CU23713B7 - Cristales anhidros que incluyen una sal del ácido málico de una 2-indolinona sustituida con 3-pirrol, métodos de preparación y composiciones que las contienen - Google Patents

Cristales anhidros que incluyen una sal del ácido málico de una 2-indolinona sustituida con 3-pirrol, métodos de preparación y composiciones que las contienen

Info

Publication number
CU23713B7
CU23713B7 CU20040029A CU20040029A CU23713B7 CU 23713 B7 CU23713 B7 CU 23713B7 CU 20040029 A CU20040029 A CU 20040029A CU 20040029 A CU20040029 A CU 20040029A CU 23713 B7 CU23713 B7 CU 23713B7
Authority
CU
Cuba
Prior art keywords
degrees
acid salt
anhyding
pirrol
indolinone
Prior art date
Application number
CU20040029A
Other languages
English (en)
Other versions
CU20040029A7 (es
Inventor
Mark T Maloney
Stephen P Prescot
Thomas J Fleck
Michael Hawley
Original Assignee
Pharmacia & Upjohn Co Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23211067&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CU23713(B7) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharmacia & Upjohn Co Llc filed Critical Pharmacia & Upjohn Co Llc
Publication of CU20040029A7 publication Critical patent/CU20040029A7/es
Publication of CU23713B7 publication Critical patent/CU23713B7/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Cristales anhidros de una sal de ácido málico de un compuesto que tiene la estructura: ESPACIO PARA FÓRMULA donde el cristal es preferentemente ácido málico es ácido L-málico o una sal del ácido málico de N-[2-(dietilamino)etil]-5-[(5-fluoro-1,2-dihidro-2-oxo-3H-indol-3-iliden)metil]-2,4-dimetil-1H-pirrol-3-carboxamida, y tiene picos de difracción característicos a aproximadamente 13,2 y 24,2 grados dos teta (forma cristalina I) en un patrón de difracción de polvo por rayos X, preferentemente a aproximadamente 13,2, 19,4, 24,2 y 25,5 grados dos teta, o picos de difracción característicos a aproximadamente 3,0 y 27,2 grados dos teta en un patrón de difracción del polvo por rayos X, preferentemenete a aproximadamente 13,2, 19,4, 24,2 y 25,5 grados dos teta (forma cristalina II) en un patrón de difracción del polvo por rayos X, preferentemente a aproximadamente 3,0, 12,1, 14,5 y 27,7 grados teta; métodos para preparar dichos cristales anhidros; y composición que los comprende.
CU20040029A 2001-08-15 2004-02-12 Cristales anhidros que incluyen una sal del ácido málico de una 2-indolinona sustituida con 3-pirrol, métodos de preparación y composiciones que las contienen CU23713B7 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US31235301P 2001-08-15 2001-08-15

Publications (2)

Publication Number Publication Date
CU20040029A7 CU20040029A7 (es) 2008-03-14
CU23713B7 true CU23713B7 (es) 2011-10-05

Family

ID=23211067

Family Applications (1)

Application Number Title Priority Date Filing Date
CU20040029A CU23713B7 (es) 2001-08-15 2004-02-12 Cristales anhidros que incluyen una sal del ácido málico de una 2-indolinona sustituida con 3-pirrol, métodos de preparación y composiciones que las contienen

Country Status (43)

Country Link
US (2) US20030069298A1 (es)
EP (3) EP2332934B1 (es)
JP (1) JP4159988B2 (es)
KR (1) KR100639281B1 (es)
CN (2) CN100439360C (es)
AP (1) AP1660A (es)
AR (1) AR036261A1 (es)
AU (1) AU2002324684B2 (es)
BG (1) BG108553A (es)
BR (1) BR0211612A (es)
CA (1) CA2455050C (es)
CO (1) CO5550431A2 (es)
CU (1) CU23713B7 (es)
CY (1) CY1121552T1 (es)
CZ (1) CZ2004196A3 (es)
DK (2) DK1419151T3 (es)
EA (1) EA006445B9 (es)
EC (1) ECSP044975A (es)
ES (3) ES2623094T3 (es)
GE (1) GEP20063777B (es)
HK (2) HK1066542A1 (es)
HR (1) HRP20040112B1 (es)
HU (1) HU229206B1 (es)
IL (1) IL160097A0 (es)
IS (1) IS7147A (es)
MA (1) MA27058A1 (es)
ME (1) ME00414B (es)
MX (1) MXPA04001452A (es)
MY (1) MY139383A (es)
NO (1) NO326508B1 (es)
NZ (1) NZ531232A (es)
OA (1) OA12650A (es)
PL (1) PL216524B1 (es)
PT (2) PT1419151E (es)
RS (1) RS53251B (es)
SI (2) SI1419151T1 (es)
SK (1) SK902004A3 (es)
TN (1) TNSN04028A1 (es)
TR (1) TR201900509T4 (es)
TW (1) TWI269796B (es)
UA (1) UA76483C2 (es)
WO (1) WO2003016305A1 (es)
ZA (1) ZA200400706B (es)

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MY139383A (en) 2009-09-30
TWI269796B (en) 2007-01-01
KR20040030074A (ko) 2004-04-08
BR0211612A (pt) 2004-08-24
CN100364991C (zh) 2008-01-30
HU229206B1 (en) 2013-09-30
EP2332934B1 (en) 2017-03-01
EP3168218A1 (en) 2017-05-17
AU2002324684B2 (en) 2006-10-05
SK902004A3 (sk) 2005-03-04
PL368317A1 (en) 2005-03-21
EA006445B1 (ru) 2005-12-29
ME00414B (me) 2011-10-10
KR100639281B1 (ko) 2006-10-31
DK1419151T3 (da) 2014-03-31
JP4159988B2 (ja) 2008-10-01
DK3168218T3 (en) 2019-01-14
IL160097A0 (en) 2004-06-20
GEP20063777B (en) 2006-03-27
US20070191458A1 (en) 2007-08-16
PT3168218T (pt) 2019-01-11
HRP20040112B1 (en) 2012-03-31
EA006445B9 (ru) 2017-02-28
ECSP044975A (es) 2004-03-23
CZ2004196A3 (cs) 2005-01-12
HK1088008A1 (en) 2006-10-27
EP1419151B1 (en) 2014-02-26
ZA200400706B (en) 2005-05-25
AP2004002976A0 (en) 2004-03-31
OA12650A (en) 2006-06-19
NO326508B1 (no) 2008-12-15
CY1121552T1 (el) 2020-05-29
MA27058A1 (fr) 2004-12-20
PT1419151E (pt) 2014-03-27
CN100439360C (zh) 2008-12-03
AR036261A1 (es) 2004-08-25
EP2332934A1 (en) 2011-06-15
CU20040029A7 (es) 2008-03-14
RS53251B (sr) 2014-08-29
NO20041054L (no) 2004-03-12
AP1660A (en) 2006-09-09
HRP20040112A2 (en) 2004-06-30
HUP0700036A2 (en) 2008-10-28
EP1419151A1 (en) 2004-05-19
TNSN04028A1 (fr) 2006-06-01
RS10304A (en) 2007-02-05
TR201900509T4 (tr) 2019-02-21
ES2623094T3 (es) 2017-07-10
SI1419151T1 (sl) 2014-04-30
EA200400183A1 (ru) 2004-08-26
JP2005503386A (ja) 2005-02-03
ES2453164T3 (es) 2014-04-04
WO2003016305A1 (en) 2003-02-27
IS7147A (is) 2004-02-10
NZ531232A (en) 2004-11-26
EP3168218B1 (en) 2018-11-14
UA76483C2 (en) 2006-08-15
CO5550431A2 (es) 2005-08-31
ES2705063T3 (es) 2019-03-21
SI3168218T1 (sl) 2019-05-31
HK1066542A1 (en) 2005-03-24
PL216524B1 (pl) 2014-04-30
BG108553A (bg) 2005-04-30
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