ES509659A0 - Un procedimiento para la produccion de un derivado de carbostirilo - Google Patents

Un procedimiento para la produccion de un derivado de carbostirilo

Info

Publication number
ES509659A0
ES509659A0 ES509659A ES509659A ES509659A0 ES 509659 A0 ES509659 A0 ES 509659A0 ES 509659 A ES509659 A ES 509659A ES 509659 A ES509659 A ES 509659A ES 509659 A0 ES509659 A0 ES 509659A0
Authority
ES
Spain
Prior art keywords
carbostirile
derivative
procedure
production
carbostirile derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES509659A
Other languages
English (en)
Other versions
ES8306141A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2880580A external-priority patent/JPS56125370A/ja
Priority claimed from JP11502280A external-priority patent/JPS5738772A/ja
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of ES8306141A1 publication Critical patent/ES8306141A1/es
Publication of ES509659A0 publication Critical patent/ES509659A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
ES509659A 1980-03-06 1982-02-16 Un procedimiento para la produccion de un derivado de carbostirilo Granted ES509659A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2880580A JPS56125370A (en) 1980-03-06 1980-03-06 Carbostyril derivative
JP11502280A JPS5738772A (en) 1980-08-20 1980-08-20 Carbostyril derivative

Publications (2)

Publication Number Publication Date
ES8306141A1 ES8306141A1 (es) 1983-05-01
ES509659A0 true ES509659A0 (es) 1983-05-01

Family

ID=26366952

Family Applications (4)

Application Number Title Priority Date Filing Date
ES500137A Expired ES8301962A1 (es) 1980-03-06 1981-03-05 Un procedimiento para la produccion de un derivado de carboslivilo.
ES509658A Expired ES8305356A1 (es) 1980-03-06 1982-02-16 Un procedimiento para la produccion de un derivado de carbostirilo
ES509659A Granted ES509659A0 (es) 1980-03-06 1982-02-16 Un procedimiento para la produccion de un derivado de carbostirilo
ES518667A Expired ES8405782A1 (es) 1980-03-06 1982-12-29 Un procedimiento para la produccion de un derivado de carbostirilo.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES500137A Expired ES8301962A1 (es) 1980-03-06 1981-03-05 Un procedimiento para la produccion de un derivado de carboslivilo.
ES509658A Expired ES8305356A1 (es) 1980-03-06 1982-02-16 Un procedimiento para la produccion de un derivado de carbostirilo

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES518667A Expired ES8405782A1 (es) 1980-03-06 1982-12-29 Un procedimiento para la produccion de un derivado de carbostirilo.

Country Status (21)

Country Link
US (4) US4460593A (es)
AT (1) AT381307B (es)
AU (1) AU523005B2 (es)
BE (1) BE887800A (es)
CA (1) CA1155119A (es)
CH (1) CH647775A5 (es)
DE (2) DE3152880C2 (es)
DK (1) DK155282C (es)
ES (4) ES8301962A1 (es)
FI (1) FI76323C (es)
FR (1) FR2477542A1 (es)
GB (1) GB2071094B (es)
IT (1) IT1144315B (es)
MX (1) MX6980E (es)
NL (1) NL184364C (es)
NO (1) NO159531C (es)
PH (1) PH17194A (es)
PT (1) PT72622B (es)
RU (1) RU1779249C (es)
SE (1) SE447255B (es)
SU (1) SU1367857A3 (es)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
FI77852C (fi) * 1981-02-17 1989-05-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av nya, saosom hjaertmediciner anvaendbara substituerade amid- och (maettad heterocykel)karbonylkarbostyrilderivat.
AU532361B2 (en) * 1981-09-01 1983-09-29 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
US4578381A (en) * 1982-07-05 1986-03-25 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
CH655110A5 (de) * 1982-09-03 1986-03-27 Otsuka Pharma Co Ltd Carbostyrilderivate, verfahren zu deren herstellung und arzneimittel, welche diese enthalten.
DE3434271A1 (de) * 1984-09-19 1986-03-20 Beiersdorf Ag, 2000 Hamburg Substituierte 3,4-dihydro-chinolin-2(1h)-one verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen
DE3509131A1 (de) * 1985-03-14 1986-09-18 Fa. Carl Zeiss, 7920 Heidenheim Verfahren zur justierten montage der optischen bauteile eines optischen geraetes
US4704390A (en) * 1986-02-13 1987-11-03 Warner-Lambert Company Phenyl and heterocyclic tetrahydropyridyl alkoxy-benzheterocyclic compounds as antipsychotic agents
KR940000785B1 (ko) * 1986-04-02 1994-01-31 오오쓰까세이야꾸 가부시끼가이샤 카르보스티릴 유도체 및 그의 염의 제조 방법
DK167187A (da) * 1986-04-02 1987-10-03 Otsuka Pharma Co Ltd Carbostyrilderivater og salte deraf, fremgangsmaade til fremstilling af saadanne forbindelser og laegemiddel indeholdende disse
US4792561A (en) * 1986-05-29 1988-12-20 Syntex (U.S.A.) Inc. Carbostyril derivatives as combined thromboxane synthetase and cyclic-AMP phosphodiesterase inhibitors
JPH0696555B2 (ja) * 1986-07-31 1994-11-30 大塚製薬株式会社 カルボスチリル誘導体
ES2053480T3 (es) * 1986-07-31 1994-08-01 Otsuka Pharma Co Ltd Un procedimiento para preparar un derivado de carboestirilo.
DE3802030A1 (de) * 1988-01-25 1989-07-27 Hoechst Ag Makroporoese, asymmetrische, hydrophile membran aus polyaramid
FR2640266B2 (fr) * 1988-07-12 1992-07-10 Synthelabo Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2, quinoleinones-2, benzo(b)azepinones-2 et benzimidazolones-2, leur preparation et leur application en therapeutique
FR2634206B1 (fr) * 1988-07-12 1992-05-15 Synthelabo Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2 et quinoleinones-2, leur preparation et leur application en therapeutique
FR2637591B1 (fr) * 1988-10-11 1992-10-23 Synthelabo Derives de quinoleinone, leur preparation et leur application en therapeutique
US5006528A (en) * 1988-10-31 1991-04-09 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
ES2146578T3 (es) * 1990-05-10 2000-08-16 Pfizer Indolona neuroprotectora y derivados relacionados.
FR2668149B1 (fr) * 1990-10-18 1994-09-23 Synthelabo Le 1-(3,4-dihydro-2-oxo-1h-quinolein-6-yl)-2-[4-(2-phenyl-ethyl)piperidin-1-yl]ethanol, sa preparation et son application en therapeutique.
US5147881A (en) * 1990-11-14 1992-09-15 Pfizer Inc 4-(1,2-benzisoxazolyl)piperidine antipsychotic agents
US5166367A (en) * 1991-06-21 1992-11-24 American Home Products Corporation Antipsychotic benzodioxan derivatives
US5189171A (en) * 1991-06-21 1993-02-23 American Home Products Corporation Antipsychotic benzodioxan derivatives
EP0594729A1 (en) * 1991-07-17 1994-05-04 Pfizer Inc. 2-(4-hydroxypiperidino)-1-alkanol derivatives as antiischemic agents
US6255322B1 (en) 1992-06-19 2001-07-03 Pfizer Inc. 2-(4-hydroxypiperidino)-1-alkanol derivatives as antiischemic agents
US5656642A (en) * 1993-04-07 1997-08-12 Otsuka Pharmaceutical Co., Ltd. Peripheral vasodilating agent containing piperidine derivative as active ingredient
DE59504622D1 (de) * 1994-10-31 1999-02-04 Merck Patent Gmbh Benzylpiperidinderivate mit hoher Affinität zu Bindungsstellen von Aminosäure-Rezeptoren
ZA9610745B (en) * 1995-12-22 1997-06-24 Warner Lambert Co 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists
ZA9610738B (en) 1995-12-22 1997-06-24 Warner Lambert Co Subtype selective nmda receptor ligands and the use thereof
ZA9610741B (en) 1995-12-22 1997-06-24 Warner Lambert Co 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists
ZA9610736B (en) * 1995-12-22 1997-06-27 Warner Lambert Co 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists
DE19812331A1 (de) * 1998-03-20 1999-09-23 Merck Patent Gmbh Piperidinderivate
FR2823749B1 (fr) * 2001-04-20 2004-02-20 Sanofi Synthelabo Phenyl- et pyridyl-piperidines, procede pour leur preparation et compositions pharmaceutiques les contenant
MY129350A (en) * 2001-04-25 2007-03-30 Bristol Myers Squibb Co Aripiprazole oral solution
DE10210779A1 (de) * 2002-03-12 2003-10-09 Merck Patent Gmbh Cyclische Amide
ATE398615T1 (de) * 2002-03-13 2008-07-15 Janssen Pharmaceutica Nv Piperazinyl-, piperidinyl- und morpholinylderivate als neue inhibitoren von histon-deacetylase
ES2306858T3 (es) * 2002-03-13 2008-11-16 Janssen Pharmaceutica Nv Derivados de carbonilamino como nuevos inhibidores de las histonadesacetilasas.
MXPA04007776A (es) 2002-03-13 2004-10-15 Janssen Pharmaceutica Nv Derivados de sulfonilamino como nuevos inhibidores de histona deacetilasa.
OA12790A (en) 2002-03-13 2006-07-10 Janssen Pharmaceutica Nv New inhibitors of histone deacetylase.
MY142362A (en) * 2004-01-29 2010-11-30 Otsuka Pharma Co Ltd Pharmaceutical composition for promoting angiogenesis
WO2006010750A1 (en) 2004-07-28 2006-02-02 Janssen Pharmaceutica N.V. Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase
RS51189B (sr) * 2004-07-28 2010-10-31 Janssen Pharmaceutica N.V. Supstituisani derivati propenil piperazina kao novi inhibitori histonske deacetilaze
SI1776358T1 (sl) * 2004-07-28 2009-10-31 Janssen Pharmaceutica Nv Substituirani propenil piperazinski derivati kot novi inhibitorji histon-deacetilaze
TWI320783B (en) 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
US8138198B2 (en) 2005-05-18 2012-03-20 Angibaud Patrick Rene Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase
CN101370789B (zh) * 2006-01-19 2012-05-30 詹森药业有限公司 作为组蛋白脱乙酰酶抑制剂的吡啶和嘧啶衍生物
WO2007082874A1 (en) 2006-01-19 2007-07-26 Janssen Pharmaceutica N.V. Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase
JP5137849B2 (ja) * 2006-01-19 2013-02-06 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ヒストンデアセチラーゼのインヒビターとしての置換インドリル−アルキル−アミノ−誘導体
DK1981874T3 (da) * 2006-01-19 2009-09-28 Janssen Pharmactuica N V Aminophenylderivater som nye inhibitorer af histondeacetylase
EP1988077A4 (en) * 2006-02-23 2009-09-02 Shionogi & Co NUCLEIC HETEROCYCLIC DERIVATIVES SUBSTITUTED BY CYCLIC GROUPS
WO2009034029A2 (de) * 2007-09-07 2009-03-19 Boehringer Ingelheim International Gmbh 1-substituierte 4 -heterocyclylpiperidine als cgrp antagonisten
US8575185B2 (en) 2009-02-26 2013-11-05 Reviva Pharmaceuticals, Inc. Compositions, synthesis, and methods of utilizing quinazolinedione derivatives
US9951088B2 (en) * 2012-05-09 2018-04-24 Sunovion Pharmaceuticals Inc. D2 receptor modulators and methods of use thereof in the treatment of diseases and disorders
CN106608875A (zh) 2015-10-26 2017-05-03 江苏恩华药业股份有限公司 一种稠和杂环类衍生物合成及其应用
CN108031471A (zh) * 2017-10-27 2018-05-15 苏州盖德精细材料有限公司 一种静电纺丝制备的负载型纳米纤维催化剂及其在3,5-二羟基甲苯制备中的应用
CN114409680B (zh) * 2018-01-19 2023-11-21 上海怡立舍生物技术有限公司 Ppar激动剂及其应用

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3629266A (en) * 1969-03-03 1971-12-21 Miles Lab (phenyl piperidino alkyl)3 4-dihydrocarbostyrils
US3910924A (en) * 1972-04-13 1975-10-07 Otsuka Pharma Co Ltd 3,4-Dihydrocarbostyril derivatives and a process for preparing the same
JPS5239035B2 (es) * 1972-12-14 1977-10-03
US4068076A (en) * 1972-12-29 1978-01-10 Otsuka Pharmaceutical Co., Ltd. 5-(1-Hydroxy-2-(heterocyclic amino))ethyl-8-hydroxy-3,4-dihydrocarbostyril derivatives
US4022776A (en) * 1974-01-31 1977-05-10 Otsuka Pharmaceutical Company Limited 5-[1-Hydroxy-2-(substituted-amino)]ethyl-8-hydroxycarbostyril derivatives
US4022784A (en) * 1974-01-31 1977-05-10 Otsuka Pharmaceutical Company Limited 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-substituted-carbostyril and -3,4-dihydrocarbostyril derivatives
JPS5310986B2 (es) * 1974-02-05 1978-04-18
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US3994901A (en) * 1974-06-13 1976-11-30 Otsuka Pharmaceutical Company Limited 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-hydroxy-3,4-dihydrocarbostyril derivatives
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DE2827566A1 (de) * 1978-06-23 1980-01-10 Boehringer Mannheim Gmbh 1,2-dihydro-chinolin-2-on-derivate und verfahren zu ihrer herstellung
JPS5527158A (en) * 1978-08-16 1980-02-27 Otsuka Pharmaceut Co Ltd 5-oxo-3,4,5,6,7,8-hexahydrocarbostyril derivative
JPS5583749A (en) * 1978-12-19 1980-06-24 Yoshitomi Pharmaceut Ind Ltd Quinolone derivative
JPS5589221A (en) * 1978-12-28 1980-07-05 Otsuka Pharmaceut Co Ltd Antihistaminic agent
JPS5589222A (en) * 1978-12-28 1980-07-05 Otsuka Pharmaceut Co Ltd Antihistaminic agent
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
FI77852C (fi) * 1981-02-17 1989-05-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av nya, saosom hjaertmediciner anvaendbara substituerade amid- och (maettad heterocykel)karbonylkarbostyrilderivat.
AU532361B2 (en) * 1981-09-01 1983-09-29 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives

Also Published As

Publication number Publication date
DK155282B (da) 1989-03-20
MX6980E (es) 1987-01-19
AU6797381A (en) 1981-09-10
CH647775A5 (de) 1985-02-15
DE3152880C2 (es) 1990-03-22
GB2071094A (en) 1981-09-16
ES8306141A1 (es) 1983-05-01
ES500137A0 (es) 1982-11-01
ES509658A0 (es) 1983-04-01
DK155282C (da) 1989-08-07
US4455422A (en) 1984-06-19
ES518667A0 (es) 1984-06-16
FR2477542B1 (es) 1983-09-09
ES8305356A1 (es) 1983-04-01
DE3107601A1 (de) 1982-02-04
ES8301962A1 (es) 1982-11-01
NO159531C (no) 1989-01-11
FR2477542A1 (fr) 1981-09-11
SU1367857A3 (ru) 1988-01-15
FI76323C (fi) 1988-10-10
ES8405782A1 (es) 1984-06-16
AU523005B2 (en) 1982-07-08
US4567187A (en) 1986-01-28
PT72622B (en) 1982-06-15
NL184364C (nl) 1989-07-03
GB2071094B (en) 1984-09-26
NO810765L (no) 1981-09-07
AT381307B (de) 1986-09-25
US4619932A (en) 1986-10-28
SE447255B (sv) 1986-11-03
IT1144315B (it) 1986-10-29
CA1155119A (en) 1983-10-11
ATA98481A (de) 1986-02-15
FI76323B (fi) 1988-06-30
DK99781A (da) 1981-09-07
DE3107601C2 (es) 1989-07-20
FI810669L (fi) 1981-09-07
IT8167311A0 (it) 1981-03-05
NL8101099A (nl) 1981-10-01
SE8101409L (sv) 1981-09-07
BE887800A (fr) 1981-09-07
NO159531B (no) 1988-10-03
RU1779249C (ru) 1992-11-30
PH17194A (en) 1984-06-19
US4460593A (en) 1984-07-17
NL184364B (nl) 1989-02-01
PT72622A (en) 1981-04-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401