ES2179208T3 - Derivados hidrofobos de taxano que favorecen la hidrolisis. - Google Patents
Derivados hidrofobos de taxano que favorecen la hidrolisis.Info
- Publication number
- ES2179208T3 ES2179208T3 ES96930847T ES96930847T ES2179208T3 ES 2179208 T3 ES2179208 T3 ES 2179208T3 ES 96930847 T ES96930847 T ES 96930847T ES 96930847 T ES96930847 T ES 96930847T ES 2179208 T3 ES2179208 T3 ES 2179208T3
- Authority
- ES
- Spain
- Prior art keywords
- taxan
- hydrolysis
- hydrocarbon
- hydrophobe
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000007062 hydrolysis Effects 0.000 title abstract 3
- 238000006460 hydrolysis reaction Methods 0.000 title abstract 3
- 239000004215 Carbon black (E152) Substances 0.000 abstract 2
- 229940123237 Taxane Drugs 0.000 abstract 2
- 229930195733 hydrocarbon Natural products 0.000 abstract 2
- 150000002430 hydrocarbons Chemical class 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
LA INVENCION SE REFIERE A UN TAXANO QUE PRESENTA UN HIDROCARBURO UNIDO A LAS POSICIONES 2'' Y/O 7, ESTANDO OCUPADA LA POSICION ALFA DEL HIDROCARBURO POR UN "GRUPO PROMOTOR DE HIDROLISIS" ("HPG"). LA SUSTITUCION DE UN HPG POR LA UNIDAD DE METILENO QUE OCUPA NORMALMENTE LA POSICION ALFA, PERMITE UNA HIDROLISIS IN VIVO MEJORADA DEL ENLACE HIDROCARBURO - TAXANO Y, POR TANTO, PERMITE UNA ACTIVIDAD TERAPEUTICA DE TAXANO MEJORADA. ASIMISMO, SE PROPORCIONAN COMPOSICIONES QUE CONTIENEN TAXANO Y METODOS DE ADMINISTRACION DE TAXANOS A ANIMALES, INCLUYENDO AQUELLOS AFECTADOS DE CANCERES.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US357595P | 1995-09-12 | 1995-09-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2179208T3 true ES2179208T3 (es) | 2003-01-16 |
Family
ID=21706522
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES96930847T Expired - Lifetime ES2179208T3 (es) | 1995-09-12 | 1996-09-12 | Derivados hidrofobos de taxano que favorecen la hidrolisis. |
| ES02008590T Expired - Lifetime ES2252347T3 (es) | 1995-09-12 | 1996-09-12 | Hidrolisis que promueve derivados hidrofobos de taxano. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES02008590T Expired - Lifetime ES2252347T3 (es) | 1995-09-12 | 1996-09-12 | Hidrolisis que promueve derivados hidrofobos de taxano. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5703117A (es) |
| EP (1) | EP0902783B1 (es) |
| JP (1) | JP4192208B2 (es) |
| KR (1) | KR100401220B1 (es) |
| CN (1) | CN1100770C (es) |
| AT (2) | ATE216377T1 (es) |
| CA (1) | CA2231750C (es) |
| CZ (1) | CZ288562B6 (es) |
| DE (2) | DE69620802T2 (es) |
| DK (2) | DK0902783T3 (es) |
| ES (2) | ES2179208T3 (es) |
| HK (1) | HK1016169A1 (es) |
| HU (1) | HU226325B1 (es) |
| IL (1) | IL123595A (es) |
| MX (1) | MX9801871A (es) |
| NO (1) | NO319521B1 (es) |
| NZ (1) | NZ318300A (es) |
| PL (1) | PL187738B1 (es) |
| PT (1) | PT902783E (es) |
| SK (1) | SK283199B6 (es) |
| TR (1) | TR199800443T1 (es) |
| WO (1) | WO1997010234A1 (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6107332A (en) * | 1995-09-12 | 2000-08-22 | The Liposome Company, Inc. | Hydrolysis-promoting hydrophobic taxane derivatives |
| US6667053B1 (en) * | 1996-02-16 | 2003-12-23 | Elan Pharmaceuticals, Inc. | D and L etherlipid stereoisomers and liposomes |
| US5912264A (en) * | 1997-03-03 | 1999-06-15 | Bristol-Myers Squibb Company | 6-halo-or nitrate-substituted paclitaxels |
| US8853260B2 (en) | 1997-06-27 | 2014-10-07 | Abraxis Bioscience, Llc | Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
| EP1964557B1 (en) | 1997-11-10 | 2013-01-02 | Memorial Sloan-Kettering Cancer Center | Process for producing arsenic trioxide formulations |
| BR9911031A (pt) * | 1998-05-20 | 2002-01-29 | Liposome Co Inc | Novas formulações em partìculas |
| US7314637B1 (en) | 1999-06-29 | 2008-01-01 | Neopharm, Inc. | Method of administering liposomal encapsulated taxane |
| US6146659A (en) * | 1998-07-01 | 2000-11-14 | Neopharm, Inc. | Method of administering liposomal encapsulated taxane |
| DE60004630T2 (de) * | 1999-01-12 | 2004-06-17 | Quanam Medical Corp., Santa Clara | Arzneimittel und verfahren zur verabreichung von wasserunlöslichen paclitaxelderivaten |
| EP2289549A3 (en) | 1999-10-01 | 2011-06-15 | Immunogen, Inc. | Immunoconjugates for treating cancer |
| EP1301500B1 (en) | 2000-06-22 | 2007-11-21 | Nitromed, Inc. | Nitrosated and nitrosylated taxanes, compositions and methods of use |
| US6607689B1 (en) * | 2000-08-29 | 2003-08-19 | Micron Technology, Inc. | Layer thickness control for stereolithography utilizing variable liquid elevation and laser focal length |
| EP1304103B1 (en) * | 2001-10-22 | 2008-12-31 | Viroblock SA | New non-phospholipid lipid vesicles (npLV) and their use in cosmetic, therapeutic and prophylactic applications |
| CA2466851C (en) * | 2001-11-26 | 2012-09-11 | Supergen, Inc. | Method for preparing and using polyoxyethylated castor oil in pharmaceutical compositions |
| EP1553924B1 (en) * | 2002-06-26 | 2010-12-08 | MediGene AG | Novel method of stabilizing diagnostic and therapeutic compounds in a cationic carrier system |
| BRPI0407096A (pt) | 2003-02-03 | 2006-01-24 | Neopharm Inc | Taxano encapsulado em lipossomo estável, estéril e filtrável e outros fármacos antineoplásicos |
| WO2006089207A2 (en) * | 2005-02-18 | 2006-08-24 | Abraxis Bioscience, Inc. | Drugs with improved hydrophobicity for incorporation in medical devices |
| US8173167B2 (en) | 2005-04-12 | 2012-05-08 | Wisconsin Alumni Research Foundation | Micelle composition of polymer and passenger drug |
| MX2010011165A (es) * | 2008-04-10 | 2011-02-22 | Abraxis Bioscience Llc | Composiciones de derivados de taxano hidrofobos y sus usos. |
| KR20150136137A (ko) * | 2008-04-10 | 2015-12-04 | 아브락시스 바이오사이언스, 엘엘씨 | 소수성 탁산 유도체의 조성물 및 그의 용도 |
| WO2011038278A2 (en) | 2009-09-25 | 2011-03-31 | Wisconsin Alumni Research Foundation | Micelle encapsulation of therapeutic agents |
| CN105503844A (zh) * | 2015-12-11 | 2016-04-20 | 上海大学 | C-13和c-7位结构改造的紫杉醇类化合物及其制备方法 |
| CN111004195B (zh) * | 2019-12-03 | 2022-01-28 | 沈阳药科大学 | 卡巴他赛弱碱性衍生物及其制剂 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5059699A (en) * | 1990-08-28 | 1991-10-22 | Virginia Tech Intellectual Properties, Inc. | Water soluble derivatives of taxol |
| US5278324A (en) * | 1990-08-28 | 1994-01-11 | Virginia Tech Intellectual Properties, Inc. | Water soluble derivatives of taxol |
| DK1251127T3 (da) * | 1992-12-23 | 2006-03-06 | Bristol Myers Squibb Co | Nye sidekædede-bærende taxaner og mellemprodukter deraf |
| IL108316A (en) * | 1993-01-15 | 2006-10-31 | Univ Florida State | History of C-10 Texan and pharmaceuticals containing them |
| US5580899A (en) * | 1995-01-09 | 1996-12-03 | The Liposome Company, Inc. | Hydrophobic taxane derivatives |
-
1996
- 1996-09-12 SK SK334-98A patent/SK283199B6/sk unknown
- 1996-09-12 DK DK96930847T patent/DK0902783T3/da active
- 1996-09-12 PT PT96930847T patent/PT902783E/pt unknown
- 1996-09-12 TR TR1998/00443T patent/TR199800443T1/xx unknown
- 1996-09-12 ES ES96930847T patent/ES2179208T3/es not_active Expired - Lifetime
- 1996-09-12 CZ CZ1998711A patent/CZ288562B6/cs not_active IP Right Cessation
- 1996-09-12 DK DK02008590T patent/DK1229030T3/da active
- 1996-09-12 AT AT96930847T patent/ATE216377T1/de not_active IP Right Cessation
- 1996-09-12 US US08/712,684 patent/US5703117A/en not_active Expired - Fee Related
- 1996-09-12 HU HU9901433A patent/HU226325B1/hu unknown
- 1996-09-12 DE DE69620802T patent/DE69620802T2/de not_active Expired - Fee Related
- 1996-09-12 KR KR10-1998-0701653A patent/KR100401220B1/ko not_active IP Right Cessation
- 1996-09-12 ES ES02008590T patent/ES2252347T3/es not_active Expired - Lifetime
- 1996-09-12 CA CA002231750A patent/CA2231750C/en not_active Expired - Fee Related
- 1996-09-12 CN CN96198237A patent/CN1100770C/zh not_active Expired - Fee Related
- 1996-09-12 WO PCT/US1996/014631 patent/WO1997010234A1/en active IP Right Grant
- 1996-09-12 AT AT02008590T patent/ATE309235T1/de not_active IP Right Cessation
- 1996-09-12 MX MX9801871A patent/MX9801871A/es not_active IP Right Cessation
- 1996-09-12 IL IL12359596A patent/IL123595A/xx not_active IP Right Cessation
- 1996-09-12 PL PL96325477A patent/PL187738B1/pl not_active IP Right Cessation
- 1996-09-12 NZ NZ318300A patent/NZ318300A/xx unknown
- 1996-09-12 JP JP51210297A patent/JP4192208B2/ja not_active Expired - Fee Related
- 1996-09-12 DE DE69635428T patent/DE69635428T2/de not_active Expired - Fee Related
- 1996-09-12 EP EP96930847A patent/EP0902783B1/en not_active Expired - Lifetime
-
1998
- 1998-03-11 NO NO19981071A patent/NO319521B1/no unknown
-
1999
- 1999-03-18 HK HK99101119A patent/HK1016169A1/xx not_active IP Right Cessation
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