MA32723B1 - Derives d'anilino-pyrimidine a substitution sulfoximine en tant qu'inhibiteurs de cdk, leur preparation et leur utilisation comme medicaments - Google Patents
Derives d'anilino-pyrimidine a substitution sulfoximine en tant qu'inhibiteurs de cdk, leur preparation et leur utilisation comme medicamentsInfo
- Publication number
- MA32723B1 MA32723B1 MA33786A MA33786A MA32723B1 MA 32723 B1 MA32723 B1 MA 32723B1 MA 33786 A MA33786 A MA 33786A MA 33786 A MA33786 A MA 33786A MA 32723 B1 MA32723 B1 MA 32723B1
- Authority
- MA
- Morocco
- Prior art keywords
- anilino
- drugs
- preparation
- sulfoximine
- marked
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
Abstract
L'INVENTION PORTE SUR DES DÉRIVÉS D'ANILINO-PYRIMIDINE À SUBSTITUTION SULFOXIMINE DE FORMULE (I), SUR DES PROCÉDÉS POUR LES PRÉPARER, AINSI QUE SUR LEUR UTILISATION EN TANT QUE MÉDICAMENTS POUR LE TRAITEMENT DE DIFFÉRENTES MALADIES.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08167113A EP2179991A1 (fr) | 2008-10-21 | 2008-10-21 | Dérivés d'anilino-pyrimidine substitués par sulfoximine en tant qu'inhibiteurs de CDK, leur fabrication et leur utilisation en tant que médicaments |
PCT/EP2009/007247 WO2010046035A1 (fr) | 2008-10-21 | 2009-10-09 | Dérivés d'anilino-pyrimidine à substitution sulfoximine en tant qu'inhibiteurs de cdk, leur préparation et leur utilisation comme médicaments |
Publications (1)
Publication Number | Publication Date |
---|---|
MA32723B1 true MA32723B1 (fr) | 2011-10-02 |
Family
ID=40282208
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA33786A MA32723B1 (fr) | 2008-10-21 | 2011-04-20 | Derives d'anilino-pyrimidine a substitution sulfoximine en tant qu'inhibiteurs de cdk, leur preparation et leur utilisation comme medicaments |
Country Status (38)
Country | Link |
---|---|
US (1) | US8735412B2 (fr) |
EP (2) | EP2179991A1 (fr) |
JP (1) | JP5564054B2 (fr) |
KR (1) | KR20110069115A (fr) |
CN (1) | CN102197029B (fr) |
AR (1) | AR074053A1 (fr) |
AU (1) | AU2009306733C1 (fr) |
BR (1) | BRPI0920112A2 (fr) |
CA (1) | CA2739739C (fr) |
CO (1) | CO6361926A2 (fr) |
CR (1) | CR20110210A (fr) |
CU (1) | CU24052B1 (fr) |
CY (1) | CY1115590T1 (fr) |
DK (1) | DK2350026T3 (fr) |
DO (1) | DOP2011000107A (fr) |
EA (1) | EA019230B1 (fr) |
EC (1) | ECSP11010992A (fr) |
ES (1) | ES2499028T3 (fr) |
HN (1) | HN2011001019A (fr) |
HR (1) | HRP20140830T1 (fr) |
IL (1) | IL211713A (fr) |
MA (1) | MA32723B1 (fr) |
MX (1) | MX2011004238A (fr) |
MY (1) | MY155230A (fr) |
NZ (1) | NZ592314A (fr) |
PA (1) | PA8846201A1 (fr) |
PE (1) | PE20110546A1 (fr) |
PL (1) | PL2350026T3 (fr) |
PT (1) | PT2350026E (fr) |
RS (1) | RS53523B1 (fr) |
SA (1) | SA109300632B1 (fr) |
SI (1) | SI2350026T1 (fr) |
TN (1) | TN2011000199A1 (fr) |
TW (2) | TWI458716B (fr) |
UA (1) | UA103500C2 (fr) |
UY (1) | UY32190A (fr) |
WO (1) | WO2010046035A1 (fr) |
ZA (1) | ZA201103727B (fr) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2464633A1 (fr) | 2009-08-14 | 2012-06-20 | Boehringer Ingelheim International GmbH | Préparation régiosélective de dérivés de 2-amino-5-trifluorométhylpyrimidine |
US8933227B2 (en) | 2009-08-14 | 2015-01-13 | Boehringer Ingelheim International Gmbh | Selective synthesis of functionalized pyrimidines |
DE102010014427A1 (de) | 2010-04-01 | 2011-10-06 | Bayer Schering Pharma Aktiengesellschaft | Kombinationen neuer pan-CDK-Inhibitoren zur Behandlung von Tumoren |
DE102010014426A1 (de) | 2010-04-01 | 2011-10-06 | Bayer Schering Pharma Aktiengesellschaft | Verwendung neuer pan-CDK-Inhibitoren zur Behandlung von Tumoren |
DE102010046720A1 (de) * | 2010-09-23 | 2012-03-29 | Bayer Schering Pharma Aktiengesellschaft | Verfahren zur Herstellung von pan-CDK-Inhibitoren der Formel (l), sowie Intermediate der Herstellung |
TW201636330A (zh) * | 2011-05-24 | 2016-10-16 | 拜耳知識產權公司 | 含有硫醯亞胺基團之4-芳基-n-苯基-1,3,5-三氮雜苯-2-胺 |
DE102011080991A1 (de) | 2011-08-16 | 2013-02-21 | Bayer Pharma AG | Verwendung von CCNE2 als Stratifikationsmarker bei der Behandlung von Brusttumoren mit neuen pan-CDK-Inhibitoren |
DE102011080992A1 (de) * | 2011-08-16 | 2013-02-21 | Bayer Pharma AG | Verwendung von MAD2L2 als Stratifikationsmarker bei der Behandlung von Brusttumoren mit neuen pan-CDK-Inhibitoren |
US9133171B2 (en) | 2011-09-16 | 2015-09-15 | Bayer Intellectual Property Gmbh | Disubstituted 5-fluoro pyrimidine derivatives containing a sulfoximine group |
MX2014011240A (es) * | 2012-03-21 | 2014-10-15 | Bayer Ip Gmbh | Uso de (rs)-s-ciclopropil-s-(4-{[4-{[(1r, 2r)-2-hidroxi-1-metilpro pil]oxi}-5-(trifluorometil)pirimidin-2-il]amino}fenil)sulfoximida para el tratamiento de tumores especificos. |
WO2016059086A1 (fr) * | 2014-10-16 | 2016-04-21 | Bayer Pharma Aktiengesellschaft | Dérivés de benzofuranyle-pyrimidine fluorés contenant un groupe sulfoximine |
JP2022500388A (ja) | 2018-09-10 | 2022-01-04 | ミラティ セラピューティクス, インコーポレイテッド | 組み合わせ療法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4029650A1 (de) | 1990-09-19 | 1992-03-26 | Hoechst Ag | 2-anilino-pyrimidine, verfahren zu ihrer herstellung, sie enthaltene mittel und ihre verwendung als fungizide |
EP1017394B1 (fr) | 1997-07-12 | 2005-12-07 | Cancer Research Technology Limited | Derives de purine inhibant la kinase dependant de la cycline |
US6440965B1 (en) | 1997-10-15 | 2002-08-27 | Krenitsky Pharmaceuticals, Inc. | Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system |
US6632820B1 (en) | 1998-08-29 | 2003-10-14 | Astrazeneca Ab | Pyrimidine compounds |
GB9828511D0 (en) | 1998-12-24 | 1999-02-17 | Zeneca Ltd | Chemical compounds |
GB9919778D0 (en) | 1999-08-21 | 1999-10-27 | Zeneca Ltd | Chemical compounds |
GB0016877D0 (en) | 2000-07-11 | 2000-08-30 | Astrazeneca Ab | Chemical compounds |
AU2002312933B2 (en) | 2001-05-29 | 2007-12-06 | Schering Ag | CDK inhibiting pyrimidines, production thereof and their use as medicaments |
AU2003212282A1 (en) * | 2002-03-11 | 2003-09-22 | Schering Aktiengesellschaft | Cdk inhibiting 2-heteroaryl pyrimidine, the production thereof, and use thereof as a medicament |
US7504410B2 (en) | 2002-11-28 | 2009-03-17 | Schering Aktiengesellschaft | Chk-, Pdk- and Akt-inhibitory pyrimidines, their production and use as pharmaceutical agents |
DE10349423A1 (de) | 2003-10-16 | 2005-06-16 | Schering Ag | Sulfoximinsubstituierte Parimidine als CDK- und/oder VEGF-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel |
JP2008514571A (ja) * | 2004-09-29 | 2008-05-08 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | 細胞周期−キナーゼまたはレセプター−チロシン−キナーゼインヒビターとしての置換2−置換アニリノピリミジン類、それらの製造および薬剤としての使用 |
DE102005062742A1 (de) | 2005-12-22 | 2007-06-28 | Bayer Schering Pharma Ag | Sulfoximin substituierte Pyrimidine, Verfahren zu deren Herstellung und ihre Verwendung als Arzneimittel |
DE102006027156A1 (de) * | 2006-06-08 | 2007-12-13 | Bayer Schering Pharma Ag | Sulfimide als Proteinkinaseinhibitoren |
EP2179992A1 (fr) * | 2008-10-21 | 2010-04-28 | Bayer Schering Pharma Aktiengesellschaft | Dérivés d'anilino-pyrimidine substitués par sulfone en tant qu'inhibiteurs de CDK, leur fabrication et leur utilisation en tant que médicaments |
-
2008
- 2008-10-21 EP EP08167113A patent/EP2179991A1/fr not_active Withdrawn
-
2009
- 2009-10-09 BR BRPI0920112A patent/BRPI0920112A2/pt not_active IP Right Cessation
- 2009-10-09 DK DK09778874.9T patent/DK2350026T3/da active
- 2009-10-09 MY MYPI2011001632A patent/MY155230A/en unknown
- 2009-10-09 JP JP2011532519A patent/JP5564054B2/ja not_active Expired - Fee Related
- 2009-10-09 PT PT97788749T patent/PT2350026E/pt unknown
- 2009-10-09 RS RSP20140466 patent/RS53523B1/en unknown
- 2009-10-09 KR KR1020117009024A patent/KR20110069115A/ko active IP Right Grant
- 2009-10-09 PE PE2011000917A patent/PE20110546A1/es not_active Application Discontinuation
- 2009-10-09 UA UAA201106183A patent/UA103500C2/uk unknown
- 2009-10-09 CA CA2739739A patent/CA2739739C/fr not_active Expired - Fee Related
- 2009-10-09 US US13/125,066 patent/US8735412B2/en not_active Expired - Fee Related
- 2009-10-09 EP EP09778874.9A patent/EP2350026B1/fr active Active
- 2009-10-09 AU AU2009306733A patent/AU2009306733C1/en not_active Ceased
- 2009-10-09 CN CN200980141978.7A patent/CN102197029B/zh not_active Expired - Fee Related
- 2009-10-09 EA EA201100623A patent/EA019230B1/ru not_active IP Right Cessation
- 2009-10-09 SI SI200931004T patent/SI2350026T1/sl unknown
- 2009-10-09 ES ES09778874.9T patent/ES2499028T3/es active Active
- 2009-10-09 NZ NZ592314A patent/NZ592314A/xx not_active IP Right Cessation
- 2009-10-09 PL PL09778874T patent/PL2350026T3/pl unknown
- 2009-10-09 WO PCT/EP2009/007247 patent/WO2010046035A1/fr active Application Filing
- 2009-10-09 MX MX2011004238A patent/MX2011004238A/es active IP Right Grant
- 2009-10-19 PA PA20098846201A patent/PA8846201A1/es unknown
- 2009-10-20 UY UY0001032190A patent/UY32190A/es not_active Application Discontinuation
- 2009-10-20 SA SA109300632A patent/SA109300632B1/ar unknown
- 2009-10-21 TW TW098135674A patent/TWI458716B/zh not_active IP Right Cessation
- 2009-10-21 AR ARP090104043A patent/AR074053A1/es not_active Application Discontinuation
- 2009-10-21 TW TW103126302A patent/TWI496774B/zh not_active IP Right Cessation
-
2011
- 2011-03-14 IL IL211713A patent/IL211713A/en not_active IP Right Cessation
- 2011-04-15 HN HN2011001019A patent/HN2011001019A/es unknown
- 2011-04-20 CU CU2011000088A patent/CU24052B1/es active IP Right Grant
- 2011-04-20 TN TN2011000199A patent/TN2011000199A1/fr unknown
- 2011-04-20 CO CO11049624A patent/CO6361926A2/es active IP Right Grant
- 2011-04-20 EC EC2011010992A patent/ECSP11010992A/es unknown
- 2011-04-20 DO DO2011000107A patent/DOP2011000107A/es unknown
- 2011-04-20 MA MA33786A patent/MA32723B1/fr unknown
- 2011-04-25 CR CR20110210A patent/CR20110210A/es unknown
- 2011-05-20 ZA ZA2011/03727A patent/ZA201103727B/en unknown
-
2014
- 2014-09-03 HR HRP20140830AT patent/HRP20140830T1/hr unknown
- 2014-09-05 CY CY20141100717T patent/CY1115590T1/el unknown
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