HRP20040112B1 - Crystals including a malic acid salt of n-[2-(diethylamino)ethyl]-5-[(5-fluoro-2-oxo-3h-indole-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide, processes for its preparation and compositions thereof - Google Patents

Crystals including a malic acid salt of n-[2-(diethylamino)ethyl]-5-[(5-fluoro-2-oxo-3h-indole-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide, processes for its preparation and compositions thereof

Info

Publication number
HRP20040112B1
HRP20040112B1 HR20040112A HRP20040112A HRP20040112B1 HR P20040112 B1 HRP20040112 B1 HR P20040112B1 HR 20040112 A HR20040112 A HR 20040112A HR P20040112 A HRP20040112 A HR P20040112A HR P20040112 B1 HRP20040112 B1 HR P20040112B1
Authority
HR
Croatia
Prior art keywords
acid salt
ylidene
carboxamide
diethylamino
indole
Prior art date
Application number
HR20040112A
Other languages
English (en)
Croatian (hr)
Inventor
Hawley Michael
J. Fleck Thomas
P. Prescott Stephen
T. Maloney Mark
Original Assignee
Pharmacia & Upjohn Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23211067&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20040112(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharmacia & Upjohn Company filed Critical Pharmacia & Upjohn Company
Publication of HRP20040112A2 publication Critical patent/HRP20040112A2/hr
Publication of HRP20040112B1 publication Critical patent/HRP20040112B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
HR20040112A 2001-08-15 2004-02-02 Crystals including a malic acid salt of n-[2-(diethylamino)ethyl]-5-[(5-fluoro-2-oxo-3h-indole-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide, processes for its preparation and compositions thereof HRP20040112B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31235301P 2001-08-15 2001-08-15
PCT/US2002/025649 WO2003016305A1 (fr) 2001-08-15 2002-08-13 Cristaux comprenant un sel d'acide malique de n-[2-(diethylamino)ethyl]-5-[(5-fluoro-1,2-dihydro-2-oxo-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide, procedes de preparation associes et compositions correspondantes

Publications (2)

Publication Number Publication Date
HRP20040112A2 HRP20040112A2 (en) 2004-06-30
HRP20040112B1 true HRP20040112B1 (en) 2012-03-31

Family

ID=23211067

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20040112A HRP20040112B1 (en) 2001-08-15 2004-02-02 Crystals including a malic acid salt of n-[2-(diethylamino)ethyl]-5-[(5-fluoro-2-oxo-3h-indole-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide, processes for its preparation and compositions thereof

Country Status (43)

Country Link
US (2) US20030069298A1 (fr)
EP (3) EP3168218B1 (fr)
JP (1) JP4159988B2 (fr)
KR (1) KR100639281B1 (fr)
CN (2) CN100439360C (fr)
AP (1) AP1660A (fr)
AR (1) AR036261A1 (fr)
AU (1) AU2002324684B2 (fr)
BG (1) BG108553A (fr)
BR (1) BR0211612A (fr)
CA (1) CA2455050C (fr)
CO (1) CO5550431A2 (fr)
CU (1) CU23713B7 (fr)
CY (1) CY1121552T1 (fr)
CZ (1) CZ2004196A3 (fr)
DK (2) DK3168218T3 (fr)
EA (1) EA006445B9 (fr)
EC (1) ECSP044975A (fr)
ES (3) ES2453164T3 (fr)
GE (1) GEP20063777B (fr)
HK (2) HK1066542A1 (fr)
HR (1) HRP20040112B1 (fr)
HU (1) HU229206B1 (fr)
IL (1) IL160097A0 (fr)
IS (1) IS7147A (fr)
MA (1) MA27058A1 (fr)
ME (1) ME00414B (fr)
MX (1) MXPA04001452A (fr)
MY (1) MY139383A (fr)
NO (1) NO326508B1 (fr)
NZ (1) NZ531232A (fr)
OA (1) OA12650A (fr)
PL (1) PL216524B1 (fr)
PT (2) PT3168218T (fr)
RS (1) RS53251B (fr)
SI (2) SI3168218T1 (fr)
SK (1) SK902004A3 (fr)
TN (1) TNSN04028A1 (fr)
TR (1) TR201900509T4 (fr)
TW (1) TWI269796B (fr)
UA (1) UA76483C2 (fr)
WO (1) WO2003016305A1 (fr)
ZA (1) ZA200400706B (fr)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3168218T (pt) 2001-08-15 2019-01-11 Pharmacia & Upjohn Co Llc Um cristal compreendendo um sal de ácido l-málico de n-[2- (dietilamino)etil]-5-[(5-fluoro-1,2-dihidro-2-oxo-3h-indol- 3-ilideno)metil]-2,4-dimetil-1h-pirrol-3-carboxamida para utilização como um medicamento
HN2003000272A (es) * 2002-09-10 2008-07-29 Pharmacia Italia Spa Formulaciones que comprenden un compuesto de indolinona
KR20060058728A (ko) * 2003-10-02 2006-05-30 파마시아 앤드 업존 캄파니 엘엘씨 피롤-치환된 인돌리논 화합물의 염 및 다형체
US20060009510A1 (en) * 2004-07-09 2006-01-12 Pharmacia & Upjohn Company Llc Method of synthesizing indolinone compounds
EP1773811B1 (fr) * 2004-07-22 2010-09-08 Eli Lilly And Company Hydrate variable cristallin de sel (s)-6-(4-(2-((3-(9h-carbazol-4-yloxy)-2-hydroxypropyl)amino)-2-methylpropyl)phenoxy)-3-pyridinicarbox amide hemisuccinate
KR20070119745A (ko) * 2005-05-12 2007-12-20 화이자 인코포레이티드 수니티닙 말레이트를 사용하는 항암 병행 요법
SI1928858T1 (sl) * 2005-09-19 2009-10-31 Pfizer Prod Inc Trde solne oblike s pirolom substituiranega 2-indolinona
US20090004213A1 (en) * 2007-03-26 2009-01-01 Immatics Biotechnologies Gmbh Combination therapy using active immunotherapy
EP2253629A1 (fr) * 2007-11-21 2010-11-24 Teva Pharmaceutical Industries Ltd. Polymorphes de malate de sunitinib racémique, compositions les contenant et leur préparation
US20100256392A1 (en) * 2007-11-21 2010-10-07 Teva Pharmaceutical Industries Ltd. Polymorphs of sunitinib base and processes for preparation thereof
CN101939314B (zh) * 2007-12-12 2014-04-02 麦迪凯姆股份公司 3-吡咯取代的2-吲哚酮的多晶型物
EP2090306A1 (fr) 2008-02-13 2009-08-19 Ratiopharm GmbH Compositions pharmaceutiques comportant du N-[2-(diethylamino)ethyl]-5-[5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
EP2113248A1 (fr) 2008-04-29 2009-11-04 Ratiopharm GmbH Composition pharmaceutique comportant du N-[2-(diethylamino)ethyl]-5-[5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2-dimethyl-1H-pyrrole-3-carboxamide
JP2011512396A (ja) * 2008-02-21 2011-04-21 ジェネリクス・（ユーケー）・リミテッド 新規な多形およびその調製方法
EP2098521A1 (fr) * 2008-03-06 2009-09-09 Ratiopharm GmbH Formules cristallines de N-[2-(diéthylamino)éthyl]-5-[5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidène)méthyl]-2,4-diméthyl-1H-pyrrole-3-carboxamide
JP2011516488A (ja) * 2008-03-31 2011-05-26 テバ ファーマシューティカル インダストリーズ リミティド スニチニブ及びその塩の調製方法
KR20100135910A (ko) 2008-04-16 2010-12-27 낫코 파마 리미티드 수니티닙 염기의 신규한 다형 형태
CN102066362B (zh) * 2008-05-23 2014-07-30 上海医药工业研究院 二氢吲哚酮衍生物
EP2313371B1 (fr) * 2008-06-13 2012-08-15 Medichem, S.A. Procédé de préparation d un sel 2-indolinone malate à substitution 3 pyrrole
EP2138167A1 (fr) 2008-06-24 2009-12-30 ratiopharm GmbH Compositions pharmaceutiques comportant du N-[2-(diethylamino)ethyl]-5-[5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
WO2009156837A2 (fr) * 2008-06-26 2009-12-30 Medichem, S.A. Forme amorphe d'un sel de malate de 2-indolinone à substitution 3-pyrrole
WO2010004339A1 (fr) 2008-07-10 2010-01-14 Generics [Uk] Limited Procédés de préparation de formes cristallines de malate de sunitinib
EP2342195B1 (fr) 2008-07-24 2014-09-10 Medichem, S.A. Formes cristallines d un sel de malate de 2-indolinone à substitution 3-pyrrole
KR20110036588A (ko) 2008-07-24 2011-04-07 테바 파마슈티컬 인더스트리즈 리미티드 수니티닙 아세테이트 및 이의 다형을 통한 수니티닙 말레이트의 제조 방법
WO2010023473A2 (fr) * 2008-08-25 2010-03-04 Generics [Uk] Limited Nouvelle forme cristalline et ses procédés de préparation
JP2012500838A (ja) * 2008-08-25 2012-01-12 ジェネリクス・（ユーケー）・リミテッド スニチニブの新規な多形およびその調製方法
EP2350056A1 (fr) * 2008-10-10 2011-08-03 Medichem, S.A. Procédé pour la préparation d'un sel de malate de 2-indolinone substituée par pyrrole en position 3
EP2181991A1 (fr) 2008-10-28 2010-05-05 LEK Pharmaceuticals D.D. Nouveaux sels de sunitinib
EP2186809A1 (fr) * 2008-11-13 2010-05-19 LEK Pharmaceuticals D.D. Nouvelle forme cristalline du malate de sunitinib
EP2373643A4 (fr) * 2009-01-02 2013-08-07 Hetero Research Foundation Nouveaux polymorphes de malate de sunitinib
KR101733773B1 (ko) 2009-01-16 2017-05-10 엑셀리시스, 인코포레이티드 Ｎ-（４-｛〔６，７-비스（메틸옥시）퀴놀린-4-일〕옥시｝페닐）-ｎ＇-（４-플루오로페닐）사이클로프로판-1,1-디카르복사미드의 말산염 및 그 결정형
EP2255792A1 (fr) 2009-05-20 2010-12-01 Ratiopharm GmbH Composition pharmaceutique pour n-[2-(diethylamino)ethyl]5-[(fluoro-1,2-dihydro-2-oxo-3H-indole-3-ylidene) methyl]-2,4-dimenthyl-1h-pyrrole-3-carboxamide
WO2011004200A1 (fr) 2009-07-10 2011-01-13 Generics [Uk] Limited Nouveaux dérivés de pyrrole
EP2477978A1 (fr) 2009-09-16 2012-07-25 Ranbaxy Laboratories Limited Sels de sunitinib
EP2499133A2 (fr) * 2009-11-12 2012-09-19 Ranbaxy Laboratories Limited Procédé de préparation de la forme cristalline i du sel d'acide l-malique de sunitinib
WO2011061613A1 (fr) 2009-11-19 2011-05-26 Ranbaxy Laboratories Limited Procédé de préparation de la forme cristalline ii du sel d'acide malique l du sunitinib
EP2528913A1 (fr) 2010-01-29 2012-12-05 Ranbaxy Laboratories Limited Formes cristallines du sel d'acide l-malique du sunitinib
WO2011100325A2 (fr) 2010-02-09 2011-08-18 Sicor Inc. Polymorphes de sels de sunitinib
WO2011104555A2 (fr) 2010-02-25 2011-09-01 Generics [Uk] Limited Nouveau procédé
US20130123511A1 (en) 2010-03-04 2013-05-16 Ranbaxy Laboratories Limited Process for the direct preparation of malic acid salt of sunitinib
WO2011114246A1 (fr) 2010-03-18 2011-09-22 Ranbaxy Laboratories Limited Procédé pour la préparation du sel de l'acide maléique du sunitinib
WO2011128699A2 (fr) 2010-04-16 2011-10-20 Generics [Uk] Limited Procédés inédits
WO2012042421A1 (fr) 2010-09-29 2012-04-05 Pfizer Inc. Procédé de traitement de la croissance cellulaire anormale
DK2699598T3 (en) 2011-04-19 2019-04-23 Pfizer COMBINATIONS OF ANTI-4-1BB ANTIBODIES AND ADCC-INducing ANTIBODIES FOR TREATMENT OF CANCER
ES2709110T3 (es) 2012-03-23 2019-04-15 Laurus Labs Ltd Un proceso mejorado para la preparación de sunitinib y sus sales de adición de ácido
PL399027A1 (pl) 2012-04-27 2013-10-28 Instytut Farmaceutyczny Sposób otrzymywania N-[2-(dietylamino)etylo]-5-formylo-2,4-dimetylo-1H-pirolo-3-karboksyamidu o wysokiej czystosci i jego zastosowanie do wytwarzania sunitynibu
CN104284674A (zh) 2012-05-04 2015-01-14 辉瑞公司 ***相关抗原及基于疫苗的免疫治疗疗法
CA2838587A1 (fr) 2013-10-18 2015-04-18 Hari Babu Matta Forme cristalline pure ii de sel d'acide l-malique de sunitinib et procede pour sa preparation
CA2838585A1 (fr) * 2013-10-18 2015-04-18 Hari Babu Matta Sel de sunitinib d'acide ascorbique
PE20171142A1 (es) 2013-11-01 2017-08-10 Pfizer Vectores para expresion de antigenos asociados a prostata
CN104693187A (zh) * 2013-12-10 2015-06-10 安杰世纪生物科技（北京）有限公司 一种舒尼替尼L-苹果酸盐晶型λ及其制备方法
CN104744442B (zh) * 2013-12-25 2019-05-28 江苏豪森药业集团有限公司 苹果酸舒尼替尼的制备方法
RU2567535C1 (ru) * 2014-10-01 2015-11-10 Олег Ростиславович Михайлов КРИСТАЛЛИЧЕСКАЯ ε-МОДИФИКАЦИЯ N-[2-(ДИЭТИЛАМИНО)ЭТИЛ]-5-[(Z)-(5-ФТОР-1,2-ДИГИДРО-2-ОКСО-3Н-ИНДОЛ-3-ИЛИДЕН)МЕТИЛ]-2,4-ДИМЕТИЛ-1Н-ПИРРОЛ-3-КАРБОКСАМИД МАЛАТА, СПОСОБ ЕЕ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ЕЕ ОСНОВЕ
CN105712979A (zh) * 2014-12-05 2016-06-29 广州白云山医药集团股份有限公司白云山制药总厂 一种苹果酸舒尼替尼晶型ⅰ的制备方法
EP3539536A1 (fr) 2018-03-15 2019-09-18 MH10 Spolka z ograniczona odpowiedzialnoscia Composition pharmaceutique de sunitinib ou de son sel dans sa forme polymorphe i
WO2020216450A1 (fr) 2019-04-25 2020-10-29 Synthon B.V. Composition pharmaceutique comprenant du sunitinib amorphe
CN113766932A (zh) * 2019-04-18 2021-12-07 米特健康有限公司 用于治疗呼吸性心律失常的方法和组合物
KR20240025990A (ko) 2022-08-19 2024-02-27 주식회사 스카이테라퓨틱스 무정형 수니티닙, 그 제조방법 및 이를 포함한 의약 조성물

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001037820A2 (fr) * 1999-11-24 2001-05-31 Sugen, Inc. Formulations pour agents pharmaceutiques ionisables comme acides libres ou bases libres
WO2001060814A2 (fr) * 2000-02-15 2001-08-23 Sugen, Inc. Inhibiteurs de la proteine kinase 2-indolinone a substitution pyrrole

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU225055B1 (en) 1990-10-15 2006-05-29 Pfizer Indole derivatives, their intermediates, process for production them and pharmaceutical compositions containing the compounds
IL100091A (en) 1990-12-12 1998-08-16 Zeneca Ltd Pharmaceutical preparations containing the physical form of [4] 5) Cyclopentyloxycarbyl (amino 1 methyl indole 3 methyl methyl [3 methoxybenzoyl [2 methylbenzole)
SK279211B6 (sk) 1992-06-05 1998-08-05 Merck Sharp & Dohme Limited Sulfátová soľ substituovaného triazolu, spôsob jej
JP3852946B2 (ja) 1993-03-12 2006-12-06 ファルマシア・アンド・アップジョン・カンパニー 結晶性セフチオフル遊離酸
US6288057B1 (en) 1994-08-31 2001-09-11 Eli Lilly And Company Physical form of dihydro-2,3-benzodiazepine derivative
DE19503966C2 (de) 1995-02-07 1998-07-02 Mack Chem Pharm Kristallmodifikation von 2,4-Diamino-6-hydroxymethylpteridin-Hydrobromid, Verfahren zu dessen Herstellung und dessen Verwendung
US5597663A (en) * 1995-05-30 1997-01-28 Motorola, Inc. Low temperature molten lithium salt electrolytes for electrochemical cells
US5880141A (en) * 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
US5673451A (en) * 1995-07-06 1997-10-07 Moore; James R. Instructional toothbrush
US20020045746A1 (en) 1995-12-11 2002-04-18 Barton Kathleen P. Eplerenone crystalline form
US20020038021A1 (en) 1995-12-11 2002-03-28 Barton Kathleen P. Eplerenone crystalline form exhibiting enhanced dissolution rate
US6066647A (en) 1996-07-29 2000-05-23 Pfizer Inc. Zwitterionic forms of trovafloxacin
RO120771B1 (ro) * 1996-08-14 2006-07-28 G.D. Searle & Co. Formă cristalină b a 4-(5-metil-3-fenilizoxazol-4-il) benzensulfonamidei
WO1998029344A1 (fr) 1996-12-25 1998-07-09 Nippon Kayaku Kabushiki Kaisha Poudre de cisplatine fine et son procede de production
US5777185A (en) * 1997-09-09 1998-07-07 Laroche Industries Inc. Production of organic fluorine compounds
US6133305A (en) * 1997-09-26 2000-10-17 Sugen, Inc. 3-(substituted)-2-indolinones compounds and use thereof as inhibitors of protein kinase activity
US6012678A (en) * 1998-01-26 2000-01-11 The Boeing Company Galley vacuum waste disposal system
DK1020454T4 (da) * 1998-06-19 2013-11-25 Teijin Ltd Polymorfe former af 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazol-carboxylsyre og fremgangsmåde til fremstilling deraf
TR200101860T2 (tr) * 1998-12-17 2001-12-21 F.Hoffmann-La Roche Ag Sikline bağlı kinaz inhibitörleri olarak 4-alkenil (ve alkinil) oksidoller
US6239141B1 (en) 1999-06-04 2001-05-29 Pfizer Inc. Trovafloxacin oral suspensions
US6316672B1 (en) 2001-01-31 2001-11-13 Grayson Walker Stowell Form a of fluoxetine hydrochloride
PT3168218T (pt) 2001-08-15 2019-01-11 Pharmacia & Upjohn Co Llc Um cristal compreendendo um sal de ácido l-málico de n-[2- (dietilamino)etil]-5-[(5-fluoro-1,2-dihidro-2-oxo-3h-indol- 3-ilideno)metil]-2,4-dimetil-1h-pirrol-3-carboxamida para utilização como um medicamento
JP2011512396A (ja) 2008-02-21 2011-04-21 ジェネリクス・（ユーケー）・リミテッド 新規な多形およびその調製方法
WO2009156837A2 (fr) 2008-06-26 2009-12-30 Medichem, S.A. Forme amorphe d'un sel de malate de 2-indolinone à substitution 3-pyrrole

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001037820A2 (fr) * 1999-11-24 2001-05-31 Sugen, Inc. Formulations pour agents pharmaceutiques ionisables comme acides libres ou bases libres
WO2001060814A2 (fr) * 2000-02-15 2001-08-23 Sugen, Inc. Inhibiteurs de la proteine kinase 2-indolinone a substitution pyrrole

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Publication number Publication date
RS53251B (sr) 2014-08-29
PT3168218T (pt) 2019-01-11
EP2332934A1 (fr) 2011-06-15
TR201900509T4 (tr) 2019-02-21
GEP20063777B (en) 2006-03-27
CA2455050A1 (fr) 2003-02-27
CN1543462A (zh) 2004-11-03
IS7147A (is) 2004-02-10
MA27058A1 (fr) 2004-12-20
AR036261A1 (es) 2004-08-25
SI3168218T1 (sl) 2019-05-31
CN100439360C (zh) 2008-12-03
EA006445B9 (ru) 2017-02-28
ZA200400706B (en) 2005-05-25
EA200400183A1 (ru) 2004-08-26
HK1066542A1 (en) 2005-03-24
HK1088008A1 (en) 2006-10-27
EP1419151A1 (fr) 2004-05-19
CA2455050C (fr) 2007-02-20
CY1121552T1 (el) 2020-05-29
EA006445B1 (ru) 2005-12-29
EP2332934B1 (fr) 2017-03-01
CN100364991C (zh) 2008-01-30
HU229206B1 (en) 2013-09-30
CU23713B7 (es) 2011-10-05
MY139383A (en) 2009-09-30
NO326508B1 (no) 2008-12-15
CU20040029A7 (es) 2008-03-14
NO20041054L (no) 2004-03-12
ECSP044975A (es) 2004-03-23
SI1419151T1 (sl) 2014-04-30
HRP20040112A2 (en) 2004-06-30
EP3168218A1 (fr) 2017-05-17
ME00414B (me) 2011-10-10
DK1419151T3 (da) 2014-03-31
JP2005503386A (ja) 2005-02-03
SK902004A3 (sk) 2005-03-04
BR0211612A (pt) 2004-08-24
US20070191458A1 (en) 2007-08-16
AU2002324684B2 (en) 2006-10-05
MXPA04001452A (es) 2004-05-20
ES2453164T3 (es) 2014-04-04
OA12650A (en) 2006-06-19
HUP0700036A2 (en) 2008-10-28
JP4159988B2 (ja) 2008-10-01
RS10304A (en) 2007-02-05
PT1419151E (pt) 2014-03-27
UA76483C2 (en) 2006-08-15
CN1789264A (zh) 2006-06-21
TWI269796B (en) 2007-01-01
WO2003016305A1 (fr) 2003-02-27
PL216524B1 (pl) 2014-04-30
AP1660A (en) 2006-09-09
TNSN04028A1 (fr) 2006-06-01
US20030069298A1 (en) 2003-04-10
DK3168218T3 (en) 2019-01-14
PL368317A1 (en) 2005-03-21
ES2705063T3 (es) 2019-03-21
BG108553A (bg) 2005-04-30
EP3168218B1 (fr) 2018-11-14
KR100639281B1 (ko) 2006-10-31
ES2623094T3 (es) 2017-07-10
NZ531232A (en) 2004-11-26
CZ2004196A3 (cs) 2005-01-12
AP2004002976A0 (en) 2004-03-31
EP1419151B1 (fr) 2014-02-26
IL160097A0 (en) 2004-06-20
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US7435832B2 (en) 2008-10-14
CO5550431A2 (es) 2005-08-31

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