PL399027A1 - Sposób otrzymywania N-[2-(dietylamino)etylo]-5-formylo-2,4-dimetylo-1H-pirolo-3-karboksyamidu o wysokiej czystosci i jego zastosowanie do wytwarzania sunitynibu - Google Patents
Sposób otrzymywania N-[2-(dietylamino)etylo]-5-formylo-2,4-dimetylo-1H-pirolo-3-karboksyamidu o wysokiej czystosci i jego zastosowanie do wytwarzania sunitynibuInfo
- Publication number
- PL399027A1 PL399027A1 PL399027A PL39902712A PL399027A1 PL 399027 A1 PL399027 A1 PL 399027A1 PL 399027 A PL399027 A PL 399027A PL 39902712 A PL39902712 A PL 39902712A PL 399027 A1 PL399027 A1 PL 399027A1
- Authority
- PL
- Poland
- Prior art keywords
- formyl
- pyrrole
- dimethyl
- ethyl
- carboxamide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Abstract
Wynalazek dotyczy sposobu otrzymywania N-[2-(dietylamino)etylo]-5-formylo-2,4-dimetylo-1H-pirolo-3-karboksyamidu o wysokiej czystosci obejmujacego jego oczyszczanie do zawartosci ponizej 0,07% desetylowej pochodnej, N-[2-(etylamino)etylo]-5-formylo-2,4-dimetylo-1H-pirolo-3-karboksyamidu. N-[2-(dietylamino)etylo]-5-formylo-2,4-dimetylo-1H-pirolo-3-karboksyamid zawierajacy ponizej 0,07% desetylowej pochodnej ma zastosowanie do wytwarzania inhibitora kinaz tyrozynowych sunitynibu o czystosci farmaceutycznej.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL399027A PL399027A1 (pl) | 2012-04-27 | 2012-04-27 | Sposób otrzymywania N-[2-(dietylamino)etylo]-5-formylo-2,4-dimetylo-1H-pirolo-3-karboksyamidu o wysokiej czystosci i jego zastosowanie do wytwarzania sunitynibu |
PCT/PL2013/000059 WO2013162390A1 (en) | 2012-04-27 | 2013-04-26 | Process for preparation of high purity n- [2- (diethylamine) ethyl] - 5 - formyl - 2, 4 - dimethyl - 1h - pyrrole - 3 - carboxyamide |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL399027A PL399027A1 (pl) | 2012-04-27 | 2012-04-27 | Sposób otrzymywania N-[2-(dietylamino)etylo]-5-formylo-2,4-dimetylo-1H-pirolo-3-karboksyamidu o wysokiej czystosci i jego zastosowanie do wytwarzania sunitynibu |
Publications (1)
Publication Number | Publication Date |
---|---|
PL399027A1 true PL399027A1 (pl) | 2013-10-28 |
Family
ID=48539365
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL399027A PL399027A1 (pl) | 2012-04-27 | 2012-04-27 | Sposób otrzymywania N-[2-(dietylamino)etylo]-5-formylo-2,4-dimetylo-1H-pirolo-3-karboksyamidu o wysokiej czystosci i jego zastosowanie do wytwarzania sunitynibu |
Country Status (2)
Country | Link |
---|---|
PL (1) | PL399027A1 (pl) |
WO (1) | WO2013162390A1 (pl) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10377749B2 (en) | 2015-08-10 | 2019-08-13 | Sumitomo Dainippon Pharma Co., Ltd. | Purification method for 5-(thiazol-4-yl)indolin-2-one derivative |
CN106588888B (zh) * | 2015-10-16 | 2021-02-26 | 江苏创诺制药有限公司 | 一种制备高纯度l-苹果酸舒尼替尼的方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR034118A1 (es) | 2000-02-15 | 2004-02-04 | Sugen Inc | Compuestos de 2-indolinonas sustituidas con pirroles inhibidoras de proteinquinasas; sus composiciones farmaceuticas e intermediarios de sintesis |
DK3168218T3 (en) | 2001-08-15 | 2019-01-14 | Pharmacia & Upjohn Co Llc | Crystalline comprising an L-malic acid salt of N- [2- (DIETHYLAMINO) ETHYL] -5 - [(5-FLUOR-1,2-DIHYDRO-2-OXO-3H-INDOL-3-YLIDE) METHYL] -2,4 -DIMETHYL-1H-PYRROL-3-CARBOXAMIDE FOR USE AS A MEDICINE |
KR20110036055A (ko) * | 2008-06-23 | 2011-04-06 | 낫코 파마 리미티드 | 고순도의 수니티닙 및 이의 약학적으로 허용가능한 염의 개선된 제조 방법 |
CA2774634A1 (en) * | 2009-09-16 | 2011-03-24 | Ranbaxy Laboratories Limited | Salts of sunitinib |
WO2012059941A1 (en) * | 2010-11-04 | 2012-05-10 | Ind-Swift Laboratories Limited | Process for preparation of sunitinib malate and salts thereof |
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2012
- 2012-04-27 PL PL399027A patent/PL399027A1/pl unknown
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2013
- 2013-04-26 WO PCT/PL2013/000059 patent/WO2013162390A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2013162390A1 (en) | 2013-10-31 |
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