MX340574B - Imidazo pirazinas. - Google Patents

Imidazo pirazinas.

Info

Publication number
MX340574B
MX340574B MX2013010183A MX2013010183A MX340574B MX 340574 B MX340574 B MX 340574B MX 2013010183 A MX2013010183 A MX 2013010183A MX 2013010183 A MX2013010183 A MX 2013010183A MX 340574 B MX340574 B MX 340574B
Authority
MX
Mexico
Prior art keywords
pyrazines
imidazo
compounds
pharmaceutically acceptable
pharmaceutical compositions
Prior art date
Application number
MX2013010183A
Other languages
English (en)
Other versions
MX2013010183A (es
Inventor
Thomas Luk Kin-Chun
Soth Michael
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2013010183A publication Critical patent/MX2013010183A/es
Publication of MX340574B publication Critical patent/MX340574B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Abstract

Se proporcionan los compuestos de la fórmula (ver Fórmula) y sus sales farmacéuticas aceptables se describen, así como las composiciones farmacéuticas que contienen dichos compuestos y sus sales farmacéuticas aceptables, y el uso de dichos compuestos y composiciones farmacéuticas para el tratamiento, control o mejora de AML.
MX2013010183A 2011-03-17 2012-03-14 Imidazo pirazinas. MX340574B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161453601P 2011-03-17 2011-03-17
PCT/EP2012/054415 WO2012123470A1 (en) 2011-03-17 2012-03-14 Imidazo pyrazines

Publications (2)

Publication Number Publication Date
MX2013010183A MX2013010183A (es) 2013-10-03
MX340574B true MX340574B (es) 2016-07-13

Family

ID=45855775

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013010183A MX340574B (es) 2011-03-17 2012-03-14 Imidazo pirazinas.

Country Status (12)

Country Link
US (1) US8673905B2 (es)
EP (1) EP2686319B1 (es)
JP (1) JP5796094B2 (es)
KR (1) KR101561756B1 (es)
CN (1) CN103429593B (es)
BR (1) BR112013019160A2 (es)
CA (1) CA2830131A1 (es)
ES (1) ES2590928T3 (es)
HK (1) HK1187614A1 (es)
MX (1) MX340574B (es)
RU (1) RU2600327C2 (es)
WO (1) WO2012123470A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9653770B2 (en) 2014-10-21 2017-05-16 At&T Intellectual Property I, L.P. Guided wave coupler, coupling module and methods for use therewith
WO2016130501A1 (en) 2015-02-09 2016-08-18 Incyte Corporation Aza-heteroaryl compounds as pi3k-gamma inhibitors
EP3371190B1 (en) 2015-11-06 2022-03-30 Incyte Corporation Heterocyclic compounds as pi3k-gamma inhibitors
AR107293A1 (es) 2016-01-05 2018-04-18 Incyte Corp COMPUESTOS DE PIRIDINA Y PIRIDIMINA COMO INHIBIDORES DE PI3K-g
WO2017223414A1 (en) 2016-06-24 2017-12-28 Incyte Corporation HETEROCYCLIC COMPOUNDS AS PI3K-γ INHIBITORS
MX2019011138A (es) * 2017-04-12 2020-01-27 Magenta Therapeutics Inc Antagonistas del receptor de hidrocarburo de arilo y sus usos.
US10738057B2 (en) 2017-10-18 2020-08-11 Incyte Corporation Tertiary alcohols as PI3K-γ inhibitors
SG11202006701TA (en) * 2018-01-29 2020-08-28 Merck Patent Gmbh Gcn2 inhibitors and uses thereof
WO2020051169A1 (en) 2018-09-05 2020-03-12 Incyte Corporation Crystalline forms of a phosphoinositide 3-kinase (pi3k) inhibitor
CN111646978B (zh) * 2020-06-11 2021-12-21 浙江大学 N2-取代烷氧芳环-2-氨基嘧啶类衍生物及应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7186832B2 (en) 2003-02-20 2007-03-06 Sugen Inc. Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors
WO2006025567A1 (ja) * 2004-08-31 2006-03-09 Banyu Pharmaceutical Co., Ltd. 新規置換イミダゾール誘導体
US20070055743A1 (en) 2005-09-02 2007-03-08 Pirtle Ross M Remote control media player
CA2620223A1 (en) * 2005-09-02 2007-03-08 Abbott Laboratories Novel imidazo based heterocycles
US7683060B2 (en) 2006-08-07 2010-03-23 Incyte Corporation Triazolotriazines as kinase inhibitors
WO2008047307A1 (en) 2006-10-16 2008-04-24 Gpc Biotech Inc. Pyrido [2, 3-d] pyrimidines and their use as kinase inhibitors
AR063581A1 (es) * 2006-11-08 2009-02-04 Schering Corp Imidazopirazinas como inhibidores de proteina quinasa
UY30892A1 (es) 2007-02-07 2008-09-02 Smithkline Beckman Corp Inhibidores de la actividad akt
AR066958A1 (es) * 2007-06-14 2009-09-23 Schering Corp Imidazopirazinas como inhibidores de proteina quinasa
TW200942537A (en) * 2008-02-01 2009-10-16 Irm Llc Compounds and compositions as kinase inhibitors
CA2722418C (en) * 2008-05-13 2013-09-17 Irm Llc Fused nitrogen containing heterocycles and compositions thereof as kinase inhibitors

Also Published As

Publication number Publication date
HK1187614A1 (zh) 2014-04-11
WO2012123470A1 (en) 2012-09-20
KR20130133870A (ko) 2013-12-09
BR112013019160A2 (pt) 2016-10-04
ES2590928T3 (es) 2016-11-24
RU2013142881A (ru) 2015-04-27
JP5796094B2 (ja) 2015-10-21
JP2014508180A (ja) 2014-04-03
US20120238564A1 (en) 2012-09-20
US8673905B2 (en) 2014-03-18
KR101561756B1 (ko) 2015-10-19
EP2686319B1 (en) 2016-07-13
RU2600327C2 (ru) 2016-10-20
CN103429593B (zh) 2015-09-09
CA2830131A1 (en) 2012-09-20
EP2686319A1 (en) 2014-01-22
CN103429593A (zh) 2013-12-04
MX2013010183A (es) 2013-10-03

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Legal Events

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