MX2013006418A - Derivados de oxazolil-metileter como agonistas del receptor de alx. - Google Patents

Derivados de oxazolil-metileter como agonistas del receptor de alx.

Info

Publication number
MX2013006418A
MX2013006418A MX2013006418A MX2013006418A MX2013006418A MX 2013006418 A MX2013006418 A MX 2013006418A MX 2013006418 A MX2013006418 A MX 2013006418A MX 2013006418 A MX2013006418 A MX 2013006418A MX 2013006418 A MX2013006418 A MX 2013006418A
Authority
MX
Mexico
Prior art keywords
oxazolyl
receptor agonists
alx receptor
methylether derivatives
methylether
Prior art date
Application number
MX2013006418A
Other languages
English (en)
Inventor
Daniel Bur
Olivier Corminboeuf
Sylvaine Cren
Corinna Grisostomi
Xavier Leroy
Sylvia Richard-Bildstein
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of MX2013006418A publication Critical patent/MX2013006418A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

La invención se refiere a derivados de oxazolil-metiléter de fórmula (I), donde R1, R2, R3, R4 y R5 son como se define en la descripción, a su preparación y a su uso como compuestos farmacéuticamente activos.
MX2013006418A 2010-12-07 2011-12-06 Derivados de oxazolil-metileter como agonistas del receptor de alx. MX2013006418A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2010055616 2010-12-07
PCT/IB2011/055487 WO2012077049A1 (en) 2010-12-07 2011-12-06 Oxazolyl-methylether derivatives as alx receptor agonists

Publications (1)

Publication Number Publication Date
MX2013006418A true MX2013006418A (es) 2013-07-15

Family

ID=45444667

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013006418A MX2013006418A (es) 2010-12-07 2011-12-06 Derivados de oxazolil-metileter como agonistas del receptor de alx.

Country Status (19)

Country Link
US (1) US8846733B2 (es)
EP (1) EP2649068B1 (es)
JP (1) JP5923107B2 (es)
KR (1) KR101864463B1 (es)
CN (1) CN103261194B (es)
AR (1) AR084173A1 (es)
AU (1) AU2011340146B2 (es)
CA (1) CA2816376C (es)
CY (1) CY1116004T1 (es)
DK (1) DK2649068T3 (es)
ES (1) ES2526132T3 (es)
HR (1) HRP20150049T1 (es)
MX (1) MX2013006418A (es)
PL (1) PL2649068T3 (es)
PT (1) PT2649068E (es)
RU (1) RU2588567C2 (es)
SI (1) SI2649068T1 (es)
TW (1) TWI523853B (es)
WO (1) WO2012077049A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5917541B2 (ja) 2010-11-17 2016-05-18 アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ 架橋スピロ［２．４］ヘプタンエステル誘導体
MA37618B1 (fr) 2012-05-16 2017-08-31 Actelion Pharmaceuticals Ltd Dérivés pontés fluorés de spiro[2.4]heptane en tant qu'agonistes de récepteur alx
CN104284887B (zh) 2012-05-16 2016-06-22 埃科特莱茵药品有限公司 作为alx受体激动剂的经1-(对-甲苯基)环丙基取代的桥联螺[2.4]庚烷衍生物
AR096686A1 (es) 2013-06-25 2016-01-27 Actelion Pharmaceuticals Ltd Derivados de espiro[2.4]heptano puenteados sustituidos con difluoroetil-oxazol como agonistas del receptor de alx
AU2014292064B2 (en) 2013-07-18 2018-07-05 Idorsia Pharmaceuticals Ltd Piperazine substituted bridged spiro[2.4]heptane derivatives as alx receptor agonists
AR097279A1 (es) 2013-08-09 2016-03-02 Actelion Pharmaceuticals Ltd Derivados de benzimidazolil-metil urea como agonistas del receptor de alx
TWI649305B (zh) 2013-11-28 2019-02-01 杏林製藥股份有限公司 脲衍生物、或其藥理學上所容許之鹽
CN107849049B (zh) 2015-05-27 2021-03-16 杏林制药株式会社 脲衍生物或其药用盐
EP3303284B1 (en) 2015-05-27 2020-04-08 Kyorin Pharmaceutical Co., Ltd. Urea derivative or pharmacologically acceptable salt thereof
WO2018161175A1 (en) * 2017-03-09 2018-09-13 University Health Network Lipoxin and lipoxin analogue mediated neuroprotection and treatments
PT3762380T (pt) 2018-03-05 2022-01-25 Bristol Myers Squibb Co Agonistas do recetor do péptido de fenilpirrolidinona formilo 2

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62234018A (ja) 1986-04-02 1987-10-14 Rooto Seiyaku Kk 糖尿病併発症治療剤
WO2002024656A1 (fr) 2000-09-22 2002-03-28 Nihon Nohyaku Co., Ltd. Derives de n-(4-pyrazolyl amide, produits chimiques pour utilisation agricole et horticole et applications desdits derives
AU2003214249A1 (en) 2002-04-03 2003-10-13 Bayer Aktiengesellschaft Diagnostics and therapeutics for diseases associated with n-formyl peptide receptor like 1 (fprl1)
CA2544983A1 (en) 2003-11-07 2005-05-26 Acadia Pharmaceuticals Inc. Use of the lipoxin receptor, fprl1, as a tool for identifying compounds effective in the treatment of pain and inflammation
WO2005115383A2 (en) * 2004-05-25 2005-12-08 Metabolex, Inc. Substituted triazoles as modulators of ppar and methods of their preparation
US8026260B2 (en) 2005-11-03 2011-09-27 Merck Sharp & Dohme Corp. Histone deacetylase inhibitors with aryl-pyrazolyl-motifs
EP2195656A4 (en) 2007-08-21 2011-10-19 Senomyx Inc HUMAN T2R BITTERITY RECEPTORS AND USES THEREOF
AR069650A1 (es) 2007-12-14 2010-02-10 Actelion Pharmaceuticals Ltd Derivados de aminopirazol como agonistas no peptidicos del receptor alx humano
AU2008337097B2 (en) 2007-12-18 2014-03-20 Idorsia Pharmaceuticals Ltd Aminotriazole derivatives as ALX agonists
AU2010250789B2 (en) 2009-05-18 2015-05-14 Actelion Pharmaceuticals Ltd Bridged spiro [2.4] heptane derivatives as ALX receptor and/or FPRL2 agonists
CN101909306A (zh) * 2009-06-08 2010-12-08 中兴通讯股份有限公司 中继站管理方法及基站
MY161243A (en) * 2009-06-09 2017-04-14 Actelion Pharmaceuticals Ltd Fluorinated aminotriazole derivatives
JP5624130B2 (ja) 2009-06-12 2014-11-12 アクテリオンファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ Ａｌｘ受容体アゴニストとしてのオキサゾール及びチアゾール誘導体
JP2012254939A (ja) * 2009-10-07 2012-12-27 Astellas Pharma Inc オキサゾール化合物

Also Published As

Publication number Publication date
HRP20150049T1 (hr) 2015-02-27
KR101864463B1 (ko) 2018-06-04
EP2649068B1 (en) 2014-10-29
KR20130133240A (ko) 2013-12-06
CY1116004T1 (el) 2017-01-25
PT2649068E (pt) 2014-12-23
SI2649068T1 (sl) 2015-01-30
JP5923107B2 (ja) 2016-05-24
CA2816376A1 (en) 2012-06-14
CA2816376C (en) 2018-11-20
EP2649068A1 (en) 2013-10-16
WO2012077049A1 (en) 2012-06-14
TWI523853B (zh) 2016-03-01
DK2649068T3 (en) 2014-12-08
RU2588567C2 (ru) 2016-07-10
US8846733B2 (en) 2014-09-30
US20130261159A1 (en) 2013-10-03
AU2011340146A1 (en) 2013-07-25
PL2649068T3 (pl) 2015-03-31
CN103261194B (zh) 2016-02-24
AR084173A1 (es) 2013-04-24
RU2013130879A (ru) 2015-01-20
ES2526132T3 (es) 2015-01-07
AU2011340146B2 (en) 2016-05-19
JP2013544878A (ja) 2013-12-19
TW201305151A (zh) 2013-02-01
CN103261194A (zh) 2013-08-21

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