GB1419789A
(en)
|
1972-08-02 |
1975-12-31 |
Pfizer |
2-trifluoromethyl-4-quinolinols
|
WO1992000075A1
(en)
|
1990-06-29 |
1992-01-09 |
Pfizer Inc. |
Pyridopyrazine derivatives for treating substance abuse and addiction
|
US5482967A
(en)
|
1992-09-04 |
1996-01-09 |
Takeda Chemical Industries, Ltd. |
Condensed heterocyclic compounds, their production and use
|
DE69432629T3
(de)
|
1993-01-25 |
2008-01-17 |
Takeda Pharmaceutical Co. Ltd. |
Antikörper gegen beta-amyloid oder derivative davon und seine verwendung
|
TW394773B
(en)
|
1995-03-24 |
2000-06-21 |
Takeda Chemical Industries Ltd |
Cyclic compounds for antagonizing tachykinin receptor, substance p receptor and neurokinin a receptor, their production and pharmaceutical composition
|
DE19709877A1
(de)
|
1997-03-11 |
1998-09-17 |
Bayer Ag |
1,5-Dihydro-pyrazolo[3,4-d]-pyrimidinon-derivate
|
US8173127B2
(en)
|
1997-04-09 |
2012-05-08 |
Intellect Neurosciences, Inc. |
Specific antibodies to amyloid beta peptide, pharmaceutical compositions and methods of use thereof
|
ATE402717T1
(de)
|
1997-04-09 |
2008-08-15 |
Intellect Neurosciences Inc |
Für die termini des beta-amyloids spezifische, rekombinante antikörper, dafür kodierende dna und verfahren zu ihrer verwendung
|
GB9722520D0
(en)
|
1997-10-24 |
1997-12-24 |
Pfizer Ltd |
Compounds
|
US6905686B1
(en)
|
1997-12-02 |
2005-06-14 |
Neuralab Limited |
Active immunization for treatment of alzheimer's disease
|
TWI239847B
(en)
|
1997-12-02 |
2005-09-21 |
Elan Pharm Inc |
N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
|
CN1229296C
(zh)
|
1998-03-03 |
2005-11-30 |
Ppg工业俄亥俄公司 |
浸渍玻璃纤维束以及包括它的产品
|
US20020132817A1
(en)
|
1998-03-19 |
2002-09-19 |
Hideaki Natsugari |
Heterocyclic compounds, their production and use
|
AU1409100A
(en)
|
1998-11-27 |
2000-06-19 |
Takeda Chemical Industries Ltd. |
Drugs
|
TR200202799T3
(tr)
|
2000-02-24 |
2003-03-21 |
Washington University St.Louis |
AB peptidini sekanslayan insanlaştırılmış antikorlar
|
DE10045112A1
(de)
|
2000-09-11 |
2002-03-21 |
Merck Patent Gmbh |
Verwendung von Indolderivaten zur Behandlung von Erkrankungen des zentralen Nervensystems
|
JP4708675B2
(ja)
|
2000-11-03 |
2011-06-22 |
プロテオテック・インコーポレーテッド |
ウンカリア・トメントーサおよび関連植物からアミロイド阻害化合物を単離する方法ならびに単離した化合物の使用
|
WO2003016466A2
(en)
|
2001-08-17 |
2003-02-27 |
Eli Lilly And Company |
ANTI-Aβ ANTIBODIES
|
US20030195205A1
(en)
|
2001-11-02 |
2003-10-16 |
Pfizer Inc. |
PDE9 inhibitors for treating cardiovascular disorders
|
DE10238723A1
(de)
|
2002-08-23 |
2004-03-11 |
Bayer Ag |
Phenyl-substituierte Pyrazolyprimidine
|
DE10238724A1
(de)
|
2002-08-23 |
2004-03-04 |
Bayer Ag |
Alkyl-substituierte Pyrazolpyrimidine
|
JP2006506352A
(ja)
|
2002-09-11 |
2006-02-23 |
メルク エンド カムパニー インコーポレーテッド |
Hivインテグラーゼ阻害剤として有用なジヒドロキシピリドピラジン−1,6−ジオン化合物
|
CA2501945A1
(en)
|
2002-10-09 |
2004-04-22 |
Rinat Neuroscience Corp. |
Methods of treating alzheimer's disease using antibodies directed against amyloid beta peptide and compositions thereof
|
BR0315158A
(pt)
|
2002-10-09 |
2005-08-16 |
Pfizer Prod Inc |
Compostos de pirazol para o tratamento de distúrbios neurodegenarativos
|
WO2004035577A2
(en)
|
2002-10-16 |
2004-04-29 |
Gilead Sciences, Inc. |
Pre-organized tricyclic integrase inhibitor compounds
|
US20040220186A1
(en)
|
2003-04-30 |
2004-11-04 |
Pfizer Inc. |
PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease
|
CA2528652A1
(en)
|
2003-06-19 |
2004-12-23 |
Pfizer Products Inc. |
Nk1 antagonist
|
CA2534532A1
(en)
|
2003-08-21 |
2005-03-10 |
Pfizer Products, Inc. |
Compounds for the treatment of neurodegenerative disorders
|
CA2538220A1
(en)
|
2003-09-09 |
2005-03-24 |
Takeda Pharmaceutical Company Limited |
Use of antibody
|
GB0327319D0
(en)
|
2003-11-24 |
2003-12-24 |
Pfizer Ltd |
Novel pharmaceuticals
|
US7572799B2
(en)
|
2003-11-24 |
2009-08-11 |
Pfizer Inc |
Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
|
JP2007519734A
(ja)
|
2004-01-28 |
2007-07-19 |
メルク エンド カムパニー インコーポレーテッド |
アミノシクロペンチルピリドピラジノン系ケモカイン受容体活性調節剤
|
WO2005080361A1
(en)
|
2004-02-02 |
2005-09-01 |
Pfizer Products Inc. |
Histamine-3 receptor modulators
|
WO2005092099A1
(en)
|
2004-03-09 |
2005-10-06 |
Merck & Co., Inc. |
Hiv integrase inhibitors
|
CN1934091B
(zh)
|
2004-03-23 |
2012-02-08 |
辉瑞产品公司 |
治疗神经变性障碍的咪唑化合物
|
EP1742642B1
(en)
|
2004-04-14 |
2008-10-15 |
Gilead Sciences, Inc. |
Phosphonate analogs of hiv integrase inhibitor compounds
|
US7456164B2
(en)
|
2004-05-07 |
2008-11-25 |
Pfizer, Inc |
3- or 4-monosubtituted phenol and thiophenol derivatives useful as H3 ligands
|
EP1595881A1
(en)
|
2004-05-12 |
2005-11-16 |
Pfizer Limited |
Tetrahydronaphthyridine derivates useful as histamine H3 receptor ligands
|
EA016357B1
(ru)
|
2004-07-30 |
2012-04-30 |
Ринат Ньюросайенс Корп. |
Антитела, направленные против бета-амилоидного пептида, и способы их применения
|
FR2877015B1
(fr)
|
2004-10-21 |
2007-10-26 |
Commissariat Energie Atomique |
Revetement nanostructure et procede de revetement.
|
GB0423356D0
(en)
|
2004-10-21 |
2004-11-24 |
Merck Sharp & Dohme |
Therapeutic agents
|
WO2006069081A2
(en)
|
2004-12-22 |
2006-06-29 |
Washington University In St. Louis |
USE OF ANTI-Aβ ANTIBODY TO TREAT TRAUMATIC BRAIN INJURY
|
MY148086A
(en)
|
2005-04-29 |
2013-02-28 |
Rinat Neuroscience Corp |
Antibodies directed against amyloid-beta peptide and methods using same
|
US7741315B2
(en)
|
2005-05-10 |
2010-06-22 |
Merck Sharp & Dohme Corp. |
HIV integrase inhibitors
|
DE602006019231D1
(en)
|
2005-05-12 |
2011-02-10 |
Pfizer |
Wasserfreie kristalline formen von n-ä1,2-ethoxyethyl)-5-(n-ethyl-n-methylaminoü-7-(4-methylpyridin-2-yl-aminoü-1h-pyrazoloä4,3-düpyrimidin-3-carbonylümethansulfonsäureamid
|
CA2608672A1
(en)
|
2005-05-24 |
2006-11-30 |
Pharmacia & Upjohn Company Llc |
Pyridine [3,4-b] pyrazinones as pde-5 inhibitors
|
CA2603830A1
(en)
|
2005-05-24 |
2006-11-30 |
Pharmacia & Upjohn Co Llc |
PYRIDINE [2,3-B] PYRAZINONES
|
WO2006126083A1
(en)
|
2005-05-24 |
2006-11-30 |
Pharmacia & Upjohn Company Llc |
Pyridine [3 , 4-b] pyrazinone compounds as pde-5 inhibitors
|
DE602006018301D1
(de)
|
2005-06-22 |
2010-12-30 |
Pfizer Prod Inc |
Histamin-3-rezeptorantagonisten
|
US20070060534A1
(en)
|
2005-06-30 |
2007-03-15 |
Threshold Pharmaceuticals, Inc. |
Anthracycline analogs
|
US8158673B2
(en)
|
2005-10-27 |
2012-04-17 |
Pfizer Inc. |
Histamine-3 receptor antagonists
|
WO2007052124A1
(en)
|
2005-11-04 |
2007-05-10 |
Pfizer Limited |
Tetrahydronaphthyridine derivative
|
US20080275251A1
(en)
|
2005-11-18 |
2008-11-06 |
Glaxo Group Limited |
Novel Intermediates and Their Use
|
EP1948614A2
(en)
|
2005-11-18 |
2008-07-30 |
Takeda San Diego, Inc. |
Glucokinase activators
|
US20070117839A1
(en)
|
2005-11-24 |
2007-05-24 |
Eisai R&D Management Co., Ltd. |
Two cyclic cinnamide compound
|
JP5221144B2
(ja)
|
2005-11-24 |
2013-06-26 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
モルホリンタイプ・シンナミド化合物
|
WO2007063385A2
(en)
|
2005-12-01 |
2007-06-07 |
Pfizer Products Inc. |
Spirocyclic amine histamine-3 receptor antagonists
|
WO2007069053A1
(en)
|
2005-12-14 |
2007-06-21 |
Pfizer Products Inc. |
Benzimidazole antagonists of the h-3 receptor
|
RU2448964C2
(ru)
*
|
2006-01-20 |
2012-04-27 |
Шеринг Корпорейшн |
КАРБОЦИКЛИЧЕСКИЕ И ГЕТЕРОЦИКЛИЧЕСКИЕ АРИЛСУЛЬФОНЫ, ИХ ПРИМЕНЕНИЕ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ИХ ОСНОВЕ, ОБЛАДАЮЩАЯ СВОЙСТВАМИ ИНГИБИТОРА γ-СЕКРЕТАЗЫ
|
WO2007088450A2
(en)
|
2006-02-01 |
2007-08-09 |
Pfizer Products Inc. |
Chromane antagonist of the h-3 receptor
|
WO2007088462A1
(en)
|
2006-02-01 |
2007-08-09 |
Pfizer Products Inc. |
Spirochromane antagonists of the h-3 receptor
|
WO2007099423A1
(en)
|
2006-03-02 |
2007-09-07 |
Pfizer Products Inc. |
1-pyrrolidine indane derivatives as histamine-3 receptor antagonists
|
TWI378091B
(en)
|
2006-03-09 |
2012-12-01 |
Eisai R&D Man Co Ltd |
Multi-cyclic cinnamide derivatives
|
JP2009539762A
(ja)
|
2006-03-13 |
2009-11-19 |
ファイザー・プロダクツ・インク |
H3受容体のテトラリン拮抗薬
|
RS51885B
(en)
|
2006-04-21 |
2012-02-29 |
Pfizer Products Inc. |
PYRIDIN [3,4-b] PYRAZINNES
|
PE20080069A1
(es)
|
2006-05-15 |
2008-02-22 |
Merck & Co Inc |
Compuestos biciclicos como agonistas del receptor 40 acoplado a proteina g (gpr40)
|
JP2009537546A
(ja)
|
2006-05-16 |
2009-10-29 |
ギリアード サイエンシーズ, インコーポレイテッド |
インテグラーゼ阻害剤
|
US20100105904A1
(en)
|
2006-05-19 |
2010-04-29 |
Teiji Kimura |
Urea type cinnamide derivative
|
WO2007138431A2
(en)
|
2006-05-30 |
2007-12-06 |
Pfizer Products Inc. |
Azabicyclic ether histamine-3 antagonists
|
AU2008208653B2
(en)
|
2007-01-22 |
2012-11-22 |
Pfizer Products Inc. |
Tosylate salt of a therapeutic compound and pharmaceutical compositions thereof
|
JP2010518083A
(ja)
|
2007-02-12 |
2010-05-27 |
メルク・シャープ・エンド・ドーム・コーポレイション |
ピペリジン誘導体
|
EP2121633A2
(en)
|
2007-02-12 |
2009-11-25 |
Merck & Co., Inc. |
Piperazine derivatives for treatment of ad and related conditions
|
PE20081791A1
(es)
|
2007-02-28 |
2009-02-07 |
Eisai Randd Man Co Ltd |
Dos derivados ciclicos de oxomorfolina
|
WO2008137102A2
(en)
|
2007-05-04 |
2008-11-13 |
Torreypines Therapeutics, Inc. |
Methods of modulating amyloid beta and compounds useful therefor
|
EP2155737A1
(en)
|
2007-05-07 |
2010-02-24 |
Schering Corporation |
Gamma secretase modulators
|
KR101138045B1
(ko)
|
2007-05-11 |
2012-04-24 |
에프. 호프만-라 로슈 아게 |
아밀로이드 베타에 대한 조절제로서의 헤트아릴아닐린
|
CL2008001540A1
(es)
|
2007-05-29 |
2009-05-22 |
Sgx Pharmaceuticals Inc |
Compuestos derivados de pirrolopiridinas y pirazolopiridinas; composicion farmaceutica; y uso en el tratamiento del cancer.
|
KR20100037053A
(ko)
|
2007-06-01 |
2010-04-08 |
쉐링 코포레이션 |
감마 세크레타제 조절인자
|
US8580956B2
(en)
|
2007-06-01 |
2013-11-12 |
Merck Sharp & Dohme Corp. |
Gamma secretase modulators
|
US8242150B2
(en)
|
2007-06-13 |
2012-08-14 |
Merck Sharp & Dohme Corp. |
Triazole derivatives for treating alzheimer'S disease and related conditions
|
CA2692253A1
(en)
|
2007-06-29 |
2009-01-08 |
Schering Corporation |
Gamma secretase modulators
|
WO2009020580A1
(en)
|
2007-08-06 |
2009-02-12 |
Schering Corporation |
Gamma secretase modulators
|
US7935815B2
(en)
|
2007-08-31 |
2011-05-03 |
Eisai R&D Management Co., Ltd. |
Imidazoyl pyridine compounds and salts thereof
|
CL2008002542A1
(es)
|
2007-08-31 |
2009-01-02 |
Eisai R&D Man Co Ltd |
Compuestos derivados de imidazolil piridina ligados a un heterociclo mediante un vinilo, moduladores de la actividad de amiloide-beta; composicion farmaceutica que comprende a dichos compuestos; y su uso para el tratamiento de enfermedades tales como alzheimer, demencia, sindrome de down o amiloidosis.
|
JP2010538068A
(ja)
|
2007-09-06 |
2010-12-09 |
シェーリング コーポレイション |
ガンマセクレターゼモジュレーター
|
CA2700964A1
(en)
|
2007-09-28 |
2009-04-09 |
Schering Corporation |
Gamma secretase modulators
|
GB0720444D0
(en)
|
2007-10-18 |
2007-11-28 |
Glaxo Group Ltd |
Novel compounds
|
MX2010005028A
(es)
|
2007-11-05 |
2010-05-27 |
Schering Corp |
Moduladores de gamma secretasa.
|
CN101939312A
(zh)
*
|
2007-12-06 |
2011-01-05 |
先灵公司 |
γ分泌酶调节剂
|
JP2011506460A
(ja)
|
2007-12-11 |
2011-03-03 |
シェーリング コーポレイション |
γ−セクレターゼモジュレーター
|
MX2010006378A
(es)
|
2007-12-11 |
2010-09-07 |
Schering Corp |
Moduladores de gamma secretasa.
|
WO2009075874A1
(en)
|
2007-12-13 |
2009-06-18 |
Amgen Inc. |
Gamma secretase modulators
|
AU2009203773B2
(en)
|
2008-01-11 |
2013-04-18 |
F. Hoffmann-La Roche Ag |
Modulators for amyloid beta
|
CN101952275B
(zh)
|
2008-02-22 |
2014-06-18 |
弗·哈夫曼-拉罗切有限公司 |
β-淀粉样蛋白的调节剂
|
JP2011513323A
(ja)
|
2008-02-29 |
2011-04-28 |
シェーリング コーポレイション |
アルツハイマー病の治療のためのγ−セクレターゼモジュレーター
|
US20100137320A1
(en)
|
2008-02-29 |
2010-06-03 |
Schering Corporation |
Gamma secretase modulators
|
JP2011520809A
(ja)
|
2008-05-05 |
2011-07-21 |
アムジエン・インコーポレーテツド |
γセクレターゼモジュレーターとしての尿素化合物
|
FR2933700B1
(fr)
*
|
2008-07-08 |
2010-07-30 |
Sanofi Aventis |
Derives de pyridino-pyridinones, leur preparation et leur application en therapeutique
|
TW201006801A
(en)
|
2008-07-18 |
2010-02-16 |
Lilly Co Eli |
Imidazole carboxamides
|
US8685972B2
(en)
|
2008-08-13 |
2014-04-01 |
Merck Sharp & Dohme Corp. |
Pyrimidine derivatives for treatment of alzheimer's disease
|
US20110251172A1
(en)
|
2008-08-13 |
2011-10-13 |
Rivkin Alexey A |
Purine derivatives for treatment of alzheimer's disease
|
MX2011002002A
(es)
|
2008-08-27 |
2011-03-29 |
Eisai R&D Man Co Ltd |
Proceso para preparar ciertos compuestos de cinnamida.
|
WO2010040661A1
(en)
|
2008-10-09 |
2010-04-15 |
F. Hoffmann-La Roche Ag |
Modulators for amyloid beta
|
CA2742897A1
(en)
|
2008-11-06 |
2010-05-14 |
Astrazeneca Ab |
Modulators of amyloid beta.
|
WO2010054064A1
(en)
|
2008-11-06 |
2010-05-14 |
Schering Corporation |
Gamma secretase modulators
|
EP2356115A1
(en)
|
2008-11-06 |
2011-08-17 |
Schering Corporation |
Gamma secretase modulators
|
EP2355817A1
(en)
|
2008-11-10 |
2011-08-17 |
F. Hoffmann-La Roche AG |
Heterocyclic gamma secretase modulators
|
EP2379075A4
(en)
|
2008-12-16 |
2012-05-30 |
Merck Sharp & Dohme |
TRIAZOL DERIVATIVES FOR THE TREATMENT OF ALZHEIMER DISEASE
|
EP2378879A4
(en)
|
2008-12-16 |
2012-06-06 |
Merck Sharp & Dohme |
TRIAZONE DERIVATIVES FOR THE TREATMENT OF MORBUS ALZHEIMER
|
PA8854101A1
(es)
|
2008-12-18 |
2010-07-27 |
Ortho Mcneil Janssen Pharm |
Derivados de imidazol bicíclicos sustituidos como moduladores de gamma secretasa
|
MA33085B1
(fr)
|
2008-12-19 |
2012-03-01 |
Boehringer Ingelheim Int |
Pyrimidine-4 carboxamides cycliques en tant qu'antagonistes du recepteur ccr2 pour le traitement d'inflammations, de l'asthme et des broncho-pneumopathies chroniques obstructives
|
EP2379566A2
(en)
|
2008-12-22 |
2011-10-26 |
Schering Corporation |
Gamma secretase modulators
|
AU2009330233A1
(en)
|
2008-12-22 |
2011-07-07 |
Merck Sharp & Dohme Corp. |
Gamma secretase modulators
|
TW201030002A
(en)
|
2009-01-16 |
2010-08-16 |
Bristol Myers Squibb Co |
Bicyclic compounds for the reduction of beta-amyloid production
|
CN102325765B
(zh)
|
2009-02-06 |
2014-12-24 |
杨森制药公司 |
作为γ-分泌酶调节剂的取代的双环杂环化合物
|
TWI461425B
(zh)
|
2009-02-19 |
2014-11-21 |
Janssen Pharmaceuticals Inc |
作為伽瑪分泌酶調節劑之新穎經取代的苯并唑、苯并咪唑、唑并吡啶及咪唑并吡啶衍生物類
|
JP2012051806A
(ja)
|
2009-02-26 |
2012-03-15 |
Eisai R & D Management Co Ltd |
イミダゾリルピラジン誘導体
|
BRPI1007883A2
(pt)
|
2009-02-26 |
2016-02-23 |
Eisai R&D Man Co Ltd |
sal, e, cristal.
|
JP2012051807A
(ja)
|
2009-02-26 |
2012-03-15 |
Eisai R & D Management Co Ltd |
アリールイミダゾール化合物
|
JP2012051805A
(ja)
|
2009-02-26 |
2012-03-15 |
Eisai R & D Management Co Ltd |
テトラヒドロトリアゾロピリジン誘導体の製造方法
|
JP2012121809A
(ja)
|
2009-02-26 |
2012-06-28 |
Eisai R & D Management Co Ltd |
多環式化合物の製造法およびその中間体
|
US20120053165A1
(en)
|
2009-03-03 |
2012-03-01 |
Pfizer Inc. |
Novel Phenyl Imidazoles and Phenyl Triazoles As Gamma-Secretase Modulators
|
UA108208C2
(xx)
|
2009-08-07 |
2015-04-10 |
|
Пестицидні композиції
|
CA2776480A1
(en)
*
|
2009-10-20 |
2011-04-28 |
Pfizer Inc. |
Novel heteroaryl imidazoles and heteroaryl triazoles as gamma-secretase modulators
|
KR101758046B1
(ko)
*
|
2009-12-22 |
2017-07-14 |
버텍스 파마슈티칼스 인코포레이티드 |
포스파티딜이노시톨 3-키나제의 이소인돌리논 억제제
|
ES2602794T3
(es)
|
2011-03-31 |
2017-02-22 |
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|
JP6106745B2
(ja)
*
|
2012-05-16 |
2017-04-05 |
ヤンセン ファーマシューティカルズ,インコーポレーテッド |
(特に)アルツハイマー病の治療に有用な置換3,4−ジヒドロ−2H−ピリド[1,2−a]ピラジン−1,6−ジオン誘導体
|
UA110688C2
(uk)
|
2012-09-21 |
2016-01-25 |
Пфайзер Інк. |
Біциклічні піридинони
|
TWI614238B
(zh)
|
2012-09-21 |
2018-02-11 |
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雙(氟烷基)-1,4-苯并二氮呯酮化合物及其前藥
|
US10112943B2
(en)
|
2012-12-20 |
2018-10-30 |
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|
AU2014206834B2
(en)
|
2013-01-17 |
2017-06-22 |
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|
JP6425717B2
(ja)
|
2013-10-04 |
2018-11-21 |
ファイザー・インク |
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|
CN111772834B
(zh)
|
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2022-07-15 |
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|
AP2016009465A0
(en)
|
2014-04-01 |
2016-09-30 |
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Chromene and 1,1 a,2,7b-tetrahydrocyclopropa[c]chromene pyridopyrazinediones as gamma-secretase modulators
|