MX352415B - Derivados de 1, 2, 4-triazin-4-amina. - Google Patents

Derivados de 1, 2, 4-triazin-4-amina.

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Publication number
MX352415B
MX352415B MX2012009073A MX2012009073A MX352415B MX 352415 B MX352415 B MX 352415B MX 2012009073 A MX2012009073 A MX 2012009073A MX 2012009073 A MX2012009073 A MX 2012009073A MX 352415 B MX352415 B MX 352415B
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MX
Mexico
Prior art keywords
group
substituents
rings
optionally substituted
partially unsaturated
Prior art date
Application number
MX2012009073A
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English (en)
Other versions
MX2012009073A (es
Inventor
Miles Stuart Congreve
Stephen Philippe Andrews
Jonathan Stephen Mason
Christine Mary Richardson
Giles Albert Brown
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Heptares Therapeutics Ltd Star
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Publication date
Application filed by Heptares Therapeutics Ltd Star filed Critical Heptares Therapeutics Ltd Star
Publication of MX2012009073A publication Critical patent/MX2012009073A/es
Publication of MX352415B publication Critical patent/MX352415B/es

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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D487/04—Ortho-condensed systems

Abstract

De acuerdo con la invención se proporciona un compuesto de fórmula A1 que puede ser útil en el tratamiento de una afección o trastorno mejorada por la inhibición del receptor de A1- A2b o, en particular, del receptor de A2a en donde el compuesto de fórmula A1 tiene la estructura (ver fórmula) en donde A representa Cy1 o HetA; Cy1 representa un sistema de anillo carbocíclico de 5 a 14 miembros aromático, completamente saturado o parcialmente insaturado que comprende uno, dos o tres anillos, cuyo grupo Cy1 es opcionalmente sustituido por uno o más sustituyentes R4a; HetA representa un grupo heterocícliclo de 5 a 14 miembros que puede ser aromático, completamente saturado o parcialmente insaturado, y que contiene uno o más heteroátomos seleccionados de O, S y N, cuyo grupo heterocíclico puede comprender uno, dos o tres anillos y cuyo grupo HetA es opcionalmente sustituido por uno o más sustituyentes R4b; B representa un Cy2 o HetB; Cy2 representa un sistema de anillo carbocíclico de 3 a 10 miembros aromático, completamente saturado o parcialmente insaturado que comprende uno o dos anillos, cuyo grupo Cy2 es opcionalmente sustituido por uno o más sustituyentes R4c; HetB representa un grupo heterocíclico de 3 a 10 miembros que puede ser aromático, completamente saturado o parcialmente insaturado, y que contiene uno o más heteroátomos seleccionados de O, S y N, cuyo grupo heterocíclico puede comprender uno o dos anillos u cuyo grupo HetB es opcionalmente sustituido por uno o más sustituyentes R4d.
MX2012009073A 2010-02-05 2011-02-07 Derivados de 1, 2, 4-triazin-4-amina. MX352415B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30206010P 2010-02-05 2010-02-05
US38176410P 2010-09-10 2010-09-10
PCT/EP2011/051755 WO2011095625A1 (en) 2010-02-05 2011-02-07 1,2,4-triazine-4-amine derivatives

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MX2012009073A MX2012009073A (es) 2012-12-17
MX352415B true MX352415B (es) 2017-11-22

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US (6) US8809525B2 (es)
EP (1) EP2531492B1 (es)
JP (1) JP5914361B2 (es)
KR (2) KR101993867B1 (es)
CN (1) CN102822150B (es)
AU (1) AU2011212430B2 (es)
BR (1) BR112012019540B1 (es)
CA (1) CA2789279C (es)
CY (1) CY1117780T1 (es)
DK (1) DK2531492T3 (es)
ES (1) ES2579949T3 (es)
HR (1) HRP20160636T1 (es)
HU (1) HUE028640T2 (es)
IL (1) IL221160A (es)
MX (1) MX352415B (es)
MY (1) MY180024A (es)
PL (1) PL2531492T3 (es)
PT (1) PT2531492T (es)
RU (1) RU2625791C2 (es)
SG (1) SG183146A1 (es)
SI (1) SI2531492T1 (es)
SM (1) SMT201600198B (es)
WO (1) WO2011095625A1 (es)
ZA (1) ZA201205788B (es)

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Publication number Priority date Publication date Assignee Title
ES2579949T3 (es) * 2010-02-05 2016-08-17 Heptares Therapeutics Limited Derivados de 1,2,4-triazin-4-amina
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