SI2858499T1 - Inhibitorji pirimidinil tirozin kinaze - Google Patents

Inhibitorji pirimidinil tirozin kinaze

Info

Publication number: SI2858499T1
Authority: SI; Slovenia
Prior art keywords: tyrosine kinase; kinase inhibitors; pyrimidinyl; pyrimidinyl tyrosine; inhibitors
Prior art date: 2012-06-08

Application number

SI201331130T

Other languages

English (en)

Inventor

Brian T. Hopkins

Patrick Conlon

Timothy R. Chan

Tracy J. Jenkins

Xiongwei Cai

Michael Humora

Xianglin Shi

Ross A. Miller

Andrew Thompson

Original Assignee

Biogen MA Inc.,

Sunesis Pharmaceuticals, Inc.,

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-06-08

Filing date

2013-06-07

Publication date

2018-10-30

2013-06-07 Application filed by Biogen MA Inc.,, Sunesis Pharmaceuticals, Inc., filed Critical Biogen MA Inc.,

2018-10-30 Publication of SI2858499T1 publication Critical patent/SI2858499T1/sl

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics

SI201331130T 2012-06-08 2013-06-07 Inhibitorji pirimidinil tirozin kinaze SI2858499T1 (sl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201261657360P	2012-06-08	2012-06-08
PCT/US2013/044800 WO2013185084A1 (en)	2012-06-08	2013-06-07	Pyrimidinyl tyrosine kinase inhibitors
EP13800042.7A EP2858499B1 (en)	2012-06-08	2013-06-07	Pyrimidinyl tyrosine kinase inhibitors

Publications (1)

Publication Number	Publication Date
SI2858499T1 true SI2858499T1 (sl)	2018-10-30

Family

ID=49712704

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI201331130T SI2858499T1 (sl)	2012-06-08	2013-06-07	Inhibitorji pirimidinil tirozin kinaze

Country Status (30)

Country	Link
US (5)	US9394277B2 (sl)
EP (3)	EP2858499B1 (sl)
JP (6)	JP6214643B2 (sl)
KR (4)	KR20200043497A (sl)
CN (3)	CN104540385B (sl)
AR (1)	AR091273A1 (sl)
AU (5)	AU2013271407B2 (sl)
BR (2)	BR112014030655B1 (sl)
CA (2)	CA3108186A1 (sl)
CY (1)	CY1120638T1 (sl)
DK (1)	DK2858499T3 (sl)
EA (2)	EA027823B1 (sl)
ES (2)	ES2834333T3 (sl)
HK (1)	HK1209284A1 (sl)
HR (1)	HRP20181294T1 (sl)
HU (1)	HUE039897T2 (sl)
IL (2)	IL235938B (sl)
IN (1)	IN2014DN10576A (sl)
LT (1)	LT2858499T (sl)
MX (2)	MX363672B (sl)
NZ (1)	NZ702715A (sl)
PH (2)	PH12014502699B1 (sl)
PL (1)	PL2858499T3 (sl)
PT (1)	PT2858499T (sl)
RS (1)	RS57978B1 (sl)
SG (2)	SG11201408173WA (sl)
SI (1)	SI2858499T1 (sl)
TW (3)	TWI719209B (sl)
WO (1)	WO2013185084A1 (sl)
ZA (1)	ZA201409255B (sl)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ598985A (en) *	2009-09-04	2013-07-26	Biogen Idec Inc	Bruton's tyrosine kinase inhibitors
WO2012058645A1 (en)	2010-10-29	2012-05-03	Biogen Idec Ma Inc.	Heterocyclic tyrosine kinase inhibitors
AR091273A1 (es)	2012-06-08	2015-01-21	Biogen Idec Inc	Inhibidores de pirimidinil tirosina quinasa
EP2858500A4 (en)	2012-06-08	2016-04-06	Biogen Ma Inc	INHIBITORS OF BRUTON TYROSINE KINASE
MX370103B (es) *	2013-12-11	2019-12-02	Biogen Ma Inc	Compuestos de biarilo utiles para el tratamiento de enfermedades humanas en oncologia, neurologia e inmunologia.
WO2015151006A1 (en)	2014-03-29	2015-10-08	Lupin Limited	Substituted purine compounds as btk inhibitors
WO2015170266A1 (en)	2014-05-07	2015-11-12	Lupin Limited	Substituted pyrimidine compounds as btk inhibitors
DK3209656T3 (da) *	2014-10-24	2020-07-13	Bristol Myers Squibb Co	Indolcarboxamidforbindelser, der er anvendelige som kinasehæmmere
CA3031443A1 (en) *	2016-07-21	2018-01-25	Biogen Ma Inc.	Succinate of pyrimidinyl derivatives and solid forms thereof as bruton's tyrosine kinase inhibitors
US20210113568A1 (en)	2018-04-27	2021-04-22	Ono Pharmaceutical Co., Ltd.	PREVENTIVE AND/OR THERAPEUTIC AGENT FOR AUTOIMMUNE DISEASE COMPRISING COMPOUND HAVING Btk INHIBITORY ACTIVITY AS ACTIVE INGREDIENT
KR102653681B1 (ko)	2018-07-31	2024-04-03	록쏘 온콜로지, 인코포레이티드	(s)-5-아미노-3-(4-((5-플루오로-2-메톡시벤즈아미도)메틸)페닐)-1-(1,1,1-트리플루오로프로판-2-일)-1h-피라졸-4-카르복스아미드의분무-건조된 분산물 및 제제
AU2020242287A1 (en)	2019-03-21	2021-09-02	INSERM (Institut National de la Santé et de la Recherche Médicale)	A Dbait molecule in combination with kinase inhibitor for the treatment of cancer
US20220401436A1 (en)	2019-11-08	2022-12-22	INSERM (Institute National de la Santé et de la Recherche Médicale)	Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
WO2021148581A1 (en)	2020-01-22	2021-07-29	Onxeo	Novel dbait molecule and its use
WO2022140246A1 (en)	2020-12-21	2022-06-30	Hangzhou Jijing Pharmaceutical Technology Limited	Methods and compounds for targeted autophagy
EP4313023A1 (en)	2021-04-02	2024-02-07	Biogen MA Inc.	Combination treatment methods of multiple sclerosis
WO2023081715A1 (en)	2021-11-03	2023-05-11	Viracta Therapeutics, Inc.	Combination of car t-cell therapy with btk inhibitors and methods of use thereof
WO2023081709A1 (en)	2021-11-03	2023-05-11	Viracta Therapeutics, Inc.	Vecabrutinib for the treatment of graft-versus-host disease
WO2023110970A1 (en)	2021-12-14	2023-06-22	Netherlands Translational Research Center Holding B.V	Macrocyclic btk inhibitors

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US1624A (en) *		1840-06-10		Cooking-stove
US4528138A (en)	1984-06-20	1985-07-09	E. R. Squibb & Sons, Inc.	16-Keto-17-substituted thia-17-alkyl(or alkenyl or alkynyl) androstenes
US4911920A (en)	1986-07-30	1990-03-27	Alcon Laboratories, Inc.	Sustained release, comfort formulation for glaucoma therapy
FR2588189B1 (fr)	1985-10-03	1988-12-02	Merck Sharp & Dohme	Composition pharmaceutique de type a transition de phase liquide-gel
DE69212850T2 (de)	1991-01-15	1997-03-06	Alcon Lab Inc	Verwendung von Karrageenan in topischen ophthalmologischen Zusammensetzungen
US5212162A (en)	1991-03-27	1993-05-18	Alcon Laboratories, Inc.	Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions
US6309853B1 (en)	1994-08-17	2001-10-30	The Rockfeller University	Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
PA8474101A1 (es)	1998-06-19	2000-09-29	Pfizer Prod Inc	Compuestos de pirrolo [2,3-d] pirimidina
US6919178B2 (en)	2000-11-21	2005-07-19	Sunesis Pharmaceuticals, Inc.	Extended tethering approach for rapid identification of ligands
AU2001250849A1 (en)	2000-03-17	2001-10-03	Bristol-Myers Squibb Pharma Company	Cyclic beta-amino acid derivatives as inhibitors of matrix metalloproteases and tnf-alpha
MY137020A (en)	2000-04-27	2008-12-31	Abbott Lab	Diazabicyclic central nervous system active agents
EE200200711A (et)	2000-06-26	2004-06-15	Pfizer Products Inc.	Pürrolo[2,3-d]pürimidiinühendid kui immunosupressiivsed vahendid
PE20020507A1 (es) *	2000-10-17	2002-06-25	Schering Corp	Compuestos no-imidazoles como antagonistas del receptor histamina h3
AU2002363236A1 (en)	2001-10-30	2003-05-12	Millennium Pharmaceuticals, Inc.	Compounds, pharmaceutical compositions and methods of use therefor
WO2003037898A1 (en)	2001-10-31	2003-05-08	Bayer Healthcare Ag	Pyrimido [4,5-b] indole derivatives
EP1599468B1 (en)	2003-01-14	2007-10-03	Arena Pharmaceuticals, Inc.	1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia
PL1678166T3 (pl)	2003-10-14	2009-12-31	Univ Arizona	Inhibitory kinaz białkowych
WO2006073419A2 (en) *	2004-04-01	2006-07-13	Gang Zheng	Lipoprotein nanoplatforms
WO2005117909A2 (en)	2004-04-23	2005-12-15	Exelixis, Inc.	Kinase modulators and methods of use
FR2870541B1 (fr)	2004-05-18	2006-07-14	Proskelia Sas	Derives de pyrimidines antigonistes du recepteur de la vitronectine
AR050865A1 (es)	2004-09-09	2006-11-29	Sanofi Aventis	Derivados de 2- morfolino-4-pirimidona
US7528138B2 (en) *	2004-11-04	2009-05-05	Vertex Pharmaceuticals Incorporated	Pyrazolo[1,5-a]pyrimidines useful as inhibitors of protein kinases
AU2005311930B9 (en)	2004-12-03	2009-09-10	Merck Sharp & Dohme Corp.	Substituted piperazines as CB1 antagonists
ATE543821T1 (de)	2004-12-28	2012-02-15	Exelixis Inc	Ä1h-pyrazoloä3,4-düpyrimidin-4-ylü-piperidin- oder piperazinverbindungen als serin-threonin- kinasemodulatoren (p70s6k, atk1 und atk2) zur behandlung von immunologischen, entzündlichen und proliferativen erkrankungen
US7880002B2 (en)	2004-12-29	2011-02-01	Millennium Pharmaceuticals, Inc.	Substituted piperazinyl-pyrrolidine compounds useful as chemokine receptor antagonists
WO2006091450A1 (en) *	2005-02-18	2006-08-31	Lexicon Genetics Incorporated	4-piperidin-1-yl-7h-pyrrolo[2,3-d]pyrimidine compounds
US20060281700A1 (en)	2005-06-10	2006-12-14	Baumann Christian A	Synergistic modulation of flt3 kinase using aminopyrimidines kinase modulators
US20060281764A1 (en)	2005-06-10	2006-12-14	Gaul Michael D	Aminopyrimidines as kinase modulators
TW200740779A (en)	2005-07-22	2007-11-01	Mitsubishi Pharma Corp	Intermediate compound for synthesizing pharmaceutical agent and production method thereof
DK1951684T3 (en)	2005-11-01	2016-10-24	Targegen Inc	BIARYLMETAPYRIMIDIN kinase inhibitors
WO2007075555A2 (en) *	2005-12-21	2007-07-05	Schering Corporation	Combination of an h3 antagonist/inverse agonist and an appetite suppressant
WO2008005368A2 (en)	2006-06-30	2008-01-10	Abbott Laboratories	Piperazines as p2x7 antagonists
WO2008012635A2 (en)	2006-07-26	2008-01-31	Pfizer Products Inc.	Amine derivatives useful as anticancer agents
AU2007276804A1 (en)	2006-07-26	2008-01-31	Novartis Ag	Inhibitors of undecaprenyl pyrophosphate synthase
US20100160292A1 (en)	2006-09-11	2010-06-24	Cgi Pharmaceuticals, Inc	Kinase Inhibitors, and Methods of Using and Identifying Kinase Inhibitors
EP2081435B1 (en)	2006-09-22	2016-05-04	Pharmacyclics LLC	Inhibitors of bruton's tyrosine kinase
EP2136805A2 (en) *	2007-03-02	2009-12-30	Schering Corporation	Piperidinyl-piperidine and piperazinyl-piperidine for use in the treatment of diabetes or pain
EP2125819B1 (en)	2007-03-21	2014-10-22	Bristol-Myers Squibb Company	Fused heterocyclic compounds useful for the treatment of proliferative, allergic, autoimmune or inflammatory diseases
WO2008144253A1 (en)	2007-05-14	2008-11-27	Irm Llc	Protein kinase inhibitors and methods for using thereof
RU2469036C2 (ru)	2007-06-01	2012-12-10	ГЛАКСОСМИТКЛАЙН ЭлЭлСи	Имидазопиридиновые ингибиторы киназ
CN101932573B (zh)	2008-02-05	2014-06-11	霍夫曼-拉罗奇有限公司	吡啶酮类和哒嗪酮类
EP2283358B1 (en)	2008-04-29	2015-04-22	Immunexcite, Inc.	Immunomodulating compositions and methods of use thereof
EP3311818A3 (en)	2008-07-16	2018-07-18	Pharmacyclics, LLC	Inhibitors of bruton's tyrosine kinase for the treatment of solid tumors
WO2010068788A1 (en) *	2008-12-10	2010-06-17	Cgi Pharmaceuticals, Inc.	Heterocyclic amides as btk inhibitors
ES2443948T3 (es)	2008-12-19	2014-02-21	Bristol-Myers Squibb Company	Compuestos de carbazol carboxamida útiles como inhibidores de quinasas
EP3255047B1 (en) *	2009-01-06	2021-06-30	Dana-Farber Cancer Institute, Inc.	Pyrimido-diazepinone kinase scaffold compounds and uses in treating disorders
CN102448966A (zh)	2009-05-25	2012-05-09	桑多斯股份公司	生产头孢托罗酯的方法
US9029359B2 (en)	2009-09-04	2015-05-12	Biogen Idec Ma, Inc.	Heteroaryl Btk inhibitors
NZ598985A (en) *	2009-09-04	2013-07-26	Biogen Idec Inc	Bruton's tyrosine kinase inhibitors
US8685880B2 (en) *	2010-06-30	2014-04-01	Chevron U.S.A. Inc.	On-site drying of aqueous salt for ionic liquid make-up
WO2012058645A1 (en)	2010-10-29	2012-05-03	Biogen Idec Ma Inc.	Heterocyclic tyrosine kinase inhibitors
EP2858500A4 (en)	2012-06-08	2016-04-06	Biogen Ma Inc	INHIBITORS OF BRUTON TYROSINE KINASE
AR091273A1 (es) *	2012-06-08	2015-01-21	Biogen Idec Inc	Inhibidores de pirimidinil tirosina quinasa
MX370103B (es)	2013-12-11	2019-12-02	Biogen Ma Inc	Compuestos de biarilo utiles para el tratamiento de enfermedades humanas en oncologia, neurologia e inmunologia.
EP3444251B1 (en)	2013-12-11	2023-06-07	Biogen MA Inc.	Biaryl compounds useful for the treatment of human diseases in oncology, neurology and immunology
US20170298446A1 (en)	2014-10-03	2017-10-19	Ohio State Innovation Foundation	Biomarkers of bruton tyrosine kinase inhibitor resistance

2013
- 2013-06-05 AR ARP130101980 patent/AR091273A1/es not_active Application Discontinuation
- 2013-06-07 SG SG11201408173WA patent/SG11201408173WA/en unknown
- 2013-06-07 EA EA201492056A patent/EA027823B1/ru unknown
- 2013-06-07 TW TW106116775A patent/TWI719209B/zh active
- 2013-06-07 PT PT13800042T patent/PT2858499T/pt unknown
- 2013-06-07 SI SI201331130T patent/SI2858499T1/sl unknown
- 2013-06-07 ES ES18171833T patent/ES2834333T3/es active Active
- 2013-06-07 CN CN201380036869.5A patent/CN104540385B/zh active Active
- 2013-06-07 LT LTEP13800042.7T patent/LT2858499T/lt unknown
- 2013-06-07 WO PCT/US2013/044800 patent/WO2013185084A1/en active Application Filing
- 2013-06-07 CA CA3108186A patent/CA3108186A1/en not_active Abandoned
- 2013-06-07 DK DK13800042.7T patent/DK2858499T3/en active
- 2013-06-07 RS RS20180950A patent/RS57978B1/sr unknown
- 2013-06-07 CN CN201810384098.3A patent/CN109305959B/zh active Active
- 2013-06-07 PL PL13800042T patent/PL2858499T3/pl unknown
- 2013-06-07 BR BR112014030655-9A patent/BR112014030655B1/pt active IP Right Grant
- 2013-06-07 CN CN202110783143.4A patent/CN113549055A/zh active Pending
- 2013-06-07 EP EP13800042.7A patent/EP2858499B1/en active Active
- 2013-06-07 ES ES13800042.7T patent/ES2684268T3/es active Active
- 2013-06-07 IN IN10576DEN2014 patent/IN2014DN10576A/en unknown
- 2013-06-07 AU AU2013271407A patent/AU2013271407B2/en active Active
- 2013-06-07 HU HUE13800042A patent/HUE039897T2/hu unknown
- 2013-06-07 TW TW110102365A patent/TWI792158B/zh active
- 2013-06-07 EP EP20186539.1A patent/EP3753934A1/en active Pending
- 2013-06-07 EP EP18171833.9A patent/EP3385263B1/en active Active
- 2013-06-07 NZ NZ702715A patent/NZ702715A/en unknown
- 2013-06-07 BR BR122021002178-3A patent/BR122021002178B1/pt active IP Right Grant
- 2013-06-07 TW TW102120447A patent/TWI592406B/zh active
- 2013-06-07 KR KR1020207010675A patent/KR20200043497A/ko active Application Filing
- 2013-06-07 KR KR1020227039393A patent/KR20220154850A/ko not_active Application Discontinuation
- 2013-06-07 SG SG10201708535UA patent/SG10201708535UA/en unknown
- 2013-06-07 MX MX2014015044A patent/MX363672B/es unknown
- 2013-06-07 EA EA201790418A patent/EA201790418A1/ru unknown
- 2013-06-07 KR KR1020217017552A patent/KR102468430B1/ko active IP Right Grant
- 2013-06-07 KR KR1020157000393A patent/KR102102587B1/ko active IP Right Grant
- 2013-06-07 JP JP2015516256A patent/JP6214643B2/ja active Active
- 2013-06-07 US US14/406,315 patent/US9394277B2/en active Active
- 2013-06-07 CA CA2875799A patent/CA2875799C/en active Active
2014
- 2014-11-27 IL IL235938A patent/IL235938B/en active IP Right Grant
- 2014-12-03 PH PH12014502699A patent/PH12014502699B1/en unknown
- 2014-12-08 MX MX2019003618A patent/MX2019003618A/es unknown
- 2014-12-15 ZA ZA2014/09255A patent/ZA201409255B/en unknown
2015
- 2015-10-20 HK HK15110301.6A patent/HK1209284A1/xx unknown
2016
- 2016-06-29 US US15/196,389 patent/US9944622B2/en active Active
2017
- 2017-03-07 AU AU2017201536A patent/AU2017201536B2/en active Active
- 2017-08-03 JP JP2017150480A patent/JP2017193583A/ja not_active Withdrawn
2018
- 2018-03-05 US US15/911,546 patent/US10618887B2/en active Active
- 2018-07-09 PH PH12018501463A patent/PH12018501463A1/en unknown
- 2018-08-08 HR HRP20181294TT patent/HRP20181294T1/hr unknown
- 2018-08-16 CY CY181100861T patent/CY1120638T1/el unknown
2019
- 2019-02-04 JP JP2019017850A patent/JP2019077728A/ja not_active Withdrawn
- 2019-05-17 AU AU2019203476A patent/AU2019203476B2/en active Active
2020
- 2020-02-27 US US16/802,959 patent/US20210017155A1/en not_active Abandoned
- 2020-10-11 IL IL277951A patent/IL277951A/en unknown
2021
- 2021-02-08 JP JP2021018128A patent/JP2021073299A/ja active Pending
- 2021-02-08 JP JP2021018127A patent/JP2021073298A/ja active Pending
- 2021-04-21 AU AU2021202412A patent/AU2021202412A1/en not_active Abandoned
2022
- 2022-08-08 US US17/883,202 patent/US20230174511A1/en active Pending
- 2022-11-25 AU AU2022275504A patent/AU2022275504A1/en active Pending
2023
- 2023-01-16 JP JP2023004462A patent/JP2023052415A/ja active Pending

Also Published As

Publication number	Publication date
BR112014030655B1 (pt)	2021-04-20
MX2019003618A (es)	2019-07-18
AU2013271407A1 (en)	2015-01-22
KR102468430B1 (ko)	2022-11-21
KR20150036020A (ko)	2015-04-07
PH12014502699A1 (en)	2015-02-02
US20210017155A1 (en)	2021-01-21
KR20210072139A (ko)	2021-06-16
IL235938A0 (en)	2015-02-01
AU2013271407B2 (en)	2016-12-08
JP6214643B2 (ja)	2017-10-18
PH12014502699B1 (en)	2015-02-02
JP2017193583A (ja)	2017-10-26
JP2019077728A (ja)	2019-05-23
RS57978B1 (sr)	2019-01-31
NZ702715A (en)	2016-11-25
DK2858499T3 (en)	2018-08-20
LT2858499T (lt)	2018-09-10
EA027823B1 (ru)	2017-09-29
US20230174511A1 (en)	2023-06-08
JP2023052415A (ja)	2023-04-11
ES2834333T3 (es)	2021-06-17
JP2015518903A (ja)	2015-07-06
TWI792158B (zh)	2023-02-11
IL235938B (en)	2020-10-29
CN109305959A (zh)	2019-02-05
HUE039897T2 (hu)	2019-02-28
SG10201708535UA (en)	2017-11-29
CN104540385B (zh)	2018-06-05
US20160304494A1 (en)	2016-10-20
BR112014030655A2 (pt)	2017-06-27
AU2019203476A1 (en)	2019-06-06
BR122021002178B1 (pt)	2022-03-22
CN104540385A (zh)	2015-04-22
AU2019203476B2 (en)	2021-01-28
EA201790418A1 (ru)	2017-11-30
EP2858499B1 (en)	2018-05-16
CY1120638T1 (el)	2019-12-11
TW202142535A (zh)	2021-11-16
AU2017201536A1 (en)	2017-03-23
US20190047986A1 (en)	2019-02-14
JP2021073299A (ja)	2021-05-13
EP3385263A1 (en)	2018-10-10
EP3385263B1 (en)	2020-07-22
US9394277B2 (en)	2016-07-19
IN2014DN10576A (sl)	2015-08-28
HK1209284A1 (en)	2016-04-01
KR20220154850A (ko)	2022-11-22
ES2684268T3 (es)	2018-10-02
IL277951A (en)	2020-11-30
AU2021202412A1 (en)	2021-05-20
MX2014015044A (es)	2015-09-22
US20150158843A1 (en)	2015-06-11
TWI592406B (zh)	2017-07-21
EP2858499A4 (en)	2016-01-20
JP2021073298A (ja)	2021-05-13
TWI719209B (zh)	2021-02-21
CA2875799A1 (en)	2013-12-12
CN113549055A (zh)	2021-10-26
KR20200043497A (ko)	2020-04-27
EA201492056A1 (ru)	2015-05-29
US9944622B2 (en)	2018-04-17
AU2017201536B2 (en)	2019-03-07
SG11201408173WA (en)	2015-01-29
PH12018501463A1 (en)	2019-03-04
BR112014030655A8 (pt)	2018-01-02
EP2858499A1 (en)	2015-04-15
AU2022275504A1 (en)	2023-01-05
ZA201409255B (en)	2015-12-23
TW201805279A (zh)	2018-02-16
WO2013185084A1 (en)	2013-12-12
KR102102587B1 (ko)	2020-04-22
EP3753934A1 (en)	2020-12-23
PT2858499T (pt)	2018-10-24
TW201410668A (zh)	2014-03-16
CN109305959B (zh)	2022-02-08
US10618887B2 (en)	2020-04-14
CA3108186A1 (en)	2013-12-12
PL2858499T3 (pl)	2019-03-29
HRP20181294T1 (hr)	2018-10-05
AR091273A1 (es)	2015-01-21
CA2875799C (en)	2021-03-23
MX363672B (es)	2019-03-29

Publication	Publication Date	Title
IL277951A (en)	2020-11-30	Pyrimidinyls are tyrosine kinase inhibitors
HK1211293A1 (en)	2016-05-20	Brutons tyrosine kinase inhibitors
HK1210775A1 (en)	2016-05-06	Imidazotriazinecarbonitriles useful as kinase inhibitors
HK1212689A1 (zh)	2016-06-17	布魯頓氏酪氨酸激酶抑制劑
HK1249759A1 (zh)	2018-11-09	取代的嘧啶基和吡啶基吡咯並吡啶酮類、其製備方法及其作為激酶抑制劑的用途
HK1208442A1 (en)	2016-03-04	Substituted pyrrolopyrimidinylamino-benzothiazolones as mknk kinase inhibitors mknk
HK1215577A1 (zh)	2016-09-02	蛋白激酶抑制劑
PL2710005T3 (pl)	2017-07-31	Inhibitory kinazy tyrozynowej
GB201211310D0 (en)	2012-08-08	CSF-1R kinase inhibitors
HK1210461A1 (en)	2016-04-22	Inhibitors of brutons tyrosine kinase
HK1206624A1 (en)	2016-01-15	Brutons tyrosine kinase inhibitors for hematopoietic mobilization
HK1209726A1 (en)	2016-04-08	Protein kinase inhibitors
EP2934525A4 (en)	2016-06-08	THIAZOLSUBSTITUTED AMINOPYRIDINE AS MILTSTYROSINKINASE INHIBITOR
HK1205507A1 (en)	2015-12-18	Protein kinase inhibitors
HK1210779A1 (en)	2016-05-06	Inhibitors of brutons tyrosine kinase
PL2634185T3 (pl)	2016-06-30	Inhibitory kinazy TYK2
IL237158A0 (en)	2015-04-30	Amino quinzolines as kinase inhibitors
EP2903970A4 (en)	2016-11-30	SUBSTITUTED PYRIMIDINYL KINASE INHIBITORS
HK1208460A1 (en)	2016-03-04	Protein kinase inhibitors
EP2968331A4 (en)	2016-08-24	PYRROLOPYRIMIDINE COMPOUNDS AS KINASEINHIBITORS
HK1215855A1 (zh)	2016-09-23	酪氨酸蛋白激酶抑制劑
HK1209316A1 (en)	2016-04-01	Substituted picolinamide kinase inhibitors
EP2922823A4 (en)	2016-05-04	PDE10 PYRIMIDININHIBITOREN