DK1165576T3 - Fremgangsmåde til fremstilling af amin-platin-komplekser - Google Patents

Fremgangsmåde til fremstilling af amin-platin-komplekser

Info

Publication number
DK1165576T3
DK1165576T3 DK00918620T DK00918620T DK1165576T3 DK 1165576 T3 DK1165576 T3 DK 1165576T3 DK 00918620 T DK00918620 T DK 00918620T DK 00918620 T DK00918620 T DK 00918620T DK 1165576 T3 DK1165576 T3 DK 1165576T3
Authority
DK
Denmark
Prior art keywords
amine
preparation
platinum complexes
complexes
platinum
Prior art date
Application number
DK00918620T
Other languages
English (en)
Inventor
Ernest S Y Wong
Christen M Giandomenico
Original Assignee
Anormed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anormed Inc filed Critical Anormed Inc
Application granted granted Critical
Publication of DK1165576T3 publication Critical patent/DK1165576T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086Platinum compounds
    • C07F15/0093Platinum compounds without a metal-carbon linkage

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
DK00918620T 1999-04-13 2000-04-11 Fremgangsmåde til fremstilling af amin-platin-komplekser DK1165576T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12893999P 1999-04-13 1999-04-13

Publications (1)

Publication Number Publication Date
DK1165576T3 true DK1165576T3 (da) 2006-03-27

Family

ID=22437722

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00918620T DK1165576T3 (da) 1999-04-13 2000-04-11 Fremgangsmåde til fremstilling af amin-platin-komplekser

Country Status (32)

Country Link
US (1) US6518428B1 (da)
EP (1) EP1165576B1 (da)
JP (1) JP4756669B2 (da)
KR (1) KR100711955B1 (da)
CN (3) CN1916009B (da)
AR (1) AR043084A1 (da)
AT (1) ATE309257T1 (da)
AU (1) AU770006B2 (da)
BG (1) BG65429B1 (da)
BR (1) BR0009780B1 (da)
CA (1) CA2368849C (da)
CY (1) CY1104965T1 (da)
CZ (1) CZ303156B6 (da)
DE (1) DE60023859T2 (da)
DK (1) DK1165576T3 (da)
EE (1) EE04747B1 (da)
ES (1) ES2253214T3 (da)
HK (2) HK1039336B (da)
HU (1) HUP0200748A3 (da)
IL (1) IL145671A0 (da)
IS (1) IS2711B3 (da)
MX (1) MXPA01010430A (da)
MY (1) MY122706A (da)
NO (1) NO330429B1 (da)
NZ (1) NZ514736A (da)
PL (1) PL202731B1 (da)
RU (1) RU2245340C2 (da)
SK (1) SK286374B6 (da)
TW (1) TWI289565B (da)
UA (1) UA71614C2 (da)
WO (1) WO2000061590A1 (da)
ZA (1) ZA200107965B (da)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9502799D0 (en) * 1995-02-14 1995-04-05 Johnson Matthey Plc Improvements in platinum complexes
US6413953B1 (en) * 1999-04-13 2002-07-02 Anormed Inc. Pt(IV) antitumor agent
BR0009780B1 (pt) 1999-04-13 2013-09-24 processo para preparar um complexo de cisplatina
GB0011903D0 (en) * 2000-05-18 2000-07-05 Astrazeneca Ab Combination chemotherapy
US6806289B1 (en) * 2000-07-14 2004-10-19 Stephen J. Lippard Coordination complexes, and methods for preparing by combinatorial methods, assaying and using the same
US6894049B1 (en) * 2000-10-04 2005-05-17 Anormed, Inc. Platinum complexes as antitumor agents
RS50605B (sr) 2004-02-18 2010-05-07 Gpc Biotech Ag. Satraplatina za tretiranje rezistentnih i otpornih tumora
CZ296459B6 (cs) * 2004-09-14 2006-03-15 Pliva-Lachema A. S. Perorální farmaceutická kompozice pro cílený transport komplexu platiny do kolorektální oblasti, zpusob její prípravy a tato kompozice pro pouzití jako lécivo
ES2257178B1 (es) * 2004-09-30 2007-08-16 Universidad Autonoma De Madrid Compuestos de platino de formula trans-(ptc12(isopropilamina)(4-(hidroximetil)-piridina)) y trans-(ptc12(isopropilamina)(3-hidroximetil)-piridina y su aplicacion como farmaco antitumoral.
US8173686B2 (en) 2006-11-06 2012-05-08 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8168661B2 (en) * 2006-11-06 2012-05-01 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8178564B2 (en) * 2006-11-06 2012-05-15 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8168662B1 (en) 2006-11-06 2012-05-01 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US20110033528A1 (en) * 2009-08-05 2011-02-10 Poniard Pharmaceuticals, Inc. Stabilized picoplatin oral dosage form
TW200916094A (en) * 2007-06-27 2009-04-16 Poniard Pharmaceuticals Inc Stabilized picoplatin dosage form
US20100260832A1 (en) * 2007-06-27 2010-10-14 Poniard Pharmaceuticals, Inc. Combination therapy for ovarian cancer
EP2178893A4 (en) * 2007-07-16 2012-09-19 Poniard Pharmaceuticals Inc ORAL FORMULATIONS FOR PICOPLATIN
JP2011511071A (ja) * 2008-02-08 2011-04-07 ポニアード ファーマシューティカルズ, インコーポレイテッド 肺癌を治療するためのピコプラチンおよびアムルビシン
CA2763170A1 (en) * 2009-06-12 2010-12-16 Poniard Pharmaceuticals, Inc. Improved synthesis of picoplatin
RU2451010C1 (ru) * 2011-01-11 2012-05-20 Закрытое Акционерное Общество "Ива Фарм" Палладиево-медные катализаторы гомогенного селективного окисления тиольных групп, комбинация и композиция на их основе и способ терапевтического воздействия
CN105254679B (zh) * 2013-11-19 2018-05-15 辽宁大学 单6-(氮杂环取代)蒽醌二氯化铂配合物及其制备方法和应用
CN103860539B (zh) * 2014-04-14 2016-02-10 于迎涛 一种具有混合轴向配体的Pt(IV)类抗癌药物及制备方法
CN104231000A (zh) * 2014-08-20 2014-12-24 山东铂源药业有限公司 一种抗肿瘤药物甲啶铂的合成方法
US10987353B2 (en) 2016-05-04 2021-04-27 The Wistar Institute Of Anatomy And Biology Methods of treating cancers overexpressing CARM1 with EZH2 inhibitors and platinum-based antineoplastic drugs
KR102137669B1 (ko) * 2019-08-05 2020-07-27 한국과학기술연구원 메탄올 또는 그 전구체 합성용 촉매, 이의 제조방법 및 이를 이용한 메탄올 또는 그 전구체의 제조방법
AU2021306808A1 (en) 2020-07-08 2023-02-02 Dayton Therapeutics Ag Satraplatin for use in the treatment of lymphoid neoplasms
CN113402565B (zh) * 2021-06-16 2023-07-28 中国人民解放军空军军医大学 一类含有泊沙康唑的四价铂配合物、制备方法及其应用
WO2023131524A1 (en) 2022-01-07 2023-07-13 Dayton Therapeutics Ag Treating haematological malignancies by means of satraplatin

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA805101B (en) * 1979-08-23 1981-08-26 Johnson Matthey Co Ltd Compositions containing platinium
US4533502A (en) 1983-02-22 1985-08-06 Rochon Fernande D Platinum (II) compounds and their preparation
EP0167310B1 (en) * 1984-06-27 1991-05-29 Johnson Matthey Public Limited Company Platinum co-ordination compounds
US5244919A (en) 1988-02-02 1993-09-14 Johnson Matthey, Inc. Pt(IV) complexes as anti-tumor agents
GB9105037D0 (en) 1991-03-09 1991-04-24 Johnson Matthey Plc Improvements in chemical compounds
GB9502799D0 (en) * 1995-02-14 1995-04-05 Johnson Matthey Plc Improvements in platinum complexes
US5547982A (en) * 1995-02-27 1996-08-20 Johnson Matthey, Inc. Anti-tumor platinum complexes
CA2367282A1 (en) 1999-03-19 2000-09-28 Simon Fricker Pharmaceutical compositions comprising metal complexes
BR0009780B1 (pt) 1999-04-13 2013-09-24 processo para preparar um complexo de cisplatina

Also Published As

Publication number Publication date
AU3951000A (en) 2000-11-14
CN100460412C (zh) 2009-02-11
CN1916009B (zh) 2010-12-15
NO20014957D0 (no) 2001-10-12
CA2368849A1 (en) 2000-10-19
UA71614C2 (en) 2004-12-15
DE60023859T2 (de) 2006-08-03
KR20020018189A (ko) 2002-03-07
CY1104965T1 (el) 2010-03-03
HK1039336B (zh) 2006-01-27
ES2253214T3 (es) 2006-06-01
WO2000061590A1 (en) 2000-10-19
EP1165576B1 (en) 2005-11-09
PL202731B1 (pl) 2009-07-31
CZ303156B6 (cs) 2012-05-09
HK1100562A1 (en) 2007-09-21
CN1847253A (zh) 2006-10-18
ZA200107965B (en) 2003-01-02
HK1039336A1 (en) 2002-04-19
IS2709B (is) 2011-01-15
AU770006B2 (en) 2004-02-12
EE04747B1 (et) 2006-12-15
MY122706A (en) 2006-04-29
JP2002541263A (ja) 2002-12-03
IS6092A (is) 2001-09-28
MXPA01010430A (es) 2002-03-27
CN1916009A (zh) 2007-02-21
HUP0200748A3 (en) 2010-01-28
HUP0200748A2 (hu) 2002-07-29
SK286374B6 (sk) 2008-08-05
AR043084A1 (es) 2005-07-20
BG65429B1 (bg) 2008-07-31
EP1165576A1 (en) 2002-01-02
BR0009780B1 (pt) 2013-09-24
JP4756669B2 (ja) 2011-08-24
ATE309257T1 (de) 2005-11-15
EE200100536A (et) 2003-02-17
US6518428B1 (en) 2003-02-11
NO330429B1 (no) 2011-04-11
CZ20013648A3 (cs) 2002-02-13
PL351612A1 (en) 2003-05-05
IL145671A0 (en) 2002-06-30
BG106090A (en) 2002-06-28
NZ514736A (en) 2004-01-30
RU2245340C2 (ru) 2005-01-27
TWI289565B (en) 2007-11-11
KR100711955B1 (ko) 2007-05-02
BR0009780A (pt) 2002-01-02
CN1350540A (zh) 2002-05-22
CA2368849C (en) 2011-01-25
IS2711B3 (is) 2011-01-15
CN1250559C (zh) 2006-04-12
NO20014957L (no) 2001-12-03
DE60023859D1 (de) 2005-12-15
SK14682001A3 (sk) 2002-01-07

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