PT1419151E - Cristais que incluem um sal do ácido málico de n-[2- (dietilamino)etil]-5-[(5-fluoro-1,2-di-hidro-2-oxo-3hindol- 3-ilideno)metil-2,4-dimetil-1h-pirrol-3-carboxamida, processos para a sua preparação e suas composições - Google Patents

Cristais que incluem um sal do ácido málico de n-[2- (dietilamino)etil]-5-[(5-fluoro-1,2-di-hidro-2-oxo-3hindol- 3-ilideno)metil-2,4-dimetil-1h-pirrol-3-carboxamida, processos para a sua preparação e suas composições Download PDF

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Publication number
PT1419151E
PT1419151E PT2759342T PT02759342T PT1419151E PT 1419151 E PT1419151 E PT 1419151E PT 2759342 T PT2759342 T PT 2759342T PT 02759342 T PT02759342 T PT 02759342T PT 1419151 E PT1419151 E PT 1419151E
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PT
Portugal
Prior art keywords
chrystals
ylidene
carboxamide
diethylamino
indole
Prior art date
Application number
PT2759342T
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English (en)
Inventor
Thomas J Fleck
Michael Hawley
Stephen P Prescott
Mark T Maloney
Original Assignee
Pharmacia & Upjohn Co Llc
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Publication date
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Application filed by Pharmacia & Upjohn Co Llc filed Critical Pharmacia & Upjohn Co Llc
Publication of PT1419151E publication Critical patent/PT1419151E/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
PT2759342T 2001-08-15 2002-08-13 Cristais que incluem um sal do ácido málico de n-[2- (dietilamino)etil]-5-[(5-fluoro-1,2-di-hidro-2-oxo-3hindol- 3-ilideno)metil-2,4-dimetil-1h-pirrol-3-carboxamida, processos para a sua preparação e suas composições PT1419151E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US31235301P 2001-08-15 2001-08-15

Publications (1)

Publication Number Publication Date
PT1419151E true PT1419151E (pt) 2014-03-27

Family

ID=23211067

Family Applications (2)

Application Number Title Priority Date Filing Date
PT16196036T PT3168218T (pt) 2001-08-15 2002-08-13 Um cristal compreendendo um sal de ácido l-málico de n-[2- (dietilamino)etil]-5-[(5-fluoro-1,2-dihidro-2-oxo-3h-indol- 3-ilideno)metil]-2,4-dimetil-1h-pirrol-3-carboxamida para utilização como um medicamento
PT2759342T PT1419151E (pt) 2001-08-15 2002-08-13 Cristais que incluem um sal do ácido málico de n-[2- (dietilamino)etil]-5-[(5-fluoro-1,2-di-hidro-2-oxo-3hindol- 3-ilideno)metil-2,4-dimetil-1h-pirrol-3-carboxamida, processos para a sua preparação e suas composições

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT16196036T PT3168218T (pt) 2001-08-15 2002-08-13 Um cristal compreendendo um sal de ácido l-málico de n-[2- (dietilamino)etil]-5-[(5-fluoro-1,2-dihidro-2-oxo-3h-indol- 3-ilideno)metil]-2,4-dimetil-1h-pirrol-3-carboxamida para utilização como um medicamento

Country Status (43)

Country Link
US (2) US20030069298A1 (pt)
EP (3) EP3168218B1 (pt)
JP (1) JP4159988B2 (pt)
KR (1) KR100639281B1 (pt)
CN (2) CN100439360C (pt)
AP (1) AP1660A (pt)
AR (1) AR036261A1 (pt)
AU (1) AU2002324684B2 (pt)
BG (1) BG108553A (pt)
BR (1) BR0211612A (pt)
CA (1) CA2455050C (pt)
CO (1) CO5550431A2 (pt)
CU (1) CU23713B7 (pt)
CY (1) CY1121552T1 (pt)
CZ (1) CZ2004196A3 (pt)
DK (2) DK3168218T3 (pt)
EA (1) EA006445B9 (pt)
EC (1) ECSP044975A (pt)
ES (3) ES2453164T3 (pt)
GE (1) GEP20063777B (pt)
HK (2) HK1066542A1 (pt)
HR (1) HRP20040112B1 (pt)
HU (1) HU229206B1 (pt)
IL (1) IL160097A0 (pt)
IS (1) IS7147A (pt)
MA (1) MA27058A1 (pt)
ME (1) ME00414B (pt)
MX (1) MXPA04001452A (pt)
MY (1) MY139383A (pt)
NO (1) NO326508B1 (pt)
NZ (1) NZ531232A (pt)
OA (1) OA12650A (pt)
PL (1) PL216524B1 (pt)
PT (2) PT3168218T (pt)
RS (1) RS53251B (pt)
SI (2) SI3168218T1 (pt)
SK (1) SK902004A3 (pt)
TN (1) TNSN04028A1 (pt)
TR (1) TR201900509T4 (pt)
TW (1) TWI269796B (pt)
UA (1) UA76483C2 (pt)
WO (1) WO2003016305A1 (pt)
ZA (1) ZA200400706B (pt)

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RS53251B (sr) 2014-08-29
PT3168218T (pt) 2019-01-11
EP2332934A1 (en) 2011-06-15
TR201900509T4 (tr) 2019-02-21
GEP20063777B (en) 2006-03-27
CA2455050A1 (en) 2003-02-27
CN1543462A (zh) 2004-11-03
IS7147A (is) 2004-02-10
MA27058A1 (fr) 2004-12-20
AR036261A1 (es) 2004-08-25
SI3168218T1 (sl) 2019-05-31
CN100439360C (zh) 2008-12-03
EA006445B9 (ru) 2017-02-28
ZA200400706B (en) 2005-05-25
EA200400183A1 (ru) 2004-08-26
HK1066542A1 (en) 2005-03-24
HK1088008A1 (en) 2006-10-27
EP1419151A1 (en) 2004-05-19
CA2455050C (en) 2007-02-20
CY1121552T1 (el) 2020-05-29
EA006445B1 (ru) 2005-12-29
EP2332934B1 (en) 2017-03-01
CN100364991C (zh) 2008-01-30
HU229206B1 (en) 2013-09-30
CU23713B7 (es) 2011-10-05
MY139383A (en) 2009-09-30
NO326508B1 (no) 2008-12-15
CU20040029A7 (es) 2008-03-14
NO20041054L (no) 2004-03-12
ECSP044975A (es) 2004-03-23
SI1419151T1 (sl) 2014-04-30
HRP20040112A2 (en) 2004-06-30
EP3168218A1 (en) 2017-05-17
ME00414B (me) 2011-10-10
DK1419151T3 (da) 2014-03-31
JP2005503386A (ja) 2005-02-03
SK902004A3 (sk) 2005-03-04
BR0211612A (pt) 2004-08-24
US20070191458A1 (en) 2007-08-16
AU2002324684B2 (en) 2006-10-05
MXPA04001452A (es) 2004-05-20
ES2453164T3 (es) 2014-04-04
OA12650A (en) 2006-06-19
HUP0700036A2 (en) 2008-10-28
HRP20040112B1 (en) 2012-03-31
JP4159988B2 (ja) 2008-10-01
RS10304A (en) 2007-02-05
UA76483C2 (en) 2006-08-15
CN1789264A (zh) 2006-06-21
TWI269796B (en) 2007-01-01
WO2003016305A1 (en) 2003-02-27
PL216524B1 (pl) 2014-04-30
AP1660A (en) 2006-09-09
TNSN04028A1 (fr) 2006-06-01
US20030069298A1 (en) 2003-04-10
DK3168218T3 (en) 2019-01-14
PL368317A1 (en) 2005-03-21
ES2705063T3 (es) 2019-03-21
BG108553A (bg) 2005-04-30
EP3168218B1 (en) 2018-11-14
KR100639281B1 (ko) 2006-10-31
ES2623094T3 (es) 2017-07-10
NZ531232A (en) 2004-11-26
CZ2004196A3 (cs) 2005-01-12
AP2004002976A0 (en) 2004-03-31
EP1419151B1 (en) 2014-02-26
IL160097A0 (en) 2004-06-20
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US7435832B2 (en) 2008-10-14
CO5550431A2 (es) 2005-08-31

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