EA201190158A1 - Производные бензофуранила для применения в качестве ингибиторов глюкокиназы - Google Patents

Производные бензофуранила для применения в качестве ингибиторов глюкокиназы

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Publication number
EA201190158A1
EA201190158A1 EA201190158A EA201190158A EA201190158A1 EA 201190158 A1 EA201190158 A1 EA 201190158A1 EA 201190158 A EA201190158 A EA 201190158A EA 201190158 A EA201190158 A EA 201190158A EA 201190158 A1 EA201190158 A1 EA 201190158A1
Authority
EA
Eurasian Patent Office
Prior art keywords
benzofuranyl
derivatives
kinase inhibitors
glucose kinase
glucose
Prior art date
Application number
EA201190158A
Other languages
English (en)
Other versions
EA018894B1 (ru
Inventor
Энтони Лэй Линг
Джеффри Аллен Пфефферкорн
Original Assignee
Пфайзер Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42124287&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201190158(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Пфайзер Инк. filed Critical Пфайзер Инк.
Publication of EA201190158A1 publication Critical patent/EA201190158A1/ru
Publication of EA018894B1 publication Critical patent/EA018894B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

В настоящем изобретении предложены соединения формулы (I), обладающие активностью в качестве активаторов глюкокиназы; их фармацевтические композиции и способы лечения заболеваний, расстройств или состояний, опосредованных глюкокиназой.
EA201190158A 2009-03-11 2010-03-04 N,n-диметил-5-(2-метил-6-((5-метилпиразин-2-ил)карбамоил)бензо-фуран-4-илокси)пиримидин-2-карбоксамид, используемый в качестве активатора глюкокиназы, и содержащая его фармацев-тическая композиция EA018894B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15909909P 2009-03-11 2009-03-11
PCT/IB2010/050943 WO2010103437A1 (en) 2009-03-11 2010-03-04 Benzofuranyl derivatives used as glucokinase inhibitors

Publications (2)

Publication Number Publication Date
EA201190158A1 true EA201190158A1 (ru) 2012-04-30
EA018894B1 EA018894B1 (ru) 2013-11-29

Family

ID=42124287

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201190158A EA018894B1 (ru) 2009-03-11 2010-03-04 N,n-диметил-5-(2-метил-6-((5-метилпиразин-2-ил)карбамоил)бензо-фуран-4-илокси)пиримидин-2-карбоксамид, используемый в качестве активатора глюкокиназы, и содержащая его фармацев-тическая композиция

Country Status (38)

Country Link
US (2) US8455496B2 (ru)
EP (2) EP2406253B1 (ru)
JP (1) JP5086480B2 (ru)
KR (1) KR101295937B1 (ru)
CN (1) CN102388038B (ru)
AP (1) AP3179A (ru)
AR (1) AR075729A1 (ru)
AU (1) AU2010222589B2 (ru)
BR (1) BRPI1013246B1 (ru)
CA (1) CA2754681C (ru)
CL (1) CL2011002185A1 (ru)
CO (1) CO6430427A2 (ru)
CR (1) CR20110467A (ru)
CU (1) CU24036B1 (ru)
DK (1) DK2406253T3 (ru)
DO (1) DOP2011000279A (ru)
EA (1) EA018894B1 (ru)
EC (1) ECSP11011306A (ru)
ES (1) ES2427279T3 (ru)
GE (1) GEP20156239B (ru)
HK (1) HK1164281A1 (ru)
HR (1) HRP20130661T1 (ru)
IL (1) IL214942A (ru)
MA (1) MA33119B1 (ru)
MY (1) MY151246A (ru)
NI (1) NI201100166A (ru)
NZ (1) NZ595024A (ru)
PE (1) PE20120668A1 (ru)
PL (1) PL2406253T3 (ru)
PT (1) PT2406253E (ru)
RS (1) RS52903B (ru)
SI (1) SI2406253T1 (ru)
TN (1) TN2011000454A1 (ru)
TW (1) TWI383981B (ru)
UA (1) UA99882C2 (ru)
UY (1) UY32480A (ru)
WO (1) WO2010103437A1 (ru)
ZA (1) ZA201106632B (ru)

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