DK1159274T3 - Fremgangsmåde til fremstilling af citalopram - Google Patents

Fremgangsmåde til fremstilling af citalopram

Info

Publication number
DK1159274T3
DK1159274T3 DK99968622T DK99968622T DK1159274T3 DK 1159274 T3 DK1159274 T3 DK 1159274T3 DK 99968622 T DK99968622 T DK 99968622T DK 99968622 T DK99968622 T DK 99968622T DK 1159274 T3 DK1159274 T3 DK 1159274T3
Authority
DK
Denmark
Prior art keywords
citalopram
preparation
Prior art date
Application number
DK99968622T
Other languages
Danish (da)
English (en)
Inventor
Hans Petersen
Michael Harold Rock
Henrik Svane
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Application granted granted Critical
Publication of DK1159274T3 publication Critical patent/DK1159274T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
    • B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
    • B01J23/44—Palladium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Materials Engineering (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
DK99968622T 1999-06-25 1999-11-22 Fremgangsmåde til fremstilling af citalopram DK1159274T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA199900920 1999-06-25
PCT/DK1999/000640 WO2000013648A2 (en) 1999-06-25 1999-11-22 Method for the preparation of citalopram

Publications (1)

Publication Number Publication Date
DK1159274T3 true DK1159274T3 (da) 2003-07-21

Family

ID=8099035

Family Applications (2)

Application Number Title Priority Date Filing Date
DK99968622T DK1159274T3 (da) 1999-06-25 1999-11-22 Fremgangsmåde til fremstilling af citalopram
DK200100060A DK200100060A (da) 1999-06-25 2001-01-15 Fremgangsmåde til fremstilling af citalopram

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK200100060A DK200100060A (da) 1999-06-25 2001-01-15 Fremgangsmåde til fremstilling af citalopram

Country Status (36)

Country Link
US (2) US20020077353A1 (pl)
EP (1) EP1159274B1 (pl)
JP (1) JP3447267B2 (pl)
KR (1) KR100491368B1 (pl)
CN (2) CN1502616A (pl)
AR (1) AR020863A1 (pl)
AT (3) ATE235478T1 (pl)
AU (2) AU1374500A (pl)
BG (1) BG65574B1 (pl)
BR (1) BR9917368B1 (pl)
CA (2) CA2475401A1 (pl)
CH (1) CH691305A5 (pl)
CZ (1) CZ292198B6 (pl)
DE (2) DE19983487C1 (pl)
DK (2) DK1159274T3 (pl)
EA (1) EA002560B1 (pl)
ES (2) ES2194545T3 (pl)
FI (1) FI108641B (pl)
GB (2) GB2354239B (pl)
HK (1) HK1049002B (pl)
HU (1) HUP0103235A3 (pl)
IL (2) IL145959A0 (pl)
IS (1) IS2343B (pl)
IT (1) ITMI991581A1 (pl)
MX (1) MXPA01010989A (pl)
NO (1) NO328542B1 (pl)
NZ (1) NZ514979A (pl)
PL (1) PL205579B1 (pl)
PT (1) PT1159274E (pl)
SE (1) SE516690C2 (pl)
SI (1) SI1159274T1 (pl)
SK (1) SK285813B6 (pl)
TR (1) TR200103702T2 (pl)
UA (1) UA63034C2 (pl)
WO (1) WO2000013648A2 (pl)
ZA (1) ZA200108854B (pl)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL203275B1 (pl) 1998-12-23 2009-09-30 Lundbeck & Co As H Sposób wytwarzania 5-cyjanoftalidu
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
AU759716B2 (en) 1999-04-14 2003-04-17 H. Lundbeck A/S Method for the preparation of citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
GB2360281B (en) 1999-10-25 2002-01-16 Lundbeck & Co As H Method for the preparation of citalopram
DE69935355T2 (de) 1999-10-25 2007-11-08 H. Lundbeck A/S, Valby Verfahren zur Herstellung von Citalopram
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
CZ20022213A3 (cs) 1999-12-28 2002-09-11 H. Lundbeck A/S Způsob výroby citalopramu
DK1246813T3 (da) 1999-12-30 2004-03-01 Lundbeck & Co As H Fremgangsmåde til fremstilling af Citalopram
UA72569C2 (uk) 2000-01-14 2005-03-15 Х. Луннбек А/С Спосіб одержання 5-ціанофталіду
FR2805812A1 (fr) 2000-02-24 2001-09-07 Lundbeck & Co As H Procede de preparation du citalopram
NL1017417C1 (nl) 2000-03-03 2001-03-16 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
CZ20023100A3 (cs) * 2000-03-13 2003-02-12 H. Lundbeck A/S Způsob výroby citalopramu
GB2357762B (en) * 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
CZ20023384A3 (cs) 2000-03-13 2003-01-15 H. Lundbeck A/S Způsob výroby citalopramu a meziprodukt
BR0109268A (pt) 2000-03-14 2002-12-03 Lundbeck & Co As H Método de preparação de citalopram, composto e citaplopram
WO2001068632A1 (en) * 2000-03-16 2001-09-20 H. Lundbeck A/S Method for the preparation of 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
IL148525A0 (en) * 2000-07-06 2002-09-12 Lundbeck & Co As H Method for the preparation of citalopram
IL144817A0 (en) * 2000-08-18 2002-06-30 Lundbeck & Co As H Method for the preparation of citalopram
EP1181713B1 (en) * 2000-12-22 2004-09-29 H. Lundbeck A/S Method for the preparation of pure citalopram
BR0106271A (pt) * 2000-12-28 2002-05-21 Lundbeck & Co As H Processo para preparação de citalopram puro
CA2435925A1 (en) 2001-01-30 2002-08-08 Orion Corporation Fermion Process for the preparation of 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
GB0105627D0 (en) * 2001-03-07 2001-04-25 Cipla Ltd Preparation of phthalanes
RU2003130073A (ru) * 2001-03-09 2005-04-10 Ранбакси Лабораторис Лимитед (In) Способ получения циталопрама
US6967259B2 (en) * 2001-09-24 2005-11-22 Pharmachem Technologies Limited Process for the preparation of Citalopram intermediate
US7148364B2 (en) * 2002-01-07 2006-12-12 Sun Pharmaceutical Industries Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran carbonitrile
AR040970A1 (es) 2002-08-12 2005-04-27 Lundbeck & Co As H Metodo para la separacion de intermediarios que pueden ser utilizados para la preparacion de escitalopram
WO2004085416A1 (en) * 2003-03-24 2004-10-07 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
EP1486492A3 (en) 2003-06-10 2005-02-23 Sun Pharmaceuticals Industries Ltd. A process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran.
TWI339651B (en) 2004-02-12 2011-04-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
EP2141156A1 (en) 2004-08-23 2010-01-06 Sun Pharma Global FZE Process for Preparation of Citalopram and Enantiomers
US7834201B2 (en) 2005-06-22 2010-11-16 H. Lundbeck A/S Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
TWI358407B (en) 2005-06-22 2012-02-21 Lundbeck & Co As H Crystalline base of escitalopram and orodispersibl
EP2017271A1 (en) 2007-07-06 2009-01-21 Aurobindo Pharma Limited Process for the preparation of escitalopram

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143703A (pl) * 1965-03-18
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
DK213290D0 (da) * 1990-09-06 1990-09-06 Lundbeck & Co As H Treatment of cerebrovascular disorders
US5296507A (en) * 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DE19626659A1 (de) * 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) * 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
DE69801764T2 (de) * 1997-07-08 2002-07-04 H. Lundbeck A/S, Kobenhavn-Valby Verfahren zur herstellung von citalopram
UA62985C2 (en) * 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
CZ292911B6 (cs) * 1997-11-11 2004-01-14 H. Lundbeck A/S Způsob výroby citalopramu
EP1123284B1 (en) * 1998-10-20 2003-01-08 H. Lundbeck A/S Method for the preparation of citalopram
PL203275B1 (pl) * 1998-12-23 2009-09-30 Lundbeck & Co As H Sposób wytwarzania 5-cyjanoftalidu
AR022329A1 (es) * 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
AU759716B2 (en) * 1999-04-14 2003-04-17 H. Lundbeck A/S Method for the preparation of citalopram
ITMI991579A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
GB2360281B (en) * 1999-10-25 2002-01-16 Lundbeck & Co As H Method for the preparation of citalopram
AR026063A1 (es) * 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
FR2805812A1 (fr) * 2000-02-24 2001-09-07 Lundbeck & Co As H Procede de preparation du citalopram
IES20010143A2 (en) * 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
IL144817A0 (en) * 2000-08-18 2002-06-30 Lundbeck & Co As H Method for the preparation of citalopram
EP1181713B1 (en) * 2000-12-22 2004-09-29 H. Lundbeck A/S Method for the preparation of pure citalopram
BR0106271A (pt) * 2000-12-28 2002-05-21 Lundbeck & Co As H Processo para preparação de citalopram puro

Also Published As

Publication number Publication date
CA2290127C (en) 2005-01-25
EA002560B1 (ru) 2002-06-27
WO2000013648A8 (en) 2000-05-11
IS2343B (is) 2008-02-15
MXPA01010989A (es) 2002-06-04
GB2354239B (en) 2001-06-06
IL145959A0 (en) 2002-07-25
DK200100060A (da) 2001-04-10
EP1159274B1 (en) 2003-03-26
FI20010155A (fi) 2001-02-09
CA2475401A1 (en) 2000-12-25
DE69906389D1 (de) 2003-04-30
DE19983487C1 (de) 2002-07-25
CN1367786A (zh) 2002-09-04
BG65574B1 (bg) 2009-01-30
KR20020012204A (ko) 2002-02-15
US20020077353A1 (en) 2002-06-20
CZ292198B6 (cs) 2003-08-13
NO20010319D0 (no) 2001-01-19
NO328542B1 (no) 2010-03-15
WO2000013648B1 (en) 2001-03-15
WO2000013648A3 (en) 2000-07-13
SK18402001A3 (sk) 2002-06-04
ITMI991581A1 (it) 2001-01-15
ES2194545T3 (es) 2003-11-16
ITMI991581A0 (it) 1999-07-15
BR9917368B1 (pt) 2010-02-09
JP2002526386A (ja) 2002-08-20
JP3447267B2 (ja) 2003-09-16
CN1140521C (zh) 2004-03-03
ATE235478T1 (de) 2003-04-15
GB2357761B (en) 2001-09-05
AT4365U1 (de) 2001-06-25
HUP0103235A2 (hu) 2002-01-28
BG106191A (en) 2002-08-30
CN1502616A (zh) 2004-06-09
PL346237A1 (en) 2002-01-28
GB2357761A (en) 2001-07-04
CA2290127A1 (en) 2000-12-25
KR100491368B1 (ko) 2005-05-24
SE516690C2 (sv) 2002-02-12
IL145959A (en) 2007-07-24
CZ2001320A3 (en) 2001-05-16
GB2354239A (en) 2001-03-21
WO2000013648A2 (en) 2000-03-16
GB0101504D0 (en) 2001-03-07
AU2001100440A4 (en) 2001-11-01
SE0100193L (sv) 2001-04-25
CH691305A5 (de) 2001-06-29
AT409961B (de) 2002-12-27
PT1159274E (pt) 2003-08-29
EA200101072A1 (ru) 2002-02-28
UA63034C2 (en) 2004-01-15
SK285813B6 (sk) 2007-08-02
ES2189699A1 (es) 2003-07-01
BR9917368A (pt) 2002-03-05
ZA200108854B (en) 2002-08-28
EP1159274A2 (en) 2001-12-05
NO20010319L (no) 2001-02-23
GB0105182D0 (en) 2001-04-18
SE0100193D0 (sv) 2001-01-24
NZ514979A (en) 2004-01-30
IS5861A (is) 2001-02-23
AU2001100440B4 (en) 2002-01-24
US20090088469A1 (en) 2009-04-02
ATA904199A (de) 2002-05-15
AR020863A1 (es) 2002-05-29
PL205579B1 (pl) 2010-05-31
HK1049002A1 (en) 2003-04-25
HUP0103235A3 (en) 2003-01-28
FI108641B (fi) 2002-02-28
HK1049002B (zh) 2004-12-31
TR200103702T2 (tr) 2002-06-21
DE69906389T2 (de) 2003-10-30
AU1374500A (en) 2000-03-27
SI1159274T1 (en) 2003-10-31

Similar Documents

Publication Publication Date Title
DK1173431T3 (da) Fremgangsmåde til fremstilling af citalopram
DK1105382T3 (da) Fremgangsmåde til fremstilling af citalopram
DK1159274T3 (da) Fremgangsmåde til fremstilling af citalopram
DK1123284T3 (da) Fremgangsmåde til fremstilling af citalopram
DK1032566T5 (da) Fremgangsmåde til fremstilling af citalopram
DK1309581T3 (da) Fremgangsmåde til fremstilling af citalopram
DK1150966T3 (da) Fremgangsmåde til fremstilling af 5-cyanophthalid
DK1296935T3 (da) Fremgangsmåde til fremstilling af substituerede octanoylamider
DK1181272T3 (da) Fremgangsmåde til fremstilling af rent citalopram
DK1181713T3 (da) Fremgangsmåde til fremstilling af rent citalopram
DK1165576T3 (da) Fremgangsmåde til fremstilling af amin-platin-komplekser
DK1140886T3 (da) Fremgangsmåde til fremstilling af 5-cyanophtalid
DK1187833T3 (da) Fremgangsmåde til fremstilling af thiamethoxam
DK1296970T3 (da) Fremgangsmåde til fremstilling af citalopram
DK1228056T3 (da) Fremgangsmåde til fremstilling af citalopram
DK0973769T3 (da) Fremgangsmåde til fremstilling af eprosartan
NO20021118D0 (no) Fremgangsmåte for fremstilling av citalopram
DK0970073T3 (da) Fremgangsmåde til fremstilling af eprosartan
DK1203000T3 (da) Fremgangsmåde til fremstilling af phosphonomethylglycin
DK1240173T3 (da) Fremgangsmåde til fremstilling af N-phosphonomethylglycin
DK1012152T3 (da) Fremgangsmåde til fremstilling af oxazaphosphorin-2-aminer
DK1029867T3 (da) Fremgangsmåde til fremstilling af organiske azider
DK0949246T3 (da) Fremgangsmåde til fremstilling af phenoxyphenylsulfonylhalogenider
DK1226125T3 (da) Fremgangsmåde til fremstilling af mavesårsmidler
DK0949237T3 (da) Fremgangsmåde til fremstilling af dihydrocitral