IN2014DN10576A - - Google Patents

Info

Publication number
IN2014DN10576A
IN2014DN10576A IN10576DEN2014A IN2014DN10576A IN 2014DN10576 A IN2014DN10576 A IN 2014DN10576A IN 10576DEN2014 A IN10576DEN2014 A IN 10576DEN2014A IN 2014DN10576 A IN2014DN10576 A IN 2014DN10576A
Authority
IN
India
Prior art keywords
bruton
inhibitors
compositions
useful
same
Prior art date
Application number
Other languages
English (en)
Inventor
Brian T Hopkins
Patrick Conlon
Timothy R Chan
Tracy J Jenkins
Xiongwei Cai
Michael Humora
Xianglin Shi
Ross A Miller
Andrew Thompson
Original Assignee
Biogen Idec Inc
Sunesis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Idec Inc, Sunesis Pharmaceuticals Inc filed Critical Biogen Idec Inc
Publication of IN2014DN10576A publication Critical patent/IN2014DN10576A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
IN10576DEN2014 2012-06-08 2013-06-07 IN2014DN10576A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261657360P 2012-06-08 2012-06-08
PCT/US2013/044800 WO2013185084A1 (fr) 2012-06-08 2013-06-07 Inhibiteurs de tyrosine kinase au pyrimidinyle

Publications (1)

Publication Number Publication Date
IN2014DN10576A true IN2014DN10576A (fr) 2015-08-28

Family

ID=49712704

Family Applications (1)

Application Number Title Priority Date Filing Date
IN10576DEN2014 IN2014DN10576A (fr) 2012-06-08 2013-06-07

Country Status (30)

Country Link
US (5) US9394277B2 (fr)
EP (3) EP2858499B1 (fr)
JP (6) JP6214643B2 (fr)
KR (4) KR20200043497A (fr)
CN (3) CN104540385B (fr)
AR (1) AR091273A1 (fr)
AU (5) AU2013271407B2 (fr)
BR (2) BR112014030655B1 (fr)
CA (2) CA3108186A1 (fr)
CY (1) CY1120638T1 (fr)
DK (1) DK2858499T3 (fr)
EA (2) EA027823B1 (fr)
ES (2) ES2834333T3 (fr)
HK (1) HK1209284A1 (fr)
HR (1) HRP20181294T1 (fr)
HU (1) HUE039897T2 (fr)
IL (2) IL235938B (fr)
IN (1) IN2014DN10576A (fr)
LT (1) LT2858499T (fr)
MX (2) MX363672B (fr)
NZ (1) NZ702715A (fr)
PH (2) PH12014502699B1 (fr)
PL (1) PL2858499T3 (fr)
PT (1) PT2858499T (fr)
RS (1) RS57978B1 (fr)
SG (2) SG11201408173WA (fr)
SI (1) SI2858499T1 (fr)
TW (3) TWI719209B (fr)
WO (1) WO2013185084A1 (fr)
ZA (1) ZA201409255B (fr)

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WO2012058645A1 (fr) 2010-10-29 2012-05-03 Biogen Idec Ma Inc. Inhibiteurs de tyrosine kinase hétérocycliques
AR091273A1 (es) 2012-06-08 2015-01-21 Biogen Idec Inc Inhibidores de pirimidinil tirosina quinasa
EP2858500A4 (fr) 2012-06-08 2016-04-06 Biogen Ma Inc Inhibiteurs de la tyrosine kinase de bruton
MX370103B (es) * 2013-12-11 2019-12-02 Biogen Ma Inc Compuestos de biarilo utiles para el tratamiento de enfermedades humanas en oncologia, neurologia e inmunologia.
WO2015151006A1 (fr) 2014-03-29 2015-10-08 Lupin Limited Composés de purine substitués en tant qu'inhibiteurs de btk
WO2015170266A1 (fr) 2014-05-07 2015-11-12 Lupin Limited Composés pyrimidine substitués en tant qu'inhibiteurs de la tyrosine kinase de bruton (btk)
DK3209656T3 (da) * 2014-10-24 2020-07-13 Bristol Myers Squibb Co Indolcarboxamidforbindelser, der er anvendelige som kinasehæmmere
CA3031443A1 (fr) * 2016-07-21 2018-01-25 Biogen Ma Inc. Succinate de derives de pyrimidinyle et formes solides connexes comme inhibiteurs de tyrosine kinase de bruton
US20210113568A1 (en) 2018-04-27 2021-04-22 Ono Pharmaceutical Co., Ltd. PREVENTIVE AND/OR THERAPEUTIC AGENT FOR AUTOIMMUNE DISEASE COMPRISING COMPOUND HAVING Btk INHIBITORY ACTIVITY AS ACTIVE INGREDIENT
KR102653681B1 (ko) 2018-07-31 2024-04-03 록쏘 온콜로지, 인코포레이티드 (s)-5-아미노-3-(4-((5-플루오로-2-메톡시벤즈아미도)메틸)페닐)-1-(1,1,1-트리플루오로프로판-2-일)-1h-피라졸-4-카르복스아미드의분무-건조된 분산물 및 제제
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US20220401436A1 (en) 2019-11-08 2022-12-22 INSERM (Institute National de la Santé et de la Recherche Médicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
WO2021148581A1 (fr) 2020-01-22 2021-07-29 Onxeo Nouvelle molécule dbait et son utilisation
WO2022140246A1 (fr) 2020-12-21 2022-06-30 Hangzhou Jijing Pharmaceutical Technology Limited Procédés et composés destinés à l'autophagie ciblée
EP4313023A1 (fr) 2021-04-02 2024-02-07 Biogen MA Inc. Méthodes de traitement combiné de la sclérose en plaques
WO2023081715A1 (fr) 2021-11-03 2023-05-11 Viracta Therapeutics, Inc. Association d'une thérapie de lymphocytes car t avec des inhibiteurs de tyrosine kinase de bruton et procédés d'utilisation associés
WO2023081709A1 (fr) 2021-11-03 2023-05-11 Viracta Therapeutics, Inc. Vecabrutinib destiné au traitement d'une maladie du greffon contre l'hôte
WO2023110970A1 (fr) 2021-12-14 2023-06-22 Netherlands Translational Research Center Holding B.V Inhibiteurs macrocycliques de btk

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Also Published As

Publication number Publication date
BR112014030655B1 (pt) 2021-04-20
MX2019003618A (es) 2019-07-18
AU2013271407A1 (en) 2015-01-22
KR102468430B1 (ko) 2022-11-21
KR20150036020A (ko) 2015-04-07
PH12014502699A1 (en) 2015-02-02
US20210017155A1 (en) 2021-01-21
KR20210072139A (ko) 2021-06-16
IL235938A0 (en) 2015-02-01
AU2013271407B2 (en) 2016-12-08
JP6214643B2 (ja) 2017-10-18
PH12014502699B1 (en) 2015-02-02
JP2017193583A (ja) 2017-10-26
JP2019077728A (ja) 2019-05-23
RS57978B1 (sr) 2019-01-31
NZ702715A (en) 2016-11-25
DK2858499T3 (en) 2018-08-20
LT2858499T (lt) 2018-09-10
EA027823B1 (ru) 2017-09-29
US20230174511A1 (en) 2023-06-08
JP2023052415A (ja) 2023-04-11
ES2834333T3 (es) 2021-06-17
JP2015518903A (ja) 2015-07-06
TWI792158B (zh) 2023-02-11
IL235938B (en) 2020-10-29
CN109305959A (zh) 2019-02-05
HUE039897T2 (hu) 2019-02-28
SG10201708535UA (en) 2017-11-29
CN104540385B (zh) 2018-06-05
US20160304494A1 (en) 2016-10-20
BR112014030655A2 (pt) 2017-06-27
AU2019203476A1 (en) 2019-06-06
BR122021002178B1 (pt) 2022-03-22
CN104540385A (zh) 2015-04-22
AU2019203476B2 (en) 2021-01-28
EA201790418A1 (ru) 2017-11-30
EP2858499B1 (fr) 2018-05-16
CY1120638T1 (el) 2019-12-11
TW202142535A (zh) 2021-11-16
AU2017201536A1 (en) 2017-03-23
US20190047986A1 (en) 2019-02-14
JP2021073299A (ja) 2021-05-13
EP3385263A1 (fr) 2018-10-10
EP3385263B1 (fr) 2020-07-22
US9394277B2 (en) 2016-07-19
HK1209284A1 (en) 2016-04-01
KR20220154850A (ko) 2022-11-22
ES2684268T3 (es) 2018-10-02
IL277951A (en) 2020-11-30
AU2021202412A1 (en) 2021-05-20
MX2014015044A (es) 2015-09-22
US20150158843A1 (en) 2015-06-11
TWI592406B (zh) 2017-07-21
EP2858499A4 (fr) 2016-01-20
JP2021073298A (ja) 2021-05-13
TWI719209B (zh) 2021-02-21
CA2875799A1 (fr) 2013-12-12
CN113549055A (zh) 2021-10-26
KR20200043497A (ko) 2020-04-27
EA201492056A1 (ru) 2015-05-29
US9944622B2 (en) 2018-04-17
AU2017201536B2 (en) 2019-03-07
SG11201408173WA (en) 2015-01-29
PH12018501463A1 (en) 2019-03-04
BR112014030655A8 (pt) 2018-01-02
EP2858499A1 (fr) 2015-04-15
AU2022275504A1 (en) 2023-01-05
ZA201409255B (en) 2015-12-23
TW201805279A (zh) 2018-02-16
WO2013185084A1 (fr) 2013-12-12
KR102102587B1 (ko) 2020-04-22
EP3753934A1 (fr) 2020-12-23
PT2858499T (pt) 2018-10-24
TW201410668A (zh) 2014-03-16
CN109305959B (zh) 2022-02-08
US10618887B2 (en) 2020-04-14
SI2858499T1 (sl) 2018-10-30
CA3108186A1 (fr) 2013-12-12
PL2858499T3 (pl) 2019-03-29
HRP20181294T1 (hr) 2018-10-05
AR091273A1 (es) 2015-01-21
CA2875799C (fr) 2021-03-23
MX363672B (es) 2019-03-29

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