HRP20201513T1 - Cd40l-specifični tn3-izvedeni skeleti i postupci njihove uporabe - Google Patents
Cd40l-specifični tn3-izvedeni skeleti i postupci njihove uporabe Download PDFInfo
- Publication number
- HRP20201513T1 HRP20201513T1 HRP20201513TT HRP20201513T HRP20201513T1 HR P20201513 T1 HRP20201513 T1 HR P20201513T1 HR P20201513T T HRP20201513T T HR P20201513TT HR P20201513 T HRP20201513 T HR P20201513T HR P20201513 T1 HRP20201513 T1 HR P20201513T1
- Authority
- HR
- Croatia
- Prior art keywords
- skeleton
- seq
- disease
- cd40l
- skeleton according
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 4
- 101150093750 CD40LG gene Proteins 0.000 title 1
- 108010029697 CD40 Ligand Proteins 0.000 claims 10
- 102100032937 CD40 ligand Human genes 0.000 claims 10
- 208000023275 Autoimmune disease Diseases 0.000 claims 3
- 201000004681 Psoriasis Diseases 0.000 claims 3
- 206010025135 lupus erythematosus Diseases 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 102000009027 Albumins Human genes 0.000 claims 2
- 108010088751 Albumins Proteins 0.000 claims 2
- 208000023328 Basedow disease Diseases 0.000 claims 2
- 101150013553 CD40 gene Proteins 0.000 claims 2
- 208000011231 Crohn disease Diseases 0.000 claims 2
- 208000001640 Fibromyalgia Diseases 0.000 claims 2
- 208000007465 Giant cell arteritis Diseases 0.000 claims 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- 208000015023 Graves' disease Diseases 0.000 claims 2
- 208000035186 Hemolytic Autoimmune Anemia Diseases 0.000 claims 2
- 102000008100 Human Serum Albumin Human genes 0.000 claims 2
- 108091006905 Human Serum Albumin Proteins 0.000 claims 2
- 206010034277 Pemphigoid Diseases 0.000 claims 2
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 2
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 2
- 206010063837 Reperfusion injury Diseases 0.000 claims 2
- 206010040047 Sepsis Diseases 0.000 claims 2
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 2
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 2
- 206010047115 Vasculitis Diseases 0.000 claims 2
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 230000011664 signaling Effects 0.000 claims 2
- 206010043207 temporal arteritis Diseases 0.000 claims 2
- 208000020576 Adrenal disease Diseases 0.000 claims 1
- 208000008190 Agammaglobulinemia Diseases 0.000 claims 1
- 208000032671 Allergic granulomatous angiitis Diseases 0.000 claims 1
- 206010002199 Anaphylactic shock Diseases 0.000 claims 1
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 1
- 208000003343 Antiphospholipid Syndrome Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 206010003827 Autoimmune hepatitis Diseases 0.000 claims 1
- 206010050245 Autoimmune thrombocytopenia Diseases 0.000 claims 1
- 208000009137 Behcet syndrome Diseases 0.000 claims 1
- 208000008439 Biliary Liver Cirrhosis Diseases 0.000 claims 1
- 208000033222 Biliary cirrhosis primary Diseases 0.000 claims 1
- 201000002829 CREST Syndrome Diseases 0.000 claims 1
- 208000031229 Cardiomyopathies Diseases 0.000 claims 1
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 claims 1
- 208000030939 Chronic inflammatory demyelinating polyneuropathy Diseases 0.000 claims 1
- 208000006344 Churg-Strauss Syndrome Diseases 0.000 claims 1
- 208000015943 Coeliac disease Diseases 0.000 claims 1
- 208000011038 Cold agglutinin disease Diseases 0.000 claims 1
- 206010009868 Cold type haemolytic anaemia Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000019707 Cryoglobulinemic vasculitis Diseases 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 201000004624 Dermatitis Diseases 0.000 claims 1
- 206010012468 Dermatitis herpetiformis Diseases 0.000 claims 1
- 206010014824 Endotoxic shock Diseases 0.000 claims 1
- 208000018428 Eosinophilic granulomatosis with polyangiitis Diseases 0.000 claims 1
- 208000010412 Glaucoma Diseases 0.000 claims 1
- 206010018364 Glomerulonephritis Diseases 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- 206010018498 Goitre Diseases 0.000 claims 1
- 206010072579 Granulomatosis with polyangiitis Diseases 0.000 claims 1
- 208000030836 Hashimoto thyroiditis Diseases 0.000 claims 1
- 206010020983 Hypogammaglobulinaemia Diseases 0.000 claims 1
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims 1
- 208000003456 Juvenile Arthritis Diseases 0.000 claims 1
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
- 208000027530 Meniere disease Diseases 0.000 claims 1
- 208000003250 Mixed connective tissue disease Diseases 0.000 claims 1
- 201000011152 Pemphigus Diseases 0.000 claims 1
- 208000031845 Pernicious anaemia Diseases 0.000 claims 1
- 206010065159 Polychondritis Diseases 0.000 claims 1
- 208000007048 Polymyalgia Rheumatica Diseases 0.000 claims 1
- 208000012654 Primary biliary cholangitis Diseases 0.000 claims 1
- 208000012322 Raynaud phenomenon Diseases 0.000 claims 1
- 208000033464 Reiter syndrome Diseases 0.000 claims 1
- 206010038923 Retinopathy Diseases 0.000 claims 1
- 206010038933 Retinopathy of prematurity Diseases 0.000 claims 1
- 206010039710 Scleroderma Diseases 0.000 claims 1
- 206010040070 Septic Shock Diseases 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- 206010072148 Stiff-Person syndrome Diseases 0.000 claims 1
- 208000001106 Takayasu Arteritis Diseases 0.000 claims 1
- 102000007000 Tenascin Human genes 0.000 claims 1
- 108010008125 Tenascin Proteins 0.000 claims 1
- 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 206010046851 Uveitis Diseases 0.000 claims 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 1
- 206010047112 Vasculitides Diseases 0.000 claims 1
- 206010047642 Vitiligo Diseases 0.000 claims 1
- 206010064930 age-related macular degeneration Diseases 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- 208000004631 alopecia areata Diseases 0.000 claims 1
- 150000001413 amino acids Chemical group 0.000 claims 1
- 208000003455 anaphylaxis Diseases 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 230000001363 autoimmune Effects 0.000 claims 1
- 201000000448 autoimmune hemolytic anemia Diseases 0.000 claims 1
- 208000006424 autoimmune oophoritis Diseases 0.000 claims 1
- 208000036923 autoimmune primary adrenal insufficiency Diseases 0.000 claims 1
- 208000000594 bullous pemphigoid Diseases 0.000 claims 1
- 208000037976 chronic inflammation Diseases 0.000 claims 1
- 230000006020 chronic inflammation Effects 0.000 claims 1
- 201000005795 chronic inflammatory demyelinating polyneuritis Diseases 0.000 claims 1
- 239000003246 corticosteroid Substances 0.000 claims 1
- 229960001334 corticosteroids Drugs 0.000 claims 1
- 201000003278 cryoglobulinemia Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 201000001981 dermatomyositis Diseases 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 206010014665 endocarditis Diseases 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 claims 1
- 201000011066 hemangioma Diseases 0.000 claims 1
- 208000026278 immune system disease Diseases 0.000 claims 1
- 208000036971 interstitial lung disease 2 Diseases 0.000 claims 1
- 208000028867 ischemia Diseases 0.000 claims 1
- 229960000310 isoleucine Drugs 0.000 claims 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 1
- 201000011486 lichen planus Diseases 0.000 claims 1
- 208000002780 macular degeneration Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000000116 mitigating effect Effects 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 claims 1
- 206010028417 myasthenia gravis Diseases 0.000 claims 1
- 201000003142 neovascular glaucoma Diseases 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 201000005737 orchitis Diseases 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 201000001976 pemphigus vulgaris Diseases 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 206010034674 peritonitis Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 201000006292 polyarteritis nodosa Diseases 0.000 claims 1
- 208000005987 polymyositis Diseases 0.000 claims 1
- 208000002574 reactive arthritis Diseases 0.000 claims 1
- 201000000306 sarcoidosis Diseases 0.000 claims 1
- 230000037390 scarring Effects 0.000 claims 1
- 208000013223 septicemia Diseases 0.000 claims 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 1
- 208000020431 spinal cord injury Diseases 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
- 239000004474 valine Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2318/00—Antibody mimetics or scaffolds
- C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Ophthalmology & Optometry (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
Claims (17)
1. Tenascin 3 (Tn3) skelet koji sadrži dvije CD40L-specifične monomerne podjedinice povezane u tandem,
pri čemu monomerna podjedinica sadrži sedam beta lanaca označenih A, B, C, D, E, F, i G, te šest regija petlje označenih AB, BC, CD, DE, EF, i FG, i pri čemu se Tn3 skelet specifično veže na CD40L,
pri čemu CD40L-specifična monomerna podjedinica sadrži aminokiselinsku sekvencu:
IEV(XAB)nALITW(XBC)nCELX1YGI(XCD)nTTIDL(XDE)nYSI(XEF)nYEVSLIC(XFG)nKETFTT pri čemu:
(a) XAB, XBC, XCD, XDE, XEF, i XFG predstavljaju aminokiselinske ostatke prisutne u sekvencama petlji AB, BC, CD, DE, EF, i FG, redom;
(b) X1 predstavlja aminokiselinski ostatak A ili T; i,
(c) duljina petlje n je cijeli broj između 2 i 26,
pri čemu sekvenca BC petlje sadrži SEQ ID NO: 86, sekvenca DE petlje sadrži SEQ ID NO: 96, i sekvenca FG petlje sadrži SEQ ID NO: 9 ili 139.
2. Tn3 skelet prema patentnom zahtjevu 1, naznačen time što sekvenca AB petlje sadrži SEQ ID NO: 4 ili SEQ ID NO: 136, sekvenca CD petlje sadrži SEQ ID NO: 6, i sekvenca EF petlje sadrži SEQ ID NO: 8 ili SEQ ID NO: 137.
3. Tn3 skelet prema patentnom zahtjevu 1 ili 2, naznačen time što CD40L-specifična monomerna podjedinica sadrži sekvencu SEQ ID NO: 28 ili 146.
4. Tn3 skelet prema bilo kojem od patentnih zahtjeva 1-3, naznačen time što su dvije CD40L-specifične monomerne podjedinice izravno povezane.
5. Tn3 skelet prema bilo kojem od patentnih zahtjeva 1-4, naznačen time što su dvije CD40L-specifične monomerne podjedinice povezane s poveznicom.
6. Tn3 skelet prema patentnom zahtjevu 5, naznačen time što poveznica sadrži peptidnu poveznicu.
7. Tn3 skelet prema patentnom zahtjevu 5 ili 6, naznačen time što peptidna poveznica sadrži (GmX)n sekvencu pri čemu:
(a) X je serin (S), alanin (A), glicin (G), Leu (L), izoleucin (I), ili valin (V);
(b) m i n su cijeli brojevi;
(c) m je 1, 2, 3 ili 4; i
(d) n je 1, 2, 3, 4, 5, 6, ili 7.
8. Tn3 skelet prema patentnom zahtjevu 7, naznačen time što peptidna poveznica sadrži SEQ ID NO: 131, SEQ ID NO: 132, SEQ ID NO: 142 ili SEQ ID NO: 143.
9. Tn3 skelet prema bilo kojem od patentnih zahtjeva 1-8, naznačen time što je najmanje jedna CD40L-specifična monomerna podjedinica vezana na poveznicu, ili na heterologni dio.
10. Tn3 skelet prema patentnom zahtjevu 9, naznačen time što je najmanje jedna CD40L-specifična monomerna podjedinica konjugirana na PEG ili albumin.
11. Tn3 skelet prema patentnom zahtjevu 10, naznačen time što je albumin humani serumski albumin (HSA).
12. Tn3 skelet prema bilo kojem od patentnih zahtjeva 1-11, naznačen time što Tn3 skelet sadrži ili se sastoji od sekvence SEQ ID NO: 145.
13. Tn3 skelet prema bilo kojem od prethodnih patentnih zahtjeva naznačen time što je za uporabu u postupku mijenjanja CD40 posredovanog signalnog odgovora koji obuhvaća dovođenje u kontakt stanice koja eksprimira CD40L sa Tn3 skeletom, pri čemu Tn3 skelet veže CD40L i ometa CD40 posredovanu signalizaciju.
14. Izolirana molekula nukleinske kiseline naznačena time što kodira Tn3 skelet prema bilo kojem od patentnih zahtjeva 1-12.
15. Postupak za proizvodnju Tn3 skeleta koji uključuje kultiviranje stanice domaćina, pri čemu navedena stanica domaćina sadrži ekspresijski vektor koji sadrži molekulu nukleinske kiseline iz zahtjeva 14, pod uvjetima u kojima se eksprimira Tn3 skelet kodiran molekulom nukleinske kiseline.
16. Pripravak naznačen time što sadrži Tn3 skelet prema bilo kojem od patentnih zahtjeva 1-12 i farmaceutski prihvatljivu pomoćnu tvar.
17. Pripravak prema patentnom zahtjevu 16 naznačen time što je za uporabu u:
1) postupku sprječavanja, liječenja ili ublažavanja autoimune bolesti kod pacijenta kojem je potrebno; ili
2) postupku smanjenja učestalosti ili količine kortikosteroida koji se daje pacijentu s autoimunom bolešću, proizvoljno
pri čemu je autoimuna bolest izabrana iz skupine koja sadrži alopeciju areata, ankilozirajući spondilitis, antifosfolipidni sindrom, autoimunu Addisonovu bolest, autoimunu bolest nadbubrežne žlijezde, autoimunu hemolitičku anemiju, autoimuni hepatitis, autoimuni ooforitis i orhitis, Sjogrenov sindrom, psorijazu, aterosklerozu, dijabetičke i druge retinopatije, retrolentalnu fibroplaziju, makularnu degeneraciju povezanu sa starenjem, neovaskularni glaukom, hemangiome, hiperplazije štitnjače (uključujući Gravesovu bolest), transplantaciju rožnice i drugih tkiva, i kroničnu upalu, sepsu, reumatoidni artritis, peritonitis, Crohnovu bolest, reperfuzijsku ozljedu, septikemiju, endotoksični šok, cističnu fibrozu, endokarditis, psorijazu, artritis (npr. psorijatični artritis), anafilaktički šok, ishemiju organa, reperfuzijsku ozljedu, ozljedu leđne moždine i odbacivanje alografta, autoimunu trombocitopeniju, Behcetovu bolest, bulozni pemfigoid, kardiomiopatiju, celijačni sprue-dermatitis, sindrom kroničnog umora zbog imunološke disfunkcije (CFIDS), kronična upalna demijelinizirajuća polineuropatija, Churg-Straussov sindrom, ožiljkasti pemfigoid, CREST sindrom, bolest hladnih aglutinina, Crohnovu bolest, diskoidni lupus, esencijalna mješovita krioglobulinemija, fibromijalgija-fibromiozitis, glomerulonefritis, Gravesovu bolest, Guillain-Barre, Hashimotov tireoiditis, idiopatska plućna fibroza, idiopatska trombocitopenija purpura (ITP), IgA neuropatija, juvenilni artritis, lichen planus, eritemski lupus, Meniereovu bolest, miješana bolest vezivnog tkiva, multiplu sklerozu, dijabetes melitus tipa 1 ili imunološki posredovani dijabetes, miastenija gravis, pemfigus vulgaris, pernicioznu anemiju, poliarteritis nodosa, polihondritis, poliglandularne sindrome, reumatičnu polimialgiju, polimiozitis i dermatomiozitis, primarnu agamaglobulinemiju, primarnu bilijarnu cirozu, psorijazu, psorijatični artritis, Raynaudov fenomen, Reiterov sindrom, reumatoidni artritis, sarkoidozu, sklerodermu, Sjogrenov sindrom, sindrom ukočenog čovjeka, sistemski eritemski lupus, eritemski lupus, takayasu arteritis, temporalni arteristis / arteritis divovskih stanica, ulcerozni kolitis, uveitis, vaskulitide, kao što su dermatitis herpetiformis vaskulitis, vitiligo, i Wegenerovu granulomatozu.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161546028P | 2011-10-11 | 2011-10-11 | |
EP12840074.4A EP2771022B1 (en) | 2011-10-11 | 2012-10-10 | Cd40l-specific tn3-derived scaffolds and methods of use thereof |
PCT/US2012/059477 WO2013055745A2 (en) | 2011-10-11 | 2012-10-10 | Cd40l-specific tn3-derived scaffolds and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20201513T1 true HRP20201513T1 (hr) | 2020-12-11 |
Family
ID=48082729
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20201513TT HRP20201513T1 (hr) | 2011-10-11 | 2020-09-22 | Cd40l-specifični tn3-izvedeni skeleti i postupci njihove uporabe |
Country Status (22)
Country | Link |
---|---|
US (4) | US10000553B2 (hr) |
EP (2) | EP3753567A1 (hr) |
JP (4) | JP6140712B2 (hr) |
KR (3) | KR102434073B1 (hr) |
CN (3) | CN108948196B (hr) |
AU (1) | AU2012323316B2 (hr) |
BR (1) | BR112014008804A2 (hr) |
CA (1) | CA2851667A1 (hr) |
CY (1) | CY1123690T1 (hr) |
DK (1) | DK2771022T3 (hr) |
ES (1) | ES2819075T3 (hr) |
HK (1) | HK1201463A1 (hr) |
HR (1) | HRP20201513T1 (hr) |
HU (1) | HUE051439T2 (hr) |
LT (1) | LT2771022T (hr) |
MX (2) | MX367013B (hr) |
PT (1) | PT2771022T (hr) |
RS (1) | RS60828B1 (hr) |
RU (2) | RU2704992C2 (hr) |
SG (2) | SG10201707813YA (hr) |
SI (1) | SI2771022T1 (hr) |
WO (1) | WO2013055745A2 (hr) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8956849B2 (en) * | 2007-11-01 | 2015-02-17 | The Board Of Trustees Of The University Of Arkansas | Compositions and methods of enhancing immune responses to Eimeria |
CN108948196B (zh) * | 2011-10-11 | 2022-09-23 | 维埃拉生物股份有限公司 | Cd40l-特异性tn3-衍生的支架及其使用方法 |
MA41044A (fr) | 2014-10-08 | 2017-08-15 | Novartis Ag | Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer |
SI3218406T1 (sl) | 2014-11-10 | 2021-08-31 | Medimmune Limited | Vezavne molekule specifične za CD73 in njihove uporabe |
US10683340B2 (en) | 2015-03-12 | 2020-06-16 | Medimmune, Llc | Method of purifying albumin-fusion proteins |
KR101810778B1 (ko) * | 2015-06-23 | 2017-12-20 | 서울대학교산학협력단 | Cd154 결합 폴리펩타이드 및 그 용도 |
BR112018002319A2 (pt) | 2015-08-05 | 2018-12-11 | Janssen Biotech, Inc. | anticorpos anti-cd154 e métodos de uso dos mesmos |
CN110520444A (zh) * | 2017-01-09 | 2019-11-29 | 拜奥穆尼克斯制药 | 用于制备多特异性抗体的多肽接头 |
WO2019108541A1 (en) * | 2017-11-28 | 2019-06-06 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Recombinant rsv g proteins and their use |
CN112770774A (zh) * | 2018-09-24 | 2021-05-07 | 詹森生物科技公司 | 提供安全施用抗cd154抗体的方法 |
CN113474364A (zh) * | 2018-09-26 | 2021-10-01 | 维埃拉生物股份有限公司 | Cd40l拮抗剂及其用途 |
US20220090055A1 (en) * | 2018-10-24 | 2022-03-24 | Brandeis University | Multivalent glycopeptides that tightly bind to carbohydrate-binding monoclonal antibody family pgt128 |
KR20210111792A (ko) | 2018-12-28 | 2021-09-13 | 스팍스 테라퓨틱스 인크. | 암 및 다른 질환을 치료하기 위한 클라우딘 18.2에 특이적인 결합 분자, 이의 조성물 및 방법 |
CN111440253B (zh) * | 2019-01-17 | 2021-08-27 | 中国科学院上海药物研究所 | 立方形环糊精骨架-rgd组合物及其制备方法 |
WO2022246225A1 (en) * | 2021-05-21 | 2022-11-24 | Viela Bio, Inc. | Cd40l antagonist and uses thereof in the treatment of lupus nephritis |
Family Cites Families (72)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4666884A (en) | 1984-04-10 | 1987-05-19 | New England Deaconess Hospital | Method of inhibiting binding of von Willebrand factor to human platelets and inducing interaction of platelets with vessel walls |
EP0307434B2 (en) | 1987-03-18 | 1998-07-29 | Scotgen Biopharmaceuticals, Inc. | Altered antibodies |
US5314995A (en) | 1990-01-22 | 1994-05-24 | Oncogen | Therapeutic interleukin-2-antibody based fusion proteins |
WO1991014438A1 (en) | 1990-03-20 | 1991-10-03 | The Trustees Of Columbia University In The City Of New York | Chimeric antibodies with receptor binding ligands in place of their constant region |
JP4251406B2 (ja) | 1990-04-05 | 2009-04-08 | クレア,ロベルト | ウォーク―スルー突然変異誘発 |
US7063943B1 (en) | 1990-07-10 | 2006-06-20 | Cambridge Antibody Technology | Methods for producing members of specific binding pairs |
US5843701A (en) | 1990-08-02 | 1998-12-01 | Nexstar Pharmaceticals, Inc. | Systematic polypeptide evolution by reverse translation |
US5866344A (en) | 1991-11-15 | 1999-02-02 | Board Of Regents, The University Of Texas System | Antibody selection methods using cell surface expressed libraries |
FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
ZA932522B (en) | 1992-04-10 | 1993-12-20 | Res Dev Foundation | Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens |
US5440018A (en) | 1992-05-20 | 1995-08-08 | The Green Cross Corporation | Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same |
CA2141602A1 (en) | 1992-08-26 | 1994-03-03 | Philip Leder | Use of the cytokine ip-10 as an anti-tumor agent |
US5922545A (en) | 1993-10-29 | 1999-07-13 | Affymax Technologies N.V. | In vitro peptide and antibody display libraries |
US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
EP0781297A4 (en) | 1994-09-16 | 1999-05-19 | Scripps Research Inst | CYTOTACTINE DERIVATIVES THAT STIMULATE NEURONAL CONNECTION AND GROWTH OF AXONES AND DENDRITES, THEIR PREPARATION AND USE METHODS |
US6096871A (en) | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
US5747035A (en) | 1995-04-14 | 1998-05-05 | Genentech, Inc. | Polypeptides with increased half-life for use in treating disorders involving the LFA-1 receptor |
WO1997043316A1 (en) | 1996-05-10 | 1997-11-20 | Beth Israel Deaconess Medical Center, Inc. | Physiologically active molecules with extended half-lives and methods of using same |
US6699658B1 (en) | 1996-05-31 | 2004-03-02 | Board Of Trustees Of The University Of Illinois | Yeast cell surface display of proteins and uses thereof |
EP2380906A2 (en) | 1997-06-12 | 2011-10-26 | Novartis International Pharmaceutical Ltd. | Artificial antibody polypeptides |
WO1999043713A1 (en) | 1998-02-25 | 1999-09-02 | Lexigen Pharmaceuticals Corporation | Enhancing the circulating half-life of antibody-based fusion proteins |
US6160089A (en) | 1998-07-08 | 2000-12-12 | Mitsui Chemicals, Inc. | Method for secretory production of human growth hormone |
EP1105427A2 (en) | 1998-08-17 | 2001-06-13 | Abgenix, Inc. | Generation of modified molecules with increased serum half-lives |
NZ511699A (en) | 1998-12-02 | 2003-02-28 | Phylos Inc | DNA-protein fusions and uses thereof |
EP2154535A1 (en) | 1998-12-10 | 2010-02-17 | Bristol-Myers Squibb Company | Protein scaffolds for antibody mimics and other binding proteins |
US6818418B1 (en) | 1998-12-10 | 2004-11-16 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
US7115396B2 (en) | 1998-12-10 | 2006-10-03 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
PT1196637E (pt) | 1999-07-27 | 2007-07-04 | Adnexus Therapeutics Inc | Métodos de ligação de aceitadores de péptidos. |
US7022479B2 (en) | 2000-01-24 | 2006-04-04 | Compound Therapeutics, Inc. | Sensitive, multiplexed diagnostic assays for protein analysis |
AU2001277867B2 (en) | 2000-07-11 | 2006-12-07 | Research Corporation Technologies, Inc. | Artificial antibody polypeptides |
EP2141243A3 (en) | 2000-10-16 | 2010-01-27 | Brystol-Myers Squibb Company | Protein scaffolds for antibody mimics and other binding proteins |
ATE489395T1 (de) | 2000-12-12 | 2010-12-15 | Medimmune Llc | Moleküle mit längeren halbwertszeiten, zusammensetzungen und deren verwendung |
AU2002310502A1 (en) | 2001-06-21 | 2003-01-08 | Phylos, Inc. | In vitro protein interaction detection systems |
KR101271635B1 (ko) * | 2001-12-21 | 2013-06-12 | 휴먼 게놈 사이언시즈, 인코포레이티드 | 알부민 융합 단백질 |
AU2003228393A1 (en) | 2002-03-29 | 2003-10-13 | Genencor International, Inc. | Ehanced protein expression in bacillus |
AU2003243436A1 (en) | 2002-06-06 | 2003-12-22 | Shohei Koide | Reconstituted polypeptides |
US20060141561A1 (en) | 2002-06-24 | 2006-06-29 | Kelley Robert F | Apo-2 ligand/trail variants and uses thereof |
KR100524872B1 (ko) | 2003-12-04 | 2005-11-01 | 씨제이 주식회사 | 인터페론 베타의 정제방법 |
BRPI0417302A (pt) | 2003-12-05 | 2007-03-06 | Compound Therapeutics Inc | inibidores de receptores de fator de crescimento endotelial vascular do tipo 2 |
ES2372503T3 (es) | 2004-07-06 | 2012-01-20 | Bioren, Inc. | Mutagénesis revisada para desarrollar polipéptidos alterados con propiedades potenciadas. |
KR100852415B1 (ko) | 2004-07-13 | 2008-08-18 | 재단법인서울대학교산학협력재단 | 인간 테나신―c 유래의 신규한 헤파린-결합부위를포함하는 폴리펩타이드 및 그의 유도체 |
GB0416651D0 (en) | 2004-07-26 | 2004-08-25 | Proteo Target Aps | Polypeptide |
PL1885399T3 (pl) * | 2005-05-26 | 2011-04-29 | Seattle Genetics Inc | Humanizowane przeciwciała anty-CD40 i sposoby ich stosowania |
JP4959226B2 (ja) | 2006-05-19 | 2012-06-20 | 独立行政法人産業技術総合研究所 | スリーフィンガー様蛋白質ライブラリ |
WO2008031098A1 (en) | 2006-09-09 | 2008-03-13 | The University Of Chicago | Binary amino acid libraries for fibronectin type iii polypeptide monobodies |
BRPI0719597A2 (pt) | 2006-11-22 | 2013-12-17 | Adnexus A Bristol Myers Squibb R & D Company | Produtos terapêuticos objetivados baseados em proteínas manipuladas para receptores de quinases de tirosina, incluindo igf-ir |
CN102014888A (zh) | 2007-07-03 | 2011-04-13 | 达努塔·克鲁谢夫斯卡 | α-酮戊二酸的新医药用途 |
AU2008287426B2 (en) | 2007-08-10 | 2014-06-26 | Protelica, Inc. | Universal fibronectin type III binding-domain libraries |
US8470966B2 (en) | 2007-08-10 | 2013-06-25 | Protelica, Inc. | Universal fibronectin type III binding-domain libraries |
KR101686247B1 (ko) | 2007-10-31 | 2016-12-14 | 메디뮨 엘엘씨 | 단백질 스캐폴드 |
KR20100111283A (ko) | 2007-12-27 | 2010-10-14 | 노파르티스 아게 | 개선된 피브로넥틴계 결합 분자 및 그들의 용도 |
EP2383292A1 (en) | 2008-05-02 | 2011-11-02 | Novartis AG | Improved fibronectin-based binding molecules and uses thereof |
WO2009142773A2 (en) | 2008-05-22 | 2009-11-26 | Bristol-Myers Squibb Company | Multivalent fibronectin based scaffold domain proteins |
ES2828721T3 (es) * | 2008-10-14 | 2021-05-27 | Genentech Inc | Variantes de inmunoglobulina y usos de las mismas |
ES2705714T3 (es) | 2008-10-31 | 2019-03-26 | Janssen Biotech Inc | Métodos y usos de dominio de Fibronectina tipo III basado en estructuras de composiciones |
TWI496582B (zh) | 2008-11-24 | 2015-08-21 | 必治妥美雅史谷比公司 | 雙重專一性之egfr/igfir結合分子 |
CN102596992B (zh) | 2009-02-12 | 2015-09-09 | 詹森生物科技公司 | 基于ⅲ型纤连蛋白结构域的支架组合物、方法及用途 |
CN102549012B (zh) | 2009-05-07 | 2015-07-01 | 诺维信生物制药丹麦公司 | 纯化白蛋白的方法 |
WO2011020033A2 (en) | 2009-08-13 | 2011-02-17 | Massachusetts Institute Of Technology | Engineered proteins including mutant fibronectin domains |
JP2013509170A (ja) | 2009-10-30 | 2013-03-14 | ノボザイムス バイオファーマ デーコー アクティーゼルスカブ | アルブミン変異体 |
WO2011051466A1 (en) * | 2009-11-02 | 2011-05-05 | Novartis Ag | Anti-idiotypic fibronectin-based binding molecules and uses thereof |
WO2011103076A1 (en) | 2010-02-16 | 2011-08-25 | Medlmmune, Llc | Hsa-related compositions and methods of use |
AU2011240624B2 (en) | 2010-04-13 | 2017-02-23 | Medimmune, Llc | TRAIL R2-specific multimeric scaffolds |
KR20140008305A (ko) | 2010-11-05 | 2014-01-21 | 노파르티스 아게 | Il-17 길항제를 사용한 류마티스성 관절염의 치료 방법 |
JP2014177354A (ja) | 2011-07-05 | 2014-09-25 | Asahi Glass Co Ltd | 窓ガラス |
CN108948196B (zh) * | 2011-10-11 | 2022-09-23 | 维埃拉生物股份有限公司 | Cd40l-特异性tn3-衍生的支架及其使用方法 |
MX2015005363A (es) | 2012-11-08 | 2015-11-06 | Novozymes Biopharma Dk As | Variantes de albumina. |
EP3145541A1 (en) | 2014-05-19 | 2017-03-29 | Medimmune Limited | Treatment for rheumatoid arthritis |
US10683340B2 (en) | 2015-03-12 | 2020-06-16 | Medimmune, Llc | Method of purifying albumin-fusion proteins |
CN113474364A (zh) | 2018-09-26 | 2021-10-01 | 维埃拉生物股份有限公司 | Cd40l拮抗剂及其用途 |
-
2012
- 2012-10-10 CN CN201810653215.1A patent/CN108948196B/zh active Active
- 2012-10-10 SG SG10201707813YA patent/SG10201707813YA/en unknown
- 2012-10-10 BR BR112014008804A patent/BR112014008804A2/pt not_active Application Discontinuation
- 2012-10-10 HU HUE12840074A patent/HUE051439T2/hu unknown
- 2012-10-10 KR KR1020207019515A patent/KR102434073B1/ko active IP Right Grant
- 2012-10-10 RU RU2014117511A patent/RU2704992C2/ru active
- 2012-10-10 JP JP2014535807A patent/JP6140712B2/ja active Active
- 2012-10-10 SG SG11201400567QA patent/SG11201400567QA/en unknown
- 2012-10-10 CN CN201280049742.2A patent/CN103874501B/zh active Active
- 2012-10-10 KR KR1020227028109A patent/KR20220116585A/ko not_active IP Right Cessation
- 2012-10-10 EP EP20177799.2A patent/EP3753567A1/en active Pending
- 2012-10-10 US US14/347,016 patent/US10000553B2/en active Active
- 2012-10-10 PT PT128400744T patent/PT2771022T/pt unknown
- 2012-10-10 SI SI201231843T patent/SI2771022T1/sl unknown
- 2012-10-10 RU RU2019133467A patent/RU2019133467A/ru unknown
- 2012-10-10 AU AU2012323316A patent/AU2012323316B2/en active Active
- 2012-10-10 ES ES12840074T patent/ES2819075T3/es active Active
- 2012-10-10 MX MX2014004065A patent/MX367013B/es active IP Right Grant
- 2012-10-10 CA CA2851667A patent/CA2851667A1/en active Pending
- 2012-10-10 DK DK12840074.4T patent/DK2771022T3/da active
- 2012-10-10 RS RS20201146A patent/RS60828B1/sr unknown
- 2012-10-10 LT LTEP12840074.4T patent/LT2771022T/lt unknown
- 2012-10-10 EP EP12840074.4A patent/EP2771022B1/en active Active
- 2012-10-10 KR KR1020147012468A patent/KR102132997B1/ko active IP Right Grant
- 2012-10-10 CN CN202211152182.5A patent/CN116063509A/zh active Pending
- 2012-10-10 WO PCT/US2012/059477 patent/WO2013055745A2/en active Application Filing
-
2014
- 2014-04-03 MX MX2019009104A patent/MX2019009104A/es unknown
-
2015
- 2015-03-02 HK HK15102049.0A patent/HK1201463A1/xx unknown
-
2017
- 2017-05-01 JP JP2017090963A patent/JP6539300B2/ja active Active
-
2018
- 2018-05-31 US US15/993,964 patent/US11104720B2/en active Active
-
2019
- 2019-06-07 JP JP2019106642A patent/JP7068231B2/ja active Active
-
2020
- 2020-09-22 HR HRP20201513TT patent/HRP20201513T1/hr unknown
- 2020-10-02 CY CY20201100927T patent/CY1123690T1/el unknown
-
2021
- 2021-07-28 US US17/387,269 patent/US11555062B2/en active Active
-
2022
- 2022-04-28 JP JP2022073975A patent/JP2022115916A/ja active Pending
- 2022-11-01 US US18/051,704 patent/US20230242619A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HRP20201513T1 (hr) | Cd40l-specifični tn3-izvedeni skeleti i postupci njihove uporabe | |
JP2015501147A5 (hr) | ||
CA2330170A1 (en) | Process for producing immunoglobulins for intravenous administration and other immunoglobulin products | |
CN102970975A (zh) | 从血浆制备富含IgG的组合物的方法 | |
HRP20210777T1 (hr) | Pripravci protiv cgrp-a njihova upotreba | |
HRP20170757T1 (hr) | Terapeutski pripravci nukleaze i postupci | |
ES2335211T3 (es) | Separacion de polipeptidos comprendiendo un aminoacido racemizado. | |
WO2019084064A4 (en) | Compositions and methods for the depletion of cd117+ cells | |
ES2928954T3 (es) | Precipitación de la fracción I-IV-1 de inmunoglobulinas a partir de plasma | |
JP2017510575A5 (hr) | ||
JP2018509413A5 (hr) | ||
SI2705058T1 (en) | The amino acid sequences directed against IL-17A, IL-17F and / or IL-17A / F, and polypeptides comprising these sequences | |
HRP20151259T1 (hr) | Humanizirana protutijela anti-faktora-d i njihove uporabe | |
FI3250610T3 (fi) | Fcrn-vasta-aineita ja menetelmiä niiden käyttämiseksi | |
US20140056897A1 (en) | Bispecific three-chain antibody-like molecules | |
US20200347093A1 (en) | Improved method for purification of immunoglobulin | |
US20140141021A1 (en) | Method for preparing a concentrate of polyvalent immunoglobulin | |
WO2015061526A1 (en) | Antibody purification | |
CA3096374A1 (en) | Methods for making stable protein compositions | |
US11591388B2 (en) | Pharmaceutical formulations of FcRn inhibitors suitable for subcutaneous administration | |
JP2021075580A5 (hr) | ||
AU2021303496A1 (en) | Method for obtaining a composition comprising human plasma-derived immunoglobulin M | |
NZ746741A (en) | Icos ligand variant immunomodulatory proteins and uses thereof | |
US20220306731A1 (en) | Metallothionein antibodies and their use | |
JP2022060182A5 (hr) |