HUP9901433A2 - Hidrofób taxán-származékok és azokat tartalmazó gyógyszerkészítmények - Google Patents
Hidrofób taxán-származékok és azokat tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP9901433A2 HUP9901433A2 HU9901433A HUP9901433A HUP9901433A2 HU P9901433 A2 HUP9901433 A2 HU P9901433A2 HU 9901433 A HU9901433 A HU 9901433A HU P9901433 A HUP9901433 A HU P9901433A HU P9901433 A2 HUP9901433 A2 HU P9901433A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- integer
- hydrogen atom
- value
- general formula
- Prior art date
Links
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 230000002209 hydrophobic effect Effects 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 101001003232 Mus musculus Immediate early response gene 2 protein Proteins 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000001093 anti-cancer Effects 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
A találmány (I) általános képletű taxánvegyületekre vonatkozik, aképletben A1 jelentése hidrogénatom vagy egy Z-C(O)NHCH(C6H5)-CH(OR)C(O)-általános képletű csoport; A2 jelentése hidrogénatom vagy CH3C(O)- csoport; és A3 jelentése hidrogénatom vagy hidroxilcsoport; Z jelentése C6H5-, C6H5CH2-O-, C(CH3)3-O- vagy CH(CH3)=C(CH3)-csoport; R és R1 mindegyikének jelentése hidrogénatom vagy -Y1Y2 általánosképletű csoport; Y1 jelentése egy C(O)CHX1(CH2)n1(CH=CH)n2(CH2)n3-(CH=CH)n4(CH2)n5-(CH=CH)n6(CH2)n7(CH=CH)n8(CH2)n9-általános képletű csoport;n1+2n2+n3+2n4+n5+2n6+n7+ +2n8+n9 összege 1 és 21 közötti szám, és n2,n4, n6 és n8 mindegyikének értéke egymástól függetlenül 0 vagy 1, n1értéke 0 vagy 1 és 21 közötti egész szám, n3 értéke 0 vagy 1 és 18közötti egész szám, n5 értéke 0 vagy 1 és 15 közötti egész szám, n7értéke 0 vagy 1 és 12 közötti egész szám, n9 értéke 0 vagy 1 és 9közötti egész szám, és n1-n9 értéke azonos vagy különböző lehet mindenelőfordulás alkalmával; X1 jelentése egy hidrolízist elősegítő csoport; és Y2 jelentése -CH3, -CO2H vagy -CH2OH csoport. A vegyületek rákelleneshatásúak és gyógyászati készítmények hatóanyagaként alkalmazhatók. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US357595P | 1995-09-12 | 1995-09-12 | |
| PCT/US1996/014631 WO1997010234A1 (en) | 1995-09-12 | 1996-09-12 | Hydrolysis-promoting taxane hydrophobic derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP9901433A2 true HUP9901433A2 (hu) | 2001-04-28 |
| HUP9901433A3 HUP9901433A3 (en) | 2001-05-28 |
| HU226325B1 HU226325B1 (en) | 2008-08-28 |
Family
ID=21706522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9901433A HU226325B1 (en) | 1995-09-12 | 1996-09-12 | Hydrolysis-promoting hydrophobic taxane derivatives, medicaments comprising them and the use of medicaments |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5703117A (hu) |
| EP (1) | EP0902783B1 (hu) |
| JP (1) | JP4192208B2 (hu) |
| KR (1) | KR100401220B1 (hu) |
| CN (1) | CN1100770C (hu) |
| AT (2) | ATE216377T1 (hu) |
| CA (1) | CA2231750C (hu) |
| CZ (1) | CZ288562B6 (hu) |
| DE (2) | DE69620802T2 (hu) |
| DK (2) | DK0902783T3 (hu) |
| ES (2) | ES2179208T3 (hu) |
| HK (1) | HK1016169A1 (hu) |
| HU (1) | HU226325B1 (hu) |
| IL (1) | IL123595A (hu) |
| MX (1) | MX9801871A (hu) |
| NO (1) | NO319521B1 (hu) |
| NZ (1) | NZ318300A (hu) |
| PL (1) | PL187738B1 (hu) |
| PT (1) | PT902783E (hu) |
| SK (1) | SK283199B6 (hu) |
| TR (1) | TR199800443T1 (hu) |
| WO (1) | WO1997010234A1 (hu) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6107332A (en) * | 1995-09-12 | 2000-08-22 | The Liposome Company, Inc. | Hydrolysis-promoting hydrophobic taxane derivatives |
| US6667053B1 (en) * | 1996-02-16 | 2003-12-23 | Elan Pharmaceuticals, Inc. | D and L etherlipid stereoisomers and liposomes |
| US5912264A (en) * | 1997-03-03 | 1999-06-15 | Bristol-Myers Squibb Company | 6-halo-or nitrate-substituted paclitaxels |
| US8853260B2 (en) | 1997-06-27 | 2014-10-07 | Abraxis Bioscience, Llc | Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
| EP1964557B1 (en) | 1997-11-10 | 2013-01-02 | Memorial Sloan-Kettering Cancer Center | Process for producing arsenic trioxide formulations |
| BR9911031A (pt) * | 1998-05-20 | 2002-01-29 | Liposome Co Inc | Novas formulações em partìculas |
| US7314637B1 (en) | 1999-06-29 | 2008-01-01 | Neopharm, Inc. | Method of administering liposomal encapsulated taxane |
| US6146659A (en) * | 1998-07-01 | 2000-11-14 | Neopharm, Inc. | Method of administering liposomal encapsulated taxane |
| DE60004630T2 (de) * | 1999-01-12 | 2004-06-17 | Quanam Medical Corp., Santa Clara | Arzneimittel und verfahren zur verabreichung von wasserunlöslichen paclitaxelderivaten |
| EP2289549A3 (en) | 1999-10-01 | 2011-06-15 | Immunogen, Inc. | Immunoconjugates for treating cancer |
| EP1301500B1 (en) | 2000-06-22 | 2007-11-21 | Nitromed, Inc. | Nitrosated and nitrosylated taxanes, compositions and methods of use |
| US6607689B1 (en) * | 2000-08-29 | 2003-08-19 | Micron Technology, Inc. | Layer thickness control for stereolithography utilizing variable liquid elevation and laser focal length |
| EP1304103B1 (en) * | 2001-10-22 | 2008-12-31 | Viroblock SA | New non-phospholipid lipid vesicles (npLV) and their use in cosmetic, therapeutic and prophylactic applications |
| CA2466851C (en) * | 2001-11-26 | 2012-09-11 | Supergen, Inc. | Method for preparing and using polyoxyethylated castor oil in pharmaceutical compositions |
| EP1553924B1 (en) * | 2002-06-26 | 2010-12-08 | MediGene AG | Novel method of stabilizing diagnostic and therapeutic compounds in a cationic carrier system |
| BRPI0407096A (pt) | 2003-02-03 | 2006-01-24 | Neopharm Inc | Taxano encapsulado em lipossomo estável, estéril e filtrável e outros fármacos antineoplásicos |
| WO2006089207A2 (en) * | 2005-02-18 | 2006-08-24 | Abraxis Bioscience, Inc. | Drugs with improved hydrophobicity for incorporation in medical devices |
| US8173167B2 (en) | 2005-04-12 | 2012-05-08 | Wisconsin Alumni Research Foundation | Micelle composition of polymer and passenger drug |
| MX2010011165A (es) * | 2008-04-10 | 2011-02-22 | Abraxis Bioscience Llc | Composiciones de derivados de taxano hidrofobos y sus usos. |
| KR20150136137A (ko) * | 2008-04-10 | 2015-12-04 | 아브락시스 바이오사이언스, 엘엘씨 | 소수성 탁산 유도체의 조성물 및 그의 용도 |
| WO2011038278A2 (en) | 2009-09-25 | 2011-03-31 | Wisconsin Alumni Research Foundation | Micelle encapsulation of therapeutic agents |
| CN105503844A (zh) * | 2015-12-11 | 2016-04-20 | 上海大学 | C-13和c-7位结构改造的紫杉醇类化合物及其制备方法 |
| CN111004195B (zh) * | 2019-12-03 | 2022-01-28 | 沈阳药科大学 | 卡巴他赛弱碱性衍生物及其制剂 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5059699A (en) * | 1990-08-28 | 1991-10-22 | Virginia Tech Intellectual Properties, Inc. | Water soluble derivatives of taxol |
| US5278324A (en) * | 1990-08-28 | 1994-01-11 | Virginia Tech Intellectual Properties, Inc. | Water soluble derivatives of taxol |
| DK1251127T3 (da) * | 1992-12-23 | 2006-03-06 | Bristol Myers Squibb Co | Nye sidekædede-bærende taxaner og mellemprodukter deraf |
| IL108316A (en) * | 1993-01-15 | 2006-10-31 | Univ Florida State | History of C-10 Texan and pharmaceuticals containing them |
| US5580899A (en) * | 1995-01-09 | 1996-12-03 | The Liposome Company, Inc. | Hydrophobic taxane derivatives |
-
1996
- 1996-09-12 SK SK334-98A patent/SK283199B6/sk unknown
- 1996-09-12 DK DK96930847T patent/DK0902783T3/da active
- 1996-09-12 PT PT96930847T patent/PT902783E/pt unknown
- 1996-09-12 TR TR1998/00443T patent/TR199800443T1/xx unknown
- 1996-09-12 ES ES96930847T patent/ES2179208T3/es not_active Expired - Lifetime
- 1996-09-12 CZ CZ1998711A patent/CZ288562B6/cs not_active IP Right Cessation
- 1996-09-12 DK DK02008590T patent/DK1229030T3/da active
- 1996-09-12 AT AT96930847T patent/ATE216377T1/de not_active IP Right Cessation
- 1996-09-12 US US08/712,684 patent/US5703117A/en not_active Expired - Fee Related
- 1996-09-12 HU HU9901433A patent/HU226325B1/hu unknown
- 1996-09-12 DE DE69620802T patent/DE69620802T2/de not_active Expired - Fee Related
- 1996-09-12 KR KR10-1998-0701653A patent/KR100401220B1/ko not_active IP Right Cessation
- 1996-09-12 ES ES02008590T patent/ES2252347T3/es not_active Expired - Lifetime
- 1996-09-12 CA CA002231750A patent/CA2231750C/en not_active Expired - Fee Related
- 1996-09-12 CN CN96198237A patent/CN1100770C/zh not_active Expired - Fee Related
- 1996-09-12 WO PCT/US1996/014631 patent/WO1997010234A1/en active IP Right Grant
- 1996-09-12 AT AT02008590T patent/ATE309235T1/de not_active IP Right Cessation
- 1996-09-12 MX MX9801871A patent/MX9801871A/es not_active IP Right Cessation
- 1996-09-12 IL IL12359596A patent/IL123595A/xx not_active IP Right Cessation
- 1996-09-12 PL PL96325477A patent/PL187738B1/pl not_active IP Right Cessation
- 1996-09-12 NZ NZ318300A patent/NZ318300A/xx unknown
- 1996-09-12 JP JP51210297A patent/JP4192208B2/ja not_active Expired - Fee Related
- 1996-09-12 DE DE69635428T patent/DE69635428T2/de not_active Expired - Fee Related
- 1996-09-12 EP EP96930847A patent/EP0902783B1/en not_active Expired - Lifetime
-
1998
- 1998-03-11 NO NO19981071A patent/NO319521B1/no unknown
-
1999
- 1999-03-18 HK HK99101119A patent/HK1016169A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB9A | Succession in title |
Owner name: CEPHALON LIMITED, GB Free format text: FORMER OWNER(S): THE LIPOSOME COMPANY, INC., US |