MX2019009104A - Matrices de soporte derivadas de tn3 especificas para cd40l y sus metodos de empleo. - Google Patents

Matrices de soporte derivadas de tn3 especificas para cd40l y sus metodos de empleo.

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Publication number
MX2019009104A
MX2019009104A MX2019009104A MX2019009104A MX2019009104A MX 2019009104 A MX2019009104 A MX 2019009104A MX 2019009104 A MX2019009104 A MX 2019009104A MX 2019009104 A MX2019009104 A MX 2019009104A MX 2019009104 A MX2019009104 A MX 2019009104A
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MX
Mexico
Prior art keywords
cd40l
methods
specific
scaffolds
derived scaffolds
Prior art date
Application number
MX2019009104A
Other languages
English (en)
Inventor
Coyle Anthony
Baca Manuel
Thisted Thomas
Drabic Stacey
Grinberg Luba
Novarra Shabazz
Oganesyan Vaheh
Kenneth Spencer David
Herbst Ronald
Original Assignee
Medimmune Llc
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Publication of MX2019009104A publication Critical patent/MX2019009104A/es

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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
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    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

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Abstract

La presente invención proporciona matrices de soporte basadas en el dominio FnIII de la tenascina 3 que se unen específicamente a CD40L. La invención proporciona además variantes modificadas con una mayor afinidad por la diana. La presente invención también se refiere a matrices de soporte diseñadas como agentes profilácticos, terapéuticos o de diagnóstico, en particular para usos terapéuticos contra el LES y otras enfermedades y afecciones autoinmunes.
MX2019009104A 2011-10-11 2014-04-03 Matrices de soporte derivadas de tn3 especificas para cd40l y sus metodos de empleo. MX2019009104A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161546028P 2011-10-11 2011-10-11

Publications (1)

Publication Number Publication Date
MX2019009104A true MX2019009104A (es) 2019-09-10

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ID=48082729

Family Applications (2)

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MX2014004065A MX367013B (es) 2011-10-11 2012-10-10 Matrices de soporte derivadas de tn3 especificas para cd40l y sus metodos de empleo.
MX2019009104A MX2019009104A (es) 2011-10-11 2014-04-03 Matrices de soporte derivadas de tn3 especificas para cd40l y sus metodos de empleo.

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Country Status (22)

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US (4) US10000553B2 (es)
EP (2) EP2771022B1 (es)
JP (4) JP6140712B2 (es)
KR (3) KR102434073B1 (es)
CN (3) CN103874501B (es)
AU (1) AU2012323316B2 (es)
BR (1) BR112014008804A2 (es)
CA (1) CA2851667A1 (es)
CY (1) CY1123690T1 (es)
DK (1) DK2771022T3 (es)
ES (1) ES2819075T3 (es)
HK (1) HK1201463A1 (es)
HR (1) HRP20201513T1 (es)
HU (1) HUE051439T2 (es)
LT (1) LT2771022T (es)
MX (2) MX367013B (es)
PT (1) PT2771022T (es)
RS (1) RS60828B1 (es)
RU (2) RU2019133467A (es)
SG (2) SG10201707813YA (es)
SI (1) SI2771022T1 (es)
WO (1) WO2013055745A2 (es)

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CN107921128B (zh) 2015-08-05 2022-04-26 詹森生物科技公司 抗cd154抗体及其使用方法
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WO2020086885A2 (en) * 2018-10-24 2020-04-30 Brandeis University Multivalent glycopeptides that tightly bind to carbohydrate-binding monoclonal antibody family pgt128
JP2022516505A (ja) 2018-12-28 2022-02-28 スパークス・セラピューティクス・インコーポレイテッド 癌および他の疾患の治療のための、クローディン１８．２に特異的な結合分子、その組成物および方法
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