HUP0101305A2 - 2-(Purin-9-il)-tetrahidrofurán-3,4-diol-származékok, eljárás az előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények - Google Patents
2-(Purin-9-il)-tetrahidrofurán-3,4-diol-származékok, eljárás az előállításukra és a vegyületeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0101305A2 HUP0101305A2 HU0101305A HUP0101305A HUP0101305A2 HU P0101305 A2 HUP0101305 A2 HU P0101305A2 HU 0101305 A HU0101305 A HU 0101305A HU P0101305 A HUP0101305 A HU P0101305A HU P0101305 A2 HUP0101305 A2 HU P0101305A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- group
- aryl
- formula
- ch2oh
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- YQUJSBYIKMQCIT-UHFFFAOYSA-N 2-purin-9-yloxolane-3,4-diol Chemical class OC1C(O)COC1N1C2=NC=NC=C2N=C1 YQUJSBYIKMQCIT-UHFFFAOYSA-N 0.000 title 1
- -1 pyrrolidinyl- Chemical group 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- WINXNKPZLFISPD-UHFFFAOYSA-M Saccharin sodium Chemical compound [Na+].C1=CC=C2C(=O)[N-]S(=O)(=O)C2=C1 WINXNKPZLFISPD-UHFFFAOYSA-M 0.000 abstract 1
- 241000615724 Sucra Species 0.000 abstract 1
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical class 0.000 abstract 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
- SNVLJLYUUXKWOJ-UHFFFAOYSA-N methylidenecarbene Chemical group C=[C] SNVLJLYUUXKWOJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
Abstract
A tal lm ny új (I) ltal nos képletű vegyületekre, elő llít sukraalkalmas elj r sokra, ilyen vegyületeket tartalmazó gyógy szatikészítményekre és gyógy szatban való alkalmaz sukra vonatkozik, aképletben R1 és R2 jelentése hidrogénatom, cikloalkil-, (aril)2CHCH2-,cikloalkil-alkil-, alkil-, aril-alkil-, R4R5N-alkil-, alkil-CH(CH2OH)-, aril-alkil-CH(CH2OH)-, aril-alkil-C(CH2OH)2-,cikloalkilcsoport, amely egym stól függetlenül egy vagy t"bb -(CH2)PR6ltal nos képletű csoporttal helyettesített, H2NC(=NH)NHalkil-csoport,(a) ltal nos képletű csoport vagy olyan csoport, amelyben egymetilénszénatom, amely az X-szel szomszédos, vagy mindkettő, ha kétilyen szénatom van, metilcsoporttal helyettesített, hidroxi-alkilcsoport, halogén-alkilcsoport, (b) ltal nos képletű csoport,arilcsoport, adott esetben helyettesített szulfonamido-alkilcsoport;R3 jelentése adott esetben helyettesített vagy heteroatommalmegszakított alkil-, alkenil-, cikloalkil-, cikloalkil-alkilcsoport;R4 és R5 jelentése egym stól függetlenül hidrogénatom, alkil-, aril-,aril-alkilcsoport, vagy az -NR4R5 ltal nos képletű csoport együttpiridinil-, pirrolidinil-, piperidinil-, morfolinil-, azetidinil-,azepinil-, piperazinil-, N-alkil-piperazinil- vagy 2-(1-metil-1H-imidazol-4-il)-csoportot alkothat; R6 jelentése -OH, -NH2, -NHCOCH3csoport vagy halogénatom; R7 jelentése hidrogénatom, alkil-, alkil-aril- vagy -CO-alkilcsoport; X jelentése -NR7, -O-, -S-, -SO- vagy -SO2-csoport. Ó
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9802066.2A GB9802066D0 (en) | 1998-01-31 | 1998-01-31 | Chemical compounds |
GBGB9813528.8A GB9813528D0 (en) | 1998-06-23 | 1998-06-23 | Chemical compounds |
PCT/EP1999/000503 WO1999038877A2 (en) | 1998-01-31 | 1999-01-29 | 2-(PURIN-9-yl)-TETRAHYDROFURAN-3,4-DIOL DERIVATIVES |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0101305A2 true HUP0101305A2 (hu) | 2002-04-29 |
HUP0101305A3 HUP0101305A3 (en) | 2002-08-28 |
Family
ID=26313042
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0101305A HUP0101305A3 (en) | 1998-01-31 | 1999-01-29 | 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives, process for their preparation and medicaments containing them |
Country Status (39)
Country | Link |
---|---|
US (1) | US6762170B1 (hu) |
EP (1) | EP1051425B1 (hu) |
JP (1) | JP2002501928A (hu) |
KR (1) | KR20010034473A (hu) |
CN (1) | CN1289338A (hu) |
AP (1) | AP2000001875A0 (hu) |
AR (1) | AR014508A1 (hu) |
AT (1) | ATE226957T1 (hu) |
AU (1) | AU757183B2 (hu) |
BG (1) | BG63783B1 (hu) |
BR (1) | BR9907270A (hu) |
CA (1) | CA2318278A1 (hu) |
CO (1) | CO4980872A1 (hu) |
DE (1) | DE69903708T2 (hu) |
DK (1) | DK1051425T3 (hu) |
EA (1) | EA003194B1 (hu) |
EE (1) | EE200000441A (hu) |
ES (1) | ES2186330T3 (hu) |
GE (1) | GEP20022839B (hu) |
HK (1) | HK1030611A1 (hu) |
HR (1) | HRP20000511A2 (hu) |
HU (1) | HUP0101305A3 (hu) |
ID (1) | ID26326A (hu) |
IL (1) | IL137042A0 (hu) |
IS (1) | IS5550A (hu) |
MA (1) | MA26601A1 (hu) |
NO (1) | NO20003867D0 (hu) |
NZ (1) | NZ505452A (hu) |
OA (1) | OA11447A (hu) |
PE (1) | PE20000280A1 (hu) |
PL (1) | PL342670A1 (hu) |
PT (1) | PT1051425E (hu) |
SI (1) | SI1051425T1 (hu) |
SK (1) | SK11192000A3 (hu) |
SV (1) | SV1999000009A (hu) |
TR (1) | TR200002218T2 (hu) |
TW (1) | TW434250B (hu) |
WO (1) | WO1999038877A2 (hu) |
YU (1) | YU44900A (hu) |
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GB9813565D0 (en) * | 1998-06-23 | 1998-08-19 | Glaxo Group Ltd | Chemical compounds |
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AU4772493A (en) | 1992-07-15 | 1994-02-14 | United States Of America, Represented By The Secretary, Department Of Health And Human Services, The | Sulfo-derivatives of adenosine |
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AU7331094A (en) | 1993-07-13 | 1995-02-13 | United States Of America, As Represented By The Secretary, Department Of Health And Human Services, The | A3 adenosine receptor agonists |
US5446046A (en) | 1993-10-28 | 1995-08-29 | University Of Florida Research Foundation | A1 adenosine receptor agonists and antagonists as diuretics |
WO1995018817A1 (fr) | 1994-01-07 | 1995-07-13 | Laboratoires Upsa | Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant |
GB9414208D0 (en) | 1994-07-14 | 1994-08-31 | Glaxo Group Ltd | Compounds |
GB9414193D0 (en) * | 1994-07-14 | 1994-08-31 | Glaxo Group Ltd | Compounds |
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YU44900A (sh) | 1998-01-31 | 2003-01-31 | Glaxo Group Limited | Derivati 2-(purin-9-il)tetrahidrofuran-3,4-diola |
PE20000270A1 (es) * | 1998-02-14 | 2000-05-20 | Glaxo Group Ltd | Derivados de 2-(purin-9-il)-tetrahidrofuran-3,4-diol |
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GB9813535D0 (en) | 1998-06-23 | 1998-08-19 | Glaxo Group Ltd | Chemical compounds |
-
1998
- 1998-01-31 YU YU44900A patent/YU44900A/sh unknown
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1999
- 1999-01-28 CO CO99004721A patent/CO4980872A1/es unknown
- 1999-01-28 PE PE1999000060A patent/PE20000280A1/es not_active Application Discontinuation
- 1999-01-28 AR ARP990100336A patent/AR014508A1/es not_active Application Discontinuation
- 1999-01-29 PL PL99342670A patent/PL342670A1/xx unknown
- 1999-01-29 CN CN99802548A patent/CN1289338A/zh active Pending
- 1999-01-29 SV SV1999000009A patent/SV1999000009A/es unknown
- 1999-01-29 AT AT99907427T patent/ATE226957T1/de not_active IP Right Cessation
- 1999-01-29 EP EP99907427A patent/EP1051425B1/en not_active Expired - Lifetime
- 1999-01-29 AU AU27197/99A patent/AU757183B2/en not_active Ceased
- 1999-01-29 JP JP2000529344A patent/JP2002501928A/ja active Pending
- 1999-01-29 DE DE69903708T patent/DE69903708T2/de not_active Expired - Lifetime
- 1999-01-29 WO PCT/EP1999/000503 patent/WO1999038877A2/en not_active Application Discontinuation
- 1999-01-29 ES ES99907427T patent/ES2186330T3/es not_active Expired - Lifetime
- 1999-01-29 GE GEAP19995495A patent/GEP20022839B/en unknown
- 1999-01-29 AP APAP/P/2000/001875A patent/AP2000001875A0/en unknown
- 1999-01-29 SK SK1119-2000A patent/SK11192000A3/sk unknown
- 1999-01-29 HU HU0101305A patent/HUP0101305A3/hu unknown
- 1999-01-29 PT PT99907427T patent/PT1051425E/pt unknown
- 1999-01-29 ID IDW20001467A patent/ID26326A/id unknown
- 1999-01-29 MA MA25443A patent/MA26601A1/fr unknown
- 1999-01-29 US US09/601,301 patent/US6762170B1/en not_active Expired - Lifetime
- 1999-01-29 BR BR9907270-0A patent/BR9907270A/pt not_active IP Right Cessation
- 1999-01-29 EE EEP200000441A patent/EE200000441A/xx unknown
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- 1999-01-29 EA EA200000723A patent/EA003194B1/ru not_active IP Right Cessation
- 1999-01-29 SI SI9930187T patent/SI1051425T1/xx unknown
- 1999-01-29 TW TW088101391A patent/TW434250B/zh active
- 1999-01-29 KR KR1020007008297A patent/KR20010034473A/ko not_active Application Discontinuation
- 1999-01-29 TR TR2000/02218T patent/TR200002218T2/xx unknown
- 1999-01-29 CA CA002318278A patent/CA2318278A1/en not_active Abandoned
- 1999-01-29 DK DK99907427T patent/DK1051425T3/da active
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2000
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- 2000-07-21 OA OA1200000211A patent/OA11447A/en unknown
- 2000-07-28 NO NO20003867A patent/NO20003867D0/no unknown
- 2000-07-28 HR HR20000511A patent/HRP20000511A2/hr not_active Application Discontinuation
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2001
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