TR200101860T2 - Sikline bağlı kinaz inhibitörleri olarak 4-alkenil (ve alkinil) oksidoller - Google Patents

Sikline bağlı kinaz inhibitörleri olarak 4-alkenil (ve alkinil) oksidoller

Info

Publication number
TR200101860T2
TR200101860T2 TR2001/01860T TR200101860T TR200101860T2 TR 200101860 T2 TR200101860 T2 TR 200101860T2 TR 2001/01860 T TR2001/01860 T TR 2001/01860T TR 200101860 T TR200101860 T TR 200101860T TR 200101860 T2 TR200101860 T2 TR 200101860T2
Authority
TR
Turkey
Prior art keywords
cyclin
alkynyl
alkenyl
oxidols
kinase inhibitors
Prior art date
Application number
TR2001/01860T
Other languages
English (en)
Inventor
Chen Yi
Lea Corbett Wendy
Dematakis Apostolos
Liu Jin-Jun
Luk Kin-Chun
E.Mahaney Paige
Gregory Mischke Steven
Original Assignee
F.Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.Hoffmann-La Roche Ag filed Critical F.Hoffmann-La Roche Ag
Publication of TR200101860T2 publication Critical patent/TR200101860T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

R1,R2,R3,a,b ve X tarifnamede tanimlandiklari gibi olmak üzere, asagidaki (I) ve (II) formüllerine sahip yeni 4-alkenil-ve 4-alkinil oksindoller ve bunlarin, ilaç sanayiinde kullanilmaya uygun tuzlari, sikline bagli kinazlari (CDK'lar) özellikle CDK2'yi önlemektedir ve bunlar, hücre çogalmasina bagli bozukluklarin, özellikle de gügüs ve kalin bagirsak tümörlerinin tedavi edilmesinde ya da kontrol altina alinmasinda, hücre çogalmasini önleyici etkenler olarak yararlidir.(FORMÜL VAR)
TR2001/01860T 1998-12-17 1999-12-08 Sikline bağlı kinaz inhibitörleri olarak 4-alkenil (ve alkinil) oksidoller TR200101860T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11259198P 1998-12-17 1998-12-17
US14907399P 1999-08-16 1999-08-16

Publications (1)

Publication Number Publication Date
TR200101860T2 true TR200101860T2 (tr) 2001-12-21

Family

ID=26810131

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/01860T TR200101860T2 (tr) 1998-12-17 1999-12-08 Sikline bağlı kinaz inhibitörleri olarak 4-alkenil (ve alkinil) oksidoller

Country Status (20)

Country Link
US (3) US6130239A (tr)
EP (1) EP1157019B1 (tr)
JP (1) JP2002532492A (tr)
KR (1) KR100649925B1 (tr)
CN (1) CN1138773C (tr)
AR (1) AR024847A1 (tr)
AT (1) ATE234830T1 (tr)
AU (1) AU770375B2 (tr)
BR (1) BR9916327A (tr)
CA (1) CA2354873A1 (tr)
CO (1) CO5261600A1 (tr)
DE (1) DE69906152T2 (tr)
DK (1) DK1157019T3 (tr)
ES (1) ES2192877T3 (tr)
PE (1) PE20001537A1 (tr)
PT (1) PT1157019E (tr)
TR (1) TR200101860T2 (tr)
TW (1) TW550262B (tr)
UY (1) UY25857A1 (tr)
WO (1) WO2000035908A1 (tr)

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WO2002002551A1 (en) * 2000-06-30 2002-01-10 Sugen, Inc. 4-heteroaryl-3-heteroarylidenyl-2-indolinones and their use as protein kinase inhibitors
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FR2822155B1 (fr) 2001-03-13 2003-12-12 Aventis Pharma Sa Composes derives des oxindoles et leur application therapeutique en cancerologie
RS53251B (sr) * 2001-08-15 2014-08-29 Pharmacia & Upjohn Company Llc Kristali koji sadrže n-[2-dietilamino)etil]-5-[(5-fluoro-2-okso-3h-indol-3-iliden)metil]-2,4-dimetil-1h-pirol-3- karboksamid so jabučne kiseline, procesi za njihovu pripremu i njihovi preparati
JP2005508953A (ja) 2001-10-10 2005-04-07 スージェン・インコーポレーテッド キナーゼ阻害剤としての３−［４−（置換ヘテロサイクリル）−ピロール−２−イルメチリデン］−２−インドリノン誘導体
AU2002360753B2 (en) * 2001-12-27 2008-08-21 Theravance, Inc. Indolinone derivatives useful as protein kinase inhibitors
FR2948940B1 (fr) * 2009-08-04 2011-07-22 Servier Lab Nouveaux derives dihydroindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2012178015A2 (en) * 2011-06-24 2012-12-27 Zenobia Therapeutics, Inc. Lrrk2 inhibitors
CN106187904B (zh) * 2015-05-25 2021-07-06 中国医学科学院药物研究所 含丙炔酰胺基的2-苯基咪唑类衍生物及其制法和药物组合物与用途
UA126589C2 (uk) 2017-09-14 2022-11-02 Даїті Санкіо Компані, Лімітед Сполука, яка має циклічну структуру
TW202237585A (zh) 2020-11-27 2022-10-01 瑞士商瑞森製藥公司 Ｃｄｋ抑制劑
WO2022149057A1 (en) 2021-01-05 2022-07-14 Rhizen Pharmaceuticals Ag Cdk inhibitors

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Also Published As

Publication number Publication date
EP1157019B1 (en) 2003-03-19
CN1138773C (zh) 2004-02-18
CO5261600A1 (es) 2003-03-31
PT1157019E (pt) 2003-06-30
BR9916327A (pt) 2001-09-18
UY25857A1 (es) 2001-07-31
US6303793B1 (en) 2001-10-16
KR20010101274A (ko) 2001-11-14
EP1157019A1 (en) 2001-11-28
ATE234830T1 (de) 2003-04-15
CN1330647A (zh) 2002-01-09
AU1972700A (en) 2000-07-03
KR100649925B1 (ko) 2007-02-28
WO2000035908A1 (en) 2000-06-22
AR024847A1 (es) 2002-10-30
ES2192877T3 (es) 2003-10-16
PE20001537A1 (es) 2001-01-09
US6252086B1 (en) 2001-06-26
JP2002532492A (ja) 2002-10-02
AU770375B2 (en) 2004-02-19
DK1157019T3 (da) 2003-07-14
CA2354873A1 (en) 2000-06-22
DE69906152T2 (de) 2004-02-12
TW550262B (en) 2003-09-01
DE69906152D1 (de) 2003-04-24
US6130239A (en) 2000-10-10

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