HRP20040005A2 - Combination continuous/batch fermentation processes - Google Patents
Combination continuous/batch fermentation processesInfo
- Publication number
- HRP20040005A2 HRP20040005A2 HRP20040005A HRP20040005A2 HR P20040005 A2 HRP20040005 A2 HR P20040005A2 HR P20040005 A HRP20040005 A HR P20040005A HR P20040005 A2 HRP20040005 A2 HR P20040005A2
- Authority
- HR
- Croatia
- Prior art keywords
- yeast
- fermentation
- beer
- immobilized
- continuous
- Prior art date
Links
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12C—BEER; PREPARATION OF BEER BY FERMENTATION; PREPARATION OF MALT FOR MAKING BEER; PREPARATION OF HOPS FOR MAKING BEER
- C12C11/00—Fermentation processes for beer
- C12C11/02—Pitching yeast
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12C—BEER; PREPARATION OF BEER BY FERMENTATION; PREPARATION OF MALT FOR MAKING BEER; PREPARATION OF HOPS FOR MAKING BEER
- C12C11/00—Fermentation processes for beer
- C12C11/07—Continuous fermentation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12C—BEER; PREPARATION OF BEER BY FERMENTATION; PREPARATION OF MALT FOR MAKING BEER; PREPARATION OF HOPS FOR MAKING BEER
- C12C11/00—Fermentation processes for beer
- C12C11/07—Continuous fermentation
- C12C11/075—Bioreactors for continuous fermentation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12C—BEER; PREPARATION OF BEER BY FERMENTATION; PREPARATION OF MALT FOR MAKING BEER; PREPARATION OF HOPS FOR MAKING BEER
- C12C11/00—Fermentation processes for beer
- C12C11/09—Fermentation with immobilised yeast
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Distillation Of Fermentation Liquor, Processing Of Alcohols, Vinegar And Beer (AREA)
- Detergent Compositions (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Processing Of Solid Wastes (AREA)
- Non-Alcoholic Beverages (AREA)
- Alcoholic Beverages (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US29915301P | 2001-06-20 | 2001-06-20 | |
US29918601P | 2001-06-20 | 2001-06-20 | |
PCT/CA2002/000970 WO2002102961A2 (en) | 2001-06-20 | 2002-06-20 | Combination continuous/batch fermentation processes |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20040005A2 true HRP20040005A2 (en) | 2004-12-31 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20040005 HRP20040005A2 (en) | 2001-06-20 | 2004-01-07 | Combination continuous/batch fermentation processes |
Country Status (18)
Country | Link |
---|---|
US (2) | US20030153059A1 (sh) |
EP (1) | EP1397481B1 (sh) |
JP (1) | JP2004532646A (sh) |
KR (1) | KR100910238B1 (sh) |
AT (1) | ATE322535T1 (sh) |
BG (1) | BG66230B1 (sh) |
BR (1) | BR0210552B1 (sh) |
CA (1) | CA2451330C (sh) |
CZ (1) | CZ304820B6 (sh) |
DE (1) | DE60210451T2 (sh) |
HR (1) | HRP20040005A2 (sh) |
MX (1) | MXPA03011982A (sh) |
RO (1) | RO122457B1 (sh) |
RU (1) | RU2361908C2 (sh) |
SI (1) | SI21561A (sh) |
SK (1) | SK288157B6 (sh) |
WO (1) | WO2002102961A2 (sh) |
YU (1) | YU100503A (sh) |
Families Citing this family (90)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI21561A (sl) * | 2001-06-20 | 2005-02-28 | Labatt Brewing Company Limited | Kombinacija kontinuirnih/saržnih fermentacijskih procesov |
US7592173B1 (en) * | 2003-04-25 | 2009-09-22 | The United States Of America As Represented By The Secretary Of The Navy | Operationally enhanced bioreactor |
US7669349B1 (en) * | 2004-03-04 | 2010-03-02 | TD*X Associates LP | Method separating volatile components from feed material |
US7608438B2 (en) * | 2005-04-05 | 2009-10-27 | Jessica Laviolette | Process for the continuous production of ethanol |
US20060240147A1 (en) * | 2005-04-21 | 2006-10-26 | Padhye Vinod W | Alcoholic beverages containing corn syrup substitutes |
ITMI20050962A1 (it) * | 2005-05-25 | 2006-11-26 | Lpe Spa | Dispositivo per introurre gas di reazione in una camera di reazione e reattore epitassiale che lo utilizza |
GB0514716D0 (en) * | 2005-07-19 | 2005-08-24 | Unilever Plc | Process to form fabric softening particle,particle obtained and its use |
EP2001991A4 (en) * | 2006-01-28 | 2013-03-20 | Abb Research Ltd | METHOD FOR ON-LINE PREDICTION OF THE FUTURE EFFICIENCY OF A FERMENTATION UNIT |
US8117924B2 (en) * | 2006-04-21 | 2012-02-21 | Bayer Healthcare Llc | Apparatus, system, and method for in-situ measurements |
US7716850B2 (en) | 2006-05-03 | 2010-05-18 | Georgia-Pacific Consumer Products Lp | Energy-efficient yankee dryer hood system |
JP5175273B2 (ja) * | 2006-05-19 | 2013-04-03 | ハイネケン・サプライ・チェーン・ビー.ブイ. | 清澄な酵母発酵飲料の製造方法 |
BRPI0712713B1 (pt) | 2006-05-19 | 2020-11-10 | Heineken Supply Chain B. V | método contínuo para fermentar mosto |
CN101484572A (zh) * | 2006-07-14 | 2009-07-15 | Abb研究有限公司 | 使产物收率最大化的补料-分批发酵设备的在线优化方法 |
AP2724A (en) | 2006-07-21 | 2013-08-31 | Xyleco Inc | Conversion systems for biomass |
US8571690B2 (en) * | 2006-10-31 | 2013-10-29 | Rockwell Automation Technologies, Inc. | Nonlinear model predictive control of a biofuel fermentation process |
US20080098900A1 (en) * | 2006-11-01 | 2008-05-01 | Babatunde Aremu | Beverage manufacture using a static mixer |
US7905930B2 (en) | 2006-12-29 | 2011-03-15 | Genifuel Corporation | Two-stage process for producing oil from microalgae |
JP5548121B2 (ja) | 2007-05-14 | 2014-07-16 | リサーチ ファウンデーション オブ ステイト ユニバーシティ オブ ニューヨーク | バイオフィルム中の細菌細胞における生理学的分散応答の誘導 |
TWI359043B (en) * | 2007-05-16 | 2012-03-01 | Univ Chung Hua | Multiple functional polymer-entrapped-cell-bead-in |
US7868129B2 (en) * | 2007-07-12 | 2011-01-11 | Eastman Chemical Company | Sloped tubular reactor with spaced sequential trays |
US20090238920A1 (en) * | 2008-03-21 | 2009-09-24 | Lewis Ted C | Process for making high grade protein product |
US20100124584A1 (en) * | 2008-11-20 | 2010-05-20 | Benjamin Alexander | Apparatus and method for continuous fermentation |
US8342043B2 (en) * | 2009-01-05 | 2013-01-01 | Velcon Filters, Llc | System for collecting a fluid sample |
DE102009011521A1 (de) * | 2009-03-06 | 2010-09-16 | Wolfgang Folger | Vorrichtung und Verfahren zur Herstellung von Eisperlen aus einem wässrigen Gemisch |
JP4781450B2 (ja) * | 2009-04-21 | 2011-09-28 | 麒麟麦酒株式会社 | ホップ香気を強調した発酵アルコール飲料の製造方法 |
US8613838B2 (en) * | 2009-07-31 | 2013-12-24 | Vertex Energy, Lp | System for making a usable hydrocarbon product from used oil |
US8398847B2 (en) * | 2009-07-31 | 2013-03-19 | Vertex Energy, Lp | Method for making a usable hydrocarbon product from used oil |
US8575403B2 (en) | 2010-05-07 | 2013-11-05 | Celanese International Corporation | Hydrolysis of ethyl acetate in ethanol separation process |
US20110217415A1 (en) * | 2010-03-05 | 2011-09-08 | Lurgi, Inc. | Hybrid fermentation process |
US8940520B2 (en) | 2010-05-20 | 2015-01-27 | Pond Biofuels Inc. | Process for growing biomass by modulating inputs to reaction zone based on changes to exhaust supply |
US11512278B2 (en) | 2010-05-20 | 2022-11-29 | Pond Technologies Inc. | Biomass production |
US8889400B2 (en) | 2010-05-20 | 2014-11-18 | Pond Biofuels Inc. | Diluting exhaust gas being supplied to bioreactor |
US8969067B2 (en) | 2010-05-20 | 2015-03-03 | Pond Biofuels Inc. | Process for growing biomass by modulating supply of gas to reaction zone |
US20120156669A1 (en) | 2010-05-20 | 2012-06-21 | Pond Biofuels Inc. | Biomass Production |
US8922560B2 (en) * | 2010-06-30 | 2014-12-30 | Exelis Inc. | Method and apparatus for correlating simulation models with physical devices based on correlation metrics |
WO2012148509A1 (en) | 2011-04-26 | 2012-11-01 | Celanese International Corporation | Process for producing ethanol using a stacked bed reactor |
US8710279B2 (en) | 2010-07-09 | 2014-04-29 | Celanese International Corporation | Hydrogenolysis of ethyl acetate in alcohol separation processes |
US8664454B2 (en) | 2010-07-09 | 2014-03-04 | Celanese International Corporation | Process for production of ethanol using a mixed feed using copper containing catalyst |
US8859827B2 (en) | 2011-11-18 | 2014-10-14 | Celanese International Corporation | Esterifying acetic acid to produce ester feed for hydrogenolysis |
US9272970B2 (en) | 2010-07-09 | 2016-03-01 | Celanese International Corporation | Hydrogenolysis of ethyl acetate in alcohol separation processes |
CA2820876C (en) * | 2010-12-09 | 2019-05-14 | Toray Industries, Inc. | Method for producing chemical by continuous fermentation |
US10035979B2 (en) * | 2015-07-23 | 2018-07-31 | Picobrew, Inc. | Beer making machine with direct steam injection |
US11678760B2 (en) | 2011-03-03 | 2023-06-20 | PB Funding Group, LLC | Multifunctional brewing system for coffee, beer, and other beverages |
US11753610B2 (en) | 2011-03-03 | 2023-09-12 | PB Funding Group, LLC | Self healing controller for beer brewing system |
CN103717289A (zh) | 2011-04-11 | 2014-04-09 | Ada-Es股份有限公司 | 用于气体组分捕集的流化床方法和*** |
US8592635B2 (en) | 2011-04-26 | 2013-11-26 | Celanese International Corporation | Integrated ethanol production by extracting halides from acetic acid |
US8754268B2 (en) | 2011-04-26 | 2014-06-17 | Celanese International Corporation | Process for removing water from alcohol mixtures |
US9073816B2 (en) | 2011-04-26 | 2015-07-07 | Celanese International Corporation | Reducing ethyl acetate concentration in recycle streams for ethanol production processes |
US20120276633A1 (en) | 2011-04-27 | 2012-11-01 | Pond Biofuels Inc. | Supplying treated exhaust gases for effecting growth of phototrophic biomass |
US8818562B2 (en) * | 2011-06-04 | 2014-08-26 | Invensys Systems, Inc. | Simulated fermentation process |
US8895786B2 (en) | 2011-08-03 | 2014-11-25 | Celanese International Corporation | Processes for increasing alcohol production |
US8802901B2 (en) | 2011-11-18 | 2014-08-12 | Celanese International Corporation | Continuous ethyl acetate production and hydrogenolysis thereof |
US8853468B2 (en) | 2011-11-18 | 2014-10-07 | Celanese International Corporation | Vapor esterification method to produce ester feed for hydrogenolysis |
US8748673B2 (en) | 2011-11-18 | 2014-06-10 | Celanese International Corporation | Process of recovery of ethanol from hydrogenolysis process |
US8829249B2 (en) | 2011-11-18 | 2014-09-09 | Celanese International Corporation | Integrated esterification and hydrogenolysis process for producing ethanol |
US9024089B2 (en) | 2011-11-18 | 2015-05-05 | Celanese International Corporation | Esterification process using extractive separation to produce feed for hydrogenolysis |
US8829251B2 (en) | 2011-11-18 | 2014-09-09 | Celanese International Corporation | Liquid esterification method to produce ester feed for hydrogenolysis |
WO2013077055A1 (ja) * | 2011-11-22 | 2013-05-30 | サントリーホールディングス株式会社 | 後味が改善されたノンアルコールのビールテイスト飲料 |
US8927790B2 (en) | 2011-12-15 | 2015-01-06 | Celanese International Corporation | Multiple vapor feeds for hydrogenation process to produce alcohol |
US9644221B2 (en) * | 2012-03-30 | 2017-05-09 | Toray Industries, Inc. | Method of producing chemical by continuous fermentation and continuous fermentation apparatus |
US9278314B2 (en) | 2012-04-11 | 2016-03-08 | ADA-ES, Inc. | Method and system to reclaim functional sites on a sorbent contaminated by heat stable salts |
US20140004610A1 (en) * | 2012-06-28 | 2014-01-02 | Uop Llc | Processes and apparatuses for converting a feedstock |
US9534261B2 (en) | 2012-10-24 | 2017-01-03 | Pond Biofuels Inc. | Recovering off-gas from photobioreactor |
EP3354717B1 (en) | 2013-03-07 | 2020-02-26 | Chr. Hansen A/S | Production of low-alcohol or alcohol-free beer with pichia kluyveri yeast strains |
US8926718B2 (en) | 2013-03-15 | 2015-01-06 | Celanese International Corporation | Thermochemically produced ethanol compositions |
US8975451B2 (en) | 2013-03-15 | 2015-03-10 | Celanese International Corporation | Single phase ester feed for hydrogenolysis |
US9663385B2 (en) | 2013-11-10 | 2017-05-30 | John D Jones | Liquid purification system |
WO2015200068A1 (en) | 2014-06-24 | 2015-12-30 | Poet Research, Inc. | Methods of pitching yeast for fermentation, and related methods of fermentation and systems |
US10308903B2 (en) | 2014-09-17 | 2019-06-04 | Picobrew, Inc. | Foam reducing device |
AT516421B1 (de) * | 2014-10-31 | 2016-07-15 | Anton Paar Gmbh | Verfahren und Messgerät zur Dichtemessung von fluiden Medien |
BR102014032908A2 (pt) * | 2014-12-29 | 2016-08-16 | Emanuel Manfred Freire Brandt | aparelho para customização de cervejas pós-maturação |
JP6778473B2 (ja) * | 2015-02-20 | 2020-11-04 | サッポロビール株式会社 | ビールテイスト飲料の製造方法及びビールテイスト飲料 |
US10377981B2 (en) | 2015-03-17 | 2019-08-13 | Picobrew, Inc. | Software tuning of recipes for beer brewing system |
US9932547B2 (en) | 2015-07-31 | 2018-04-03 | Picobrew, Inc. | Fermentation monitoring and management |
CN105372363A (zh) * | 2015-10-27 | 2016-03-02 | 深圳瀚星翔科技有限公司 | 电子烟烟油中双乙酰含量的检测方法 |
DE102015016110B4 (de) * | 2015-12-11 | 2018-12-27 | Maria Rogmans | Verfahren zur Erzeugung von Biogas, sowie Einrichtung zum Betrieb desselben |
JP6762109B2 (ja) * | 2016-02-25 | 2020-09-30 | サッポロビール株式会社 | ビールテイスト飲料、ビールテイスト飲料の製造方法、及びビールテイスト飲料の香味向上方法 |
US10161533B2 (en) | 2016-05-09 | 2018-12-25 | Picobrew, Inc. | Bi-stable electrically actuated valve |
US10463983B2 (en) | 2017-03-31 | 2019-11-05 | Picobrew, Inc. | Distillation and essence extractor insert for beer brewing machine |
CN107875873A (zh) * | 2017-11-02 | 2018-04-06 | 广东奥瑞特新能源设备科技有限公司 | 一种电池正负极粉液体全自动搅拌投料*** |
JP2019201633A (ja) * | 2018-05-18 | 2019-11-28 | サッポロビール株式会社 | ビールテイスト飲料、ビールテイスト飲料の製造方法、及び、ビールテイスト飲料の香味向上方法 |
CN109321452B (zh) * | 2018-10-23 | 2021-06-25 | 上海清美食品有限公司 | 利用微生物食品发酵筛选装置 |
TWI672373B (zh) * | 2018-10-24 | 2019-09-21 | 建國科技大學 | 智能型發酵槽 |
JP7078304B2 (ja) * | 2019-03-06 | 2022-05-31 | 国立研究開発法人物質・材料研究機構 | 水素センサー及び水素検出方法 |
RU2751493C2 (ru) * | 2019-03-25 | 2021-07-14 | Артур Беникович Балаян | Способ ускорения процессов брожения |
AU2021231973A1 (en) * | 2020-03-05 | 2022-10-27 | Bespoken Spirits, Inc. | Methods for spirits refining |
DE102021118440B4 (de) * | 2021-07-16 | 2023-03-16 | Manfred Dausch | Verfahren und Anlage zur Qualitätsüberwachung des Fermentationsprozesses bei Bier |
CN113862147B (zh) * | 2021-11-16 | 2024-02-27 | 陕西麦可罗生物科技有限公司 | 一种电磁耦合镶嵌式双罐体装置及其应用 |
US20240053314A1 (en) * | 2022-08-15 | 2024-02-15 | Preddio Technologies Inc. | Purge gas monitor |
CN116195730B (zh) * | 2023-02-28 | 2024-04-12 | 广东厨邦食品有限公司 | 一种改进广式高盐稀态酱油酿造淋油工艺的复油方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4698224A (en) * | 1984-04-10 | 1987-10-06 | Kirin Beer Kabushiki Kaisha | Production of alcoholic beverages |
US4929452A (en) * | 1987-09-30 | 1990-05-29 | University Of Georgia Research Foundation, Inc. | Method for rapidly fermenting alcoholic beverages |
US4915959A (en) * | 1988-05-09 | 1990-04-10 | Suomen Kokeri Oy | Method for the continuous maturation of fermented beer |
JP3604715B2 (ja) * | 1993-09-07 | 2004-12-22 | サッポロホールディングス株式会社 | 酒類の製造法 |
DE4430905C1 (de) * | 1994-08-31 | 1995-05-24 | Metallgesellschaft Ag | Verfahren zur kontinuierlichen Herstellung von Bier |
CA2133789A1 (en) * | 1994-10-06 | 1996-04-07 | Ronald James Neufeld | Immobilized-cell carrageenan bead production and a brewing process utilizing carrageenan bead immobilized yeast cells |
JP3594227B2 (ja) * | 1999-06-30 | 2004-11-24 | サッポロホールディングス株式会社 | 発酵生産物の製造法 |
WO2001098477A1 (en) * | 2000-06-19 | 2001-12-27 | N.V. Bekaert S.A. | Immobilising carrier comprising a porous medium |
SI21561A (sl) * | 2001-06-20 | 2005-02-28 | Labatt Brewing Company Limited | Kombinacija kontinuirnih/saržnih fermentacijskih procesov |
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Publication number | Publication date |
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CZ200455A3 (cs) | 2004-12-15 |
RU2361908C2 (ru) | 2009-07-20 |
DE60210451T2 (de) | 2007-02-01 |
CZ304820B6 (cs) | 2014-11-19 |
JP2004532646A (ja) | 2004-10-28 |
BG66230B1 (bg) | 2012-07-31 |
KR100910238B1 (ko) | 2009-07-31 |
MXPA03011982A (es) | 2004-03-26 |
RO122457B1 (ro) | 2009-06-30 |
BR0210552A (pt) | 2004-05-25 |
WO2002102961A3 (en) | 2003-02-27 |
WO2002102961A2 (en) | 2002-12-27 |
SI21561A (sl) | 2005-02-28 |
CA2451330C (en) | 2012-01-31 |
EP1397481B1 (en) | 2006-04-05 |
EP1397481A2 (en) | 2004-03-17 |
KR20040022430A (ko) | 2004-03-12 |
ATE322535T1 (de) | 2006-04-15 |
RU2004100827A (ru) | 2005-06-10 |
YU100503A (sh) | 2006-05-25 |
BR0210552B1 (pt) | 2014-06-10 |
US20050214408A1 (en) | 2005-09-29 |
CA2451330A1 (en) | 2002-12-27 |
SK482004A3 (sk) | 2005-01-03 |
BG108523A (en) | 2004-09-30 |
DE60210451D1 (de) | 2006-05-18 |
US20030153059A1 (en) | 2003-08-14 |
SK288157B6 (sk) | 2014-01-08 |
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