CN102488767B - Compound composition for treating bacterial diarrhoea of livestock and poultry - Google Patents
Compound composition for treating bacterial diarrhoea of livestock and poultry Download PDFInfo
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- CN102488767B CN102488767B CN 201110444381 CN201110444381A CN102488767B CN 102488767 B CN102488767 B CN 102488767B CN 201110444381 CN201110444381 CN 201110444381 CN 201110444381 A CN201110444381 A CN 201110444381A CN 102488767 B CN102488767 B CN 102488767B
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a sticktight-containing compound composition for treating bacterial diarrhoea of livestock and poultry. The compound composition is characterized by comprising raw materials of, by weight, 3-15 parts of lactic acid ciprofloxacin, 0.02-0.2 part of atropine sulfate, 20-70 parts of sticktight, 20-40 parts of rhizoma atractylodis, 8-20 parts of dark plum and 5-10 parts of myrobalan. The compound composition is prepared by mixing well the raw materials according to the proportion. An addition into an animal fodder is 0.1%-0.8%. The composition of the invention can kill bacteria rapidly and alleviate diarrhoea symptom caused by bacteria rapidly, has good protective effect on intestinal tract and overcomes disadvantages of a simple western medicine, such as long curative effect, weak curative effect, slow symptom alleviation and disadvantage of slow effect performance of a simple traditional Chinese medicine; besides, usage of the composition has low medicine cost and creates high benefit for farmers. The composition can be prepared into a powder, an oral liquid, a particulate agent and a tablet.
Description
Technical field
The present invention relates to a kind of compound for the treatment of fowl bacterial diarrhoea.
Background technology
Along with the development of animal husbandry, the expansion of cultivation scale, antibiotic random use and arbitrarily adding in the spreading unchecked of raiser's medication, breeding process, cause antibacterial to produce stronger drug resistance to medicine.In addition along with the interpolation of antimicrobial drug in feedstuff; intestinal microbial population in the poultry body has also suffered larger destruction; and cultivated a large amount of drug resistance harmful bacterias; therefore fowl bacterial diarrhoea often occurs in aquaculture; the speed of growth and the price of deed of animal have been had a strong impact on; the diarrhoea severe patient even causes dehydration dead; this disease has caused larger economic loss to the raiser, people in the urgent need to curative effect better, rapid recovery symptom, the medicine that has better protective effect especially can treat the livestock and poultry diarrhea that drug tolerant bacteria causes to intestinal treated.
To fowl bacterial diarrhoea people, adopt antimicrobial drug to be treated at present more, the effect of antimicrobial drug is only antibiotic, but the symptom of the pathological changes such as the intestinal mucosa that causes for antibacterial comes off, intestinal walls is poor, intestinal absorption ability and serious dehydration is helpless.In antimicrobial drug when treatment, easily produce drug resistance in addition, therapeutic effect is undesirable, administration time is long, and even diarrhoea seriously causes dehydration death.Therefore, suddenly wait to need a kind of such product in actual production, this product can be very fast kill pathogenic bacteria, the damage that pathogenic bacteria can be caused body is again carried out well repairing and the rapid recovery symptom of diarrhea, can to livestock and poultry diarrhea, comparatively fast cure faster like this, being unlikely to affect the speed of growth and dehydration death, is that the raiser creates higher economic benefit.
Summary of the invention
The purpose of this invention is to provide a kind of compound for the treatment of fowl bacterial diarrhoea; said composition is killing bacteria faster; can alleviate faster bacterial symptom of diarrhea again simultaneously; intestinal is had to protective effect preferably, overcome western medicine weak curative effect, curative effect length, relief of symptoms shortcoming slowly.
In order to meet the urgent demand of social production, the present invention is achieved through the following technical solutions above-mentioned purpose:
A kind of compound for the treatment of fowl bacterial diarrhoea is characterized in that the material composition of this complex and weight ratio thereof are:
3～15 parts of ciprofloxacin lactate, 0.02～0.2 part of atropine sulfate, 20～70 parts of Herba Bidentis Bipinnatae, 20～40 parts of Rhizoma Atractylodis, 8～20 parts of Fructus Mumes, 5～10 parts of Fructus Chebulaes.
Compound method is:
Get each material composition by described weight part ratio, mix and make compound.
The addition of compound in animal feed is: 1 ‰～8 ‰.
In the present invention, each medicine has following effect:
1, ciprofloxacin lactate is fluoroquinolones, belongs to the broad spectrum antibiotic of chemosynthesis, and this medicine belongs to the desirable antibacterials that price is lower, drug resistance is relatively less in all antimicrobial drugs in treatment diarrhoea at present; The sensitivity of this medicine is that applicant's process is separated livestock and poultry diarrhea case 480 examples, and by Susceptibility Test Analysis, this medicine of antimicrobial drug of equal price is the most responsive medicine.In the present composition, this medicine can be killed cause of disease fast, removes endogenous cause of ill, has reached the simple effect that can not suppress fast pathogenic bacteria with Chinese medicine;
2, atropine sulfate, belong to cholinolytic class medicine, can be combined with the M cholinoceptor, removes the muscarine-like effect of acetylcholine and other cholinomimetic.These product are used spasm, the inhibition glandular secretion by removing smooth muscle to be used for reducing intestinal peristalsis promoting in the diarrhoea case, alleviate symptom of diarrhea, avoid the appearance of poultry dehydration phenomenon as far as possible.Atropine also has excited respiratory center, makes the effects such as palpitating speed in addition, can complementaryly slow down the appearance of animal shock symptom;
3, Fructus Mume, have the astringing intestine to stop diarrhea of astringing the lung, promoting the production of body fluid to quench thirst, anthelmintic action, especially relieving diarrhea with astringents, Fructus Mume is better to chronic diarrhea chronic dysentery effect action effect, and this product alleviation to symptom of diarrhea in prescription has good therapeutic effect, with the Fructus Chebulae be that mutual reinforcement between is use, the two is use also, better the antidiarrheal dysentery relieving;
4, Fructus Chebulae, have relieving diarrhea with astringents, astringing lung-QI and relieving cough effect, and especially to the chronic diarrhea chronic dysentery, the damp and hot symptom effect of intestine and small intestine is better;
5, Rhizoma Atractylodis, gas is fragrant hot strong, and bitter warm nature is dry, can disperse and induce sweat again, there is the dehumidifying function of invigorating spleen, The spleen has the function to transport and transform nutrients, likes dry evil wet, and livestock and poultry diarrhea is generally the tired spleen of turbid damp, cause transporting and transforming function of the spleen and stomach mistake department to cause stomachache to be had loose bowels, therefore wet and dampness and spleen invigorating with the hot sweetening treatment of Rhizoma Atractylodis in this compositions, the function of recovering that The spleen has the function to transport and transform nutrients, contribute to antidiarrheal and recover appetite;
6, Herba Bidentis Bipinnatae, be widely distributed in the torrid zone and Temperate Region in China, is traditional herbal medicine, and source, than horn of plenty, very easily gathers, and this medicine is bitter, flat, nontoxic.There is heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling.There is sterilization, hepatoprotective effect, cure mainly the diseases such as malaria, diarrhoea, dysentery, hepatitis, acute nephritis, stomachache, especially ulcerative enteritis, ulcer diarrhoea are had to good therapeutic effect.Among the people in China, Herba Bidentis Bipinnatae often is used for the treatment of infantile diarrhea, acute gastroenteritis and bacillary dysentery, high blood pressure disease.
The compositions that the present invention makes, better to the effect of fowl bacterial diarrhoea curative effect, and drug cost is lower, can be the raiser and creates the more efficient benefit.
the specific embodiment:
The raw material of Chinese medicine Herba Bidentis Bipinnatae of this compound, Rhizoma Atractylodis, Fructus Mume, Fructus Chebulae, after pulverizing 60 mesh sieves, become basic material, with pulverous ciprofloxacin lactate, atropine sulfate by weight ratio get each raw material and put into blender and mix and get final product.In practice the raw material of following percentage by weight has been done to following experiment:
3～5 parts of ciprofloxacin lactate, 0.02～0.2 part of atropine sulfate, 50～70 parts of Herba Bidentis Bipinnatae, 10～30 parts of Rhizoma Atractylodis, 8～15 parts of Fructus Mumes, 5～10 parts of Fructus Chebulaes; Addition in animal and fowl fodder is 5～8 ‰;
4～10 parts of ciprofloxacin lactate, 0.02～0.2 part of atropine sulfate, 40～60 parts of Herba Bidentis Bipinnatae, 20～40 parts of Rhizoma Atractylodis, 10～20 parts of Fructus Mumes, 8～15 parts of Fructus Chebulaes; Addition in animal and fowl fodder is 3～6 ‰;
8～15 parts of ciprofloxacin lactate, 0.02～0.2 part of atropine sulfate, 35～50 parts of Herba Bidentis Bipinnatae, 20～40 parts of Rhizoma Atractylodis, 7～15 parts of Fructus Mumes, 6～9 parts of Fructus Chebulaes; Addition in animal and fowl fodder is 1～5 ‰;
7 parts of ciprofloxacin lactate, 0.1 part of atropine sulfate, 37 parts of Herba Bidentis Bipinnatae, 30 parts of Rhizoma Atractylodis, 16 parts of Fructus Mumes, 10 parts of Fructus Chebulaes; Addition in animal and fowl fodder is 3 ‰.
The compound that each material rate group is drawn, be applied to zoopery and find, in the material rate scope of technical scheme respectively to organize the impact that compound produces animal close.So, below the compound preparation that draws with above-mentioned each material rate group of compositions general designation do the embodiment explanation.
embodiment 1
The Efficacy of compound to the Pullorum Disease disease:
Clinical symptoms: the Guangxi Yulin chicken house, 10 Day-old Broiler Chickens, the chicken group draws white feces, and the part chicken is stuck with paste anus by feces, and indivedual chickens sound all the time, and occur fragmentary dead.
Cut open the inspection pathological changes: the chicken that dies of illness dehydration is more serious, and visible eyes sink, and toe is withered, hepatomegaly, hyperemia, but the downright bad point of the liver adularescent of part chicken.
Laboratory diagnosis: get pathologic liver and dye sheet, Gram’s staining, micro-Microscopic observation, the gram negative bacilli of red color visible; Tentatively be judged as the Salmonella disease.By the distinctive coagulation experiment of Salmonella, the judgement chicken infects for the Salmonella disease.
Therapeutic regimen: morbidity chicken group administration in two batches, first uses above-mentioned compound, by 5 ‰ administrations, is used in conjunction 5 days, and second batch ofloxacin powder, by 5 ‰ administrations, is used in conjunction 5 days.
The result of use feedback: with this compound, after 2 days, sick chicken is no longer drawn white feces, and feed intake rises, and dead chicken no longer occurs, continues to use 2 days, and chicken the group be almost recovered; But use a collection of chicken of folk prescription ofloxacin, medication is after 2 days, and chicken group majority is substantially healthy, but still draws individually white feces, continues to use 2 days, substantially gets well, but drug withdrawal is after 5 days, and recurrence appears in the chicken group.The visible compound curative effect that contains Herba Bidentis Bipinnatae is better than folk prescription.
embodiment 2
The Efficacy of compound to diarrhea of weaned piglets:
Clinical symptoms: pig farm, Nanning, 36 age in days ablactational baby pig, this swinery after wean is turn-taked, starts diarrhoea to occur, draws watery stools, feces contains indigested feedstuff, pig is material feeding but is exactly not grow, and indivedual serious diarrhea of pigs dehydrations are dead, symptoms of emesis do not occur, the raiser uses multi-medicament, and ideal effect does not all appear in treatment.
Cut open the inspection pathological changes: the pig that dies of illness dehydration is more serious, and visible eyes sink, cut open inspection after the Intestinum Sus domestica wall poor, especially small intestinal rear end and colon position, intestinal mucosa comes off, intestinal wall is congested, hemorrhage.
Therapeutic regimen: the administration in two batches of morbidity swinery, first uses above-mentioned compound, by 5 ‰ administrations, is used in conjunction 5 days, and second batch ofloxacin powder, by 5 ‰ administrations, is used in conjunction 5 days.
The result of use feedback: with this compound, after 3 days, swinery is no longer drawn watery stools, and feces is shaped, and no longer contains feedstuff in feces, continues to use 2 days the swinery recovery from illness; But use a collection of pig of folk prescription ofloxacin, medication is after 3 days, and swinery is substantially healthy, but still draws individually pasty state feces, continues to use 2 days, substantially gets well, but drug withdrawal is after 6 days, and recurrence appears in swinery.The visible compound that contains Herba Bidentis Bipinnatae is better than folk prescription ofloxacin medicine to the swinery curative effect.
embodiment 3
The observation of curative effect of compound to the meat-type duck diarrhoea of 20 ages in days:
Clinical symptoms: duck field, Nanning, 20 age in days meat-type duck, the duck group draws watery stools, and obvious indigested feedstuff is arranged in feces.A duck group material feeding is not but long, and the serious duck appearance foot gradually of suffering from diarrhoea individually is soft slowly dead.
Cut open the inspection pathological changes: the duck that dies of illness dehydration is more serious, and indivedual ducks are still very large, duck liver enlargement, hyperemia, and adularescent film on the liver of part duck, the air bag muddiness, tentative diagnosis is escherichia coli or duck oromeningitis.
Therapeutic regimen: morbidity duck group administration in two batches, first uses above-mentioned compound, by 5 ‰ administrations, is used in conjunction 5 days, and second batch ofloxacin powder, by 5 ‰ administrations, is used in conjunction 5 days.
The result of use feedback: with this compound, after 2 days, sick duck is no longer drawn watery stools, and feces is shaped, and dead duck no longer occurs, continues to use 3 days, and duck the group be almost recovered; But use a collection of duck of folk prescription ofloxacin, medication is after 2 days, duck group DeGrain, much still draw watery stools, contain indigested feedstuff, continue to use 3 days, some improvement a little, but not good thorough, rare watery stools still occurs, the raiser can't drug withdrawal to this batch of duck, have to use compound instead, continue to use 2 days, just be almost recovered, re-use 1 day, feces all transfers to normally.The visible compound that contains Herba Bidentis Bipinnatae is better than folk prescription to the curative effect of duck diarrhoea.
Claims (7)
1. one kind contains the compound that Herba Bidentis Bipinnatae treatment fowl bacterial is suffered from diarrhoea, and it is characterized in that the material composition of this compound and weight ratio thereof are:
3～15 parts of ciprofloxacin lactate, 0.02～0.2 part of atropine sulfate, 20～70 parts of Herba Bidentis Bipinnatae, 20～40 parts of Rhizoma Atractylodis, 8～20 parts of Fructus Mumes, 5～10 parts of Fructus Chebulaes;
Compound method is:
Get each material composition by described weight ratio, mix and make compound.
2. compositions according to claim 1, its dosage form is powder, tablet, oral liquid, granule.
3. compositions according to claim 1 is characterized in that:
The addition of described compositions in animal and fowl fodder is: 1～8 ‰.
4. compound according to claim 1 is characterized in that the material composition of said composition and weight ratio thereof are:
3～5 parts of ciprofloxacin lactate, 0.02～0.2 part of atropine sulfate, 50～70 parts of Herba Bidentis Bipinnatae, 20～30 parts of Rhizoma Atractylodis, 8～15 parts of Fructus Mumes, 5～10 parts of Fructus Chebulaes; The addition of said composition in animal and fowl fodder is 5～8 ‰.
5. compound according to claim 1 is characterized in that the material composition of said composition and weight ratio thereof are:
4～10 parts of ciprofloxacin lactate, 0.02～0.2 part of atropine sulfate, 40～60 parts of Herba Bidentis Bipinnatae, 20～40 parts of Rhizoma Atractylodis, 10～20 parts of Fructus Mumes, 8～10 parts of Fructus Chebulaes; The addition of said composition in animal and fowl fodder is 3～6 ‰.
6. compound according to claim 1 is characterized in that the material composition of said composition and weight ratio thereof are:
8～15 parts of ciprofloxacin lactate, 0.02～0.2 part of atropine sulfate, 35～50 parts of Herba Bidentis Bipinnatae, 20～40 parts of Rhizoma Atractylodis, 8～15 parts of Fructus Mumes, 6～9 parts of Fructus Chebulaes; The addition of said composition in animal and fowl fodder is 1～5 ‰.
7. compound according to claim 1 is characterized in that the material composition of said composition and weight ratio thereof are:
7 parts of ciprofloxacin lactate, 0.1 part of atropine sulfate, 37 parts of Herba Bidentis Bipinnatae, 30 parts of Rhizoma Atractylodis, 16 parts of Fructus Mumes, 10 parts of Fructus Chebulaes; The addition of said composition in animal and fowl fodder is 3 ‰.
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| CN 201110444381 CN102488767B (en) | 2011-12-27 | 2011-12-27 | Compound composition for treating bacterial diarrhoea of livestock and poultry |
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| CN 201110444381 CN102488767B (en) | 2011-12-27 | 2011-12-27 | Compound composition for treating bacterial diarrhoea of livestock and poultry |
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| CN103721240B (en) * | 2013-12-20 | 2015-07-08 | 湖南泰谷生物科技股份有限公司 | Compound formulation for treating bacterial infection of digestive tract of livestock and poultry and preparation method of compound formulation |
| CN105309842A (en) * | 2015-11-24 | 2016-02-10 | 广州聚注专利研发有限公司 | Fish feed additive and preparation method thereof |
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| CN1051300A (en) * | 1989-10-28 | 1991-05-15 | 李庆东 | A kind of method that Herba Bidentis Bipinnatae is manufactured oral liquid |
| CN1305491C (en) * | 2004-02-12 | 2007-03-21 | 贵州联盛药业有限公司 | Chinese medicinal composition for treating irritable bowel syndrome and its preparation method |
| CN101209320A (en) * | 2006-12-25 | 2008-07-02 | 天津市润拓生物技术有限公司 | Chinese medicinal granule with heat-clearing and detoxication, hydrops-eliminating and mass-dissipating efficacy |
| CN101548996B (en) * | 2009-05-19 | 2011-06-22 | 河南牧翔动物药业有限公司 | Compound poplar flower oral liquor and preparation method |
| KR101125482B1 (en) * | 2009-11-09 | 2012-03-19 | 이화숙 | Composition for preventing and treating nose disease comprising extract of Star anis and aroma oil as active ingredients |
| CN101698011B (en) * | 2009-11-23 | 2011-11-30 | 赵志敏 | Medicine for treating epidemic diarrhea of livestock and poultry |
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Effective date of registration: 20160513 Address after: 530100 the Guangxi Zhuang Autonomous Region Nanning Yilin Industrial Zone No. B-9 (Wuming) Patentee after: GUANGXI NANNING TAOYUAN VETERINARY DRUG FACTORY Address before: 530104 the Guangxi Zhuang Autonomous Region Nanning Yilin Industrial Zone No. B-9 Patentee before: Zhang Chaohui |
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Denomination of invention: The invention relates to a compound composition containing Bidens bipinnata for treating bacterial diarrhea of livestock and poultry Effective date of registration: 20210111 Granted publication date: 20131225 Pledgee: Guangxi Beibu Gulf Bank Limited by Share Ltd. small business financial services center Pledgor: GUANGXI NANNING TAOYUAN VETERINARY DRUG FACTORY Registration number: Y2021450000002 |
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