DE69620802D1 - Hydrolysierbare hydrophobe taxanderivate - Google Patents

Hydrolysierbare hydrophobe taxanderivate

Info

Publication number
DE69620802D1
DE69620802D1 DE69620802T DE69620802T DE69620802D1 DE 69620802 D1 DE69620802 D1 DE 69620802D1 DE 69620802 T DE69620802 T DE 69620802T DE 69620802 T DE69620802 T DE 69620802T DE 69620802 D1 DE69620802 D1 DE 69620802D1
Authority
DE
Germany
Prior art keywords
taxane
hydrocarbon
hpg
enhanced
alpha position
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69620802T
Other languages
English (en)
Other versions
DE69620802T2 (de
Inventor
Eric Mayhew
Shaukat Ali
Andrew S Janoff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cephalon Ltd
Original Assignee
Liposome Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Liposome Co Inc filed Critical Liposome Co Inc
Publication of DE69620802D1 publication Critical patent/DE69620802D1/de
Application granted granted Critical
Publication of DE69620802T2 publication Critical patent/DE69620802T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Medicinal Preparation (AREA)
DE69620802T 1995-09-12 1996-09-12 Hydrolysierbare hydrophobe taxanderivate Expired - Fee Related DE69620802T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US357595P 1995-09-12 1995-09-12
PCT/US1996/014631 WO1997010234A1 (en) 1995-09-12 1996-09-12 Hydrolysis-promoting taxane hydrophobic derivatives

Publications (2)

Publication Number Publication Date
DE69620802D1 true DE69620802D1 (de) 2002-05-23
DE69620802T2 DE69620802T2 (de) 2002-10-10

Family

ID=21706522

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69620802T Expired - Fee Related DE69620802T2 (de) 1995-09-12 1996-09-12 Hydrolysierbare hydrophobe taxanderivate
DE69635428T Expired - Fee Related DE69635428T2 (de) 1995-09-12 1996-09-12 Hydrolyse-einleitende hydrophobe Taxan-Derivate

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69635428T Expired - Fee Related DE69635428T2 (de) 1995-09-12 1996-09-12 Hydrolyse-einleitende hydrophobe Taxan-Derivate

Country Status (22)

Country Link
US (1) US5703117A (de)
EP (1) EP0902783B1 (de)
JP (1) JP4192208B2 (de)
KR (1) KR100401220B1 (de)
CN (1) CN1100770C (de)
AT (2) ATE216377T1 (de)
CA (1) CA2231750C (de)
CZ (1) CZ288562B6 (de)
DE (2) DE69620802T2 (de)
DK (2) DK0902783T3 (de)
ES (2) ES2179208T3 (de)
HK (1) HK1016169A1 (de)
HU (1) HU226325B1 (de)
IL (1) IL123595A (de)
MX (1) MX9801871A (de)
NO (1) NO319521B1 (de)
NZ (1) NZ318300A (de)
PL (1) PL187738B1 (de)
PT (1) PT902783E (de)
SK (1) SK283199B6 (de)
TR (1) TR199800443T1 (de)
WO (1) WO1997010234A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6107332A (en) * 1995-09-12 2000-08-22 The Liposome Company, Inc. Hydrolysis-promoting hydrophobic taxane derivatives
US6667053B1 (en) * 1996-02-16 2003-12-23 Elan Pharmaceuticals, Inc. D and L etherlipid stereoisomers and liposomes
US5912264A (en) * 1997-03-03 1999-06-15 Bristol-Myers Squibb Company 6-halo-or nitrate-substituted paclitaxels
US8853260B2 (en) 1997-06-27 2014-10-07 Abraxis Bioscience, Llc Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
EP1964557B1 (de) 1997-11-10 2013-01-02 Memorial Sloan-Kettering Cancer Center Verfahren zur Herstellung von Arsentrioxidformulierungen
BR9911031A (pt) * 1998-05-20 2002-01-29 Liposome Co Inc Novas formulações em partìculas
US7314637B1 (en) 1999-06-29 2008-01-01 Neopharm, Inc. Method of administering liposomal encapsulated taxane
US6146659A (en) * 1998-07-01 2000-11-14 Neopharm, Inc. Method of administering liposomal encapsulated taxane
DE60004630T2 (de) * 1999-01-12 2004-06-17 Quanam Medical Corp., Santa Clara Arzneimittel und verfahren zur verabreichung von wasserunlöslichen paclitaxelderivaten
EP2289549A3 (de) 1999-10-01 2011-06-15 Immunogen, Inc. Immunokonjugate für Krebsbehandlung
EP1301500B1 (de) 2000-06-22 2007-11-21 Nitromed, Inc. Nitrosierte und nitrosylierte taxane, zubereitungen und methoden der verwendung
US6607689B1 (en) * 2000-08-29 2003-08-19 Micron Technology, Inc. Layer thickness control for stereolithography utilizing variable liquid elevation and laser focal length
EP1304103B1 (de) * 2001-10-22 2008-12-31 Viroblock SA Non-phospholipid Vesikel (npLV) und ihre Verwendung in kosmetischen, therapeutischen und prophylaktischen Anwendungen
CA2466851C (en) * 2001-11-26 2012-09-11 Supergen, Inc. Method for preparing and using polyoxyethylated castor oil in pharmaceutical compositions
EP1553924B1 (de) * 2002-06-26 2010-12-08 MediGene AG Neues verfahren zur stabilisierung von diagnostischen und therapeutischen verbindungen in einem kationischen trägersystem
BRPI0407096A (pt) 2003-02-03 2006-01-24 Neopharm Inc Taxano encapsulado em lipossomo estável, estéril e filtrável e outros fármacos antineoplásicos
WO2006089207A2 (en) * 2005-02-18 2006-08-24 Abraxis Bioscience, Inc. Drugs with improved hydrophobicity for incorporation in medical devices
US8173167B2 (en) 2005-04-12 2012-05-08 Wisconsin Alumni Research Foundation Micelle composition of polymer and passenger drug
MX2010011165A (es) * 2008-04-10 2011-02-22 Abraxis Bioscience Llc Composiciones de derivados de taxano hidrofobos y sus usos.
KR20150136137A (ko) * 2008-04-10 2015-12-04 아브락시스 바이오사이언스, 엘엘씨 소수성 탁산 유도체의 조성물 및 그의 용도
WO2011038278A2 (en) 2009-09-25 2011-03-31 Wisconsin Alumni Research Foundation Micelle encapsulation of therapeutic agents
CN105503844A (zh) * 2015-12-11 2016-04-20 上海大学 C-13和c-7位结构改造的紫杉醇类化合物及其制备方法
CN111004195B (zh) * 2019-12-03 2022-01-28 沈阳药科大学 卡巴他赛弱碱性衍生物及其制剂

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5059699A (en) * 1990-08-28 1991-10-22 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol
US5278324A (en) * 1990-08-28 1994-01-11 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol
DK1251127T3 (da) * 1992-12-23 2006-03-06 Bristol Myers Squibb Co Nye sidekædede-bærende taxaner og mellemprodukter deraf
IL108316A (en) * 1993-01-15 2006-10-31 Univ Florida State History of C-10 Texan and pharmaceuticals containing them
US5580899A (en) * 1995-01-09 1996-12-03 The Liposome Company, Inc. Hydrophobic taxane derivatives

Also Published As

Publication number Publication date
PT902783E (pt) 2002-09-30
NO319521B1 (no) 2005-08-22
CA2231750A1 (en) 1997-03-20
IL123595A0 (en) 1998-10-30
ES2179208T3 (es) 2003-01-16
DE69635428T2 (de) 2006-06-14
IL123595A (en) 2000-10-31
HUP9901433A3 (en) 2001-05-28
DE69635428D1 (de) 2005-12-15
CN1100770C (zh) 2003-02-05
EP0902783B1 (de) 2002-04-17
NO981071D0 (no) 1998-03-11
CA2231750C (en) 2006-07-11
WO1997010234A1 (en) 1997-03-20
ATE309235T1 (de) 2005-11-15
PL325477A1 (en) 1998-07-20
JP4192208B2 (ja) 2008-12-10
CZ288562B6 (cs) 2001-07-11
KR100401220B1 (ko) 2004-03-20
TR199800443T1 (xx) 1998-06-22
ES2252347T3 (es) 2006-05-16
ATE216377T1 (de) 2002-05-15
AU706290B2 (en) 1999-06-10
EP0902783A1 (de) 1999-03-24
JP2001519755A (ja) 2001-10-23
NZ318300A (en) 1999-08-30
EP0902783A4 (de) 1999-03-24
KR19990044409A (ko) 1999-06-25
PL187738B1 (pl) 2004-09-30
AU6975696A (en) 1997-04-01
NO981071L (no) 1998-05-12
DK1229030T3 (da) 2006-02-13
CN1202166A (zh) 1998-12-16
DK0902783T3 (da) 2002-07-22
SK33498A3 (en) 1998-08-05
HK1016169A1 (en) 1999-10-29
CZ71198A3 (cs) 1998-07-15
SK283199B6 (sk) 2003-03-04
US5703117A (en) 1997-12-30
HUP9901433A2 (hu) 2001-04-28
DE69620802T2 (de) 2002-10-10
MX9801871A (es) 1998-05-31
HU226325B1 (en) 2008-08-28

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: ELAN PHARMACEUTICALS,INC.(N.D.GES.D.STAATES DELAWA

8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: CEPHALON LTD., WELWYN GARDEN CITY, HERTFORDSHI, GB

8339 Ceased/non-payment of the annual fee