ES8605989A1 - Un metodo de preparar un complejo de fibronectina, dextrano y farmaco - Google Patents

Un metodo de preparar un complejo de fibronectina, dextrano y farmaco

Info

Publication number
ES8605989A1
ES8605989A1 ES542492A ES542492A ES8605989A1 ES 8605989 A1 ES8605989 A1 ES 8605989A1 ES 542492 A ES542492 A ES 542492A ES 542492 A ES542492 A ES 542492A ES 8605989 A1 ES8605989 A1 ES 8605989A1
Authority
ES
Spain
Prior art keywords
fibronectin
dextran
preparation
drug complex
drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES542492A
Other languages
English (en)
Other versions
ES542492A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Tanabe Pharma Corp
Original Assignee
Green Cross Corp Japan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Green Cross Corp Japan filed Critical Green Cross Corp Japan
Publication of ES8605989A1 publication Critical patent/ES8605989A1/es
Publication of ES542492A0 publication Critical patent/ES542492A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6435—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a connective tissue peptide, e.g. collagen, fibronectin or gelatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Materials Engineering (AREA)
  • Zoology (AREA)
  • Polymers & Plastics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Peptides Or Proteins (AREA)

Abstract

METODO DE PREPARACION DE COMPLEJOS DE FIBRONECTINA DEXTRANO Y UN COMPUESTO CON ACTIVIDAD FARMACOLOGICA, EN EL QUE LA FIBRONECTINA SE HALLA UNIDA AL FARMACO A TRAVES DE UN DEXTRANO. CONSISTE EN LA REACCIOIN DE FIBRONECTINA, UN DEXTRANO OXIDADO QUE TIENE ESTRUCTURA DE ANILLO ROTO DE ALDOHEXOPIRANOSA, DE FORMULA (I) Y UN COMPUESTO CON ACTIVIDAD FARMACOLOGICA, SELECCIONADO ENTRE UN AGENTE ANTITUMORAL, UN ANTIBIOTICO Y UN AGENTE ANTIINFLAMATORIO, Y QUE TIENE UN GRUPO CAPAZ DE COMBINARSE CON EL DEXTRANO OXIDADO, A LA TEMPERATURA AMBIENTE O INFERIOR. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA PREVENIR LA SUPURACION DE UN SITIO HERIDO, Y PARA LA DESTRUCCION DE CELULAS CANCEROSAS
ES542492A 1984-04-25 1985-04-23 Un metodo de preparar un complejo de fibronectina, dextrano y farmaco Expired ES8605989A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59084418A JPS60226819A (ja) 1984-04-25 1984-04-25 フイブロネクチン複合体

Publications (2)

Publication Number Publication Date
ES8605989A1 true ES8605989A1 (es) 1986-04-01
ES542492A0 ES542492A0 (es) 1986-04-01

Family

ID=13830037

Family Applications (1)

Application Number Title Priority Date Filing Date
ES542492A Expired ES8605989A1 (es) 1984-04-25 1985-04-23 Un metodo de preparar un complejo de fibronectina, dextrano y farmaco

Country Status (5)

Country Link
EP (1) EP0160521A3 (es)
JP (1) JPS60226819A (es)
KR (1) KR850007433A (es)
CA (1) CA1247010A (es)
ES (1) ES8605989A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8628398D0 (en) * 1986-11-27 1986-12-31 Central Blood Lab Authority Pharmaceutically-active conjugates
JPH01190636A (ja) * 1988-01-22 1989-07-31 Green Cross Corp:The 制癌作用物質複合体
US5393737A (en) * 1992-08-20 1995-02-28 Health Research, Inc. Cytotoxic drug conjugates for treatment of neoplastic diseases
WO1995033492A1 (en) * 1994-06-09 1995-12-14 Houston Biotechnology Incorporated Methods and compositions for modulation of wound healing
CN113546087B (zh) * 2021-07-01 2022-11-25 东华大学 一种纤连蛋白包覆的单宁酸/铁配合物的载药纳米材料及其制备和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4315906A (en) * 1979-05-21 1982-02-16 New England Nuclear Corporation Cold insoluble globulin, its purification and use
US4391749A (en) * 1981-10-19 1983-07-05 La Jolla Cancer Research Foundation Method for the purification of collagens
SE446688C (sv) * 1982-09-14 1989-08-01 Magnus Hoeoek Medel foer avlaegsnande av mikroorganismer fraan vaevnader, vilket bestaar av ett protein som kan bindas till mikroorganismerna
JPS59134732A (ja) * 1983-01-21 1984-08-02 Green Cross Corp:The フイブロネクチン・生理活性物質複合体の製造法

Also Published As

Publication number Publication date
CA1247010A (en) 1988-12-20
EP0160521A3 (en) 1986-12-10
EP0160521A2 (en) 1985-11-06
ES542492A0 (es) 1986-04-01
JPS60226819A (ja) 1985-11-12
KR850007433A (ko) 1985-12-04

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970203