MA38393B1 - Composés hétéroaryle et utilisations associées - Google Patents

Composés hétéroaryle et utilisations associées

Info

Publication number
MA38393B1
MA38393B1 MA38393A MA38393A MA38393B1 MA 38393 B1 MA38393 B1 MA 38393B1 MA 38393 A MA38393 A MA 38393A MA 38393 A MA38393 A MA 38393A MA 38393 B1 MA38393 B1 MA 38393B1
Authority
MA
Morocco
Prior art keywords
protein kinase
heteroaryl compounds
related uses
compositions
carcinomas
Prior art date
Application number
MA38393A
Other languages
English (en)
Other versions
MA38393A3 (fr
Inventor
Laura Akullian D'agostino
Robert Tjin Tham Sjin
Deqiang Niu
Joseph John Mcdonald
Zhendong Zhu
Haibo Liu
Hormoz Mazdiyasni
Russell C Petter
Juswinder Singh
Matthieu Barrague
Alexandre Gross
Mark Munson
Darren Harvey
Andrew Scholte
Sachin Maniar
Original Assignee
Sanofi Sa
Celgene Avilomics Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa, Celgene Avilomics Research Inc filed Critical Sanofi Sa
Publication of MA38393A3 publication Critical patent/MA38393A3/fr
Publication of MA38393B1 publication Critical patent/MA38393B1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/78Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/80Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

L'invention concerne des composés utiles comme inhibiteurs de protéines kinases, contenant un reste de cystéine dans le site de liaison atp. L'invention concerne également des compositions pharmaceutiquement acceptables comprenant des quantités thérapeutiquement efficaces d'un ou de plusieurs composés inhibiteurs de protéines kinases, ainsi que des méthodes d'utilisation de ces compositions dans le traitement de cancers et de carcinomes.
MA38393A 2014-03-13 2014-03-14 Composés hétéroaryle et utilisations associées MA38393B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14305361 2014-03-13
PCT/US2014/029270 WO2014144737A1 (fr) 2013-03-15 2014-03-14 Composés hétéroaryle et utilisations associées

Publications (2)

Publication Number Publication Date
MA38393A3 MA38393A3 (fr) 2018-05-31
MA38393B1 true MA38393B1 (fr) 2018-11-30

Family

ID=50390019

Family Applications (1)

Application Number Title Priority Date Filing Date
MA38393A MA38393B1 (fr) 2014-03-13 2014-03-14 Composés hétéroaryle et utilisations associées

Country Status (13)

Country Link
US (1) US9663524B2 (fr)
EP (1) EP2968337B1 (fr)
JP (1) JP6576325B2 (fr)
KR (1) KR102219695B1 (fr)
CN (2) CN111793068A (fr)
AU (1) AU2014228746B2 (fr)
BR (1) BR112015022191A8 (fr)
EA (1) EA036160B1 (fr)
MA (1) MA38393B1 (fr)
MX (1) MX2015011514A (fr)
PE (1) PE20151776A1 (fr)
SG (1) SG11201507478VA (fr)
WO (1) WO2014144737A1 (fr)

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CN105307657A (zh) 2016-02-03
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EP2968337A1 (fr) 2016-01-20
BR112015022191A2 (pt) 2017-10-10
JP2016519673A (ja) 2016-07-07
CN111793068A (zh) 2020-10-20
EA036160B1 (ru) 2020-10-08
AU2014228746A1 (en) 2015-09-10
SG11201507478VA (en) 2015-10-29
KR20150131237A (ko) 2015-11-24
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WO2014144737A1 (fr) 2014-09-18
JP6576325B2 (ja) 2019-09-18
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US20160046634A1 (en) 2016-02-18
BR112015022191A8 (pt) 2018-01-23

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