JPS5527158A - 5-oxo-3,4,5,6,7,8-hexahydrocarbostyril derivative - Google Patents

5-oxo-3,4,5,6,7,8-hexahydrocarbostyril derivative

Info

Publication number
JPS5527158A
JPS5527158A JP10024578A JP10024578A JPS5527158A JP S5527158 A JPS5527158 A JP S5527158A JP 10024578 A JP10024578 A JP 10024578A JP 10024578 A JP10024578 A JP 10024578A JP S5527158 A JPS5527158 A JP S5527158A
Authority
JP
Japan
Prior art keywords
hexahydrocarbostyril
oxo
formula
derivative
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10024578A
Other languages
Japanese (ja)
Other versions
JPS617193B2 (en
Inventor
Yukio Higuchi
Takahiko Kawaguchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP10024578A priority Critical patent/JPS5527158A/en
Publication of JPS5527158A publication Critical patent/JPS5527158A/en
Publication of JPS617193B2 publication Critical patent/JPS617193B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:5-Oxo-3,4,5,6,7,8-hexahydrocarbostyril derivatives of formula I (R is H, lower alkyl, phenyl or others) or their acid adducts. EXAMPLE:6-(1-piperidinomethyl)-5-oxo-3,4,5,6,7,8-hexahydrocarbostyril. USE:Tranquilizer. PREPARATION:The reaction between 5-oxo-3,4,5,6,7,8-hexahydrocarbostyril, formaldehyde and a piperidine of formula II is carried out in an inert solvent as THF in the presence of a catalyst of mineral acid as sulfuric acid at 50-100 deg.C to form title compound of formula I.
JP10024578A 1978-08-16 1978-08-16 5-oxo-3,4,5,6,7,8-hexahydrocarbostyril derivative Granted JPS5527158A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10024578A JPS5527158A (en) 1978-08-16 1978-08-16 5-oxo-3,4,5,6,7,8-hexahydrocarbostyril derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10024578A JPS5527158A (en) 1978-08-16 1978-08-16 5-oxo-3,4,5,6,7,8-hexahydrocarbostyril derivative

Publications (2)

Publication Number Publication Date
JPS5527158A true JPS5527158A (en) 1980-02-27
JPS617193B2 JPS617193B2 (en) 1986-03-04

Family

ID=14268849

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10024578A Granted JPS5527158A (en) 1978-08-16 1978-08-16 5-oxo-3,4,5,6,7,8-hexahydrocarbostyril derivative

Country Status (1)

Country Link
JP (1) JPS5527158A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4460593A (en) * 1980-03-06 1984-07-17 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives, and central nervous system controlling agents containing the carbostyril derivatives
US5681839A (en) * 1994-02-10 1997-10-28 John Wyeth & Brother Nitrogen heterocycles

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4460593A (en) * 1980-03-06 1984-07-17 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives, and central nervous system controlling agents containing the carbostyril derivatives
US5681839A (en) * 1994-02-10 1997-10-28 John Wyeth & Brother Nitrogen heterocycles

Also Published As

Publication number Publication date
JPS617193B2 (en) 1986-03-04

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