MX2016003843A - Inhibidores de cinasas asociadas al receptor de interleucina 1 (irak) y usos de los mismos. - Google Patents
Inhibidores de cinasas asociadas al receptor de interleucina 1 (irak) y usos de los mismos.Info
- Publication number
- MX2016003843A MX2016003843A MX2016003843A MX2016003843A MX2016003843A MX 2016003843 A MX2016003843 A MX 2016003843A MX 2016003843 A MX2016003843 A MX 2016003843A MX 2016003843 A MX2016003843 A MX 2016003843A MX 2016003843 A MX2016003843 A MX 2016003843A
- Authority
- MX
- Mexico
- Prior art keywords
- irak inhibitors
- irak
- inhibitors
- compositions
- methods
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- C07D—HETEROCYCLIC COMPOUNDS
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Abstract
La presente invención proporciona compuestos, composiciones de los mismos, y métodos de uso de los mismos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361883497P | 2013-09-27 | 2013-09-27 | |
PCT/US2014/057444 WO2015048281A1 (en) | 2013-09-27 | 2014-09-25 | Irak inhibitors and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2016003843A true MX2016003843A (es) | 2017-02-15 |
Family
ID=52740744
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016003843A MX2016003843A (es) | 2013-09-27 | 2014-09-25 | Inhibidores de cinasas asociadas al receptor de interleucina 1 (irak) y usos de los mismos. |
Country Status (11)
Country | Link |
---|---|
US (2) | US9518065B2 (es) |
EP (1) | EP3049086A4 (es) |
JP (1) | JP2016531870A (es) |
KR (1) | KR20160092991A (es) |
CN (1) | CN106232122A (es) |
BR (1) | BR112016006319A2 (es) |
CA (1) | CA2925211A1 (es) |
MX (1) | MX2016003843A (es) |
RU (1) | RU2016110852A (es) |
TW (1) | TW201522349A (es) |
WO (1) | WO2015048281A1 (es) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2017004133A1 (en) * | 2015-06-29 | 2017-01-05 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
EP3331877B1 (en) | 2015-08-04 | 2021-09-22 | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. | Pyrazole pyrimidine derivative and uses thereof |
EP3719016A1 (en) | 2015-08-04 | 2020-10-07 | Rigel Pharmaceuticals, Inc. | Benzazole compounds and methods for making and using the compounds |
KR102110573B1 (ko) * | 2015-08-13 | 2020-05-13 | 베이징 한미 파마슈티컬 컴퍼니 리미티드 | Irak4억제제 및 이의 용도 |
JP6541871B2 (ja) * | 2015-08-13 | 2019-07-10 | 北京韓美薬品有限公司 | Irak4阻害剤、及びその応用 |
GB201518456D0 (en) * | 2015-10-19 | 2015-12-02 | Galapagos Nv | Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory, autoimmune and/or proliferative diseases |
SG10201508795XA (en) * | 2015-10-23 | 2017-05-30 | Agency Science Tech & Res | Method for treating cancer |
WO2017205766A1 (en) * | 2016-05-27 | 2017-11-30 | Pharmacyclics Llc | Inhibitors of interleukin-1 receptor-associated kinase |
WO2017205762A1 (en) * | 2016-05-27 | 2017-11-30 | Pharmacyclics Llc | Inhibitors of interleukin-1 receptor-associated kinase |
US11117898B2 (en) * | 2016-11-28 | 2021-09-14 | Jiangsu Hengrui Medicine Co., Ltd. | Pyrazolo-heteroaryl derivative, preparation method and medical use thereof |
JP7142646B2 (ja) | 2017-02-01 | 2022-09-27 | イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティ オブ エルサレム エルティーディー. | がんを治療するためのck1及び/又はirak1インヒビターとしてのn1-(4-(5-(シクロプロピルメチル)-1-メチル-1h-ピラゾール-4-イル)ピリジン-2-イル)シクロヘキサン-1,4-ジアミン誘導体及び関連化合物 |
JOP20180011A1 (ar) | 2017-02-16 | 2019-01-30 | Gilead Sciences Inc | مشتقات بيرولو [1، 2-b]بيريدازين |
IL307995A (en) | 2017-09-22 | 2023-12-01 | Kymera Therapeutics Inc | Protein compounds and their uses |
WO2019060693A1 (en) | 2017-09-22 | 2019-03-28 | Kymera Therapeutics, Inc. | CRBN LIGANDS AND USES THEREOF |
WO2019111218A1 (en) | 2017-12-08 | 2019-06-13 | Cadila Healthcare Limited | Novel heterocyclic compounds as irak4 inhibitors |
WO2019126106A1 (en) * | 2017-12-19 | 2019-06-27 | X4 Pharmaceuticals, Inc. | Acyclic cxcr4 inhibitors and uses thereof |
CN112105385A (zh) | 2017-12-26 | 2020-12-18 | 凯麦拉医疗公司 | Irak降解剂和其用途 |
US11485743B2 (en) | 2018-01-12 | 2022-11-01 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
WO2019140387A1 (en) | 2018-01-12 | 2019-07-18 | Kymera Therapeutics, Inc. | Crbn ligands and uses thereof |
EP3774797A1 (en) * | 2018-04-05 | 2021-02-17 | Merck Patent GmbH | Heteroaryl compounds as type ii irak inhibitors and uses hereof |
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