JPS5738772A - Carbostyril derivative - Google Patents

Carbostyril derivative

Info

Publication number
JPS5738772A
JPS5738772A JP11502280A JP11502280A JPS5738772A JP S5738772 A JPS5738772 A JP S5738772A JP 11502280 A JP11502280 A JP 11502280A JP 11502280 A JP11502280 A JP 11502280A JP S5738772 A JPS5738772 A JP S5738772A
Authority
JP
Japan
Prior art keywords
formula
alkyl
compound
halogen
carbostyril derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP11502280A
Other languages
Japanese (ja)
Other versions
JPS6320430B2 (en
Inventor
Kazuhisa Sakano
Takafumi Fujioka
Masaaki Osaki
Kazuyuki Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP11502280A priority Critical patent/JPS5738772A/en
Priority to PH25264A priority patent/PH17194A/en
Priority to DE3152880A priority patent/DE3152880C2/de
Priority to CA000371904A priority patent/CA1155119A/en
Priority to DE19813107601 priority patent/DE3107601A1/en
Priority to AU67973/81A priority patent/AU523005B2/en
Priority to AT0098481A priority patent/AT381307B/en
Priority to FI810669A priority patent/FI76323C/en
Priority to SU813257001A priority patent/SU1367857A3/en
Priority to CH1446/81A priority patent/CH647775A5/en
Priority to FR8104311A priority patent/FR2477542A1/en
Priority to IT67311/81A priority patent/IT1144315B/en
Priority to PT72622A priority patent/PT72622B/en
Priority to NO810765A priority patent/NO159531C/en
Priority to ES500137A priority patent/ES8301962A1/en
Priority to DK099781A priority patent/DK155282C/en
Priority to SE8101409A priority patent/SE447255B/en
Priority to BE0/204016A priority patent/BE887800A/en
Priority to NLAANVRAGE8101099,A priority patent/NL184364C/en
Priority to MX819337U priority patent/MX6980E/en
Priority to GB8107036A priority patent/GB2071094B/en
Priority to KR1019810000730A priority patent/KR850000024B1/en
Priority to ES509658A priority patent/ES8305356A1/en
Priority to ES509659A priority patent/ES509659A0/en
Publication of JPS5738772A publication Critical patent/JPS5738772A/en
Priority to SU823406699A priority patent/RU1779249C/en
Priority to US06/366,336 priority patent/US4567187A/en
Priority to US06/366,335 priority patent/US4455422A/en
Priority to US06/366,337 priority patent/US4460593A/en
Priority to ES518667A priority patent/ES8405782A1/en
Priority to US06/473,641 priority patent/US4619932A/en
Priority to AT0054184A priority patent/AT387215B/en
Priority to KR1019840006213A priority patent/KR850001796B1/en
Publication of JPS6320430B2 publication Critical patent/JPS6320430B2/ja
Priority to NLAANVRAGE8802223,A priority patent/NL187209C/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

NEW MATERIAL:A compound of formula I [R1 is H, alkyl, phenylalkyl, alkenyl, etc.; (R2)m are halogen, alkyl, alkoxyl, carboxy, alkanoyl, OH, NH2, etc.; m is 0 or an integer 1W3; adjacent (R2)2 link to form an alkylenedioxy group; A is CH= CR3 or CH2C(R3)H (R3 is H or alkyl); B is alkylene; l is 0 or 1; the bond between the 3- and the 4-positions of the carbostyril dkeleton is single or double bond] or a salt thereof.
EXAMPLE: 6-[1-Hydroxy-3-[4-(2-methoxyphenyl)piperazinyl]propyl]-3,4-dihydrocarbostyril.
USE: A central nervous depressant and antihistaminic agent.
PROCESS: A compound of formula II (X is halogen, alkanesulfonyloxy, etc.) is reacted with a piperazine derivative of formula III to give the compound of formula I.
COPYRIGHT: (C)1982,JPO&Japio
JP11502280A 1980-03-06 1980-08-20 Carbostyril derivative Granted JPS5738772A (en)

Priority Applications (33)

Application Number Priority Date Filing Date Title
JP11502280A JPS5738772A (en) 1980-08-20 1980-08-20 Carbostyril derivative
PH25264A PH17194A (en) 1980-03-06 1981-02-25 Novel carbostyril derivatives,and pharmaceutical composition containing the same
DE3152880A DE3152880C2 (en) 1980-03-06 1981-02-27
CA000371904A CA1155119A (en) 1980-03-06 1981-02-27 Carbostyril derivatives, process for producing thereof and pharmaceutical composition containing the same
DE19813107601 DE3107601A1 (en) 1980-03-06 1981-02-27 NEW CARBOSTYRILE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOUNDS THAT CONTAIN THEM
AU67973/81A AU523005B2 (en) 1980-03-06 1981-03-02 Carbostyril derivatives
AT0098481A AT381307B (en) 1980-03-06 1981-03-03 METHOD FOR PRODUCING NEW CARBOSTYRILE DERIVATIVES AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS
FI810669A FI76323C (en) 1980-03-06 1981-03-03 FOERFARANDE FOER FRAMSTAELLNING AV NYA TERAPEUTISKT ANVAENDBARA KARBOSTYRILDERIVAT.
SU813257001A SU1367857A3 (en) 1980-03-06 1981-03-04 Method of producing carbostyryl derivatives
CH1446/81A CH647775A5 (en) 1980-03-06 1981-03-04 BASICLY SUBSTITUTED CARBOSTYRILE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
FR8104311A FR2477542A1 (en) 1980-03-06 1981-03-04 CARBOSYRILE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
BE0/204016A BE887800A (en) 1980-03-06 1981-03-05 CARBOSTYRILE DERIVATIVES, PREPARATION METHODS THEREOF AND THERAPEUTIC APPLICATION THEREOF
PT72622A PT72622B (en) 1980-03-06 1981-03-05 Novel carbostyril derivatives process for producing thereof and pharmaceutical composition containing the same
NO810765A NO159531C (en) 1980-03-06 1981-03-05 ANALOGY PROCEDURE FOR THE PREPARATION OF PHARMASOYYTIC ACTIVE CARBOSTYRIC DERIVATIVES.
ES500137A ES8301962A1 (en) 1980-03-06 1981-03-05 Carbostyril derivatives and pharmaceutical composition containing the same
DK099781A DK155282C (en) 1980-03-06 1981-03-05 ANALOGY PROCEDURE FOR THE PREPARATION OF CARBOSTYRIC DERIVATIVES
SE8101409A SE447255B (en) 1980-03-06 1981-03-05 CARBOSTYRIL DERIVATIVES AND PROCEDURES FOR PREPARING THEREOF
IT67311/81A IT1144315B (en) 1980-03-06 1981-03-05 CARBOSTYRILIC DERIVATIVES PROCEDURE FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH DERIVATIVES
NLAANVRAGE8101099,A NL184364C (en) 1980-03-06 1981-03-06 CARBOSTYRIL DERIVATIVES AND THEIR SALTS AND THE PHARMACEUTICAL PREPARATION CONTAINING ONE OR MORE OF SUCH CARBOSTYRIL COMPOUNDS.
MX819337U MX6980E (en) 1980-03-06 1981-03-06 PROCEDURE FOR THE PRODUCTION OF CARBOESTIRILE DERIVATIVES
GB8107036A GB2071094B (en) 1980-03-06 1981-03-06 Carbostyril derivatives processes for their production andpharmaceutical composition containing them
KR1019810000730A KR850000024B1 (en) 1980-08-20 1981-03-06 Process for preparing carbonstyril derivatives
ES509658A ES8305356A1 (en) 1980-03-06 1982-02-16 Carbostyril derivatives and pharmaceutical composition containing the same
ES509659A ES509659A0 (en) 1980-03-06 1982-02-16 A PROCEDURE FOR THE PRODUCTION OF A CARBOSTIRILE DERIVATIVE
SU823406699A RU1779249C (en) 1980-03-06 1982-03-18 Process for production of carbostyril derivatives (version)
US06/366,337 US4460593A (en) 1980-03-06 1982-04-07 Carbostyril derivatives, and central nervous system controlling agents containing the carbostyril derivatives
US06/366,336 US4567187A (en) 1980-03-06 1982-04-07 Carbostyril derivatives and antihistaminic agents containing the carbostyril derivatives
US06/366,335 US4455422A (en) 1980-03-06 1982-04-07 Carbostyril derivatives and pharmaceutical composition containing the same
ES518667A ES8405782A1 (en) 1980-03-06 1982-12-29 Carbostyril derivatives and pharmaceutical composition containing the same
US06/473,641 US4619932A (en) 1980-03-06 1983-03-09 Novel carbostyril derivatives, process for producing thereof and pharmaceutical composition containing the same
AT0054184A AT387215B (en) 1980-03-06 1984-02-17 METHOD FOR PRODUCING NEW CARBOSTYRILE DERIVATIVES AND THEIR SALTS
KR1019840006213A KR850001796B1 (en) 1980-08-20 1984-10-06 Process for preparing carbostyril derivatives
NLAANVRAGE8802223,A NL187209C (en) 1980-03-06 1988-09-09 CARBOSTYRIL DERIVATIVES AND A PHARMACEUTICAL PREPARATION CONTAINING ONE OR MORE OF SUCH CARBOSTYRIL DERIVATIVES.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11502280A JPS5738772A (en) 1980-08-20 1980-08-20 Carbostyril derivative

Publications (2)

Publication Number Publication Date
JPS5738772A true JPS5738772A (en) 1982-03-03
JPS6320430B2 JPS6320430B2 (en) 1988-04-27

Family

ID=14652294

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11502280A Granted JPS5738772A (en) 1980-03-06 1980-08-20 Carbostyril derivative

Country Status (2)

Country Link
JP (1) JPS5738772A (en)
KR (2) KR850000024B1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH071028B2 (en) * 1983-11-02 1995-01-11 ミッチェル・マシュー・ピー Stirling cycle engine and heat pump

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH071028B2 (en) * 1983-11-02 1995-01-11 ミッチェル・マシュー・ピー Stirling cycle engine and heat pump

Also Published As

Publication number Publication date
JPS6320430B2 (en) 1988-04-27
KR830005205A (en) 1983-08-03
KR850001796B1 (en) 1985-12-21
KR850000024B1 (en) 1985-02-11
KR850003304A (en) 1985-06-13

Similar Documents

Publication Publication Date Title
ES8400422A1 (en) Tricyclic ethers, process for their preparation and their use in pharmaceutical preparations.
ES8503666A1 (en) 1-Aryloxy-2,3,4,5-tetrahydro-3-benzazepines, a process for preparing the same and their use as medicaments.
JPS5649378A (en) Tetrazolylalkoxycarbostyril derivative
JPS5649361A (en) Carbostyril derivative
ES8506652A1 (en) Dibenzodiazepin derivatives, a process for their preparation and their use as medicaments.
JPS5649364A (en) Carbostyril derivative
JPS5738772A (en) Carbostyril derivative
AU575197B2 (en) 2-(3,5-dislkyl -4- hydroxyphenyl) indole derivatives
ES8306143A1 (en) 1,5-Diphenylpyrazolin-3-one compounds, process and intermediates for their preparation and medicines containing these compounds.
JPS57142972A (en) Carbostyril derivative
ES8801895A1 (en) Benzamides and salts.
ES8400743A1 (en) 1-Phenylindazol-3-one compounds, process and intermediates for their preparation and medicines containing these compounds.
ES8506641A1 (en) 1-Acetonyl-2-(phenylimino)-imidazolidines, their addition salts, their pharmaceutical compositions and their preparation.
JPS56125370A (en) Carbostyril derivative
ES8604912A1 (en) 4-(Arylpiperazinylethylaminoethoxy) phenol derivatives, process for their preparation and their therapeutical application.
ES8604146A1 (en) Piperidine derivatives, process for their preparation and pharmaceutical compositions containing them.
JPS5649359A (en) Carbostyril derivative
JPS5726670A (en) Acrylonitrile derivative
EP0089635A3 (en) Phospholipid derivatives, process for preparation thereof and pharmaceutical composition of the same
JPS5576872A (en) Imidazolidinone derivative
ES8105981A1 (en) 4-(Naphthalenyloxy)piperidine Derivatives
JPS56156263A (en) Carbostyril derivative
JPS5524127A (en) 3,6-endomethylene-delta4-1,2,3,6-tetrahydrophtalimide derivative
JPS57145872A (en) Carbostyrile derivative
JPS56164186A (en) Carbostyril derivative