use as selective non-peptide delta opioid agonists

Country Status (26)

Country	Link
US (2)	US7282508B2 (hu)
EP (1)	EP1438304B1 (hu)
JP (1)	JP4417108B2 (hu)
KR (1)	KR100898562B1 (hu)
CN (1)	CN100354273C (hu)
AR (1)	AR037506A1 (hu)
AT (1)	ATE347549T1 (hu)
AU (1)	AU2002346994B2 (hu)
BR (1)	BR0213327A (hu)
CA (1)	CA2462953C (hu)
CY (1)	CY1106356T1 (hu)
DE (1)	DE60216627T2 (hu)
EA (1)	EA006507B1 (hu)
ES (1)	ES2278065T3 (hu)
HR (1)	HRP20040324A2 (hu)
HU (1)	HUP0600447A3 (hu)
IL (2)	IL161348A0 (hu)
MX (1)	MXPA04003479A (hu)
MY (1)	MY137356A (hu)
NO (1)	NO327602B1 (hu)
NZ (1)	NZ531679A (hu)
PL (1)	PL367967A1 (hu)
PT (1)	PT1438304E (hu)
UA (1)	UA76224C2 (hu)
WO (1)	WO2003033486A1 (hu)
ZA (1)	ZA200402818B (hu)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE345799T1 (de) *	2001-10-15	2006-12-15	Janssen Pharmaceutica Nv	Substituierte 4-phenyl-4-(1h-imidazol-2-yl)- piperidinderivate zur verringerung von ischämischer schädigung
TW200403058A (en) *	2002-04-19	2004-03-01	Bristol Myers Squibb Co	Heterocyclo inhibitors of potassium channel function
CA2484936A1 (en) *	2002-05-08	2004-05-21	Neurogen Corporation	Substituted imidazolylmethyl pyridine and pyrazine derivatives and their use as gabaa receptor ligands
DE60330794D1 (de) *	2002-07-03	2010-02-11	Glaxo Group Ltd	Substituierte 4-phenylpiperidinamide als tachykininantagonisten und serotoninwiederaufnahmehemmer
CL2004000754A1 (es) *	2003-04-11	2005-02-25	Janssen Pharmaceutica Nv	Uso de compuestos derivados de 4-fenil-4-(1h-imidazol-2-il)piperidina, como agonistas delta-opioides no peptidicos, para preparar un medicamento util en prevenir o tratar trastornos del sistema nervioso central.
NZ546834A (en)	2003-10-01	2010-03-26	Adolor Corp	Spirocyclic heterocyclic derivatives and methods of their use
SI2653465T1 (sl)	2004-03-15	2016-10-28	Janssen Pharmaceutica N.V.	Modulatorji opiodnih receptorjev
AU2013205089B2 (en) *	2004-03-15	2013-12-19	Janssen Pharmaceutica, N.V.	Novel compounds as opioid receptor modulators
US7598261B2 (en)	2005-03-31	2009-10-06	Adolor Corporation	Spirocyclic heterocyclic derivatives and methods of their use
US7576207B2 (en)	2006-04-06	2009-08-18	Adolor Corporation	Spirocyclic heterocyclic derivatives and methods of their use
JP2010503669A (ja)	2006-09-12	2010-02-04	アドラーコーポレーション	認知機能の強化のためのｎ含有スピロ化合物の使用
IT1396951B1 (it) *	2009-12-18	2012-12-20	Neuroscienze Pharmaness S C A R L	Composti farmaceutici
US9675587B2 (en)	2013-03-14	2017-06-13	Allergan Holdings Unlimited Company	Opioid receptor modulator dosage formulations
TWI652264B (zh) *	2013-09-26	2019-03-01	東麗股份有限公司	Cyclic amine derivatives and their medical uses
CN111417394B (zh)	2017-10-19	2023-11-07	帝人制药株式会社	苯并咪唑衍生物及其用途

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2985322B2 (ja)	1991-03-01	1999-11-29	東レ株式会社	イソキノリン誘導体およびその医薬用途
US5354863A (en) *	1992-01-21	1994-10-11	G. D. Searle & Co.	Opioid agonist compounds
GB9202238D0 (en)	1992-02-03	1992-03-18	Wellcome Found	Compounds
ES2173921T3 (es)	1993-08-06	2002-11-01	Glaxosmithkline Spa	Derivados de hidroisoquinolina.
US5618934A (en)	1994-05-17	1997-04-08	Merck & Co., Inc.	Boronic acid compound
AU4458996A (en)	1995-01-20	1996-08-07	Nippon Shinyaku Co. Ltd.	Ethylamine derivatives and drugs
IT1307327B1 (it)	1995-09-12	2001-10-30	Smithkline Beecham Spa	Derivati idroisochinolinici sostituiti
SE9604786D0 (sv)	1996-12-20	1996-12-20	Astra Pharma Inc	New compounds
TW548271B (en)	1996-12-20	2003-08-21	Astra Pharma Inc	Novel piperidine derivatives having an exocyclic double bond with analgesic effects
DE19805370A1 (de)	1997-03-14	1998-09-17	Gruenenthal Gmbh	Substituierte Aminoverbindungen und ihre Verwendung als analgetisch wirksame Substanzen
GB9709972D0 (en)	1997-05-19	1997-07-09	Pfizer Ltd	Tetrazoles
ID29268A (id) *	1998-12-19	2001-08-16	Janssen Pharmaceutica Nv	Senyawa spiro yang bersifat antihistamin
EP1038872A1 (en) *	1999-02-22	2000-09-27	Pfizer Products Inc.	4-Phenyl-4-heteroarylpiperdine derivatives as opioid receptor ligands
JP2005231995A (ja)	1999-12-22	2005-09-02	Meiji Seika Kaisha Ltd	オピオイドδ受容体アゴニスト／アンタゴニストとして有用なスピロ化合物

2002
- 2002-10-10 EP EP02782881A patent/EP1438304B1/en not_active Expired - Lifetime
- 2002-10-10 JP JP2003536226A patent/JP4417108B2/ja not_active Expired - Fee Related
- 2002-10-10 PL PL02367967A patent/PL367967A1/xx unknown
- 2002-10-10 WO PCT/EP2002/011372 patent/WO2003033486A1/en active IP Right Grant
- 2002-10-10 AT AT02782881T patent/ATE347549T1/de active
- 2002-10-10 IL IL16134802A patent/IL161348A0/xx unknown
- 2002-10-10 AU AU2002346994A patent/AU2002346994B2/en not_active Ceased
- 2002-10-10 DE DE60216627T patent/DE60216627T2/de not_active Expired - Lifetime
- 2002-10-10 CA CA2462953A patent/CA2462953C/en not_active Expired - Lifetime
- 2002-10-10 BR BR0213327-0A patent/BR0213327A/pt not_active IP Right Cessation
- 2002-10-10 NZ NZ531679A patent/NZ531679A/en not_active IP Right Cessation
- 2002-10-10 KR KR1020047002381A patent/KR100898562B1/ko not_active IP Right Cessation
- 2002-10-10 US US10/491,379 patent/US7282508B2/en not_active Expired - Fee Related
- 2002-10-10 HU HU0600447A patent/HUP0600447A3/hu unknown
- 2002-10-10 PT PT02782881T patent/PT1438304E/pt unknown
- 2002-10-10 CN CNB028203275A patent/CN100354273C/zh not_active Expired - Fee Related
- 2002-10-10 ES ES02782881T patent/ES2278065T3/es not_active Expired - Lifetime
- 2002-10-10 EA EA200400545A patent/EA006507B1/ru not_active IP Right Cessation
- 2002-10-10 UA UA20040503667A patent/UA76224C2/uk unknown
- 2002-10-10 MX MXPA04003479A patent/MXPA04003479A/es active IP Right Grant
- 2002-10-11 MY MYPI20023800A patent/MY137356A/en unknown
- 2002-10-11 AR ARP020103837A patent/AR037506A1/es unknown
2004
- 2004-04-06 HR HR20040324A patent/HRP20040324A2/xx not_active Application Discontinuation
- 2004-04-13 IL IL161348A patent/IL161348A/en not_active IP Right Cessation
- 2004-04-13 ZA ZA2004/02818A patent/ZA200402818B/en unknown
- 2004-04-22 NO NO20041666A patent/NO327602B1/no not_active IP Right Cessation
2007
- 2007-03-06 CY CY20071100311T patent/CY1106356T1/el unknown
- 2007-05-25 US US11/753,830 patent/US20080096925A1/en not_active Abandoned

Also Published As

Publication number	Publication date
ATE347549T1 (de)	2006-12-15
EA006507B1 (ru)	2005-12-29
ES2278065T3 (es)	2007-08-01
JP4417108B2 (ja)	2010-02-17
KR100898562B1 (ko)	2009-05-20
EP1438304B1 (en)	2006-12-06
NZ531679A (en)	2005-02-25
HUP0600447A2 (en)	2006-09-28
IL161348A0 (en)	2004-09-27
US20080096925A1 (en)	2008-04-24
PT1438304E (pt)	2007-03-30
UA76224C2 (en)	2006-07-17
NO20041666L (no)	2004-04-22
DE60216627D1 (de)	2007-01-18
EP1438304A1 (en)	2004-07-21
AU2002346994B2 (en)	2007-09-06
US20040260096A1 (en)	2004-12-23
KR20050035121A (ko)	2005-04-15
EA200400545A1 (ru)	2004-08-26
MY137356A (en)	2009-01-30
IL161348A (en)	2010-11-30
CN100354273C (zh)	2007-12-12
ZA200402818B (en)	2005-06-29
WO2003033486A1 (en)	2003-04-24
JP2005505625A (ja)	2005-02-24
CA2462953C (en)	2011-01-04
NO327602B1 (no)	2009-08-31
HRP20040324A2 (en)	2005-04-30
PL367967A1 (en)	2005-03-07
MXPA04003479A (es)	2004-07-30
AR037506A1 (es)	2004-11-17
US7282508B2 (en)	2007-10-16
CN1568321A (zh)	2005-01-19
CY1106356T1 (el)	2011-10-12
CA2462953A1 (en)	2003-04-24
BR0213327A (pt)	2004-10-13
DE60216627T2 (de)	2007-09-20

Legal Events

Date	Code	Title	Description
2012-07-30	FD9A	Lapse of provisional protection due to non-payment of fees

Publication	Publication Date	Title
HUP0303376A3 (en)	2007-08-28	Acylated piperidine derivatives as melanocortin-4 receptor agonists, and pharmaceutical compositions containing them and use thereof
HUP0400194A3 (en)	2004-10-28	Imidazolidindion derivatives as metalloproteinase inhibitors, their use and pharmaceutical compositions containing them
IL159725A0 (en)	2004-06-20	Pharmaceutical compositions containing benzimidazole derivatives
HUP0400467A3 (en)	2012-08-28	2-iminopyrrolidine derivatives, pharmaceutical compositions containing them and their use
HUP0203528A3 (en)	2003-11-28	Piperidine derivatives useful as ccr5 antagonists, pharmaceutical compositions containing them and their use
HUP0303069A3 (en)	2004-04-28	Imidazole derivatives, pharmaceutical compositions containing them and their use
IL164798A0 (en)	2005-12-18	Benzothiadiazepine derivatives, processes for their preparation and pharmaceutical compositions containing them
HUP0500870A3 (en)	2008-03-28	Nitrogen containing heterocyclic malanocortin receptor ligands, pharmaceutical compositions containing them and their use
HUP0600447A2 (en)	2006-09-28	Substituted 4-phenyl-4-[1h-imidazol-2-yl]-piperidine derivatives, pharmaceutical compositions containing them and their use as selective non-peptide delta opioid agonists
HK1081964A1 (en)	2006-05-26	Imidazopyridine derivatives, preparation method and pharmaceutical compositions containing same
IL174215A0 (en)	2006-08-01	Benzimidazole derivatives, compositions containing them preparation thereof and uses thereof
HUP0400193A3 (en)	2004-10-28	Imidazolindion derivatives as metalloproteinase inhibitors, their use and pharmaceutical compositions containing them
IL172023A0 (en)	2009-02-11	Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
IL172027A0 (en)	2011-08-01	Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
HUP0402019A3 (en)	2009-07-28	Piperidine derivatives useful as ccr5 antagonists and pharmaceutical compositions containing them
IL158898A0 (en)	2004-05-12	PHARMACEUTICAL COMPOSITIONS CONTAINING APOMORPHINE, 6aR-(-)-N-PROPYL-NORAPOMORPHINE AND DERIVATIVES THEREOF
IL174135A0 (en)	2006-08-01	Benzimidazole acetonitrile derivatives, their preparation and and pharmaceutical compositions containing them
HUP0300578A3 (en)	2009-01-28	Alkylated imidazopyridine derivatives, pharmaceutical compositions containing them and their use
HUP0500024A3 (en)	2009-01-28	6-aminomorphinane derivatives, their use and pharmaceutical compositions containing them
HUP0400549A3 (en)	2004-09-28	Novel imidazole derivatives, production method thereof and pharmaceutical compositions containing them
PL356911A1 (en)	2004-07-12	Novel heterocyclic derivatives, preparation method and pharmaceutical compositions containing same
IL173198A0 (en)	2006-06-11	Hydrazide derivatives, their preparation and pharmaceutical compositions containing them
HUP0402332A3 (en)	2009-07-28	Substituted 4-phenyl-4-(1h-imidazol-2-yl)-piperidine derivatives for reducing ischaemic damage and pharmaceutical compositions containing them
PL367341A1 (en)	2005-02-21	Novel piperidinecarboxamide derivatives, method for preparing same and pharmaceutical compositions containing same
HUP0401280A3 (en)	2009-06-29	Pyrimidine derivatives useful as selective cox-2 inhibitors, process for their preparation and pharmaceutical compositions containing them