JPS56125370A - Carbostyril derivative - Google Patents

Carbostyril derivative

Info

Publication number
JPS56125370A
JPS56125370A JP2880580A JP2880580A JPS56125370A JP S56125370 A JPS56125370 A JP S56125370A JP 2880580 A JP2880580 A JP 2880580A JP 2880580 A JP2880580 A JP 2880580A JP S56125370 A JPS56125370 A JP S56125370A
Authority
JP
Japan
Prior art keywords
formula
agent
lower alkyl
carbostyril derivative
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2880580A
Other languages
Japanese (ja)
Other versions
JPS6325585B2 (en
Inventor
Kazuhisa Sakano
Takafumi Fujioka
Masaaki Osaki
Kazuyuki Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP2880580A priority Critical patent/JPS56125370A/en
Priority to PH25264A priority patent/PH17194A/en
Priority to DE19813107601 priority patent/DE3107601A1/en
Priority to CA000371904A priority patent/CA1155119A/en
Priority to DE3152880A priority patent/DE3152880C2/de
Priority to AU67973/81A priority patent/AU523005B2/en
Priority to FI810669A priority patent/FI76323C/en
Priority to AT0098481A priority patent/AT381307B/en
Priority to CH1446/81A priority patent/CH647775A5/en
Priority to SU813257001A priority patent/SU1367857A3/en
Priority to FR8104311A priority patent/FR2477542A1/en
Priority to ZA00811438A priority patent/ZA811438B/en
Priority to ES500137A priority patent/ES8301962A1/en
Priority to PT72622A priority patent/PT72622B/en
Priority to DK099781A priority patent/DK155282C/en
Priority to IT67311/81A priority patent/IT1144315B/en
Priority to NO810765A priority patent/NO159531C/en
Priority to BE0/204016A priority patent/BE887800A/en
Priority to SE8101409A priority patent/SE447255B/en
Priority to NLAANVRAGE8101099,A priority patent/NL184364C/en
Priority to MX819337U priority patent/MX6980E/en
Priority to GB8107036A priority patent/GB2071094B/en
Publication of JPS56125370A publication Critical patent/JPS56125370A/en
Priority to ES509659A priority patent/ES509659A0/en
Priority to ES509658A priority patent/ES8305356A1/en
Priority to SU823406699A priority patent/RU1779249C/en
Priority to US06/366,336 priority patent/US4567187A/en
Priority to US06/366,335 priority patent/US4455422A/en
Priority to US06/366,337 priority patent/US4460593A/en
Priority to ES518667A priority patent/ES8405782A1/en
Priority to US06/473,641 priority patent/US4619932A/en
Priority to AT0054184A priority patent/AT387215B/en
Publication of JPS6325585B2 publication Critical patent/JPS6325585B2/ja
Priority to NLAANVRAGE8802223,A priority patent/NL187209C/en
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:A carbostyril derivative of formula I [R1 is H, lower alkyl, phenyl(lower alkyl), lower alkenyl, etc.; R2 is halogen, lower alkyl, lower alkoxy, carboxy, OH, amino, etc.; n is 0 or 1W3; A is C=0 or CHOH; B is lower alkylene] and its salt.
EXAMPLE: 6-[1-Oxo-4-(4-phenylpiperazinyl)butyl]-3,4-dihydrocarbostyril.
USE: Central nervous system depressand and antihistaminic agent. For example, it is useful as a central nervous system relaxant, hypnotic, preoperative agent, antischizophrenic agent, etc. having low side effects.
PROCESS: The compound of formula I is prepared by reacting a carbostyril derivative of formula II (X is halogen, etc.) with a piperazine derivative of formula III.
COPYRIGHT: (C)1981,JPO&Japio
JP2880580A 1980-03-06 1980-03-06 Carbostyril derivative Granted JPS56125370A (en)

Priority Applications (32)

Application Number Priority Date Filing Date Title
JP2880580A JPS56125370A (en) 1980-03-06 1980-03-06 Carbostyril derivative
PH25264A PH17194A (en) 1980-03-06 1981-02-25 Novel carbostyril derivatives,and pharmaceutical composition containing the same
DE19813107601 DE3107601A1 (en) 1980-03-06 1981-02-27 NEW CARBOSTYRILE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOUNDS THAT CONTAIN THEM
CA000371904A CA1155119A (en) 1980-03-06 1981-02-27 Carbostyril derivatives, process for producing thereof and pharmaceutical composition containing the same
DE3152880A DE3152880C2 (en) 1980-03-06 1981-02-27
AU67973/81A AU523005B2 (en) 1980-03-06 1981-03-02 Carbostyril derivatives
FI810669A FI76323C (en) 1980-03-06 1981-03-03 FOERFARANDE FOER FRAMSTAELLNING AV NYA TERAPEUTISKT ANVAENDBARA KARBOSTYRILDERIVAT.
AT0098481A AT381307B (en) 1980-03-06 1981-03-03 METHOD FOR PRODUCING NEW CARBOSTYRILE DERIVATIVES AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS
CH1446/81A CH647775A5 (en) 1980-03-06 1981-03-04 BASICLY SUBSTITUTED CARBOSTYRILE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
SU813257001A SU1367857A3 (en) 1980-03-06 1981-03-04 Method of producing carbostyryl derivatives
FR8104311A FR2477542A1 (en) 1980-03-06 1981-03-04 CARBOSYRILE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
ZA00811438A ZA811438B (en) 1980-03-06 1981-03-04 Carbostyril derivatives, process for producing thereof and pharmaceutica composition containing the same
BE0/204016A BE887800A (en) 1980-03-06 1981-03-05 CARBOSTYRILE DERIVATIVES, PREPARATION METHODS THEREOF AND THERAPEUTIC APPLICATION THEREOF
PT72622A PT72622B (en) 1980-03-06 1981-03-05 Novel carbostyril derivatives process for producing thereof and pharmaceutical composition containing the same
DK099781A DK155282C (en) 1980-03-06 1981-03-05 ANALOGY PROCEDURE FOR THE PREPARATION OF CARBOSTYRIC DERIVATIVES
IT67311/81A IT1144315B (en) 1980-03-06 1981-03-05 CARBOSTYRILIC DERIVATIVES PROCEDURE FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH DERIVATIVES
NO810765A NO159531C (en) 1980-03-06 1981-03-05 ANALOGY PROCEDURE FOR THE PREPARATION OF PHARMASOYYTIC ACTIVE CARBOSTYRIC DERIVATIVES.
ES500137A ES8301962A1 (en) 1980-03-06 1981-03-05 Carbostyril derivatives and pharmaceutical composition containing the same
SE8101409A SE447255B (en) 1980-03-06 1981-03-05 CARBOSTYRIL DERIVATIVES AND PROCEDURES FOR PREPARING THEREOF
NLAANVRAGE8101099,A NL184364C (en) 1980-03-06 1981-03-06 CARBOSTYRIL DERIVATIVES AND THEIR SALTS AND THE PHARMACEUTICAL PREPARATION CONTAINING ONE OR MORE OF SUCH CARBOSTYRIL COMPOUNDS.
MX819337U MX6980E (en) 1980-03-06 1981-03-06 PROCEDURE FOR THE PRODUCTION OF CARBOESTIRILE DERIVATIVES
GB8107036A GB2071094B (en) 1980-03-06 1981-03-06 Carbostyril derivatives processes for their production andpharmaceutical composition containing them
ES509658A ES8305356A1 (en) 1980-03-06 1982-02-16 Carbostyril derivatives and pharmaceutical composition containing the same
ES509659A ES509659A0 (en) 1980-03-06 1982-02-16 A PROCEDURE FOR THE PRODUCTION OF A CARBOSTIRILE DERIVATIVE
SU823406699A RU1779249C (en) 1980-03-06 1982-03-18 Process for production of carbostyril derivatives (version)
US06/366,336 US4567187A (en) 1980-03-06 1982-04-07 Carbostyril derivatives and antihistaminic agents containing the carbostyril derivatives
US06/366,335 US4455422A (en) 1980-03-06 1982-04-07 Carbostyril derivatives and pharmaceutical composition containing the same
US06/366,337 US4460593A (en) 1980-03-06 1982-04-07 Carbostyril derivatives, and central nervous system controlling agents containing the carbostyril derivatives
ES518667A ES8405782A1 (en) 1980-03-06 1982-12-29 Carbostyril derivatives and pharmaceutical composition containing the same
US06/473,641 US4619932A (en) 1980-03-06 1983-03-09 Novel carbostyril derivatives, process for producing thereof and pharmaceutical composition containing the same
AT0054184A AT387215B (en) 1980-03-06 1984-02-17 METHOD FOR PRODUCING NEW CARBOSTYRILE DERIVATIVES AND THEIR SALTS
NLAANVRAGE8802223,A NL187209C (en) 1980-03-06 1988-09-09 CARBOSTYRIL DERIVATIVES AND A PHARMACEUTICAL PREPARATION CONTAINING ONE OR MORE OF SUCH CARBOSTYRIL DERIVATIVES.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2880580A JPS56125370A (en) 1980-03-06 1980-03-06 Carbostyril derivative

Publications (2)

Publication Number Publication Date
JPS56125370A true JPS56125370A (en) 1981-10-01
JPS6325585B2 JPS6325585B2 (en) 1988-05-26

Family

ID=12258630

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2880580A Granted JPS56125370A (en) 1980-03-06 1980-03-06 Carbostyril derivative

Country Status (2)

Country Link
JP (1) JPS56125370A (en)
ZA (1) ZA811438B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0249769A (en) * 1989-06-26 1990-02-20 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JP2006513167A (en) * 2002-11-21 2006-04-20 グラクソ　グループ　リミテッド Benzoxazinone derivatives, their preparation and their use in the treatment of CNS and other disorders
JP2018536652A (en) * 2015-10-26 2018-12-13 エヌエイチダブリュエイ、ファーマ．コーポレイションＮｈｗａ Ｐｈａｒｍａ． Ｃｏｒｐｏｒａｔｉｏｎ Fused heterocyclic compound derivatives and applications thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5416478A (en) * 1977-07-08 1979-02-07 Otsuka Pharmaceut Co Ltd 3,4-dihydrocarbostyril herivative

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5416478A (en) * 1977-07-08 1979-02-07 Otsuka Pharmaceut Co Ltd 3,4-dihydrocarbostyril herivative

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0249769A (en) * 1989-06-26 1990-02-20 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JP2006513167A (en) * 2002-11-21 2006-04-20 グラクソ　グループ　リミテッド Benzoxazinone derivatives, their preparation and their use in the treatment of CNS and other disorders
JP4741842B2 (en) * 2002-11-21 2011-08-10 グラクソ グループ リミテッド Benzoxazinone derivatives, their preparation and their use in the treatment of CNS and other disorders
JP2018536652A (en) * 2015-10-26 2018-12-13 エヌエイチダブリュエイ、ファーマ．コーポレイションＮｈｗａ Ｐｈａｒｍａ． Ｃｏｒｐｏｒａｔｉｏｎ Fused heterocyclic compound derivatives and applications thereof
US10517862B2 (en) 2015-10-26 2019-12-31 Nhwa Pharma. Corporation Fused heterocyclic compound derivative and application thereof

Also Published As

Publication number Publication date
ZA811438B (en) 1982-03-31
JPS6325585B2 (en) 1988-05-26

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