TJ342B - Derivatives of 6-aryl pyrido Ä2,3-dÜ pyrimidines and naphthyridines pharmaceutical composition possess inhibiting effect of cellular proliferation pr ovoking protein tyrosine kinase and method of inhibiting cellular proliferation - Google Patents

Derivatives of 6-aryl pyrido Ä2,3-dÜ pyrimidines and naphthyridines pharmaceutical composition possess inhibiting effect of cellular proliferation pr ovoking protein tyrosine kinase and method of inhibiting cellular proliferation

Info

Publication number
TJ342B
TJ342B TJ97000469A TJ97000469A TJ342B TJ 342 B TJ342 B TJ 342B TJ 97000469 A TJ97000469 A TJ 97000469A TJ 97000469 A TJ97000469 A TJ 97000469A TJ 342 B TJ342 B TJ 342B
Authority
TJ
Tajikistan
Prior art keywords
cellular proliferation
inhibiting
naphthyridines
tyrosine kinase
protein tyrosine
Prior art date
Application number
TJ97000469A
Inventor
Clifton John Blankley
Annette Marian Doherty
James Marino Hamby
Robert Lee Panek
Mel Conrad Shroeder
Howard Daniel Hollis Owalter
Cleo Connolly
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/539,410 external-priority patent/US5733913A/en
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of TJ342B publication Critical patent/TJ342B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

6-Aryl naphthyridines are inhibitors of protein tyrosine kinase, and are thus useful in treating cellular proliferation mediated thereby. The compounds are especially useful in treating atherosclerosis, restenosis, psoriasis, as well as bacterial infections.
TJ97000469A 1994-11-14 1995-11-13 Derivatives of 6-aryl pyrido Ä2,3-dÜ pyrimidines and naphthyridines pharmaceutical composition possess inhibiting effect of cellular proliferation pr ovoking protein tyrosine kinase and method of inhibiting cellular proliferation TJ342B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33905194A 1994-11-14 1994-11-14
US08/539,410 US5733913A (en) 1994-11-14 1995-11-06 6-Aryl pyrido 2,3-d! pyrimidines and naphthyridines for inhibiting protein tyrosine kinase mediated cellular proliferation

Publications (1)

Publication Number Publication Date
TJ342B true TJ342B (en) 2002-10-06

Family

ID=26991470

Family Applications (1)

Application Number Title Priority Date Filing Date
TJ97000469A TJ342B (en) 1994-11-14 1995-11-13 Derivatives of 6-aryl pyrido Ä2,3-dÜ pyrimidines and naphthyridines pharmaceutical composition possess inhibiting effect of cellular proliferation pr ovoking protein tyrosine kinase and method of inhibiting cellular proliferation

Country Status (25)

Country Link
US (1) US5952342A (en)
EP (1) EP0790997B1 (en)
CN (1) CN1085666C (en)
AT (1) ATE190978T1 (en)
AU (1) AU711426B2 (en)
BG (1) BG63162B1 (en)
CZ (1) CZ286160B6 (en)
DE (1) DE69515898T2 (en)
DK (1) DK0790997T3 (en)
ES (1) ES2146782T3 (en)
FI (1) FI971953A (en)
GE (1) GEP20012444B (en)
GR (1) GR3033439T3 (en)
HU (1) HUT76853A (en)
IL (1) IL115970A (en)
MD (1) MD1861G2 (en)
MX (1) MX9702245A (en)
NO (1) NO308250B1 (en)
NZ (1) NZ296456A (en)
PL (1) PL181893B1 (en)
PT (1) PT790997E (en)
RU (1) RU2191188C2 (en)
SK (1) SK281724B6 (en)
TJ (1) TJ342B (en)
WO (1) WO1996015128A2 (en)

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RU2573390C2 (en) * 2009-11-26 2016-01-20 Аетерна Зентарис Гмбх Novel naphthyridine derivatives and thereof application as kinase inhibitors

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Also Published As

Publication number Publication date
NO972198L (en) 1997-05-13
GEP20012444B (en) 2001-05-25
ES2146782T3 (en) 2000-08-16
PL320169A1 (en) 1997-09-15
EP0790997B1 (en) 2000-03-22
MD1861G2 (en) 2002-09-30
MD970187A (en) 1999-02-28
RU2191188C2 (en) 2002-10-20
DE69515898T2 (en) 2000-08-17
AU4107896A (en) 1996-06-06
CZ286160B6 (en) 2000-01-12
DK0790997T3 (en) 2000-08-21
IL115970A (en) 1999-06-20
NZ296456A (en) 1999-09-29
FI971953A0 (en) 1997-05-07
US5952342A (en) 1999-09-14
MD1861F2 (en) 2002-02-28
SK60997A3 (en) 1998-05-06
AU711426B2 (en) 1999-10-14
ATE190978T1 (en) 2000-04-15
EP0790997A2 (en) 1997-08-27
BG63162B1 (en) 2001-05-31
IL115970A0 (en) 1996-01-31
MX9702245A (en) 1997-06-28
CZ139097A3 (en) 1998-02-18
FI971953A (en) 1997-05-12
HUT76853A (en) 1997-12-29
CN1085666C (en) 2002-05-29
NO308250B1 (en) 2000-08-21
NO972198D0 (en) 1997-05-13
DE69515898D1 (en) 2000-04-27
WO1996015128A3 (en) 1996-07-11
SK281724B6 (en) 2001-07-10
GR3033439T3 (en) 2000-09-29
BG101326A (en) 1998-04-30
PT790997E (en) 2000-06-30
CN1169726A (en) 1998-01-07
PL181893B1 (en) 2001-10-31
WO1996015128A2 (en) 1996-05-23

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