CN101953871A - Antibacterial medicament for animals and preparation method and application thereof - Google Patents
Antibacterial medicament for animals and preparation method and application thereof Download PDFInfo
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- CN101953871A CN101953871A CN 201010506060 CN201010506060A CN101953871A CN 101953871 A CN101953871 A CN 101953871A CN 201010506060 CN201010506060 CN 201010506060 CN 201010506060 A CN201010506060 A CN 201010506060A CN 101953871 A CN101953871 A CN 101953871A
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- folium artemisiae
- artemisiae argyi
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Abstract
The invention discloses an antibacterial medicament for animals. The medicament comprises the following active ingredients in percentage by weight: 1 to 10 percent of enrofloxacin and 5 to 20 percent of wormwood leaf extract prepared by water extraction and alcohol precipitation. The invention also discloses a preparation method for the medicament and application of the medicament in treating medicament-resistant pathogenic bacteria infection in an animal alimentary canal. The enrofloxacin and the wormwood leaf extract are taken as the active ingredients of the medicament, the defect that the enrofloxacin is easy to generate medicament resistance is overcome and the effect of killing medicament-resistant pathogenic bacteria is greatly improved; the antibacterial medicament has the advantages of reasonable and scientific formula, obviously enhanced antibacterial function of the medicament, obviously improved effect of treating the medicament-resistant pathogenic bacteria infection in the animal alimentary canal, simple and convenient preparation method, and suitability for large-scale production and application.
Description
Technical field
The present invention relates to a kind of animal and use antimicrobial drug and its production and application, particularly a kind of medicine for the treatment of the animal alimentary canal pathogenic bacterial infection and its production and application belongs to medical technical field.
Background technology
Investigation shows that animal alimentary canal diseases can cause the animal feeding cost to improve, and breeding performonce fo animals descends, and is one of two big class diseases of harm animal cultivation.Particularly the digestive tract disease that causes of pathogenic bacterial infection has very high infectiousness, can cause the morbidity of animal jumpbogroup, and case fatality rate is higher, brings about great losses to aquaculture.If the drug main antibiotic of treatment animal alimentary canal pathogenic bacterial infection commonly used as penicillin, cephalo-type, chloromycetin, chlortetracycline, berberine etc., cooperates fluid infusion salt, glucose etc.But rely on antibiotic therapy merely, often cause pathogen Drug resistance problem.Particularly at present in the aquaculture antibiotic use unorderedly, it is commonplace to culture place pathogen Drug resistance at some, relies on antibiotic therapy Drug resistance pathogenic bacterial infection merely, effect is unsatisfactory, even complete failure.In the face of increasingly serious pathogen Drug resistance problem, the medicine that searching can solve the Drug resistance pathogenic bacterial infection has become the important topic of treatment animal alimentary canal diseases, but does not find as yet that at present promptly safety is effectively treated the medicine that Drug resistance digestive tract cause of disease bacterium infects again.
Summary of the invention
The present invention is directed to the present situation that the pathogen Drug resistance is serious, treat the pathogenic bacterial infection poor effect, a kind of pharmaceutical composition for the treatment of the animal alimentary canal pathogenic bacterial infection is provided, this medicine is difficult for developing immunity to drugs, and can treat the infection of digestive tract Drug resistance pathogen more efficiently and safely.
The present invention also provides the preparation of drug combination methods and applications of this treatment animal alimentary canal pathogenic bacterial infection.
The present invention is achieved by the following measures:
A kind of animal is used antibacterials, it is characterized in that: effective ingredient is an enrofloxacin and through the Folium Artemisiae Argyi extract of water extract-alcohol precipitation gained, and contents of enrofloxacin is 1-10wt%, and the content of Folium Artemisiae Argyi extract is 5-20wt%.
Above-mentioned animal also comprises cosolvent and adjuvant with in the antibacterials, and the weight percent content of each component is in the medicine:
Enrofloxacin 1-10%;
Folium Artemisiae Argyi extract 5-20%;
Cosolvent 5%;
The adjuvant surplus.
Above-mentioned animal is with in the antibacterials, and described cosolvent is sodium bicarbonate, citric acid or nicotinic acid; Described adjuvant is one or both in glucose, lactose, sucrose and the water soluble starch.
Above-mentioned animal is with in the antibacterials, and described Folium Artemisiae Argyi water extract makes by the following method:
(1) Folium Artemisiae Argyi is decocted 3h with times water pressurization of 7 quality, decocting temperature is 115 ℃, and the purpose of pressurization is to make steam reach temperature required, and the big I of pressure is according to circumstances specifically regulated;
(2) adding dehydrated alcohol to mixed liquor in the aqueous extract after decoction, to contain the alcohol amount be 60%, then mixed liquor left standstill 12h under 4 ℃;
(3) mixed liquor after will leaving standstill is crossed the leaching supernatant, then the supernatant heating is concentrated to remove and anhydrates and alcohol, again 60 ℃ of vacuum-0.09MPa, temperature down dry 0.5-2h get Folium Artemisiae Argyi extract.
Above-mentioned animal with the preferred weight percent content of antibacterials is:
Enrofloxacin 5%;
Folium Artemisiae Argyi water extract 10%;
Cosolvent 5%;
Adjuvant 80%.
Above-mentioned animal may further comprise the steps with the preparation method of antibacterials:
(1) Folium Artemisiae Argyi is decocted 3h with times water pressurization of 7 quality, decocting temperature is 115 ℃, and the purpose of pressurization is to make steam reach temperature required, and the big I of pressure is according to circumstances specifically regulated;
(2) adding dehydrated alcohol to mixed liquor in the aqueous extract after decoction, to contain the alcohol amount be 60%, then mixed liquor left standstill 12h under 4 ℃;
(3) mixed liquor after will leaving standstill is crossed the leaching supernatant, then the supernatant heating is concentrated to remove and anhydrates and alcohol, again 60 ℃ of vacuum-0.09MPa, temperature down dry 0.5-2h get Folium Artemisiae Argyi extract;
(4) above-mentioned Folium Artemisiae Argyi extract, enrofloxacin, cosolvent and adjuvant were pulverized 40 mesh sieves, promptly got these antibacterials according to the proportioning mix homogeneously.
Above-mentioned animal is to add this medicine 50-100mg in every liter of animal drinking-water with the application of antibacterials in treatment animal alimentary canal pathogenic bacterial infection, its consumption, is generally service time five days.
Traditional animal specific enrofloxacin antibacterial drug is the broad-spectrum sterilization medicine, and escherichia coli, klebsiella, Salmonella, Bacillus proteus, bacillus pyocyaneus, haemophilus, pasteurella multocida, pasteurella haemolytica, golden Portugal bacterium, streptococcus etc. are all had sterilization effectiveness.But enrofloxacin list medicine easily develops immunity to drugs when using, and passing effect in time is more and more undesirable, even complete failure.The Chinese crude drug Folium Artemisiae Argyi has another name called that Chinese mugwort, ice platform, Radix Artemisia ordosicae, doctor's grass, moxibustion grass, Chinese mugwort, Dendrobium denneanum Kerr., family Chinese mugwort, sweet Chinese mugwort, grass are fluffy, Ai Peng, stellerin, XIANGAI, Ye Liantou, A Jiai, Chen Ai, grey grass, Folium Artemisiae Argyi, Du Aiye, Artemisia withers, its warming the spleen is good for the stomach, the secretion of facilitating digestion liquid, the body digestive function is had positive regulating action, help the pathogenic bacterial infection recovery of animal alimentary canal function later.Contain antimicrobial component in the Folium Artemisiae Argyi extract, has a broad antifungal spectrum, and be difficult for developing immunity to drugs.The present invention as effective ingredient, has overcome the deficiency that enrofloxacin easily develops immunity to drugs with enrofloxacin and Folium Artemisiae Argyi extract, has greatly improved the killing effect of antagonistic drug pathogen.
The present invention fills a prescription rationally, science, and the medicine antibacterial effect significantly strengthens, and treatment animal alimentary canal Drug resistance pathogenic bacterial infection effect significantly improves.Preparation method of the present invention is easy, is fit to large-scale production, application.
The specific embodiment
Below by specific embodiment the present invention is further set forth, should be understood that, following explanation only is in order to explain the present invention, its content not to be limited.
Embodiment 1
The percentage by weight of each component of pharmaceutical composition is: enrofloxacin 5g, Folium Artemisiae Argyi extract 10g, sodium bicarbonate 5g, glucose 80g.
Preparation method: (1) decocts 3h with Folium Artemisiae Argyi with times water pressurization of 7 quality, and decocting temperature is 115 ℃, and the purpose of pressurization is to make steam reach temperature required, and the big I of pressure is according to circumstances specifically regulated; (2) adding dehydrated alcohol to mixed liquor in the aqueous extract after decoction, to contain the alcohol amount be 60%, then mixed liquor left standstill 12h under 4 ℃; (3) mixed liquor after will leaving standstill is crossed the leaching supernatant, then the supernatant heating is concentrated to remove and anhydrates and alcohol, again 60 ℃ of vacuum-0.09MPa, temperature down dry 0.5-2h get Folium Artemisiae Argyi extract; (4) above-mentioned Folium Artemisiae Argyi extract 10g, enrofloxacin 5g, sodium bicarbonate 5g, glucose 80g were pulverized 40 mesh sieves, mix homogeneously promptly gets these antibacterials.
Embodiment 2
The percentage by weight of each component of pharmaceutical composition is: enrofloxacin 5g, Folium Artemisiae Argyi extract 5g, citric acid 5g, soluble starch 85g.
Preparation method: (1) decocts 3h with Folium Artemisiae Argyi with times water pressurization of 7 quality, and decocting temperature is 115 ℃, and the purpose of pressurization is to make steam reach temperature required, and the big I of pressure is according to circumstances specifically regulated; (2) adding dehydrated alcohol to mixed liquor in the aqueous extract after decoction, to contain the alcohol amount be 60%, then mixed liquor left standstill 12h under 4 ℃; (3) mixed liquor after will leaving standstill is crossed the leaching supernatant, then the supernatant heating is concentrated to remove and anhydrates and alcohol, again 60 ℃ of vacuum-0.09MPa, temperature down dry 1-2h get Folium Artemisiae Argyi extract; (4) with above-mentioned Folium Artemisiae Argyi extract 5g, enrofloxacin 5g, citric acid 5g, soluble starch 85g pulverized 40 mesh sieves, and mix homogeneously promptly gets these antibacterials.
Embodiment 3
The percentage by weight of each component of pharmaceutical composition is: enrofloxacin 2.5g, Folium Artemisiae Argyi extract 20g, nicotinic acid 5g, sucrose 72.5g.
Preparation method is with embodiment 1.
Embodiment 4
The percentage by weight of each component of pharmaceutical composition is: enrofloxacin 5g, Folium Artemisiae Argyi extract 20g, citric acid 5g, sucrose 70g.
Preparation method is with embodiment 1.
Embodiment 5
The percentage by weight of each component of pharmaceutical composition is: enrofloxacin 1g, Folium Artemisiae Argyi extract 15 g, citric acid 5g, lactose 79g.
Preparation method is with embodiment 1.
Embodiment 6
The percentage by weight of each component of pharmaceutical composition is: enrofloxacin 10g, Folium Artemisiae Argyi extract 10 g, citric acid 5g, sucrose and water soluble starch 75g.
Preparation method is with embodiment 1.
Embodiment 7
The percentage by weight of each component of pharmaceutical composition is: enrofloxacin 7.5g, Folium Artemisiae Argyi extract 20 g, citric acid 5g, sucrose and glucose 67.5g.
Being example with chicken and pig below describes the effect of medicine of the present invention
The using method of this medicine is: every 1L water, and chicken is added 50-80mg, and pig is added 70-100mg, mixes drink, and be five days the course of treatment.
Clinical practice example 1
Scale chicken farm, Shandong, a large amount of 15 age in days left and right sides chickling drop-head occurs, flock together, are afraid of cold, feather is in disorder, few food, spirit are depressed, draw the canescence loose stool, stick with paste the anus symptom, and tentative diagnosis is the Pullorum Disease that coli-infection causes.Be diagnosed as coli-infection through the laboratory isolation identification, further drug sensitive test detection demonstration causes that the escherichia coli of morbidity have Drug resistance to gentamycin, ampicillin etc.Choose 120 of disease chickens, be divided into 4 groups at random, 30 every group, be respectively gentamycin treatment group, furazolidone treatment group, enrofloxacin treatment group and treatment group of the present invention (medicine that uses embodiment 1 to make).After the medication 5 days, observe clinical symptoms, statistics is respectively organized cure rate and mortality rate.Result such as following table 1:
The above results shows: the Pullorum Disease cure rate that a kind of drug regimen for the treatment of the animal alimentary canal pathogenic bacterial infection of the present invention causes coli-infection is significantly higher than gentamycin and furazolidone treatment group, and mortality rate then significantly is lower than gentamycin and furazolidone treatment group.
Clinical practice example 2
The pig farm, Shandong, fervescence to 40. 5～41. 5 ℃ appear in part 30 age in days left and right sides ablactational baby pig, spirit is depressed, and loss of appetite flocks together, dysentery after the sick constipation just, feces is faint yellow or celadon, and stench is mixed with blood, slough fragment, by the thick random symptom of hair, tentative diagnosis is a hog cholera.Be diagnosed as Salmonella choleraesuls through the laboratory isolation identification and infect, drug sensitive test detects and shows that the Salmonella that causes morbidity reduces oxytetracycline and enrofloxacin sensitivity.Choose 30 of disease piglets, be divided into 3 groups at random, 10 every group, be respectively oxytetracycline treatment group, enrofloxacin treatment group and treatment group of the present invention (medicine that uses embodiment 1 to make).After the medication 7 days, observe clinical symptoms, statistics is respectively organized cure rate and mortality rate.Result such as following table 2:
The above results shows: the hog cholera cure rate that a kind of drug regimen antagonism property of medicine Salmonella infection for the treatment of the animal alimentary canal pathogenic bacterial infection of the present invention causes is significantly higher than oxytetracycline and enrofloxacin group, and mortality rate then significantly is lower than oxytetracycline and enrofloxacin treatment group.
Clinical practice example 3
270 of 13 Japanese instar chicklings are divided into 9 groups at random, 30 every group.The artificial challenge escherichia coli organize respectively after 2 days that flocking together generally appears in chickling, few food, spirit are depressed, draw white or water sample loose stool symptom, are defined as colibacillosis through laboratory diagnosis and send out.With gentamycin, furazolidone, enrofloxacin, embodiment 2, embodiment 3, embodiment 4, embodiment 5, embodiment 6, embodiment 7 treatments, medication was observed and is respectively organized clinical symptoms after 5 days, statistics mortality rate, cure rate respectively.Result such as following table 3:
As can be seen from the above table, medicine of the present invention all has notable therapeutic effect to chicken digestive tract cause of disease bacterium, and cure rate is far above existing antibacterials.
Clinical practice example 4
90 of 25 age in days piglets are divided into 9 groups at random, 10 every group.The artificial challenge escherichia coli organize respectively after 3 days that fever generally appears in piglet, depressed, the appetite of spirit descends, draws yellow or field gray loose stool symptom, are defined as colibacillosis through laboratory diagnosis and send out.With gentamycin, oxytetracycline, embodiment 2, embodiment 3, embodiment 4, embodiment 5, embodiment 6, embodiment 7 treatments, medication was observed and is respectively organized clinical symptoms after 5 days, statistics mortality rate, cure rate respectively.Result such as following table 4:
As can be seen from the above table, medicine of the present invention all has notable therapeutic effect to the swine alimentary canal pathogen, and cure rate is far above existing antibacterials.
Claims (8)
1. an animal is used antibacterials, it is characterized in that: effective ingredient is an enrofloxacin and through the Folium Artemisiae Argyi extract of water extract-alcohol precipitation gained, and contents of enrofloxacin is 1-10wt%, and the content of Folium Artemisiae Argyi extract is 5-20wt%.
2. animal according to claim 1 is used antibacterials, it is characterized in that comprising following components in weight percentage:
Enrofloxacin 1-10%;
Folium Artemisiae Argyi extract 5-20%;
Cosolvent 5%;
The adjuvant surplus.
3. animal according to claim 2 is used antibacterials, it is characterized in that: described cosolvent is sodium bicarbonate, citric acid or nicotinic acid.
4. animal according to claim 2 is used antibacterials, it is characterized in that: described adjuvant is one or both in glucose, lactose, sucrose and the water soluble starch.
5. animal according to claim 1 is used antibacterials, it is characterized in that the preparation method of described Folium Artemisiae Argyi water extract is:
(1) Folium Artemisiae Argyi is decocted 3h with 7 quality times water down at 115 ℃;
(2) adding dehydrated alcohol to mixed liquor in the aqueous extract after decoction, to contain the alcohol amount be 60%, then mixed liquor left standstill 12h under 4 ℃;
(3) mixed liquor after will leaving standstill is crossed the leaching supernatant, then the supernatant heating is concentrated to remove and anhydrates and alcohol, again 60 ℃ of vacuum-0.09MPa, temperature down dry 1-2h get Folium Artemisiae Argyi extract.
6. use antibacterials according to each described animal among the claim 2-5, it is characterized in that comprising following components in weight percentage:
Enrofloxacin 5%;
Folium Artemisiae Argyi water extract 10%;
Cosolvent 5%;
Adjuvant 80%.
7. each described animal is characterized in that may further comprise the steps with the preparation method of antibacterials among the claim 2-5:
(1) Folium Artemisiae Argyi is decocted 3h with 7 quality times water down at 115 ℃;
(2) adding dehydrated alcohol to mixed liquor in the aqueous extract after decoction, to contain the alcohol amount be 60%, then mixed liquor left standstill 12h under 4 ℃;
(3) mixed liquor after will leaving standstill is crossed the leaching supernatant, then the supernatant heating is concentrated to remove and anhydrates and alcohol, again 60 ℃ of vacuum-0.09MPa, temperature down dry 1-2h get Folium Artemisiae Argyi extract;
(4) above-mentioned Folium Artemisiae Argyi extract, enrofloxacin, cosolvent and adjuvant were pulverized 40 mesh sieves, promptly got these antibacterials according to the proportioning mix homogeneously.
8. each described animal is characterized in that: add this medicine 50-100mg in every liter of animal drinking-water with antibacterials application in treatment animal alimentary canal pathogenic bacterial infection among the claim 1-5.
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| CN 201010506060 CN101953871B (en) | 2010-10-14 | 2010-10-14 | Antibacterial medicament for animals and preparation method and application thereof |
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| CN 201010506060 CN101953871B (en) | 2010-10-14 | 2010-10-14 | Antibacterial medicament for animals and preparation method and application thereof |
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| CN101953871A true CN101953871A (en) | 2011-01-26 |
| CN101953871B CN101953871B (en) | 2012-05-23 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102697734A (en) * | 2012-05-31 | 2012-10-03 | 太原市康瑞宝兽药制造有限公司 | Method for preparing water-soluble metronidazole |
| CN104666878A (en) * | 2015-03-11 | 2015-06-03 | 四川成康动物药业有限公司 | Drug formula for preventing and treating chronic PRDC (porcine respiratory disease complex) |
| CN109464482A (en) * | 2018-12-07 | 2019-03-15 | 徐州生物工程职业技术学院 | For preventing and treating the compound enrofloxacin capsulae enterosolubilis and preparation method of piglet yellow-white dysentery |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101612204A (en) * | 2009-07-21 | 2009-12-30 | 东北农业大学 | Medicament-resistant inhibitor for porcine streptococcus |
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2010
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101612204A (en) * | 2009-07-21 | 2009-12-30 | 东北农业大学 | Medicament-resistant inhibitor for porcine streptococcus |
Non-Patent Citations (2)
| Title |
|---|
| 《中国兽医杂志》 20081231 苑丽，等 黄连和黄芩与氟喹诺酮类联用对鸡大肠杆菌的体外抗菌作用 第52-53页 1-8 第44卷, 第11期 2 * |
| 《中国药师》 20091231 刘魏，等 艾叶水提液的体外抗菌试验 第1159-1160页 1-8 第12卷, 第8期 2 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102697734A (en) * | 2012-05-31 | 2012-10-03 | 太原市康瑞宝兽药制造有限公司 | Method for preparing water-soluble metronidazole |
| CN104666878A (en) * | 2015-03-11 | 2015-06-03 | 四川成康动物药业有限公司 | Drug formula for preventing and treating chronic PRDC (porcine respiratory disease complex) |
| CN104666878B (en) * | 2015-03-11 | 2018-10-09 | 四川成康动物药业有限公司 | A kind of medicament composing prescription for preventing pig chronic respiratory syndrome |
| CN109464482A (en) * | 2018-12-07 | 2019-03-15 | 徐州生物工程职业技术学院 | For preventing and treating the compound enrofloxacin capsulae enterosolubilis and preparation method of piglet yellow-white dysentery |
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| CN101953871B (en) | 2012-05-23 |
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