JPS5527158A - 5-oxo-3,4,5,6,7,8-hexahydrocarbostyril derivative - Google Patents
5-oxo-3,4,5,6,7,8-hexahydrocarbostyril derivativeInfo
- Publication number
- JPS5527158A JPS5527158A JP10024578A JP10024578A JPS5527158A JP S5527158 A JPS5527158 A JP S5527158A JP 10024578 A JP10024578 A JP 10024578A JP 10024578 A JP10024578 A JP 10024578A JP S5527158 A JPS5527158 A JP S5527158A
- Authority
- JP
- Japan
- Prior art keywords
- hexahydrocarbostyril
- oxo
- formula
- derivative
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:5-Oxo-3,4,5,6,7,8-hexahydrocarbostyril derivatives of formula I (R is H, lower alkyl, phenyl or others) or their acid adducts. EXAMPLE:6-(1-piperidinomethyl)-5-oxo-3,4,5,6,7,8-hexahydrocarbostyril. USE:Tranquilizer. PREPARATION:The reaction between 5-oxo-3,4,5,6,7,8-hexahydrocarbostyril, formaldehyde and a piperidine of formula II is carried out in an inert solvent as THF in the presence of a catalyst of mineral acid as sulfuric acid at 50-100 deg.C to form title compound of formula I.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10024578A JPS5527158A (en) | 1978-08-16 | 1978-08-16 | 5-oxo-3,4,5,6,7,8-hexahydrocarbostyril derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10024578A JPS5527158A (en) | 1978-08-16 | 1978-08-16 | 5-oxo-3,4,5,6,7,8-hexahydrocarbostyril derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5527158A true JPS5527158A (en) | 1980-02-27 |
JPS617193B2 JPS617193B2 (en) | 1986-03-04 |
Family
ID=14268849
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10024578A Granted JPS5527158A (en) | 1978-08-16 | 1978-08-16 | 5-oxo-3,4,5,6,7,8-hexahydrocarbostyril derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5527158A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4460593A (en) * | 1980-03-06 | 1984-07-17 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives, and central nervous system controlling agents containing the carbostyril derivatives |
US5681839A (en) * | 1994-02-10 | 1997-10-28 | John Wyeth & Brother | Nitrogen heterocycles |
-
1978
- 1978-08-16 JP JP10024578A patent/JPS5527158A/en active Granted
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4460593A (en) * | 1980-03-06 | 1984-07-17 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives, and central nervous system controlling agents containing the carbostyril derivatives |
US5681839A (en) * | 1994-02-10 | 1997-10-28 | John Wyeth & Brother | Nitrogen heterocycles |
Also Published As
Publication number | Publication date |
---|---|
JPS617193B2 (en) | 1986-03-04 |
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