PE20091217A1 - Formas cristalinas de n-(terc-butoxicarbonil)-3-metil-l-valil-(4r)-4-((7-cloro-4-metoxi-1-isoquinolinil)oxi)-n-((1r,2s)-1-((ciclopropilsulfonil)carbamoil)-2-vinilciclopropil)-l-prolinamida - Google Patents
Formas cristalinas de n-(terc-butoxicarbonil)-3-metil-l-valil-(4r)-4-((7-cloro-4-metoxi-1-isoquinolinil)oxi)-n-((1r,2s)-1-((ciclopropilsulfonil)carbamoil)-2-vinilciclopropil)-l-prolinamidaInfo
- Publication number
- PE20091217A1 PE20091217A1 PE2008002161A PE2008002161A PE20091217A1 PE 20091217 A1 PE20091217 A1 PE 20091217A1 PE 2008002161 A PE2008002161 A PE 2008002161A PE 2008002161 A PE2008002161 A PE 2008002161A PE 20091217 A1 PE20091217 A1 PE 20091217A1
- Authority
- PE
- Peru
- Prior art keywords
- crystalline forms
- cyclopropylsulfonil
- butoxicarbonyl
- carbamoil
- terc
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A FORMAS CRISTALINAS DE N-(TERC-BUTOXICARBONIL)-3-METIL-L-VALIL-(4R)-4-((7-CLORO-4-METOXI-1-ISOQUINOLINIL)OXI)-N-((1R,2S)-1-((CICLOPROPILSULFONIL)CARBAMOIL)-2-VINILCICLOPROPIL)-L-PROLINAMIDA, TAL COMO i) LA FORMA H-1 CON PICOS CARACTERISTICOS EN EL PATRON DE DIFRACCION DE RAYOS X POR CRISTALES FINOS EN VALORES DE DOS THETA DE 6,3 ± 0,1; 7,1 ± 0,1; 9,4 ± 0,1; 10,3 ± 0,1; 12,7 ± 0,1; 13,8 ± 0,1; 17,5 ± 0,1; ENTRE OTROS; ii) LA FORMA T1F-1/2 CON PICOS CARACTERISTICOS EN EL PATRON DE DIFRACCION DE RAYOS X POR CRISTALES FINOS EN VALORES DE DOS THETA DE 7,3 ± 0,1; 9,1 ± 0,1; 10,0 ± 0,1; 10,6 ± 0,1; 11,1 ± 0,1; 12,3 ± 0,1; 15,6 ± 0,1; ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA QUE CONTIENE DICHAS FORMAS CRISTALINAS Y OPCIONALMENTE OTRO COMPUESTO TAL COMO INTERLEUCINA 2, RIBAVIRINA, ENTRE OTROS. DICHAS FORMAS CRISTALINAS SON UTILES EN EL TRATAMIENTO DE LA HEPATITIS C
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US1579507P | 2007-12-21 | 2007-12-21 |
Publications (1)
Publication Number | Publication Date |
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PE20091217A1 true PE20091217A1 (es) | 2009-08-14 |
Family
ID=40467309
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2008002161A PE20091217A1 (es) | 2007-12-21 | 2008-12-19 | Formas cristalinas de n-(terc-butoxicarbonil)-3-metil-l-valil-(4r)-4-((7-cloro-4-metoxi-1-isoquinolinil)oxi)-n-((1r,2s)-1-((ciclopropilsulfonil)carbamoil)-2-vinilciclopropil)-l-prolinamida |
PE2017000076A PE20170534A1 (es) | 2007-12-21 | 2008-12-19 | Formas cristalinas de n-(terc-butoxicarbonil)-3-metil-l-valil-(4r)-4-((7-cloro-4-metoxi-1-isoquinolinil)oxi)-n-((1r,2s)-1-((ciclopropilsulfonil)carbamoil)-2-vinilciclopropil)-l-prolinamida |
PE2013000341A PE20131130A1 (es) | 2007-12-21 | 2008-12-19 | Formas cristalinas de n-(terc-butoxicarbonil)-3-metil-l-valil-(4r)-4-((7-cloro-4-metoxi-1-isoquinolinil)oxi)-n-((1r,2s)-1-((ciclopropilsulfonil)carbamoil)-2-vinilciclopropil)-l-prolinamida |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2017000076A PE20170534A1 (es) | 2007-12-21 | 2008-12-19 | Formas cristalinas de n-(terc-butoxicarbonil)-3-metil-l-valil-(4r)-4-((7-cloro-4-metoxi-1-isoquinolinil)oxi)-n-((1r,2s)-1-((ciclopropilsulfonil)carbamoil)-2-vinilciclopropil)-l-prolinamida |
PE2013000341A PE20131130A1 (es) | 2007-12-21 | 2008-12-19 | Formas cristalinas de n-(terc-butoxicarbonil)-3-metil-l-valil-(4r)-4-((7-cloro-4-metoxi-1-isoquinolinil)oxi)-n-((1r,2s)-1-((ciclopropilsulfonil)carbamoil)-2-vinilciclopropil)-l-prolinamida |
Country Status (18)
Country | Link |
---|---|
US (2) | US8202996B2 (es) |
EP (1) | EP2231639B1 (es) |
JP (1) | JP5566907B2 (es) |
KR (1) | KR101560428B1 (es) |
CN (3) | CN103755784B (es) |
AR (2) | AR069886A1 (es) |
AU (1) | AU2008343423B2 (es) |
CL (1) | CL2008003849A1 (es) |
DK (1) | DK2231639T3 (es) |
ES (1) | ES2536409T3 (es) |
HR (1) | HRP20150458T1 (es) |
MX (1) | MX336329B (es) |
PE (3) | PE20091217A1 (es) |
PL (1) | PL2231639T3 (es) |
PT (1) | PT2231639E (es) |
SI (1) | SI2231639T1 (es) |
TW (1) | TWI496573B (es) |
WO (1) | WO2009085659A1 (es) |
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- 2008-12-12 EP EP08866514.6A patent/EP2231639B1/en not_active Not-in-force
- 2008-12-12 DK DK08866514.6T patent/DK2231639T3/en active
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- 2008-12-12 JP JP2010539659A patent/JP5566907B2/ja not_active Expired - Fee Related
- 2008-12-12 KR KR1020107013461A patent/KR101560428B1/ko active IP Right Grant
- 2008-12-12 CN CN201410043331.3A patent/CN103755784B/zh not_active Expired - Fee Related
- 2008-12-12 AU AU2008343423A patent/AU2008343423B2/en not_active Ceased
- 2008-12-12 SI SI200831432T patent/SI2231639T1/sl unknown
- 2008-12-12 ES ES08866514.6T patent/ES2536409T3/es active Active
- 2008-12-12 PL PL08866514T patent/PL2231639T3/pl unknown
- 2008-12-12 CN CN201610420780.4A patent/CN106146613A/zh active Pending
- 2008-12-12 MX MX2010006489A patent/MX336329B/es unknown
- 2008-12-12 CN CN200880121915.0A patent/CN101903371B/zh not_active Expired - Fee Related
- 2008-12-12 PT PT88665146T patent/PT2231639E/pt unknown
- 2008-12-19 PE PE2008002161A patent/PE20091217A1/es not_active Application Discontinuation
- 2008-12-19 PE PE2017000076A patent/PE20170534A1/es unknown
- 2008-12-19 AR ARP080105639A patent/AR069886A1/es not_active Application Discontinuation
- 2008-12-19 PE PE2013000341A patent/PE20131130A1/es not_active Application Discontinuation
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US8338606B2 (en) | 2012-12-25 |
PL2231639T3 (pl) | 2015-09-30 |
JP2011507869A (ja) | 2011-03-10 |
AU2008343423A1 (en) | 2009-07-09 |
MX2010006489A (es) | 2010-07-05 |
PE20131130A1 (es) | 2013-10-05 |
DK2231639T3 (en) | 2015-07-06 |
CN106146613A (zh) | 2016-11-23 |
US20120230949A1 (en) | 2012-09-13 |
KR20100099703A (ko) | 2010-09-13 |
CL2008003849A1 (es) | 2009-05-29 |
HRP20150458T1 (hr) | 2015-06-05 |
MX336329B (es) | 2016-01-15 |
EP2231639A1 (en) | 2010-09-29 |
AR106338A2 (es) | 2018-01-03 |
US8202996B2 (en) | 2012-06-19 |
PE20170534A1 (es) | 2017-05-11 |
CN103755784B (zh) | 2017-04-12 |
US20090202476A1 (en) | 2009-08-13 |
KR101560428B1 (ko) | 2015-10-15 |
EP2231639B1 (en) | 2015-04-01 |
AU2008343423B2 (en) | 2013-10-10 |
JP5566907B2 (ja) | 2014-08-06 |
CN101903371A (zh) | 2010-12-01 |
CN101903371B (zh) | 2014-03-19 |
SI2231639T1 (sl) | 2015-11-30 |
AR069886A1 (es) | 2010-02-24 |
CN103755784A (zh) | 2014-04-30 |
TWI496573B (zh) | 2015-08-21 |
ES2536409T3 (es) | 2015-05-25 |
TW200932214A (en) | 2009-08-01 |
PT2231639E (pt) | 2015-06-03 |
WO2009085659A1 (en) | 2009-07-09 |
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