MX2009009792A - Compuestos de fenil amino pirimidina y usos de los mismos. - Google Patents

Compuestos de fenil amino pirimidina y usos de los mismos.

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Publication number
MX2009009792A
MX2009009792A MX2009009792A MX2009009792A MX2009009792A MX 2009009792 A MX2009009792 A MX 2009009792A MX 2009009792 A MX2009009792 A MX 2009009792A MX 2009009792 A MX2009009792 A MX 2009009792A MX 2009009792 A MX2009009792 A MX 2009009792A
Authority
MX
Mexico
Prior art keywords
diseases
phenyl amino
pyrimidine compounds
amino pyrimidine
kinases
Prior art date
Application number
MX2009009792A
Other languages
English (en)
Inventor
Christopher John Burns
Andrew Frederick Wilks
Jun Zeng
Andrew Craig Donohue
John Thomas Feutrill
Thao Lien Thi Ngygen
Original Assignee
Cytopia Res Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytopia Res Pty Ltd filed Critical Cytopia Res Pty Ltd
Publication of MX2009009792A publication Critical patent/MX2009009792A/es

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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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Abstract

La presente invención se relaciona a compuestos de fenil amino pirimidina que son inhibidores de proteína quinasas que incluyen quinasas de JAK. En particular los compuestos son selectivos para las quinasas de JAK2. Los inhibidores de quinasa se pueden utilizar en el tratamiento de enfermedades asociadas con quinasa tales como enfermedades inmunológicas e inflamatorias que incluyen transplantes de órganos; enfermedades hiperproliferativas que incluyen cáncer y enfermedades mieloproliferativas; enfermedades virales; enfermedades metabólicas; y enfermedades vasculares.
MX2009009792A 2007-03-12 2008-03-12 Compuestos de fenil amino pirimidina y usos de los mismos. MX2009009792A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US89426407P 2007-03-12 2007-03-12
US1625207P 2007-12-21 2007-12-21
PCT/AU2008/000339 WO2008109943A1 (en) 2007-03-12 2008-03-12 Phenyl amino pyrimidine compounds and uses thereof

Publications (1)

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MX2009009792A true MX2009009792A (es) 2009-09-23

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MX2009009792A MX2009009792A (es) 2007-03-12 2008-03-12 Compuestos de fenil amino pirimidina y usos de los mismos.

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KR (3) KR101566840B1 (es)
CN (2) CN101861313B (es)
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Cited By (1)

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Publication number Priority date Publication date Assignee Title
USRE48285E1 (en) 2014-06-12 2020-10-27 Sierra Oncology, Inc. N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide

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