ES245891U - Estructura de parche cutaneo util para la administracion de una choga - Google Patents

Estructura de parche cutaneo util para la administracion de una choga

Info

Publication number
ES245891U
ES245891U ES1977245891U ES245891U ES245891U ES 245891 U ES245891 U ES 245891U ES 1977245891 U ES1977245891 U ES 1977245891U ES 245891 U ES245891 U ES 245891U ES 245891 U ES245891 U ES 245891U
Authority
ES
Spain
Prior art keywords
clonidine
skin
transdermally
therapeutic system
mcg
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES1977245891U
Other languages
English (en)
Other versions
ES245891Y (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CH Boehringer Sohn AG and Co KG
Alza Corp
Original Assignee
CH Boehringer Sohn AG and Co KG
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CH Boehringer Sohn AG and Co KG, Alza Corp filed Critical CH Boehringer Sohn AG and Co KG
Publication of ES245891U publication Critical patent/ES245891U/es
Application granted granted Critical
Publication of ES245891Y publication Critical patent/ES245891Y/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/06—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/32—Layered products comprising a layer of synthetic resin comprising polyolefins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2323/00—Polyalkenes
    • B32B2323/10—Polypropylene
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2556/00—Patches, e.g. medical patches, repair patches

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

1.Estructura de parche cutáneo útil para la administración de una droga continua y transdérmicamente a una velocidad controlada a través de una superficie predeterminada de la piel, durante un período de tiempo prolongado, caracterizada porque la droga en la clonidina y la velocidad es suficiente para producir una estimulación alfa-adrenergica y va opcionalmente precedida de una dósis de cebadura de clonidina. 2.La estructura, según la reivindicación 1, caracterizada además porque la droga es la 2, 6 dicloro-N-2 imidazolidinilidenbencenamina. 3.La estructura, según la reivindicación 2, caracterizada además porque la estimulación alfadrenérgica es fundamental una estimulación alfa- adrenergica central. 4.La estructura , según al reivindicación 3, caracterizada además porque la velocidad es tal que proporciona terapia de la hipertensión o terapia de la migraña. 5.La estructura, según la reivindicación 2, caracterizada además porque la velocidad ese sustancialmente constante y está comprendidaentre 0,1 y 100 mcg/h y la dosis de cebadura está comprendida entre 10 y 300 mcg/cm{sup,2} de superficie de la piel. 6.La estructura, según la reivindicación 2, caracterizado además porque la velocidad es sustancialmente constante y está comprendida, entre 0,2 y 70 mcg/h. Y la dosis de cebadura está comprendida entre 150 y 250 mcg/cm{sup,2}. De superficie de la piel. 7.La estructura , según la reivindicación 2, caracterizada además porque el sistema incluye una capa reservorio citada suficiente para suministra dicha bencenamina a la velocidad mencionada durante el periodo de tiempo prolongado indicado, dispersada en una mezcla gelificada de un líquido inerte orgánico, apolar, no volátil, y una mezcla de poliisobutenos, siendo el tamaño de partícula (diámetro promedio en número, de la bencenamina de 5 a 20 micras. 8.La estructura, según la reivindicación 7, caracterizada además porque la cantidad de la bencenamina en el reservorio es de 1 a 6 mg.el líquido inerte es aceite mineral de 10 a100 cp. A 25ºC y constituye de 35 a 65 por 100 del peso de la mezcla gelificada y la mezcla de poliisobutenos constituye del 35 al 65 por 100 de la mezcla gelificada y está formada por un poliisobuteno de bajo molecular y un poliisobuteno de alto peso molecular. 9.La estructura, según la reivindicación 7, caracterizada además porque la mezcla gelificada está constituida por 35 a 65 por 100 en peso de aceite mineral de 10 a 100 cp. A 25ºC, 10 a 40 por 100 de poliisobuteno con un peso molecular promedio por viscosidad de 35.000 a 50.000 y 10 a 40 por 100 en peso de poliisobuteno cn un peso molecular promedio de viscosidad de 1.000.000 a 1.500.000. 10.La estructura, según la reivindicación 7, caracterizada además porque el sistema también incluye una capa de refuerzo que es impermeable a la bencenamina y forma la parte superior del sistema, una capa membranosa microporosa adyacente al reservorio y a través de la cual es liberada de bencenamina desde el resevorio a la velocidad citada después deque el sistema ha sido fijado a la superficie de la piel y una capa adhesiva de contacto que es permeable a la bencenamina y opcionalmente contiene la dosis de cebadura de la bencenamina. 11.La estructura , según la reivindicación 10, caracterizado además porque la capa membranosa microporosa es¿ta formada por polipropileno, tiene una porosidad de 0,1 a 0,85 una tortuosidad de 1 a 10 y un espesor de 10{sup,3} y 10{sup,2} cm. Y el adhesivo de contacto está formado por dicha mezcla gelificada. 12.Estructura de parche cutáneo útil para la administración de una droga.
ES1977245891U 1977-07-12 1977-10-04 Estructura de parche cutaneo util para la administracion de una choga Expired ES245891Y (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/815,033 US4201211A (en) 1977-07-12 1977-07-12 Therapeutic system for administering clonidine transdermally

Publications (2)

Publication Number Publication Date
ES245891U true ES245891U (es) 1980-06-01
ES245891Y ES245891Y (es) 1980-12-16

Family

ID=25216676

Family Applications (2)

Application Number Title Priority Date Filing Date
ES1977245891U Expired ES245891Y (es) 1977-07-12 1977-10-04 Estructura de parche cutaneo util para la administracion de una choga
ES472073A Expired ES472073A1 (es) 1977-07-12 1978-07-26 Un procedimiento de construccion de un sistema terapeutico mejorado en forma de parche cutaneo para la administracion de un droga continua.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES472073A Expired ES472073A1 (es) 1977-07-12 1978-07-26 Un procedimiento de construccion de un sistema terapeutico mejorado en forma de parche cutaneo para la administracion de un droga continua.

Country Status (34)

Country Link
US (1) US4201211A (es)
JP (1) JPS5420129A (es)
AR (1) AR218037A1 (es)
AT (1) AT362884B (es)
AU (1) AU512328B2 (es)
BE (1) BE862585A (es)
BG (1) BG29866A3 (es)
CA (1) CA1089362A (es)
CH (1) CH646876A5 (es)
CS (1) CS216917B2 (es)
DD (1) DD135566A5 (es)
DE (1) DE2755661C2 (es)
DK (1) DK159375C (es)
ES (2) ES245891Y (es)
FI (1) FI772754A (es)
FR (1) FR2397190A1 (es)
GB (1) GB1577259A (es)
GR (1) GR61591B (es)
HU (1) HU179397B (es)
IE (1) IE46069B1 (es)
IL (1) IL52839A (es)
IT (1) IT1104643B (es)
LU (1) LU78845A1 (es)
NL (1) NL189800C (es)
NO (1) NO772955L (es)
NZ (1) NZ185000A (es)
PH (1) PH16059A (es)
PL (1) PL113984B1 (es)
PT (1) PT67128B (es)
RO (1) RO75336A (es)
SE (1) SE7709731L (es)
SU (1) SU1005650A3 (es)
YU (1) YU41594B (es)
ZA (1) ZA775848B (es)

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NL7710213A (nl) 1979-01-16
RO75336A (ro) 1980-12-30
NZ185000A (en) 1979-08-31
PL204853A1 (pl) 1979-09-10
AU2846277A (en) 1979-03-08
ATA905877A (de) 1980-11-15
DK159375C (da) 1991-03-18
IE46069B1 (en) 1983-02-09
JPS5420129A (en) 1979-02-15
GB1577259A (en) 1980-10-22
PL113984B1 (en) 1981-01-31
US4201211A (en) 1980-05-06
ZA775848B (en) 1978-08-30
BE862585A (fr) 1978-05-02
IL52839A0 (en) 1977-10-31
DE2755661C2 (de) 1986-05-22
HU179397B (en) 1982-10-28
ES245891Y (es) 1980-12-16
GR61591B (en) 1978-12-02
ES472073A1 (es) 1979-03-16
LU78845A1 (fr) 1979-09-06
NL189800C (nl) 1993-08-02

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