SG11201400567QA - Cd40l-specific tn3-derived scaffolds and methods of use thereof - Google Patents
Cd40l-specific tn3-derived scaffolds and methods of use thereofInfo
- Publication number
- SG11201400567QA SG11201400567QA SG11201400567QA SG11201400567QA SG11201400567QA SG 11201400567Q A SG11201400567Q A SG 11201400567QA SG 11201400567Q A SG11201400567Q A SG 11201400567QA SG 11201400567Q A SG11201400567Q A SG 11201400567QA SG 11201400567Q A SG11201400567Q A SG 11201400567QA
- Authority
- SG
- Singapore
- Prior art keywords
- cd40l
- methods
- specific
- derived scaffolds
- scaffolds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2318/00—Antibody mimetics or scaffolds
- C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161546028P | 2011-10-11 | 2011-10-11 | |
PCT/US2012/059477 WO2013055745A2 (en) | 2011-10-11 | 2012-10-10 | Cd40l-specific tn3-derived scaffolds and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201400567QA true SG11201400567QA (en) | 2014-05-29 |
Family
ID=48082729
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201707813YA SG10201707813YA (en) | 2011-10-11 | 2012-10-10 | Cd40l-specific tn3-derived scaffolds and methods of use thereof |
SG11201400567QA SG11201400567QA (en) | 2011-10-11 | 2012-10-10 | Cd40l-specific tn3-derived scaffolds and methods of use thereof |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201707813YA SG10201707813YA (en) | 2011-10-11 | 2012-10-10 | Cd40l-specific tn3-derived scaffolds and methods of use thereof |
Country Status (22)
Country | Link |
---|---|
US (4) | US10000553B2 (en) |
EP (2) | EP2771022B1 (en) |
JP (4) | JP6140712B2 (en) |
KR (3) | KR20220116585A (en) |
CN (3) | CN108948196B (en) |
AU (1) | AU2012323316B2 (en) |
BR (1) | BR112014008804A2 (en) |
CA (1) | CA2851667A1 (en) |
CY (1) | CY1123690T1 (en) |
DK (1) | DK2771022T3 (en) |
ES (1) | ES2819075T3 (en) |
HK (1) | HK1201463A1 (en) |
HR (1) | HRP20201513T1 (en) |
HU (1) | HUE051439T2 (en) |
LT (1) | LT2771022T (en) |
MX (2) | MX367013B (en) |
PT (1) | PT2771022T (en) |
RS (1) | RS60828B1 (en) |
RU (2) | RU2019133467A (en) |
SG (2) | SG10201707813YA (en) |
SI (1) | SI2771022T1 (en) |
WO (1) | WO2013055745A2 (en) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUE047164T2 (en) * | 2007-11-01 | 2020-04-28 | Univ Arkansas | Compositions and methods of enhancing immune responses to eimeria |
HUE051439T2 (en) * | 2011-10-11 | 2021-03-01 | Viela Bio Inc | Cd40l-specific tn3-derived scaffolds and methods of use thereof |
MA41044A (en) | 2014-10-08 | 2017-08-15 | Novartis Ag | COMPOSITIONS AND METHODS OF USE FOR INCREASED IMMUNE RESPONSE AND CANCER TREATMENT |
US9938356B2 (en) | 2014-11-10 | 2018-04-10 | Medimmune Limited | Binding molecules specific for CD73 and uses thereof |
BR112017019401A2 (en) | 2015-03-12 | 2018-05-02 | Medimmune, Llc | albumin fusion protein purification method |
KR101810778B1 (en) * | 2015-06-23 | 2017-12-20 | 서울대학교산학협력단 | CD154 binding polypeptide and its use |
MY188405A (en) | 2015-08-05 | 2021-12-08 | Janssen Biotech Inc | Anti-cd154 antibodies and methods of using them |
US11958913B2 (en) * | 2017-01-09 | 2024-04-16 | Biomunex Pharmaceuticals | Polypeptide linker for preparing multispecific antibodies |
US11905313B2 (en) * | 2017-11-28 | 2024-02-20 | The United States of America, as represented by the Secretary, Department of Health and Human Services. | Recombinant RSV G proteins and their use |
AU2019347730A1 (en) * | 2018-09-24 | 2021-03-25 | Janssen Biotech, Inc. | Method of providing safe administration of an anti-CD154 antibody |
CA3114394A1 (en) * | 2018-09-26 | 2020-04-02 | Viela Bio, Inc. | Cd40l antagonist and uses thereof |
US20220090055A1 (en) * | 2018-10-24 | 2022-03-24 | Brandeis University | Multivalent glycopeptides that tightly bind to carbohydrate-binding monoclonal antibody family pgt128 |
EP3902824A4 (en) | 2018-12-28 | 2023-01-04 | Sparx Therapeutics Inc. | Binding molecules specific for claudin 18.2, compositons and methods thereof, for treatment of cancer and other diseases |
CN111440253B (en) * | 2019-01-17 | 2021-08-27 | 中国科学院上海药物研究所 | Cubic cyclodextrin framework-RGD composition and preparation method thereof |
IL308488A (en) * | 2021-05-21 | 2024-01-01 | Viela Bio Inc | Cd40l antagonist and uses thereof in the treatment of lupus nephritis |
Family Cites Families (72)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4666884A (en) | 1984-04-10 | 1987-05-19 | New England Deaconess Hospital | Method of inhibiting binding of von Willebrand factor to human platelets and inducing interaction of platelets with vessel walls |
WO1988007089A1 (en) | 1987-03-18 | 1988-09-22 | Medical Research Council | Altered antibodies |
US5314995A (en) | 1990-01-22 | 1994-05-24 | Oncogen | Therapeutic interleukin-2-antibody based fusion proteins |
AU654811B2 (en) | 1990-03-20 | 1994-11-24 | Trustees Of Columbia University In The City Of New York, The | Chimeric antibodies with receptor binding ligands in place of their constant region |
DE69112207T2 (en) | 1990-04-05 | 1996-03-28 | Roberto Crea | "WALK-THROUGH" MUTAGENESIS. |
US7063943B1 (en) | 1990-07-10 | 2006-06-20 | Cambridge Antibody Technology | Methods for producing members of specific binding pairs |
US5843701A (en) | 1990-08-02 | 1998-12-01 | Nexstar Pharmaceticals, Inc. | Systematic polypeptide evolution by reverse translation |
US5866344A (en) | 1991-11-15 | 1999-02-02 | Board Of Regents, The University Of Texas System | Antibody selection methods using cell surface expressed libraries |
FR2686899B1 (en) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | NOVEL BIOLOGICALLY ACTIVE POLYPEPTIDES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
ZA932522B (en) | 1992-04-10 | 1993-12-20 | Res Dev Foundation | Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens |
US5440018A (en) | 1992-05-20 | 1995-08-08 | The Green Cross Corporation | Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same |
JPH08501085A (en) | 1992-08-26 | 1996-02-06 | プレジデント アンド フェローズ オブ ハーバード カレッジ | Use of cytokine IP-10 as an antitumor agent |
US5922545A (en) | 1993-10-29 | 1999-07-13 | Affymax Technologies N.V. | In vitro peptide and antibody display libraries |
US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
WO1996008513A1 (en) | 1994-09-16 | 1996-03-21 | The Scripps Research Institute | Cytotactin derivatives that stimulate attachment and neurite outgrowth, and methods of making and using same |
US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
US6096871A (en) | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
US5747035A (en) | 1995-04-14 | 1998-05-05 | Genentech, Inc. | Polypeptides with increased half-life for use in treating disorders involving the LFA-1 receptor |
WO1997043316A1 (en) | 1996-05-10 | 1997-11-20 | Beth Israel Deaconess Medical Center, Inc. | Physiologically active molecules with extended half-lives and methods of using same |
US6699658B1 (en) | 1996-05-31 | 2004-03-02 | Board Of Trustees Of The University Of Illinois | Yeast cell surface display of proteins and uses thereof |
EP0985039B1 (en) | 1997-06-12 | 2008-02-20 | Novartis International Pharmaceutical Ltd. | Artificial antibody polypeptides |
BR9908226A (en) | 1998-02-25 | 2000-10-24 | Lexigen Pharm Corp | Improvement of the circulating half-life of fusion proteins based on antibody |
AU731758B2 (en) | 1998-07-08 | 2001-04-05 | Mitsui Chemicals, Inc. | Method for secretory production of human growth hormone |
CA2341029A1 (en) | 1998-08-17 | 2000-02-24 | Abgenix, Inc. | Generation of modified molecules with increased serum half-lives |
AU775997B2 (en) | 1998-12-02 | 2004-08-19 | Bristol-Myers Squibb Company | DNA-protein fusions and uses thereof |
US7115396B2 (en) | 1998-12-10 | 2006-10-03 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
EP2154535A1 (en) | 1998-12-10 | 2010-02-17 | Bristol-Myers Squibb Company | Protein scaffolds for antibody mimics and other binding proteins |
US6818418B1 (en) | 1998-12-10 | 2004-11-16 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
DK1196637T3 (en) | 1999-07-27 | 2007-07-30 | Adnexus Therapeutics Inc | Peptide ligation methods |
US7022479B2 (en) | 2000-01-24 | 2006-04-04 | Compound Therapeutics, Inc. | Sensitive, multiplexed diagnostic assays for protein analysis |
ES2564161T3 (en) | 2000-07-11 | 2016-03-18 | Research Corporation Technologies, Inc | Artificial antibody polypeptides |
JP2004526419A (en) | 2000-10-16 | 2004-09-02 | フィロス インク. | Protein scaffolds for antibody mimics and other binding proteins |
ES2649037T3 (en) | 2000-12-12 | 2018-01-09 | Medimmune, Llc | Molecules with prolonged half-lives, compositions and uses thereof |
US6951725B2 (en) | 2001-06-21 | 2005-10-04 | Compound Therapeutics, Inc. | In vitro protein interaction detection systems |
KR101271635B1 (en) * | 2001-12-21 | 2013-06-12 | 휴먼 게놈 사이언시즈, 인코포레이티드 | Albumin fusion proteins |
EP2339017A3 (en) | 2002-03-29 | 2011-10-12 | Genencor International, Inc. | Enhanced protein expression in bacillus |
WO2003104418A2 (en) | 2002-06-06 | 2003-12-18 | Research Corporation Technologies, Inc. | Reconstituted polypeptides |
CA2489348A1 (en) | 2002-06-24 | 2003-12-31 | Genentech, Inc. | Apo-2 ligand/trail variants and uses thereof |
KR100524872B1 (en) | 2003-12-04 | 2005-11-01 | 씨제이 주식회사 | Processes for the purification of interferon beta |
AU2004296376B2 (en) | 2003-12-05 | 2010-03-04 | Bristol-Myers Squibb Company | Inhibitors of type 2 vascular endothelial growth factor receptors |
US9012369B2 (en) | 2004-07-06 | 2015-04-21 | Pfizer Inc. | Look-through mutagenesis for developing altered polypeptides with enhanced properties |
KR100852415B1 (en) | 2004-07-13 | 2008-08-18 | 재단법인서울대학교산학협력재단 | - Polypeptide and derivatives thereof containing novel heparin-binding site derived from human tenacin C |
GB0416651D0 (en) | 2004-07-26 | 2004-08-25 | Proteo Target Aps | Polypeptide |
BRPI0610470A2 (en) * | 2005-05-26 | 2010-06-22 | Seattle Genetics Inc | isolated antibody or antigen-binding fragment that specifically binds human cd40, kit, pharmaceutical composition, and isolated polynucleotide |
JP4959226B2 (en) | 2006-05-19 | 2012-06-20 | 独立行政法人産業技術総合研究所 | Three finger-like protein library |
WO2008031098A1 (en) | 2006-09-09 | 2008-03-13 | The University Of Chicago | Binary amino acid libraries for fibronectin type iii polypeptide monobodies |
BRPI0719597A2 (en) | 2006-11-22 | 2013-12-17 | Adnexus A Bristol Myers Squibb R & D Company | OBJECTIVE THERAPEUTIC PRODUCTS BASED ON HANDLED PROTEINS FOR TYROSINE KINASE RECEPTORS, INCLUDING IGF-IR |
CN104825433A (en) | 2007-07-03 | 2015-08-12 | 达努塔·克鲁谢夫斯卡 | New medical use of alfa-ketoglutarate |
US8470966B2 (en) | 2007-08-10 | 2013-06-25 | Protelica, Inc. | Universal fibronectin type III binding-domain libraries |
AU2008287426B2 (en) | 2007-08-10 | 2014-06-26 | Protelica, Inc. | Universal fibronectin type III binding-domain libraries |
CA2704229C (en) | 2007-10-31 | 2019-05-07 | Medimmune, Llc | Protein scaffolds comprising seven beta strand domains and six loop regions |
US20100322930A1 (en) | 2007-12-27 | 2010-12-23 | Frank Kolbinger | Fibronectin-based binding molecules and their use |
WO2009133208A1 (en) | 2008-05-02 | 2009-11-05 | Novartis Ag | Improved fibronectin-based binding molecules and uses thereof |
JP2011520961A (en) | 2008-05-22 | 2011-07-21 | ブリストル−マイヤーズ スクイブ カンパニー | Scaffold domain protein based on multivalent fibronectin |
EP2352521B1 (en) * | 2008-10-14 | 2020-09-16 | Genentech, Inc. | Immunoglobulin variants and uses thereof |
PL2356269T3 (en) | 2008-10-31 | 2016-12-30 | Fibronectin type iii domain based scaffold compositions, methods and uses | |
TWI496582B (en) | 2008-11-24 | 2015-08-21 | 必治妥美雅史谷比公司 | Bispecific egfr/igfir binding molecules |
CN102596992B (en) | 2009-02-12 | 2015-09-09 | 詹森生物科技公司 | Based on the holder combination thing of III type fibronectin domain, method and purposes |
WO2010128142A1 (en) | 2009-05-07 | 2010-11-11 | Novozymes Biopharma Dk A/S | Method for purifying albumin |
EP2464663A4 (en) | 2009-08-13 | 2013-05-29 | Massachusetts Inst Technology | Engineered proteins including mutant fibronectin domains |
CN102741280B (en) | 2009-10-30 | 2015-12-02 | 诺维信生物制药丹麦公司 | Albumin variants |
WO2011051466A1 (en) * | 2009-11-02 | 2011-05-05 | Novartis Ag | Anti-idiotypic fibronectin-based binding molecules and uses thereof |
ES2678144T3 (en) | 2010-02-16 | 2018-08-09 | Medimmune, Llc | Compositions related to SAH and methods of use |
WO2011130324A1 (en) * | 2010-04-13 | 2011-10-20 | Medimmune, Llc | Fibronectin type iii domain-based multimeric scaffolds |
KR20180129991A (en) | 2010-11-05 | 2018-12-05 | 노파르티스 아게 | Methods of treating rheumatoid arthritis using il-17 antagonists |
JP2014177354A (en) | 2011-07-05 | 2014-09-25 | Asahi Glass Co Ltd | Window glass |
HUE051439T2 (en) * | 2011-10-11 | 2021-03-01 | Viela Bio Inc | Cd40l-specific tn3-derived scaffolds and methods of use thereof |
GB2512156A (en) | 2012-11-08 | 2014-09-24 | Novozymes Biopharma Dk As | Albumin variants |
JP2017515828A (en) | 2014-05-19 | 2017-06-15 | メディミューン リミテッド | Treatment for rheumatoid arthritis |
BR112017019401A2 (en) | 2015-03-12 | 2018-05-02 | Medimmune, Llc | albumin fusion protein purification method |
CA3114394A1 (en) | 2018-09-26 | 2020-04-02 | Viela Bio, Inc. | Cd40l antagonist and uses thereof |
-
2012
- 2012-10-10 HU HUE12840074A patent/HUE051439T2/en unknown
- 2012-10-10 MX MX2014004065A patent/MX367013B/en active IP Right Grant
- 2012-10-10 KR KR1020227028109A patent/KR20220116585A/en not_active IP Right Cessation
- 2012-10-10 EP EP12840074.4A patent/EP2771022B1/en active Active
- 2012-10-10 CN CN201810653215.1A patent/CN108948196B/en active Active
- 2012-10-10 DK DK12840074.4T patent/DK2771022T3/en active
- 2012-10-10 SG SG10201707813YA patent/SG10201707813YA/en unknown
- 2012-10-10 JP JP2014535807A patent/JP6140712B2/en active Active
- 2012-10-10 RS RS20201146A patent/RS60828B1/en unknown
- 2012-10-10 RU RU2019133467A patent/RU2019133467A/en unknown
- 2012-10-10 CA CA2851667A patent/CA2851667A1/en active Pending
- 2012-10-10 AU AU2012323316A patent/AU2012323316B2/en active Active
- 2012-10-10 LT LTEP12840074.4T patent/LT2771022T/en unknown
- 2012-10-10 PT PT128400744T patent/PT2771022T/en unknown
- 2012-10-10 KR KR1020147012468A patent/KR102132997B1/en active IP Right Grant
- 2012-10-10 WO PCT/US2012/059477 patent/WO2013055745A2/en active Application Filing
- 2012-10-10 EP EP20177799.2A patent/EP3753567A1/en active Pending
- 2012-10-10 BR BR112014008804A patent/BR112014008804A2/en not_active Application Discontinuation
- 2012-10-10 RU RU2014117511A patent/RU2704992C2/en active
- 2012-10-10 CN CN201280049742.2A patent/CN103874501B/en active Active
- 2012-10-10 SG SG11201400567QA patent/SG11201400567QA/en unknown
- 2012-10-10 ES ES12840074T patent/ES2819075T3/en active Active
- 2012-10-10 KR KR1020207019515A patent/KR102434073B1/en active IP Right Grant
- 2012-10-10 CN CN202211152182.5A patent/CN116063509A/en active Pending
- 2012-10-10 SI SI201231843T patent/SI2771022T1/en unknown
- 2012-10-10 US US14/347,016 patent/US10000553B2/en active Active
-
2014
- 2014-04-03 MX MX2019009104A patent/MX2019009104A/en unknown
-
2015
- 2015-03-02 HK HK15102049.0A patent/HK1201463A1/en unknown
-
2017
- 2017-05-01 JP JP2017090963A patent/JP6539300B2/en active Active
-
2018
- 2018-05-31 US US15/993,964 patent/US11104720B2/en active Active
-
2019
- 2019-06-07 JP JP2019106642A patent/JP7068231B2/en active Active
-
2020
- 2020-09-22 HR HRP20201513TT patent/HRP20201513T1/en unknown
- 2020-10-02 CY CY20201100927T patent/CY1123690T1/en unknown
-
2021
- 2021-07-28 US US17/387,269 patent/US11555062B2/en active Active
-
2022
- 2022-04-28 JP JP2022073975A patent/JP2022115916A/en active Pending
- 2022-11-01 US US18/051,704 patent/US20230242619A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HRP20181628T1 (en) | Compounds and their methods of use | |
HK1201463A1 (en) | Cd40l-specific tn3-derived scaffolds and methods of use thereof cd40l- tn3- | |
HK1208439A1 (en) | 5-azaindazole compounds and methods of use 5- | |
EP2912178A4 (en) | Super-enhancers and methods of use thereof | |
IL227440B (en) | Ballstent device and methods of use | |
EP2672820A4 (en) | Mannoside compounds and methods of use thereof | |
EP2675471A4 (en) | Hsa-related compositions and methods of use | |
ZA201401653B (en) | Pyrazol-4yl-heterocyclyl-carboxamide compounds and methods of use | |
ZA201303793B (en) | Substituted quinoline compounds and methods of use | |
EP2721063A4 (en) | Pcsk9-binding polypeptides and methods of use | |
EP2670866A4 (en) | Biomarkers and methods of use thereof | |
HK1254533A1 (en) | Bioprobes and methods of use thereof | |
EP2766078A4 (en) | Ventilation devices and methods of use | |
EP2852397A4 (en) | Huwentoxin-iv variants and methods of use | |
EP2709999A4 (en) | Quinazoline-7-ether compounds and methods of use | |
EP2670245A4 (en) | Alpha-ketoheterocycles and methods of making and using | |
IL215720A0 (en) | Dehumidifier and method of use thereof | |
ZA201405829B (en) | Cleaning arrangement and method of use | |
GB2493595B (en) | Wheelchair and method of construction | |
GB201102364D0 (en) | Lock means and method of use thereof | |
GB201122402D0 (en) | Lock means and method of use thereof | |
GB201101586D0 (en) | Lock means and method of use thereof | |
GB201014490D0 (en) | Cleaning means and method of use thereof |