CY1123355T1 - Αντισωματα εναντι cd73 και χρησεις εξ αυτων - Google Patents
Αντισωματα εναντι cd73 και χρησεις εξ αυτωνInfo
- Publication number
- CY1123355T1 CY1123355T1 CY20201100722T CY201100722T CY1123355T1 CY 1123355 T1 CY1123355 T1 CY 1123355T1 CY 20201100722 T CY20201100722 T CY 20201100722T CY 201100722 T CY201100722 T CY 201100722T CY 1123355 T1 CY1123355 T1 CY 1123355T1
- Authority
- CY
- Cyprus
- Prior art keywords
- antibodies
- disclosure
- methods
- expressing
- human
- Prior art date
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- C—CHEMISTRY; METALLURGY
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6871—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting an enzyme
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C07K16/3023—Lung
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- C07K16/3038—Kidney, bladder
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
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- C—CHEMISTRY; METALLURGY
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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Abstract
Η παρούσα εφεύρεση παρέχει απομονωμένα μονοκλωνικά αντισώματα, ειδικότερα δε ανθρώπινα αντισώματα, που δεσμεύονται στην ανθρώπινη Συνάθροιση Διαφοροποίησης 73 (CD73) με υψηλή συγγένεια, και αναστέλλουν τη δραστηριότητα του CD73, και μεσολαβούν προαιρετικώς σε εξαρτώμενη από αντισώματα εσωτερικοποίηση CD73. Μόρια πυρηνικών οξέων που εγκωδικεύουν τα αντισώματα της αποκάλυψης, ανύσματα έκφρασης, κύτταρα ξενιστών και μέθοδοι για έκφραση των αντισωμάτων της αποκάλυψης παρέχονται επίσης. Ανοσοσυζεύγματα, δι-συγκεκριμένα μόρια και φαρμακευτικές συνθέσεις που περιλαμβάνουν τα αντισώματα της αποκάλυψης παρέχονται επίσης. Η αποκάλυψη παρέχει επίσης και μεθόδους για αναστολή της αύξησης ενός κυττάρου όγκου που εκφράζει CD73 χρησιμοποιώντας τα αντισώματα της αποκάλυψης, που συμπεριλαμβάνουν μεθόδους για αγωγή διαφόρων καρκίνων.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462083056P | 2014-11-21 | 2014-11-21 | |
PCT/US2015/061639 WO2016081748A2 (en) | 2014-11-21 | 2015-11-19 | Antibodies against cd73 and uses thereof |
Publications (1)
Publication Number | Publication Date |
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CY1123355T1 true CY1123355T1 (el) | 2021-12-31 |
Family
ID=55022668
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20201100722T CY1123355T1 (el) | 2014-11-21 | 2020-08-04 | Αντισωματα εναντι cd73 και χρησεις εξ αυτων |
Country Status (36)
Country | Link |
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US (6) | US10100129B2 (el) |
EP (2) | EP3725808A1 (el) |
JP (2) | JP6805142B2 (el) |
KR (2) | KR102569813B1 (el) |
CN (2) | CN107001474B (el) |
AR (1) | AR102698A1 (el) |
AU (2) | AU2015349878A1 (el) |
BR (1) | BR112017010110A2 (el) |
CA (1) | CA2968357A1 (el) |
CL (2) | CL2017001296A1 (el) |
CO (1) | CO2017005845A2 (el) |
CY (1) | CY1123355T1 (el) |
DK (1) | DK3221363T3 (el) |
EA (2) | EA035766B1 (el) |
ES (1) | ES2807182T3 (el) |
HK (1) | HK1244817A1 (el) |
HR (1) | HRP20201176T1 (el) |
HU (1) | HUE050596T2 (el) |
IL (2) | IL252353B (el) |
LT (1) | LT3221363T (el) |
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