AR022329A1 - Metodo para la preparacion de 5-cianoftalida - Google Patents

Metodo para la preparacion de 5-cianoftalida

Info

Publication number
AR022329A1
AR022329A1 ARP000100271A ARP000100271A AR022329A1 AR 022329 A1 AR022329 A1 AR 022329A1 AR P000100271 A ARP000100271 A AR P000100271A AR P000100271 A ARP000100271 A AR P000100271A AR 022329 A1 AR022329 A1 AR 022329A1
Authority
AR
Argentina
Prior art keywords
cyanoftalide
preparation
cyanophthalamide
carboxyphthalide
sulphonamide
Prior art date
Application number
ARP000100271A
Other languages
English (en)
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of AR022329A1 publication Critical patent/AR022329A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Furan Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Un método para la preparacion de 5-cianoftalida en la cual la 5-carboxiftalida se hace reaccionar con un agente deshidratante, tal como cloruro de tionilo,y una sulfonamida, particularmente, sulfamida. La cianoftalida se prepara con altosrendimiento s mediante un proceso conveniente de costo efectivo. La5-cianoftalida es un intermediario importante para la preparacion de la droga antidepresiva citalopram.
ARP000100271A 1999-01-29 2000-01-21 Metodo para la preparacion de 5-cianoftalida AR022329A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA199900128 1999-01-29

Publications (1)

Publication Number Publication Date
AR022329A1 true AR022329A1 (es) 2002-09-04

Family

ID=8090069

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000100271A AR022329A1 (es) 1999-01-29 2000-01-21 Metodo para la preparacion de 5-cianoftalida

Country Status (31)

Country Link
US (1) US6441201B1 (es)
EP (1) EP1150966B1 (es)
JP (1) JP2002535397A (es)
KR (1) KR100430327B1 (es)
CN (1) CN1158271C (es)
AR (1) AR022329A1 (es)
AT (1) ATE222900T1 (es)
AU (1) AU763666B2 (es)
BG (1) BG64924B1 (es)
BR (1) BR0008978A (es)
CA (1) CA2361395C (es)
CZ (1) CZ300257B6 (es)
DE (1) DE60000364T2 (es)
DK (1) DK1150966T3 (es)
EA (1) EA003257B1 (es)
ES (1) ES2180508T3 (es)
HK (1) HK1044342B (es)
HU (1) HUP0104976A3 (es)
IL (2) IL144114A0 (es)
IS (1) IS2223B (es)
IT (1) IT1317741B1 (es)
NO (1) NO326532B1 (es)
NZ (1) NZ512775A (es)
PL (1) PL198385B1 (es)
PT (1) PT1150966E (es)
SI (1) SI1150966T1 (es)
SK (1) SK284367B6 (es)
TR (1) TR200102135T2 (es)
UA (1) UA70987C2 (es)
WO (1) WO2000044738A1 (es)
ZA (1) ZA200105549B (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU228576B1 (en) 1998-10-20 2013-04-29 Lundbeck & Co As H Method for the preparation of citalopram
CA2356188C (en) 1998-12-23 2006-05-23 H. Lundbeck A/S Method for the preparation of 5-cyanophthalide
TR200102957T2 (tr) 1999-04-14 2004-12-21 H. Lundbeck A/S Sitalopram hazırlanması için metod.
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ES2169709A1 (es) 1999-10-25 2002-07-01 Lundbeck & Co As H Metodo para la preparacion de citalopram
DK1298124T3 (da) 1999-10-25 2007-07-09 Lundbeck & Co As H Fremgangsmåde til fremstilling af citalopram
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
SI1246812T1 (en) 1999-12-28 2004-08-31 H. Lundbeck A/S Method for the preparation of citalopram
PT1246813E (pt) 1999-12-30 2004-02-27 Lundbeck & Co As H Metodo para a preparacao de citalopram
EA005134B1 (ru) 2000-01-14 2004-12-30 Х.Лундбекк А/С Способ получения 5-цианофталида
FR2805812A1 (fr) 2000-02-24 2001-09-07 Lundbeck & Co As H Procede de preparation du citalopram
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
CN1427835A (zh) * 2000-03-13 2003-07-02 H·隆德贝克有限公司 5－取代的1－(4－氟苯基)－1,3－二氢异苯并呋喃的分步烷基化
IES20010206A2 (en) 2000-03-13 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
NZ521201A (en) 2000-03-13 2004-02-27 H Method for the preparation of citalopram
ATE257832T1 (de) 2000-03-14 2004-01-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
WO2001068632A1 (en) * 2000-03-16 2001-09-20 H. Lundbeck A/S Method for the preparation of 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
IL144817A0 (en) * 2000-08-18 2002-06-30 Lundbeck & Co As H Method for the preparation of citalopram
EP1181713B1 (en) 2000-12-22 2004-09-29 H. Lundbeck A/S Method for the preparation of pure citalopram
PT1181272E (pt) 2000-12-28 2003-01-31 Lundbeck & Co As H Processo para a preparacao de citalopram puro
GR1004635B (el) * 2001-08-14 2004-07-14 H@Αlundbeckαa@Sαα Μεθοδοσαπαρασκευησατησασιταλοπραμης@αα
EP1321464A1 (en) * 2001-12-21 2003-06-25 ICROM S.p.A. Process for the preparation of 5-cyanophthalide and intermediates useful therein
TWI306846B (en) 2002-08-12 2009-03-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
US7687645B2 (en) 2003-03-21 2010-03-30 H. Lundbeck A/S Intermediates for the preparation of citalopram and escitalopram
US20050154052A1 (en) * 2003-03-24 2005-07-14 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
EP1777221A1 (en) * 2005-10-14 2007-04-25 Adorkem Technology SpA Process for the preparation of 5-cyanophthalide starting from 5-carboxyphthalide

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143702A (es) 1965-03-18
GB1526331A (en) 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
PT1015416E (pt) 1997-07-08 2002-03-28 Lundbeck & Co As H Metodo para a producao de citalopram
UA62985C2 (en) * 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
AU738359B2 (en) 1997-11-11 2001-09-13 H. Lundbeck A/S Method for the preparation of citalopram
HU228576B1 (en) 1998-10-20 2013-04-29 Lundbeck & Co As H Method for the preparation of citalopram
CA2356188C (en) 1998-12-23 2006-05-23 H. Lundbeck A/S Method for the preparation of 5-cyanophthalide
TR200102957T2 (tr) 1999-04-14 2004-12-21 H. Lundbeck A/S Sitalopram hazırlanması için metod.
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ES2169709A1 (es) 1999-10-25 2002-07-01 Lundbeck & Co As H Metodo para la preparacion de citalopram
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
FR2805812A1 (fr) 2000-02-24 2001-09-07 Lundbeck & Co As H Procede de preparation du citalopram
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
IL144817A0 (en) 2000-08-18 2002-06-30 Lundbeck & Co As H Method for the preparation of citalopram
EP1181713B1 (en) 2000-12-22 2004-09-29 H. Lundbeck A/S Method for the preparation of pure citalopram
PT1181272E (pt) 2000-12-28 2003-01-31 Lundbeck & Co As H Processo para a preparacao de citalopram puro

Also Published As

Publication number Publication date
US20020028956A1 (en) 2002-03-07
DK1150966T3 (da) 2002-12-30
EA200100834A1 (ru) 2001-12-24
PT1150966E (pt) 2003-01-31
BG105692A (en) 2002-02-28
HK1044342B (zh) 2005-04-22
DE60000364D1 (de) 2002-10-02
NO20013667L (no) 2001-07-26
US6441201B1 (en) 2002-08-27
EA003257B1 (ru) 2003-02-27
ITMI20000112A0 (it) 2000-01-27
IS2223B (is) 2007-03-15
IS5982A (is) 2001-06-28
ZA200105549B (en) 2002-07-05
PL349908A1 (en) 2002-10-07
BG64924B1 (bg) 2006-09-29
CN1158271C (zh) 2004-07-21
EP1150966A1 (en) 2001-11-07
AU763666B2 (en) 2003-07-31
SK284367B6 (sk) 2005-02-04
EP1150966B1 (en) 2002-08-28
CA2361395A1 (en) 2000-08-03
HUP0104976A2 (en) 2002-06-29
IT1317741B1 (it) 2003-07-15
IL144114A (en) 2006-06-11
AU2278200A (en) 2000-08-18
CA2361395C (en) 2005-11-15
NO326532B1 (no) 2008-12-29
CZ300257B6 (cs) 2009-04-01
CN1337957A (zh) 2002-02-27
PL198385B1 (pl) 2008-06-30
BR0008978A (pt) 2001-11-27
WO2000044738A1 (en) 2000-08-03
ITMI20000112A1 (it) 2001-07-27
SI1150966T1 (en) 2003-02-28
JP2002535397A (ja) 2002-10-22
HUP0104976A3 (en) 2002-09-30
KR20010101432A (ko) 2001-11-14
NO20013667D0 (no) 2001-07-26
TR200102135T2 (tr) 2002-01-21
ES2180508T3 (es) 2003-02-16
IL144114A0 (en) 2002-05-23
CZ20012734A3 (cs) 2002-01-16
NZ512775A (en) 2003-11-28
HK1044342A1 (en) 2002-10-18
UA70987C2 (uk) 2004-11-15
SK10562001A3 (sk) 2002-01-07
KR100430327B1 (ko) 2004-05-03
DE60000364T2 (de) 2003-04-03
ATE222900T1 (de) 2002-09-15

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