ATE262515T1 - Discodermolide verbindungen und deren pharmazeutische zusammensetzungen zur krebstherapie - Google Patents

Discodermolide verbindungen und deren pharmazeutische zusammensetzungen zur krebstherapie

Info

Publication number: ATE262515T1
Authority: AT; Austria
Prior art keywords: pharmaceutical compositions; compounds; cancer therapy; cancer cells; discodermolide compounds
Prior art date: 1995-12-05

Application number

AT96943591T

Other languages

English (en)

Inventor

Ross E Longley

Sarath P Gunasekera

Shirley Pomponi

Original Assignee

Harbor Branch Oceanographic

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-05

Filing date

1996-12-05

Publication date

2004-04-15

1996-12-05 Application filed by Harbor Branch Oceanographic filed Critical Harbor Branch Oceanographic

2004-04-15 Application granted granted Critical

2004-04-15 Publication of ATE262515T1 publication Critical patent/ATE262515T1/de

Links

AADVCYNFEREWOS-OBRABYBLSA-N Discodermolide Chemical class C=C\C=C/[C@H](C)[C@H](OC(N)=O)[C@@H](C)[C@H](O)[C@@H](C)C\C(C)=C/[C@H](C)[C@@H](O)[C@@H](C)\C=C/[C@@H](O)C[C@@H]1OC(=O)[C@H](C)[C@@H](O)[C@H]1C AADVCYNFEREWOS-OBRABYBLSA-N 0.000 title 1
238000011275 oncology therapy Methods 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
206010028980 Neoplasm Diseases 0.000 abstract 2
201000011510 cancer Diseases 0.000 abstract 2
208000026310 Breast neoplasm Diseases 0.000 abstract 1
241001290275 Discodermia dissoluta Species 0.000 abstract 1
210000000481 breast Anatomy 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
208000025997 central nervous system neoplasm Diseases 0.000 abstract 1
210000001072 colon Anatomy 0.000 abstract 1
208000029742 colonic neoplasm Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
-1 lactone compounds Chemical class 0.000 abstract 1
208000032839 leukemia Diseases 0.000 abstract 1
208000037841 lung tumor Diseases 0.000 abstract 1
201000001441 melanoma Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrane Compounds (AREA)

AT96943591T 1995-12-05 1996-12-05 Discodermolide verbindungen und deren pharmazeutische zusammensetzungen zur krebstherapie ATE262515T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/567,442 US5681847A (en)	1995-12-05	1995-12-05	Methods of using discodermolide compounds
PCT/US1996/019344 WO1997020835A1 (en)	1995-12-05	1996-12-05	Discodermolide compounds and pharmaceutical compositions containing them for cancer therapy

Publications (1)

Publication Number	Publication Date
ATE262515T1 true ATE262515T1 (de)	2004-04-15

Family

ID=24267168

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96943591T ATE262515T1 (de)	1995-12-05	1996-12-05	Discodermolide verbindungen und deren pharmazeutische zusammensetzungen zur krebstherapie

Country Status (10)

Country	Link
US (2)	US5681847A (de)
EP (1)	EP0873332B1 (de)
JP (1)	JP3293833B2 (de)
AT (1)	ATE262515T1 (de)
CA (1)	CA2233716C (de)
DE (1)	DE69631975T2 (de)
DK (1)	DK0873332T3 (de)
ES (1)	ES2218608T3 (de)
PT (1)	PT873332E (de)
WO (1)	WO1997020835A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5789605A (en) *	1996-12-03	1998-08-04	Trustees Of The University Of Pennsylvania	Synthetic techniques and intermediates for polyhydroxy, dienyl lactones and mimics thereof
US6870058B2 (en) *	1996-12-03	2005-03-22	The Trustees Of The University Of Pennsylvania	Compounds which mimic the chemical and biological properties of discodermolide
US6242616B1 (en) *	1996-12-03	2001-06-05	The Trustees Of The University Of Pennsylvania	Synthetic techniques and intermediates for polyhydroxy, dienyl lactone derivatives
US20050065353A1 (en) *	1996-12-03	2005-03-24	Smith Amos B.	Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof
US6127406A (en) *	1998-10-09	2000-10-03	Harbor Branch Oceanographic Institution, Inc.	Discodermolide compounds and methods of use
US6833373B1 (en)	1998-12-23	2004-12-21	G.D. Searle & Co.	Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6384187B1 (en)	1999-05-15	2002-05-07	Harbor Branch Oceanographic Institution, Inc.	Antiproliferative activity of microsclerodermins
US6414015B1 (en)	2000-01-28	2002-07-02	Utah State University	Laulimalide microtubule stabilizing agents
DE60108359T2 (de)	2000-03-01	2005-12-22	Harbor Branch Oceanographic Institution, Inc., Fort Pierce	Biologisch wirksame, analoge verbindungen von discodermoliden
EP1274422A1 (de) *	2000-04-04	2003-01-15	Novartis AG	Verfahren zur behandlung von antineoplastika-resistenten zellen
US6774143B1 (en)	2000-04-04	2004-08-10	Novartis Ag	Method for treating cells resistant to antineoplastic agents
JP2005526689A (ja) *	2001-08-07	2005-09-08	ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア	ディスコダモライド（ｄｉｓｃｏｄｅｒｍｏｌｉｄｅ）の化学的、生物学的特徴を擬態した化合物
US6833367B2 (en) *	2001-11-16	2004-12-21	Novartis Ac	Certain substituted polyketides, pharmaceutical compositions containing them and their use in treating tumors
TW200408407A (en) *	2001-11-30	2004-06-01	Dana Farber Cancer Inst Inc	Methods and compositions for modulating the immune system and uses thereof
WO2004101508A2 (en) *	2003-04-02	2004-11-25	The Trustees Of The University Of Pennsylvania	Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof
WO2005084349A2 (en) *	2004-03-02	2005-09-15	Kosan Biosciences, Inc.	Compounds useful for the synthesis of (+)-discodermolide and methods therefor
US7214708B2 (en) *	2004-11-18	2007-05-08	Kosan Biosciences Incorporated	Synthetic discodermolide analogs
EP1883627B1 (de)	2005-05-18	2018-04-18	Pharmascience Inc.	An die bir-domäne bindende verbindungen
NZ572836A (en)	2006-05-16	2011-12-22	Pharmascience Inc	Iap bir domain binding compounds
CA2710087C (en)	2007-12-20	2015-06-02	Pharma Mar, S.A.	Antitumoral compounds
FR2937537A1 (fr) *	2008-10-29	2010-04-30	Centre Nat Rech Scient	Nanoparticules de statine
MX349513B (es)	2009-11-13	2017-08-02	Amgen Inc *	Materiales y metodos para el tratamiento o prevencion de enfermedades asociadas al her-3.
RU2567544C2 (ru)	2010-02-12	2015-11-10	Фармасайенс Инк.	Bir домен iap связывающие соединения
WO2012018404A2 (en)	2010-08-06	2012-02-09	U3 Pharma Gmbh	Use of her3 binding agents in prostate treatment
US10851121B2 (en) *	2016-12-09	2020-12-01	Akanocure Phamraceuticals, Inc.	Scalable polypropionate lactone stereotetrads
JOP20190254A1 (ar)	2017-04-27	2019-10-27	Pharma Mar Sa	مركبات مضادة للأورام

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4206221A (en) *	1979-01-03	1980-06-03	The United States Of America As Represented By The Secretary Of Agriculture	Cephalomannine and its use in treating leukemic tumors
US5157049A (en) *	1988-03-07	1992-10-20	The United States Of America As Represented By The Department Of Health & Human Services	Method of treating cancers sensitive to treatment with water soluble derivatives of taxol
US4960790A (en) *	1989-03-09	1990-10-02	University Of Kansas	Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5010099A (en) *	1989-08-11	1991-04-23	Harbor Branch Oceanographic Institution, Inc.	Discodermolide compounds, compositions containing same and method of preparation and use
US4939168A (en) *	1989-08-11	1990-07-03	Harbor Branch Oceanographics Institution, Inc.	Discodermolide compounds, compositions containing same and methods of preparation and use

1995
- 1995-12-05 US US08/567,442 patent/US5681847A/en not_active Expired - Lifetime
1996
- 1996-12-05 CA CA002233716A patent/CA2233716C/en not_active Expired - Fee Related
- 1996-12-05 JP JP52141097A patent/JP3293833B2/ja not_active Expired - Fee Related
- 1996-12-05 US US08/761,106 patent/US5840750A/en not_active Expired - Lifetime
- 1996-12-05 DK DK96943591T patent/DK0873332T3/da active
- 1996-12-05 ES ES96943591T patent/ES2218608T3/es not_active Expired - Lifetime
- 1996-12-05 DE DE69631975T patent/DE69631975T2/de not_active Expired - Lifetime
- 1996-12-05 EP EP96943591A patent/EP0873332B1/de not_active Expired - Lifetime
- 1996-12-05 AT AT96943591T patent/ATE262515T1/de not_active IP Right Cessation
- 1996-12-05 PT PT96943591T patent/PT873332E/pt unknown
- 1996-12-05 WO PCT/US1996/019344 patent/WO1997020835A1/en active IP Right Grant

Also Published As

Publication number	Publication date
US5840750A (en)	1998-11-24
DE69631975D1 (de)	2004-04-29
US5681847A (en)	1997-10-28
JP2000501710A (ja)	2000-02-15
CA2233716C (en)	2006-05-09
EP0873332A1 (de)	1998-10-28
JP3293833B2 (ja)	2002-06-17
WO1997020835A1 (en)	1997-06-12
EP0873332B1 (de)	2004-03-24
CA2233716A1 (en)	1997-06-12
ES2218608T3 (es)	2004-11-16
DE69631975T2 (de)	2005-01-20
PT873332E (pt)	2004-08-31
DK0873332T3 (da)	2004-07-26

Legal Events

Date

Code

Title

Description

2004-12-15

UEP

Publication of translation of european patent specification

Ref document number: 0873332

Country of ref document: EP

2011-09-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69631975D1 (de)	2004-04-29	Discodermolide verbindungen und deren pharmazeutische zusammensetzungen zur krebstherapie
ATE219363T1 (de)	2002-07-15	Lösliche prodrugs von paclitaxel
DE3689363D1 (de)	1994-01-20	Pharmazeutische Zusammensetzungen zur Behandlung der Metastasen von Krebstumoren.
DE69520880D1 (de)	2001-06-13	9-deoxotaxan verbindungen
IL87885A0 (en)	1989-03-31	Compounds having antiprogestational and anti-estrogenic activities for the treatment of tumours
ATE226576T1 (de)	2002-11-15	7-halo-und 7(beta), 8(beta)-methano-taxolen, antineoplastische verwendung und diese enthaltende pharmazeutische zusammenstellungen
DE69628019D1 (de)	2003-06-12	Chinolone und deren therapeutische verwendung
SE9301951D0 (sv)	1993-06-08	Methods for administration of taxol
RU95108590A (ru)	1997-03-20	Производные имидазола
DK0767786T3 (da)	1999-06-14	7-ether-taxol-analoge, antineoplastisk anvendelse deraf og farmaceutiske præparater indeholdende disse forbindelser
ATE82681T1 (de)	1992-12-15	2',3'-dideoxy-3'-fluorothymidin und verwandte verbindungen zur behandlung von adenovirusinfektionen.
RU2000131178A (ru)	2003-01-27	Метаболиты эктейнасцидина 743
AU1206292A (en)	1992-09-15	Therapeutic agents for the treatment of multidrug resistance to cancers
SE8404283D0 (sv)	1984-08-28	Anvendning av ett specifikt tumorassocierat antigen, nemligen sialosyllaktotetraos, for diagnostiska och terapeutiska forfaranden vid cancersjukdomar
IT8720181A0 (it)	1987-04-17	Composizioni farmaceutiche contenenti alcoli superiori per il trattamento di patologie della prostata.
AU3260093A (en)	1993-06-28	Use of creatine phosphate or phosphoenolpyruvic acid for the treatment of tumours
FR2500303B1 (de)	1983-12-30
GR3006834T3 (de)	1993-06-30
PL336897A1 (en)	2000-07-17	Novel salts of bpc peptides, pharmaceutic compositions conatining them and method of obtaining such salts
DE69724472D1 (de)	2003-10-02	Selenophen-antitumormittel
HUT49876A (en)	1989-11-28	Process for producing 6-oxopyridazine derivatives and pharmaceutical compositions comprising same
AU587661B2 (en)	1989-08-24	Phenylacetaldehydes substituted by basic groups, their preparation and drugs containing these compounds
CA2360419A1 (en)	2000-08-31	Molecules for the treatment and diagnosis of tumours
GB9101463D0 (en)	1991-03-06	Treatment of poisoning and compositions for use therein
AU4209097A (en)	1998-03-26	Breast carcinoma-associated gene