MX2009011951A - Compuestos y composiciones como inhibidores de cinasa c-kit y pdgfr. - Google Patents
Compuestos y composiciones como inhibidores de cinasa c-kit y pdgfr.Info
- Publication number
- MX2009011951A MX2009011951A MX2009011951A MX2009011951A MX2009011951A MX 2009011951 A MX2009011951 A MX 2009011951A MX 2009011951 A MX2009011951 A MX 2009011951A MX 2009011951 A MX2009011951 A MX 2009011951A MX 2009011951 A MX2009011951 A MX 2009011951A
- Authority
- MX
- Mexico
- Prior art keywords
- compounds
- kit
- compositions
- kinase inhibitors
- pdgfr kinase
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Abstract
La invención proporciona una clase novedosa de compuestos, composiciones farmacéuticas que comprenden estos compuestos, y métodos para utilizar tales compuestos con el fin de tratar o prevenir enfermedades o trastornos asociados con una actividad de cinasa anormal o mal regulada, en particular las enfermedades o trastornos que involucren una activación anormal de las cinasas c-kit, PDGFRa y PDGFRß.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91605107P | 2007-05-04 | 2007-05-04 | |
PCT/US2008/062568 WO2008137794A1 (en) | 2007-05-04 | 2008-05-02 | Compounds and compositions as c-kit and pdgfr kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009011951A true MX2009011951A (es) | 2009-12-11 |
Family
ID=39595782
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009011951A MX2009011951A (es) | 2007-05-04 | 2008-05-02 | Compuestos y composiciones como inhibidores de cinasa c-kit y pdgfr. |
Country Status (11)
Country | Link |
---|---|
US (1) | US8338417B2 (es) |
EP (1) | EP2152688A1 (es) |
JP (1) | JP5160637B2 (es) |
KR (1) | KR101145520B1 (es) |
CN (1) | CN101720322A (es) |
AU (1) | AU2008247442B2 (es) |
BR (1) | BRPI0811516A2 (es) |
CA (1) | CA2686382C (es) |
EA (1) | EA019524B1 (es) |
MX (1) | MX2009011951A (es) |
WO (1) | WO2008137794A1 (es) |
Families Citing this family (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE544761T1 (de) | 2007-05-04 | 2012-02-15 | Irm Llc | Pyrimidinderivate und zusammensetzungen als c-kit-und pdgfr-kinasehemmer |
AU2008289135B2 (en) | 2007-08-22 | 2012-02-23 | Irm Llc | 2-heteroarylamino-pyrimidine derivatives as kinase inhibitors |
MX2010002004A (es) | 2007-08-22 | 2010-03-11 | Irm Llc | Compuestos de 5-(4-(halo-alcoxi)-fenil)-pirimidin-2-amina y composiciones con inhibidores de cinasa. |
CL2009000400A1 (es) | 2008-02-22 | 2010-09-10 | Irm Llc | Compuestos heterociclicos derivados de 3-fenil-1,6- naftiridin-2-ona; moduladores de la actividad cinasa; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como trastornos alergicos, trastornos autoinmunes, neoplasias, rechazo en trasplante de organos, entre otras. |
EP2350075B1 (en) | 2008-09-22 | 2014-03-05 | Array Biopharma, Inc. | Substituted imidazo[1,2b]pyridazine compounds as trk kinase inhibitors |
PT2350071E (pt) | 2008-10-22 | 2014-04-11 | Array Biopharma Inc | Compostos de pirazol[1,5-a]pirimidina substituídos como inibidores da cinase trk |
EP2356102A1 (en) * | 2008-11-14 | 2011-08-17 | Bayer CropScience AG | Substituted (pyridyl)-azinylamine derivatives as plant protection agents |
AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
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AU2011331161A1 (en) * | 2010-11-17 | 2013-05-02 | Novartis Ag | 3-(aminoaryl)-pyridine compounds |
US9168245B2 (en) | 2011-07-27 | 2015-10-27 | Ab Science | Selective protein kinase inhibitors |
TWI519515B (zh) | 2011-12-21 | 2016-02-01 | 諾維拉治療公司 | B型肝炎抗病毒劑 |
BR112015004192B1 (pt) | 2012-08-28 | 2021-02-09 | Janssen Sciences Ireland Uc | sulfamoíl-arilamidas, composição farmacêutica que os compreende e uso das mesmas no tratamento da hepatite b |
KR101942151B1 (ko) | 2012-12-27 | 2019-01-24 | 드렉셀유니버시티 | Hbv 감염에 대한 항바이러스 물질 |
CN105142624A (zh) | 2013-01-10 | 2015-12-09 | 普尔莫凯恩股份有限公司 | 非选择性激酶抑制剂 |
DK2961732T3 (en) | 2013-02-28 | 2017-07-10 | Janssen Sciences Ireland Uc | SULFAMOYLARYLAMIDS AND USE THEREOF AS MEDICINES TO TREAT HEPATITIS B |
US8993771B2 (en) | 2013-03-12 | 2015-03-31 | Novira Therapeutics, Inc. | Hepatitis B antiviral agents |
BR112015025052A2 (pt) | 2013-04-03 | 2021-07-06 | Janssen Sciences Ireland Uc | derivados de n-fenil-carboxamida e o seu uso como medicamentos para o tratamento da hepatite b |
JO3603B1 (ar) | 2013-05-17 | 2020-07-05 | Janssen Sciences Ireland Uc | مشتقات سلفامويل بيرولاميد واستخدامها كادوية لمعالجة التهاب الكبد نوع بي |
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CN104458675A (zh) * | 2013-09-12 | 2015-03-25 | 中国药科大学 | 一种筛选干细胞因子受体激酶抑制剂高通量筛选方法 |
CN104458674A (zh) * | 2013-09-12 | 2015-03-25 | 中国药科大学 | 一种筛选血管内皮生长因子1激酶抑制剂高通量筛选方法 |
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KR20090130427A (ko) | 2009-12-23 |
WO2008137794A1 (en) | 2008-11-13 |
AU2008247442A1 (en) | 2008-11-13 |
CN101720322A (zh) | 2010-06-02 |
KR101145520B1 (ko) | 2012-05-16 |
JP5160637B2 (ja) | 2013-03-13 |
CA2686382C (en) | 2013-09-17 |
CA2686382A1 (en) | 2008-11-13 |
BRPI0811516A2 (pt) | 2014-11-18 |
EA019524B1 (ru) | 2014-04-30 |
US8338417B2 (en) | 2012-12-25 |
EP2152688A1 (en) | 2010-02-17 |
EA200901486A1 (ru) | 2010-06-30 |
AU2008247442B2 (en) | 2013-01-10 |
US20100234406A1 (en) | 2010-09-16 |
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