ATE299868T1 - Dihydro-benzo (b) (1,4) diazepin-2-on-derivate als mglur2 antagonisten - Google Patents

Dihydro-benzo (b) (1,4) diazepin-2-on-derivate als mglur2 antagonisten

Info

Publication number
ATE299868T1
ATE299868T1 AT02737911T AT02737911T ATE299868T1 AT E299868 T1 ATE299868 T1 AT E299868T1 AT 02737911 T AT02737911 T AT 02737911T AT 02737911 T AT02737911 T AT 02737911T AT E299868 T1 ATE299868 T1 AT E299868T1
Authority
AT
Austria
Prior art keywords
diazepine
benzo
dihydro
derivatives
mglur2 antagonists
Prior art date
Application number
AT02737911T
Other languages
English (en)
Inventor
Geo Adam
Erwin Goetschi
Vincent Mutel
Juergen Wichmann
Thomas Johannes Woltering
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE299868T1 publication Critical patent/ATE299868T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
AT02737911T 2001-04-12 2002-04-02 Dihydro-benzo (b) (1,4) diazepin-2-on-derivate als mglur2 antagonisten ATE299868T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01109125 2001-04-12
PCT/EP2002/003644 WO2002083652A1 (en) 2001-04-12 2002-04-02 DIHYDRO-BENZO [b] [1, 4] DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II

Publications (1)

Publication Number Publication Date
ATE299868T1 true ATE299868T1 (de) 2005-08-15

Family

ID=8177126

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02737911T ATE299868T1 (de) 2001-04-12 2002-04-02 Dihydro-benzo (b) (1,4) diazepin-2-on-derivate als mglur2 antagonisten

Country Status (38)

Country Link
US (1) US6544985B2 (de)
EP (1) EP1379511B1 (de)
JP (1) JP4071115B2 (de)
KR (1) KR100566171B1 (de)
CN (1) CN1264825C (de)
AR (1) AR035816A1 (de)
AT (1) ATE299868T1 (de)
AU (1) AU2002312788B2 (de)
BG (1) BG108254A (de)
BR (1) BR0208891A (de)
CA (1) CA2442557C (de)
CZ (1) CZ20033003A3 (de)
DE (1) DE60205100T2 (de)
DK (1) DK1379511T3 (de)
EC (1) ECSP034797A (de)
ES (1) ES2246012T3 (de)
GT (1) GT200200073A (de)
HK (1) HK1068888A1 (de)
HR (1) HRP20030792A2 (de)
HU (1) HUP0400851A3 (de)
IL (2) IL157873A0 (de)
JO (1) JO2285B1 (de)
MA (1) MA27012A1 (de)
MX (1) MXPA03009311A (de)
MY (1) MY140271A (de)
NO (1) NO20034576L (de)
NZ (1) NZ528315A (de)
PA (1) PA8543301A1 (de)
PE (1) PE20021041A1 (de)
PL (1) PL367064A1 (de)
PT (1) PT1379511E (de)
RU (1) RU2263112C2 (de)
SI (1) SI1379511T1 (de)
SK (1) SK13682003A3 (de)
UY (1) UY27258A1 (de)
WO (1) WO2002083652A1 (de)
YU (1) YU79003A (de)
ZA (1) ZA200307243B (de)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ20021663A3 (cs) * 1999-10-15 2002-09-11 F. Hoffmann-La Roche Ag Nové deriváty benzodiazepinu
AU2002359923B2 (en) * 2001-12-27 2007-12-20 Taisho Pharmaceutical Co., Ltd. 6-fluorobicyclo[3.1.0]hexane derivatives
KR100865410B1 (ko) 2002-03-28 2008-10-24 위시스 테크놀로지 파운데이션, 인크. 진정 및 운동실조 효과가 감소된 항불안제
EP1925614A1 (de) * 2002-03-28 2008-05-28 Wisys Technology Foundation, Inc. Anxiolytische Mittel mit reduzierter sedativer und ataxischer Wirkung
ATE374030T1 (de) * 2003-07-25 2007-10-15 Hoffmann La Roche Kombination eines mglur2 antagonists und eines ache inhibitors zur behandlung von akuten und/oder chronischen neurologischen krankheiten
US7329662B2 (en) 2003-10-03 2008-02-12 Hoffmann-La Roche Inc. Pyrazolo-pyridine
US20060160823A1 (en) * 2004-05-28 2006-07-20 Leonore Witchey-Lakshmanan Particulate-stabilized injectable pharmaceutical compositions of Posaconazole
JP4708438B2 (ja) * 2005-02-11 2011-06-22 エフ．ホフマン−ラ ロシュ アーゲー ｍＧｌｕＲ２アンタゴニストとしてのピラゾロピリミジン誘導体
RU2412943C2 (ru) 2005-03-23 2011-02-27 Ф. Хоффманн-Ля Рош Аг ПРОИЗВОДНЫЕ АЦЕТИЛЕНИЛ-ПИРАЗОЛО-ПИРИМИДИНА В КАЧЕСТВЕ АНТАГОНИСТОВ mGluR2
JP5237798B2 (ja) * 2005-06-23 2013-07-17 アレイ バイオファーマ、インコーポレイテッド ベンズイミダゾール化合物の調製方法
ATE463495T1 (de) 2005-09-27 2010-04-15 Hoffmann La Roche Oxadiazolylpyrazolopyrimidine als mglur2- antagonisten
GB0600228D0 (en) * 2006-01-06 2006-02-15 Fermentas Uab Inactivation method
AR059898A1 (es) 2006-03-15 2008-05-07 Janssen Pharmaceutica Nv Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
TW200808751A (en) * 2006-04-13 2008-02-16 Astrazeneca Ab New compounds
BRPI0717587A2 (pt) 2006-09-20 2013-10-29 Hoffmann La Roche Derivados de 4-oxo-2,3,4,5-tetra-hidro-benzo[b][1,4]diazepina
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
CN101657432B (zh) 2007-04-19 2013-04-10 弗·哈夫曼-拉罗切有限公司 二氢-苯并[b][1,4]二氮杂*-2-酮磺酰胺衍生物
TW200927731A (en) * 2007-09-14 2009-07-01 Ortho Mcneil Janssen Pharm 1,3-disubstituted-4-phenyl-1H-pyridin-2-ones
CN101801951B (zh) 2007-09-14 2013-11-13 杨森制药有限公司 1’,3’-二取代的-4-苯基-3,4,5,6-四氢-2h,1’h-[1,4’]二吡啶-2’-酮
KR20100065191A (ko) 2007-09-14 2010-06-15 오르토-맥닐-얀센 파마슈티칼스 인코포레이티드 １,３-이치환된 ４-(아릴-ｘ-페닐)-１ｈ-피리딘-２-온
ES2637794T3 (es) 2007-11-14 2017-10-17 Janssen Pharmaceuticals, Inc. Derivados de imidazo[1,2-A]piridina y su uso como moduladores alostéricos positivos de receptores MGLUR2
RU2510396C2 (ru) 2008-09-02 2014-03-27 Янссен Фармасьютикалз, Инк. 3-азабицикло[3.1.0]гексильные производные в качестве модуляторов метаботропных глутаматных рецепторов
BRPI0920354A2 (pt) 2008-10-16 2017-06-27 Addex Pharmaceuticals Sa derivados de indol e benzomorfolina como moduladores de receptores de glutamato metabotrópicos
AU2009319387B2 (en) 2008-11-28 2012-05-10 Addex Pharma S.A. Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
JP5707390B2 (ja) 2009-05-12 2015-04-30 ジャンセン ファーマシューティカルズ， インコーポレイテッド １，２，４−トリアゾロ［４，３−ａ］ピリジン誘導体およびｍＧｌｕＲ２受容体の正のアロステリック調節因子としてのその使用
RS53075B (en) 2009-05-12 2014-04-30 Janssen Pharmaceuticals Inc. 1,2,4-TRIAZOLO [4,3-A] PYRIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OR PREVENTION OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS
WO2012007500A2 (de) 2010-07-15 2012-01-19 Bayer Cropscience Ag Neue heterocyclische verbindungen als schädlingsbekämpfungsmittel
WO2012059431A1 (en) 2010-11-01 2012-05-10 Abbott Gmbh & Co. Kg Benzenesulfonyl or sulfonamide compounds suitable for treating disorders that respond to the modulation of the serotonin 5-ht6 receptor
WO2012059432A1 (en) 2010-11-01 2012-05-10 Abbott Gmbh & Co. Kg N-phenyl-(homo)piperazinyl-benzenesulfonyl or benzenesulfonamide compounds suitable for treating disorders that respond to the modulation of the 5-ht6 receptor
EP2649069B1 (de) 2010-11-08 2015-08-26 Janssen Pharmaceuticals, Inc. 1,2,4-triazol[4,3-a]pyridinderivate und ihre verwendung als positive allosterische mglur2-rezeptormodulatoren
EP2643320B1 (de) 2010-11-08 2015-03-04 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridinderivate und ihre verwendung als positiv allosterische modulatoren des mglur2 receptors
EP2661435B1 (de) 2010-11-08 2015-08-19 Janssen Pharmaceuticals, Inc. 1,2,4-triazol[4,3-a]pyridinderivate und ihre verwendung als positive allosterische mglur2-rezeptormodulatoren
WO2012149540A1 (en) 2011-04-28 2012-11-01 The Broad Institute Inc Inhibitors of histone deacetylase
JP5790195B2 (ja) * 2011-06-22 2015-10-07 セントラル硝子株式会社 ピラゾール化合物の製造方法
CA2847247C (en) * 2011-08-29 2019-10-15 Sanford-Burnham Medical Research Institute Benzodiazepinones as modulators of metabotropic glutamate receptor functions and neurological uses thereof
EP2877444B1 (de) 2012-07-27 2020-09-02 The Broad Institute, Inc. Histondeacetylase-hemmer
JP2015534993A (ja) 2012-10-23 2015-12-07 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａ 自閉症性障害の処置のためのｍＧｌｕ２／３アンタゴニスト
WO2014100438A1 (en) 2012-12-20 2014-06-26 The Broad Institute, Inc. Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors
AU2013371146C1 (en) 2012-12-28 2019-01-17 Crystalgenomics, Inc. 2,3-dihydro-isoindole-1-on derivative as BTK kinase suppressant, and pharmaceutical composition including same
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
DK3431106T3 (da) 2014-01-21 2021-03-15 Janssen Pharmaceutica Nv Kombinationer omfattende positive allosteriske modulatorer eller orthosteriske agonister af metabotrop glutamaterg subtype 2-receptor og anvendelse af disse
ES2860298T3 (es) 2014-01-21 2021-10-04 Janssen Pharmaceutica Nv Combinaciones que comprenden moduladores alostéricos positivos del receptor glutamatérgico metabotrópico de subtipo 2 y su uso
SG11201607267SA (en) 2014-03-07 2016-09-29 Biocryst Pharm Inc Human plasma kallikrein inhibitors
EP3134089A2 (de) 2014-04-23 2017-03-01 F. Hoffmann-La Roche AG Mglu2/3-antagonisten zur behandlung von geistigen behinderungen
US9969726B2 (en) 2014-06-10 2018-05-15 Sanford-Burnham Medical Research Institute Metabotropic glutamate receptor negative allosteric modulators (NAMS) and uses thereof
CN108727345B (zh) * 2017-04-25 2023-06-27 广东东阳光药业有限公司 一种咪唑环中间体的制备方法
CN108586447B (zh) * 2018-01-19 2021-01-29 中国人民解放军第四军医大学 一种苯二氮杂卓化合物及其制备方法和应用
US20220235031A1 (en) * 2019-06-06 2022-07-28 Arcus Biosciences, Inc. Processes for preparing aminopyrimidine compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1210338A2 (de) * 1999-08-05 2002-06-05 IGT Pharma Inc. 1,4-diazepin-derivate zur behandlung von krankheiten des zentralen nervensystems
BR0014859A (pt) * 1999-10-15 2002-07-16 Hoffmann La Roche Derivados de benzodiazepina
CZ20021663A3 (cs) * 1999-10-15 2002-09-11 F. Hoffmann-La Roche Ag Nové deriváty benzodiazepinu

Also Published As

Publication number Publication date
NO20034576D0 (no) 2003-10-10
CN1535266A (zh) 2004-10-06
BG108254A (bg) 2004-09-30
NZ528315A (en) 2005-04-29
RU2263112C2 (ru) 2005-10-27
DK1379511T3 (da) 2005-11-07
ES2246012T3 (es) 2006-02-01
WO2002083652A1 (en) 2002-10-24
ECSP034797A (es) 2003-12-01
JO2285B1 (en) 2005-09-12
KR100566171B1 (ko) 2006-03-29
MXPA03009311A (es) 2004-02-12
US6544985B2 (en) 2003-04-08
NO20034576L (no) 2003-11-12
PA8543301A1 (es) 2003-01-24
JP2004529925A (ja) 2004-09-30
ZA200307243B (en) 2004-12-16
IL157873A (en) 2008-11-26
EP1379511A1 (de) 2004-01-14
DE60205100T2 (de) 2006-06-01
CA2442557A1 (en) 2002-10-24
HUP0400851A3 (en) 2010-03-29
SI1379511T1 (en) 2005-10-31
AU2002312788B2 (en) 2005-11-10
BR0208891A (pt) 2004-04-20
MA27012A1 (fr) 2004-12-20
PT1379511E (pt) 2005-10-31
UY27258A1 (es) 2002-10-31
US20020193367A1 (en) 2002-12-19
KR20030087076A (ko) 2003-11-12
HK1068888A1 (en) 2005-05-06
RU2003130637A (ru) 2005-04-10
AR035816A1 (es) 2004-07-14
EP1379511B1 (de) 2005-07-20
JP4071115B2 (ja) 2008-04-02
HUP0400851A2 (hu) 2004-07-28
IL157873A0 (en) 2004-03-28
CA2442557C (en) 2008-12-23
DE60205100D1 (de) 2005-08-25
YU79003A (sh) 2006-05-25
MY140271A (en) 2009-12-31
SK13682003A3 (sk) 2004-07-07
HRP20030792A2 (en) 2005-10-31
CN1264825C (zh) 2006-07-19
CZ20033003A3 (cs) 2004-05-12
PL367064A1 (en) 2005-02-21
GT200200073A (es) 2002-11-07
PE20021041A1 (es) 2002-11-19

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