CY1105047T1 - Ενωσεις πυριδοπυριμιδινονης, η μεθοδος παρασκευης τους και φαρμακευτικες συνθεσεις που τις περιεχουν - Google Patents

Ενωσεις πυριδοπυριμιδινονης, η μεθοδος παρασκευης τους και φαρμακευτικες συνθεσεις που τις περιεχουν

Info

Publication number
CY1105047T1
CY1105047T1 CY20061100767T CY061100767T CY1105047T1 CY 1105047 T1 CY1105047 T1 CY 1105047T1 CY 20061100767 T CY20061100767 T CY 20061100767T CY 061100767 T CY061100767 T CY 061100767T CY 1105047 T1 CY1105047 T1 CY 1105047T1
Authority
CY
Cyprus
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
compounds
pyridopyrimidinone compounds
Prior art date
Application number
CY20061100767T
Other languages
English (en)
Inventor
Sylvain Rault
Jean-Charles Lancelot
Marina Kopp
Daniel-Henri Caignard
Bruno Pfeiffer
Pierre Renard
Original Assignee
Les Laboratoires Servier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier filed Critical Les Laboratoires Servier
Publication of CY1105047T1 publication Critical patent/CY1105047T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

Ενώσεις του τύπου (I) στον οποίο: τα R1, R2, R3, R4 ορίζονται στην περιγραφή, τα εναντιομερή, διαστερεοϊσομερή, ταυτομερή τους καθώς και τα άλατα τους προσθήκης με φαρμακευτικώς αποδεκτό οξύ ή βάση. Αυτές οι ενώσεις έχουν ιδιότητες διαμόρφωσης των κινασών και είναι χρήσιμες στη θεραπεία του καρκίνου, του διαβήτη, της παχυσαρκίας, κλπ.
CY20061100767T 2002-11-05 2006-06-08 Ενωσεις πυριδοπυριμιδινονης, η μεθοδος παρασκευης τους και φαρμακευτικες συνθεσεις που τις περιεχουν CY1105047T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0213804A FR2846657B1 (fr) 2002-11-05 2002-11-05 Nouveaux composes pyridopyrimidinone, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR2003/003274 WO2004043956A1 (fr) 2002-11-05 2003-11-04 Composes pyridopyrimidinone, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
CY1105047T1 true CY1105047T1 (el) 2009-11-04

Family

ID=32104442

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20061100767T CY1105047T1 (el) 2002-11-05 2006-06-08 Ενωσεις πυριδοπυριμιδινονης, η μεθοδος παρασκευης τους και φαρμακευτικες συνθεσεις που τις περιεχουν

Country Status (28)

Country Link
US (1) US7361662B2 (el)
EP (1) EP1560826B1 (el)
JP (1) JP2006512317A (el)
KR (1) KR100717489B1 (el)
CN (1) CN1330650C (el)
AR (1) AR041883A1 (el)
AT (1) ATE323092T1 (el)
AU (1) AU2003292320B2 (el)
BR (1) BR0315801A (el)
CA (1) CA2503995A1 (el)
CY (1) CY1105047T1 (el)
DE (1) DE60304599T2 (el)
DK (1) DK1560826T3 (el)
EA (1) EA009043B1 (el)
ES (1) ES2261978T3 (el)
FR (1) FR2846657B1 (el)
GE (1) GEP20084376B (el)
HK (1) HK1081965A1 (el)
MA (1) MA27410A1 (el)
MX (1) MXPA05004789A (el)
MY (1) MY140164A (el)
NO (1) NO20052683D0 (el)
NZ (1) NZ539598A (el)
PL (1) PL376399A1 (el)
PT (1) PT1560826E (el)
UA (1) UA80578C2 (el)
WO (1) WO2004043956A1 (el)
ZA (1) ZA200503233B (el)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007303846B2 (en) * 2006-10-04 2011-03-10 Pfizer Products Inc. Pyrido[4,3-d]pyrimidin-4(3H)-one derivatives as calcium receptor antagonists
CN101531638B (zh) * 2008-03-13 2011-12-28 中国科学院广州生物医药与健康研究院 用作***相关受体调节剂的化合物及其应用
CN101619063B (zh) * 2009-06-02 2011-08-10 华中师范大学 具有抗肿瘤活性的3,7,8-多取代吡啶并[4,3-d]嘧啶衍生物及制备
US8981087B2 (en) 2009-07-29 2015-03-17 Karus Therapeutics Limited Benzo [E] [1,3] oxazin-4-one derivatives as phosphoinositide 3-kinase inhibitors
PL2467387T3 (pl) 2009-08-20 2015-08-31 Karus Therapeutics Ltd Tricykliczne związki heterocykliczne jako inhibitory kinazy 3-fosfoinozytydu
GB201204125D0 (en) 2012-03-08 2012-04-25 Karus Therapeutics Ltd Compounds
EA030253B1 (ru) 2012-09-28 2018-07-31 Кэнсэр Ресерч Текнолоджи Лимитед Азахиназолиновые ингибиторы атипичной протеинкиназы c
GB201402431D0 (en) 2014-02-12 2014-03-26 Karus Therapeutics Ltd Compounds
WO2016068580A2 (en) 2014-10-29 2016-05-06 Dong-A Socio Holdings Co., Ltd. Novel pyridopyrimidinone compounds for modulating the catalytic activity of histone lysine demethylases (kdms)
GB201514751D0 (en) 2015-08-19 2015-09-30 Karus Therapeutics Ltd Compounds
GB201514754D0 (en) 2015-08-19 2015-09-30 Karus Therapeutics Ltd Compounds
GB201514760D0 (en) 2015-08-19 2015-09-30 Karus Therapeutics Ltd Compounds and method of use
GB201514758D0 (en) 2015-08-19 2015-09-30 Karus Therapeutics Ltd Formulation
US20170057955A1 (en) * 2015-08-26 2017-03-02 Dong-A Socio Holdings Co., Ltd. Pyridopyrimidinone Compounds for Modulating the Catalytic Activity of Histone Lysine Demethylases (KDMs)
CN105616420A (zh) * 2016-01-16 2016-06-01 赵国良 一种降血脂的药物组合物
IL277071B1 (en) 2018-03-08 2024-03-01 Incyte Corp Aminopyrizine diol compounds as PI3K–y inhibitors
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors
WO2021102288A1 (en) * 2019-11-22 2021-05-27 Senda Biosciences, Inc. Pyridopyrimidinone derivatives as ahr antagonists
WO2024008722A2 (en) * 2022-07-04 2024-01-11 Muna Therapeutics Aps Trem2 modulators

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6348310B1 (en) * 1994-03-04 2002-02-19 Promega Corporation Quantitation of individual protein kinase activity
US6060477A (en) * 1995-06-07 2000-05-09 Cell Pathways, Inc. Method of treating a patient having precancerous lesions with phenyl cycloamino pyrimidinone derivatives
ZA9756B (en) * 1996-01-16 1997-07-17 Warner Lambert Co Process for preparing 4,6-disubstituted pyrido[3,4-d]-pyrimidines
HRP970371A2 (en) * 1996-07-13 1998-08-31 Kathryn Jane Smith Heterocyclic compounds
KR20000029843A (ko) * 1996-08-06 2000-05-25 디. 제이. 우드;스피겔 알렌 제이 치환된피리도-또는피리미도-함유6,6-또는6,7-비시클릭유도체
US6962922B2 (en) * 2001-10-12 2005-11-08 Warner-Lambert Company Llc Alkynylated quinazoline compounds
AUPS019702A0 (en) * 2002-01-29 2002-02-21 Fujisawa Pharmaceutical Co., Ltd. Condensed heterocyclic compounds

Also Published As

Publication number Publication date
EP1560826A1 (fr) 2005-08-10
KR20050087792A (ko) 2005-08-31
EA200500690A1 (ru) 2005-10-27
MA27410A1 (fr) 2005-06-01
US7361662B2 (en) 2008-04-22
CN1711260A (zh) 2005-12-21
EA009043B1 (ru) 2007-10-26
FR2846657A1 (fr) 2004-05-07
ATE323092T1 (de) 2006-04-15
PT1560826E (pt) 2006-07-31
EP1560826B1 (fr) 2006-04-12
NZ539598A (en) 2006-11-30
HK1081965A1 (en) 2006-05-26
DK1560826T3 (da) 2006-08-14
UA80578C2 (en) 2007-10-10
US20050288311A1 (en) 2005-12-29
BR0315801A (pt) 2005-09-20
WO2004043956A8 (fr) 2005-06-09
KR100717489B1 (ko) 2007-05-14
ZA200503233B (en) 2006-06-28
PL376399A1 (en) 2005-12-27
DE60304599D1 (de) 2006-05-24
WO2004043956A1 (fr) 2004-05-27
NO20052683L (no) 2005-06-03
AR041883A1 (es) 2005-06-01
MXPA05004789A (es) 2005-07-22
ES2261978T3 (es) 2006-11-16
FR2846657B1 (fr) 2004-12-24
AU2003292320B2 (en) 2009-03-12
JP2006512317A (ja) 2006-04-13
GEP20084376B (en) 2008-05-27
MY140164A (en) 2009-11-30
AU2003292320A1 (en) 2004-06-03
CN1330650C (zh) 2007-08-08
NO20052683D0 (no) 2005-06-03
CA2503995A1 (fr) 2004-05-27
DE60304599T2 (de) 2007-05-16

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